The new therapeutic approach for schizophrenia treatment-study of the combined therapy using drug and cells-
| Project/Area Number |
20591374
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Psychiatric science
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| Research Institution | Sapporo Medical University |
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Principal Investigator |
UKAI Wataru Sapporo Medical University, 医学部, 講師 (40381256)
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| Co-Investigator(Kenkyū-buntansha) |
HASHIMOTO Eri 札幌医科大学, 医学部, 准教授 (30301401)
TATENO Masaru 札幌医科大学, 医学部, 講師 (60464492)
YOSHINAGA Toshihiro 札幌医科大学, 医学部, 助教 (70404704)
ONO Takafumi 札幌医科大学, 医学部, 研究員 (50438024)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2008: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 精神薬理学 / 脳・神経 / 神経科学 / 再生医学 / 神経幹細胞 / 胎児性アルコール症候群 / 精神疾患 / 統合失調症 / 抗精神病薬 / 細胞療法 |
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| Research Abstract |
We constructed schizophrenia model rat by injection of Poly (I:C) in the maternal period. Animals in the Poly (I:C) treatment group showed a significant memory/cognitive impairment and social dysfunction in each behavioral test and intravenous neural stem cell transplantation suppressed these behavioral abnormalities toward control levels. The transplanted marked neural stem cells were detected in the various brain regions including cingulated cortex, hippocampus and amygdale over 6 months after the intravenous injection. Specifically, we detected the transplanted neural stem cells in hippocampus and amygdale which were positive with GAD protein suggesting the successful differentiation of transplanted cells into GABAergic neurons in these areas. Moreover, it was demonstrated that combined treatment of antipsychotic olanzapine promoted the migration/survival of transplanted neural stem cells in the brain.
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Report
(4 results)
Research Products
(104 results)
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[Journal Article] Effect of antidepressants on brain-derived neurotrophic factor (BDNF) release from platelets in the rats.2010
Author(s)
渡邊公彦, 橋本恵理, 鵜飼渉, 石井貴男, 吉永敏弘, 小野貴文, 館農勝, 渡邉一平, 白坂知彦, 齋藤諭, 齋藤利和
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Journal Title
Prog Neuropsychopharmacol Biol Psychiatry 34
Pages: 1450-1454
Related Report
Peer Reviewed
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[Presentation] 末梢BDNFの体内動態を解明する2010
Author(s)
渡邊公彦, 橋本恵理, 鵜飼渉, 吉永敏弘, 館農勝, 渡邉一平, 白坂知彦, 金田博雄, 木川昌康, 五十嵐健史, 齋藤利和
Organizer
第29回躁うつ病の薬理・生化学的研究懇話会
Place of Presentation
箱根
Year and Date
2010-06-18
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[Presentation] The Change of Brain-Derived Neurotrophic Factor and TrkB Receptor on Platelet in Depression.2010
Author(s)
Saito T, Hashimoto E, Ukai W, Watanabe K, Watanabe I, Shirasaka T, Kaneta H, Kigawa M, Yoshinaga T, Tateno M, Park T, Ishii T
Organizer
49th ACNP
Place of Presentation
Florida
Related Report
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[Presentation] The possible implicasion of TLX on the regulation of impulsive behavior : focusing on the neural stem cell dysfunctions by TLX change.2010
Author(s)
Ukai W, Watanabe I, Hashimoto E, Watanabe K, Shirasaka T, Kaneta H, Kigawa M, Ono T, Ishii T, Yoshinaga T, Tateno M, Kobayashi S, Saito T
Organizer
40th Neuroscience
Place of Presentation
San Diego
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[Presentation] The change of brain-derived neurotrophic factor (BDNF) and tyrosine kinase B (TrkB) receptor on platelet in depression.2010
Author(s)
渡邊公彦, 橋本恵理, 鵜飼渉, 石井貴男, 吉永敏弘, 館農勝, 渡邉一平, 白坂知彦, 金田博雄, 木川昌康, 齋藤利和
Organizer
17th CINP
Place of Presentation
Hong Kong
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[Presentation] (シンポジウム) ストレスによる脳神経回路網変異-障害と修復の分子メカニズム-2009
Author(s)
鵜飼渉, 橋本恵理, 吉永敏弘, 白坂知彦, 石井貴男, 館農勝, 小野貴文, 渡邊公彦, 渡邉一平, 齋藤利和
Organizer
第25回日本ストレス学会学術総会,第27回日本青年期精神療法学会総会合同大会
Place of Presentation
横浜
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[Presentation] How do ethanol and depression impair neural stem cell? Dysregulation of CREB, NRSF/REST and TLX.2009
Author(s)
石井貴男, 鵜飼渉, 吉永敏弘, 館農勝, 小野貴文, 渡邊公彦, 渡邉一平, 白坂知彦,橋本恵理, 齋藤利和
Organizer
39th SfN
Place of Presentation
Chicago
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[Presentation] (シンポジウム) 精神疾患に対する幹細移植療法の可能性に関する研究2008
Author(s)
鵜飼渉, 吉永敏弘, 石井貴男, 橋本恵理, 小野貴文, 館農勝, 渡邉公彦, 渡邉一平, 白坂知彦, 向裕加, 齋藤諭, 齋藤利和
Organizer
第51回日本神経化学会
Place of Presentation
富山
Year and Date
2008-09-12
Related Report
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[Presentation] 神経細胞および神経幹細胞ダメージに対する外来性神経幹細胞の効果2008
Author(s)
小野貴文, 鵜飼渉, 石井貴男, 吉永敏弘, 渡邉公彦, 橋本恵理, 渡邉一平, 白坂知彦, 館農勝, 齋藤諭, 齋藤利和
Organizer
第51回日本神経化学会
Place of Presentation
富山
Year and Date
2008-09-12
Related Report
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[Presentation] 胎児期アルコール曝露モデルに対する神経幹細胞移植の試み2008
Author(s)
吉永敏弘, 石井貴男, 鵜飼渉, 館農勝, 小野貴文, 渡邊公彦, 渡邉一平, 白坂知彦, 齋藤諭, 橋本恵理, 齋藤利和
Organizer
第18回日本臨床精神神経薬理学会 第38回日本神経精神薬理学会合同年会
Place of Presentation
東京
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