| Project/Area Number |
20591371
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Psychiatric science
|
|---|
| Research Institution | Oita University |
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Principal Investigator |
AKIYOSHI Jotaro Oita University, 医学部, 准教授 (00159344)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
HANADA Hiroaki 大分大学, 医学部, 助教 (80444884)
TANAKA Yoshihiro 大分大学, 医学部, 医員 (60516102)
ISHITOBI Yoshinobu 大分大学, 医学部, 医員 (40516118)
児玉 健介 大分大学, 医学部, 助教 (60398261)
松下 裕貴 大分大学, 医学部, 助教 (70448546)
|
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| Project Period (FY) |
2008 – 2010
|
| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2008: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 不安障害 / 不安 / obestatin / GPR39 / アンチセンス / レセプター |
|---|
| Research Abstract |
Stomach secretes ghrelin, and brain also doses it. Ghrelin have reported to be associated with depression, anxiety and eating behavior. GPR39 is a receptor for ghrelin. We examined the relationship between obestatin, depression, anxiety and eating behavior. We GPR39-1b antisense oligonucleotides were infused at a constant rate into the cerebral lateral ventricles of rats and their effect on anxiety and food intake was monitored. GPR39-1b antisense oligonucleotides produced anxiolytic-like effects in the elevated-plus maze test, and in the black and white test. GPR39-1b antisense oligonucleotides decreased food intake. These results indicate that inhibition of GPR39-1b induces a decrease in anxiety-related behaviors and disturbs appetite.
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