Predictors of side effects induced by second generation antipsychotics
| Project/Area Number |
20591362
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Psychiatric science
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| Research Institution | Niigata University |
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Principal Investigator |
SUZUKI Yutaro (2009-2010) Niigata University, 医歯学総合病院, 講師 (60377158)
澤村 一司 (2008) Niigata University, 医歯学総合病院, 助教 (60444155)
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| Co-Investigator(Kenkyū-buntansha) |
SAWAMURA Kazushi 新潟大学, 医歯学総合病院, 助教 (60444155)
SOMEYA Toshiyuki 新潟大学, 医歯学系, 教授 (50187902)
鈴木 雄太郎 新潟大学, 医歯学総合病院, 講師 (60377158)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2010: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2009: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2008: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | 臨床精神薬理 / 抗精神病薬 / 副作用 / 薬遺伝学 / 第2世代抗精神病薬 / 糖脂質代謝異常 / 高プロラクチン血症 / QT延長 / アデイポカイン / 臨床効果 / ゲノム / 新規抗精神病薬 |
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| Research Abstract |
1) Dysregulation of the adipocytokines may have already occurred before subjects undergoing treatment with second-generation antipsychotic agents exhibit impaired fasting glucose.
2) 9-OH-risperidone (RIS) is considered to play a more important role in prolactin (PRL) elevation than RIS, and a gender difference exists in the effect of 9-OH-RIS on PRL level.
3) The mean QTcF in the RIS group was significantly longer than that of the olanzapine and control groups during nighttime.
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Report
(4 results)
Research Products
(75 results)
