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The new therapeutic approach for schizophrenia treatment-study of the combined therapy using drug and cells-

Research Project

Project/Area Number 20591374
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Psychiatric science
Research InstitutionSapporo Medical University

Principal Investigator

UKAI Wataru  Sapporo Medical University, 医学部, 講師 (40381256)

Co-Investigator(Kenkyū-buntansha) HASHIMOTO Eri  札幌医科大学, 医学部, 准教授 (30301401)
TATENO Masaru  札幌医科大学, 医学部, 講師 (60464492)
YOSHINAGA Toshihiro  札幌医科大学, 医学部, 助教 (70404704)
ONO Takafumi  札幌医科大学, 医学部, 研究員 (50438024)
Project Period (FY) 2008 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2008: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords精神薬理学 / 脳・神経 / 神経科学 / 再生医学 / 神経幹細胞 / 胎児性アルコール症候群 / 精神疾患 / 統合失調症 / 抗精神病薬 / 細胞療法
Research Abstract

We constructed schizophrenia model rat by injection of Poly (I:C) in the maternal period. Animals in the Poly (I:C) treatment group showed a significant memory/cognitive impairment and social dysfunction in each behavioral test and intravenous neural stem cell transplantation suppressed these behavioral abnormalities toward control levels. The transplanted marked neural stem cells were detected in the various brain regions including cingulated cortex, hippocampus and amygdale over 6 months after the intravenous injection. Specifically, we detected the transplanted neural stem cells in hippocampus and amygdale which were positive with GAD protein suggesting the successful differentiation of transplanted cells into GABAergic neurons in these areas. Moreover, it was demonstrated that combined treatment of antipsychotic olanzapine promoted the migration/survival of transplanted neural stem cells in the brain.

Report

(4 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (104 results)

All 2011 2010 2009 2008 Other

All Journal Article (39 results) (of which Peer Reviewed: 15 results) Presentation (62 results) Book (2 results) Remarks (1 results)

  • [Journal Article] Neuroserpin is expressed in early stage of neurogenesis in adult rat hippocampus.2010

    • Author(s)
      Yamada M, Takahashi K, Ukai W, Hashimoto E, Saito T, Yamada. M.
    • Journal Title

      Neuroreport 21

      Pages: 138-142

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] The role of neural stem cells for in vitro models of schizophrenia : Neuroprotection via Akt/ERK signal regulation.2010

    • Author(s)
      小野貴文, 橋本恵理, 鵜飼渉, 石井貴男, 齋藤利和
    • Journal Title

      Schizophr Res 122

      Pages: 239-247

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Effect of antidepressants on brain-derived neurotrophic factor (BDNF) release from platelets in the rats.2010

    • Author(s)
      渡邊公彦, 橋本恵理, 鵜飼渉, 石井貴男, 吉永敏弘, 小野貴文, 館農勝, 渡邉一平, 白坂知彦, 齋藤諭, 齋藤利和
    • Journal Title

      Prog Neuropsychopharmacol Biol Psychiatry 34

      Pages: 1450-1454

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Pervasive Developmental Disorders and Autism Spectrum Disorders : Are These Disorders One and the Same2010

    • Author(s)
      Tateno M, Kikuchi S, Uehara K, Fukita K, Uchida N, Sasaki R, Saito T
    • Journal Title

      Psychiatry Investigation 8

      Pages: 67-70

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] 精神障害が併存するアルコール依存症の病態と治療 アルコール依存症と気分障害2010

    • Author(s)
      橋本恵理, 齋藤利和
    • Journal Title

      精神神経学雑誌 112

      Pages: 780-786

    • Related Report
      2010 Final Research Report
  • [Journal Article] ストレスによる脳神経回路網変異-障害と修復の分子メカニズム-2010

    • Author(s)
      鵜飼渉, 橋本恵理, 吉永敏弘, 白坂知彦, 渡邊公彦, 渡邉一平, 金田博雄, 館農勝, 石井貴男, 齋藤利和
    • Journal Title

      ストレス科学 25

      Pages: 167-177

    • Related Report
      2010 Final Research Report
  • [Journal Article] Effect of antidepressants on brain-derived neurotrophic factor (BDNF) release from platelets in the rats.2010

    • Author(s)
      Watanabe K, Ukai W, et al.
    • Journal Title

      Prog Neuropsychopharmacol Biol Psychiatry

      Volume: 34 Pages: 1450-1454

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Neuroserpin is expressed in early stage of neurogenesis in adult rat hippocampus.2010

