| Project/Area Number |
20591363
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Psychiatric science
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| Research Institution | University of Toyama |
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Principal Investigator |
KURACHI Masayoshi University of Toyama, 理事・副学長 (80019603)
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| Co-Investigator(Kenkyū-buntansha) |
UEHARA Takashi 富山大学, 附属病院神経精神科, 講師 (70303229)
TSUNODA Masahiko 富山大学, 附属病院神経精神科, 講師 (30322762)
SUMIYOSHI Tomiki 富山大学, 医学薬学研究部(医学)・神経精神医学講座, 准教授 (80286062)
KAWAWAKI Yasuhiro 金沢医科大学, 神経精神医学講座, 教授 (80242519)
SUZUKI Michio 富山大学, 医学薬学研究部(医学)・神経精神医学講座, 教授 (40236013)
TABUCHI Akiko 富山大学, 医学薬学研究部(薬学)・分子神経生物講座, 准教授 (40303234)
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| Co-Investigator(Renkei-kenkyūsha) |
TOHDA Chihiro 富山大学, 和漢医薬学総合研究所, 准教授 (10272931)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2010: ¥390,000 (Direct Cost: ¥300,000、Indirect Cost: ¥90,000)
Fiscal Year 2009: ¥390,000 (Direct Cost: ¥300,000、Indirect Cost: ¥90,000)
Fiscal Year 2008: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
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| Keywords | 前頭葉 / 遺伝子発現 / 思春期 / MK-801 / prepulse inhibition / 統合失調症 |
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| Research Abstract |
Age-dependent changes of gene expression in the prefrontal cortex (PFC) of rats around the time of puberty were investigated by means of microarray and quantitative polymerase chain reaction (qPCR). About 127 and 138 genes were increased and decreased, respectively, in the PFC of rats at post-puberty (PD56) compared with those at pre-puberty (PD35). Functional analysis showed significant associations of these genes with aging, cellular development, and neuropsychological disorders. qPCR analysis confirmed down-regulation of seven genes related to myelination. As these genes have been reported to be diminished in the brain of patients with schizophrenia, the results of this study suggest an exaggerated maturation process may contribute to the pathogenesis of psychotic disorders.
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