| Project/Area Number |
20591373
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Psychiatric science
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| Research Institution | Sapporo Medical University |
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Principal Investigator |
HASHIMOTO Eri Sapporo Medical University, 医学部, 准教授 (30301401)
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| Co-Investigator(Kenkyū-buntansha) |
UKAI Wataru 札幌医科大学, 医学部, 講師 (40381256)
YAMADA Misa 国立精神・神経医療研究センター, 精神保健研究所, 研究員 (10384182)
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| Co-Investigator(Renkei-kenkyūsha) |
WATANABE Kimihiko 札幌医科大学, 医学部, 研究員 (70464493)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2008: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 神経科学 / 脳・神経 / うつ病 / 神経新生 / BDNF / 抗うつ薬 / 血小板 / 末梢血 |
|---|
| Research Abstract |
We analyzed the influence of antidepressants on platelet BDNF release in rats. BDNF was dose-dependently released from platelets by direct treatment with various kinds of antidepressants in vitro. Sertraline-induced BDNF release from platelets was reduced in the presence of TrkB inhibitor, K252a in a rat model of depression compared with control rats. We also investigated neuroserpin expression in adult rat SGZ and found that neuroserpin may play some roles in early stage of neurogenesis in adult rat hippocampus.
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