    • Author(s)
      Yamada M, Ukai W, et al.
    • Journal Title

      Neuroreport

      Volume: 21 Pages: 138-142

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The role of neural stem cells for in vitro models of schizophrenia : Neuroprotection via Akt/ERK signal regulation.2010

    • Author(s)
      Ono T, Ukai W, et al.
    • Journal Title

      Schizophrenia Research

      Volume: 122 Pages: 239-247

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 不安の病理と治療の今日的展開 物質依存と不安2010

    • Author(s)
      館農勝, 他
    • Journal Title

      臨床精神医学

      Volume: 39 Pages: 421-424

    • Related Report
      2010 Annual Research Report
  • [Journal Article] アルコール・薬物関連障害と精神疾患の併存2010

    • Author(s)
      橋本恵理, 他
    • Journal Title

      医学のあゆみ

      Volume: 233 Pages: 1154-1168

    • Related Report
      2010 Annual Research Report
  • [Journal Article] 精神障害が併存するアルコール依存症の病態と治療.アルコール依存症と気分障害2010

    • Author(s)
      橋本恵理, 他
    • Journal Title

      精神神経学雑誌

      Volume: 112 Pages: 780-786

    • Related Report
      2010 Annual Research Report
  • [Journal Article] ストレスによる脳神経回路網変異-障害と修復の分子メカニズム-2010

    • Author(s)
      鵜飼渉, 他
    • Journal Title

      ストレス科学

      Volume: 25 Pages: 167-177

    • Related Report
      2010 Annual Research Report
  • [Journal Article] Neuroserpin is expressed in early stage of neurogenesis in adult rat hippocampus2010

    • Author(s)
      Yamada M, Takahashi K, Ukai W, et al.
    • Journal Title

      Neuroreport 21

      Pages: 138-142

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Low serum BDNF and food intake regulation : a possible new explanation of the pathophysiology of eating disorders.2009

    • Author(s)
      齋藤諭, 渡邊公彦, 橋本恵理, 齋藤利和
    • Journal Title

      Prog Neuropsychopharmacol Biol Psychiatry 33

      Pages: 312-316

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Effects of typical (haloperidol) and atypical (risperidone) antipsychotic agents on protein expression in rat neural stem cells.2009

    • Author(s)
      Kashem MA, Ummehany R, Ukai W, Hashimoto E, Saito T, McGregor IS, Matsumoto I.
    • Journal Title

      Neurochem Int 55

      Pages: 558-565

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] 気分障害における神経回路網の修復再生と認知機能2009

    • Author(s)
      鵜飼渉, 橋本恵理, 石井貴男, 吉永敏弘, 渡邊公彦, 小野貴文, 館農勝, 渡邉一平, 白坂智彦, 齋藤利和
    • Journal Title

      臨床精神医学 38

      Pages: 421-428

    • Related Report
      2010 Final Research Report
  • [Journal Article] 非定型抗精神病薬の神経新生作用2009

    • Author(s)
      橋本恵理, 鵜飼渉, 小野貴文, 齋藤利和
    • Journal Title

      脳21 12

      Pages: 195-199

    • Related Report
      2010 Final Research Report
  • [Journal Article] アルコールによる脳障害に対する再生医療的アプローチの可能性2009

    • Author(s)
      橋本恵理, 吉永敏弘, 石井貴男, 齋藤諭, 鵜飼渉, 齋藤利和
    • Journal Title

      日本アルコール・薬物医学会雑誌 44

      Pages: 674-679

    • NAID

      10026245307

    • Related Report
      2010 Final Research Report
  • [Journal Article] The common aspects of pathophysiology of alcoholism and depression.2009

    • Author(s)
      鵜飼渉, 石井貴男, 橋本恵理, 館農勝, 吉永敏弘, 小野貴文, 渡邊公彦, 渡邉一平, 白坂知彦, 齋藤利和
    • Journal Title

      日本アルコール・薬物医学会雑誌 44

      Pages: 704-711

    • Related Report
      2010 Final Research Report
  • [Journal Article] Effects of typical(haloperidol)and atypical(risperidone)antipsychotic agents on protein expression in rat neural stem cells2009

    • Author(s)
      Kashem MA, Ummehany R, Ukai W, et al.
    • Journal Title

      Neurochem Int 55

      Pages: 558-565

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The common aspects of pathophysiolgy of alcoholism and depression2009

    • Author(s)
      鵜飼渉, 石井貴男, 橋本恵理, et al.
    • Journal Title

      日本アルコール・薬物医学会雑誌 44

      Pages: 704-711

    • NAID

      10026245371

    • Related Report
      2009 Annual Research Report
  • [Journal Article] アルコールによる脳障害に対する再生医療的アプローチの可能性2009

