| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2008: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Research Abstract |
In this study we took particular note of neurogenesis in the adult hippocampus as molecular basis of stress vulnerability in the brain. In vitro studies using adult rat dentate gyrus-derived precursor cells (ADP) were done to see the direct effects of antidepressants, mood stabilizers and monoamines on them. Among them, mood stabilizers, noradrenaline, and dopamine had some effects in the aspect the proliferation, apoptosis, and differentiation. In addition we found out the involvement of CaMKIV in the action of antidepressants through neurogenesis. All these findings will contribute to make novel antidepressants.
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