| Project/Area Number |
20591374
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Psychiatric science
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| Research Institution | Sapporo Medical University |
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Principal Investigator |
UKAI Wataru Sapporo Medical University, 医学部, 講師 (40381256)
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| Co-Investigator(Kenkyū-buntansha) |
HASHIMOTO Eri 札幌医科大学, 医学部, 准教授 (30301401)
TATENO Masaru 札幌医科大学, 医学部, 講師 (60464492)
YOSHINAGA Toshihiro 札幌医科大学, 医学部, 助教 (70404704)
ONO Takafumi 札幌医科大学, 医学部, 研究員 (50438024)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2008: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 精神薬理学 / 脳・神経 / 神経科学 / 再生医学 / 神経幹細胞 / 胎児性アルコール症候群 / 精神疾患 / 統合失調症 / 抗精神病薬 / 細胞療法 |
|---|
| Research Abstract |
We constructed schizophrenia model rat by injection of Poly (I:C) in the maternal period. Animals in the Poly (I:C) treatment group showed a significant memory/cognitive impairment and social dysfunction in each behavioral test and intravenous neural stem cell transplantation suppressed these behavioral abnormalities toward control levels. The transplanted marked neural stem cells were detected in the various brain regions including cingulated cortex, hippocampus and amygdale over 6 months after the intravenous injection. Specifically, we detected the transplanted neural stem cells in hippocampus and amygdale which were positive with GAD protein suggesting the successful differentiation of transplanted cells into GABAergic neurons in these areas. Moreover, it was demonstrated that combined treatment of antipsychotic olanzapine promoted the migration/survival of transplanted neural stem cells in the brain.
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