    • Author(s)
      橋本恵理, 吉永敏弘, 石井貴男, 他
    • Journal Title

      日本アルコール・薬物医学会雑誌 44

      Pages: 674-679

    • NAID

      10026245307

    • Related Report
      2009 Annual Research Report
  • [Journal Article] 気分障害における神経回路網の修復再生と認知機能2009

    • Author(s)
      鵜飼渉, 橋本恵理, 石井貴男, 他
    • Journal Title

      臨床精神医学 38

      Pages: 421-428

    • Related Report
      2009 Annual Research Report
  • [Journal Article] 非定型抗精神病薬の神経新生作用2009

    • Author(s)
      橋本恵理, 鵜飼渉, 小野貴文, 他
    • Journal Title

      脳21 12

      Pages: 195-199

    • Related Report
      2009 Annual Research Report
  • [Journal Article] 精神疾患の脳神経回路修復-個別診断と薬物・細胞コンバインド療法の可能性の検討-2009

    • Author(s)
      鵜飼渉, 渡邊公彦, 吉永敏弘, 他
    • Journal Title

      精神薬療研究年報 41

      Pages: 47-48

    • Related Report
      2009 Annual Research Report
  • [Journal Article] Biological studies on alcohol-induced neuronal damage.2008

    • Author(s)
      館農勝, 齋藤利和
    • Journal Title

      Psychiatry Investigation 5

      Pages: 21-27

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Lithium-induced suppression of transcription repressor NRSF/REST : Effects on the dysfunction of neuronal differentiation by ethanol.2008

    • Author(s)
      Ishii T, Hashimoto E, Ukai W, Tateno M, Yoshinaga T, Saito S, Sohma H, Saito T
    • Journal Title

      Eur J Pharmacol 593

      Pages: 36-43

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] アルコールによる脳神経回路網の異常 神経幹細胞を用いた修復の試み2008

    • Author(s)
      鵜飼渉, 橋本恵理, 吉永敏弘, 石井貴男, 館農勝, 小野貴文, 渡邊公彦, 齋藤諭, 齋藤利和
    • Journal Title

      日本神経精神薬理学雑誌 28

      Pages: 69-73

    • NAID

      10023965420

    • Related Report
      2010 Final Research Report
  • [Journal Article] 神経新生と病態 薬物と神経新生 アルコール2008

    • Author(s)
      館農勝, 齋藤利和
    • Journal Title

      Clinical Neuroscience 26

      Pages: 899-901

    • Related Report
      2010 Final Research Report
  • [Journal Article] 薬物と神経新生 向精神薬2008

    • Author(s)
      橋本恵理, 小野貴文, 渡邉公彦
    • Journal Title

      Clinical Neuroscience 26

      Pages: 887-889

    • Related Report
      2010 Final Research Report
  • [Journal Article] 新規抗精神病薬の開発動向2008

    • Author(s)
      鵜飼渉, 橋本恵理, 齋藤利和
    • Journal Title

      脳と精神の医学 19

      Pages: 173-179

    • Related Report
      2010 Final Research Report
  • [Journal Article] アルコールによる脳障害とエピジェネティクス制御機構2008

    • Author(s)
      石井貴男, 橋本恵理, 鵜飼渉, 館農勝, 吉永敏弘, 小野貴文, 渡邊公彦, 齋藤諭, 齋藤利和
    • Journal Title

      日本アルコール・薬物医学会雑誌 43

      Pages: 705-713

    • NAID

      10024436959

    • Related Report
      2010 Final Research Report
  • [Journal Article] アルコールによる脳神経回路障害のメカニズムとその修復法の探索 神経細胞・神経幹細胞を用いたin vitro、in vivo解析2008

    • Author(s)
      鵜飼渉, 石井貴男, 吉永敏弘, 館農勝, 橋本恵理, 小野貴文, 渡邊公彦, 渡邉一平, 白坂智彦, 齋藤利和
    • Journal Title

      日本アルコール・薬物医学会雑誌 43

      Pages: 763-769

    • NAID

      10023976053

    • Related Report
      2010 Final Research Report
  • [Journal Article] Lithium-induced suppression of transcriptional repressor NRSF/REST : effects on the dysfunction of neuronal differentiation by ethanol2008

    • Author(s)
      Ishii T, et al
    • Journal Title

      Eur J Pharmacol 593

      Pages: 36-43

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Neuroprotective effects of Yi-Gan San against beta amyloid-in duced cytotoxicity on rat cortical neurons.2008

    • Author(s)
      Tateno M, et al.
    • Journal Title

      Prog Neuropsychopharmacol Biol Psychiatry 32

      Pages: 1704-1707

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 新規抗精神病薬の開発動向2008

    • Author(s)
      鵜飼渉, 他
    • Journal Title

      脳と精神の医学 19

      Pages: 173-179

    • Related Report
      2008 Annual Research Report
  • [Journal Article] -神経新生と病態 : 薬物と神経新生- 向精神薬2008

    • Author(s)
      橋本恵理, 他
    • Journal Title

      Clinical Neuroscience 26

      Pages: 887-889

    • Related Report
      2008 Annual Research Report
  • [Journal Article] アルコールによる脳神経回路網の異常 : 神経幹細胞を用いた修復の試み2008

    • Author(s)
      鵜飼渉, 他
    • Journal Title

      日本神経精神薬理学雑誌 28

      Pages: 69-73

    • NAID

      10023965420

    • Related Report
      2008 Annual Research Report
  • [Presentation] 神経幹細胞移植によるFASDモデルラット「社会脳」再生の試み2011

    • Author(s)
      白坂知彦, 鵜飼渉, 吉永敏弘, 木川昌康, 渡邊公彦, 渡邉一平, 金田博雄, 館農勝, 橋本恵理, 齋藤利和
    • Organizer
      第10回日本再生医療学会総会
    • Place of Presentation
      東京
    • Related Report
      2010 Final Research Report
  • [Presentation] The possible implicasion of TLX on the regulation of impulsive behavior : focusing on the neural stem cell dysfunctions by TLX change2010

    • Author(s)
      Ukai W, et al.
    • Organizer
      Society for Neuroscience
    • Place of Presentation
      San Diego
    • Year and Date
      2010-11-13
    • Related Report
      2010 Annual Research Report
  • [Presentation] 胎児性アルコール・スペクトラム障害とcell therapyの可能性(Symposium:アルコール・薬物依存の基礎研究の動向)2010

    • Author(s)
      吉永敏弘, 鵜飼渉, 他
    • Organizer
      日本アルコール精神医学会
    • Place of Presentation
      小倉
    • Year and Date
      2010-10-07
    • Related Report
      2010 Annual Research Report
  • [Presentation] 末梢BDNFの脳内移行に関する検討2010

    • Author(s)
      渡邊公彦, 鵜飼渉, 他
    • Organizer
      日本生物学的精神医学会
    • Place of Presentation
      小倉
    • Year and Date
      2010-10-07
    • Related Report
      2010 Annual Research Report
  • [Presentation] 神経幹細胞移植によるFASDモデルラットの「社会脳」の再生2010

    • Author(s)
      白坂知彦, 鵜飼渉, 他
    • Organizer
      日本アルコール・薬物医学会
    • Place of Presentation
      小倉
    • Year and Date
      2010-10-07
    • Related Report
      2010 Annual Research Report
  • [Presentation] 末梢BDNFの体内動態を解明する2010

    • Author(s)
      渡邊公彦, 橋本恵理, 鵜飼渉, 吉永敏弘, 館農勝, 渡邉一平, 白坂知彦, 金田博雄, 木川昌康, 五十嵐健史, 齋藤利和
    • Organizer
      第29回躁うつ病の薬理・生化学的研究懇話会
    • Place of Presentation
      箱根
    • Year and Date
      2010-06-18
    • Related Report
      2010 Final Research Report
  • [Presentation] 末梢BDNFの体内動態を解明する2010

    • Author(s)
      渡邊公彦, 鵜飼渉, 他
    • Organizer
      躁うつ病の薬理・生化学的研究懇話会
    • Place of Presentation
      箱根
    • Year and Date
      2010-06-18
    • Related Report
      2010 Annual Research Report
  • [Presentation] The Change of Brain-Derived Neurotrophic Factor and TrkB Receptor on Platelet in Depression.2010

    • Author(s)
      Saito T, Hashimoto E, Ukai W, Watanabe K, Watanabe I, Shirasaka T, Kaneta H, Kigawa M, Yoshinaga T, Tateno M, Park T, Ishii T
    • Organizer
      49th ACNP
    • Place of Presentation
      Florida
    • Related Report
      2010 Final Research Report
  • [Presentation] The possible implicasion of TLX on the regulation of impulsive behavior : focusing on the neural stem cell dysfunctions by TLX change.2010

    • Author(s)
      Ukai W, Watanabe I, Hashimoto E, Watanabe K, Shirasaka T, Kaneta H, Kigawa M, Ono T, Ishii T, Yoshinaga T, Tateno M, Kobayashi S, Saito T
    • Organizer
      40th Neuroscience
    • Place of Presentation
      San Diego
    • Related Report
      2010 Final Research Report
  • [Presentation] 核内レセプタ-TLXの神経幹細胞における働きと抑肝散の与える影響2010

    • Author(s)
      渡邉一平, 鵜飼渉, 橋本恵理, 渡邊公彦, 白坂知彦, 小野貴文, 館農勝, 齋藤利和
    • Organizer
      第32回日本生物学的精神医学会
    • Place of Presentation
      小倉
    • Related Report
      2010 Final Research Report
  • [Presentation] (Symposium) Effects of psychotropics on ER stress and its potential implication for the clinical effect.2010

    • Author(s)
      鵜飼渉, 橋本恵理, 小野貴文, 吉永敏弘, 石井貴男, 渡邊公彦, 渡邉一平, 白坂知彦, 館農勝, 齋藤利和
    • Organizer
      17th CINP
    • Place of Presentation
      Hong Kong
    • Related Report
      2010 Final Research Report
  • [Presentation] Stem cell therapy. functional recovery in a neurodevelopmental model of schizophrenia.2010

    • Author(s)
      橋本恵理, 小野貴文, 鵜飼渉, 吉永敏弘, 石井貴男, 渡邊公彦, 渡邉一平, 白坂知彦, 館農勝, 齋藤利和
    • Organizer
      17th CINP
    • Place of Presentation
      Hong Kong
    • Related Report
      2010 Final Research Report
  • [Presentation] Roles of nuclear receptor TLX in neural stem cell functions.2010

    • Author(s)
      渡邉一平, 鵜飼渉, 小野貴文, 渡邊公彦, 白坂知彦, 石井貴男, 橋本恵理, 館農勝, 齋藤利和
    • Organizer
      17th CINP
    • Place of Presentation
      Hong Kong
    • Related Report
      2010 Final Research Report
  • [Presentation] The change of brain-derived neurotrophic factor (BDNF) and tyrosine kinase B (TrkB) receptor on platelet in depression.2010

    • Author(s)
      渡邊公彦, 橋本恵理, 鵜飼渉, 石井貴男, 吉永敏弘, 館農勝, 渡邉一平, 白坂知彦, 金田博雄, 木川昌康, 齋藤利和
    • Organizer
      17th CINP
    • Place of Presentation
      Hong Kong
    • Related Report
      2010 Final Research Report
  • [Presentation] Effects of psychotropics on ER stress and its potential implication for the clinical effect. (Symposium : Is there a common pathway between neurodegenerative disorders and mental disorders?)2010

    • Author(s)
      Ukai W
    • Organizer
      Collegium Internationale Neuro-Psychopharmacologicum
    • Place of Presentation
      Hong Kong
    • Related Report
      2010 Annual Research Report
  • [Presentation] Stem cell therapy functional recovery in a neurodevelopmental model of schizophrenia.2010

    • Author(s)
      Hashimoto E, Ukai W, et al.
    • Organizer
      Collegium Internationale Neuro-Psychopharmacologicum
    • Place of Presentation
      Hong Kong
    • Related Report
      2010 Annual Research Report
  • [Presentation] Roles of nuclear receptor TLX in neural stem cell funcions.2010

    • Author(s)
      Watanabe I, Ukai W, et al.
    • Organizer
      Collegium Internationale Neuro-Psychopharmacologicum
    • Place of Presentation
      Hong Kong
    • Related Report
      2010 Annual Research Report
  • [Presentation] The change of brain-derived neurotrophic factor (BDNF) and tyrosine kinase B (TrkB) receptor on platelet in depression2010

    • Author(s)
      Watanabe K, Ukai W, et al.
    • Organizer
      Collegium Internationale Neuro-Psychopharmacologicum
    • Place of Presentation
      Hong Kong
    • Related Report
      2010 Annual Research Report
  • [Presentation] Alcohol induced neurogenetic dysfunction : Roles of transcription factors and epigenetic regulation (Symposium : Epigenetic basis of alcoholic organ damage)2010

    • Author(s)
      Ukai W, et al.
    • Organizer
      International Society for Biomedical Research on Alcoholism.
    • Place of Presentation
      Paris
    • Related Report
      2010 Annual Research Report
  • [Presentation] Stem cell regulation as a new treatment strategy for alcoholism and other psychiatric disorders (Symposium : Alcohol and neuropsychiatric disorders)2010

    • Author(s)
      Saito T, Ukai W, et al.
    • Organizer
      International Society for Biomedical Research on Alcoholism.
    • Place of Presentation
      Paris
    • Related Report
      2010 Annual Research Report
  • [Presentation] Stem cell therapy-social function recovery in FASD model.2010

    • Author(s)
      Shirasaka T, Ukai W, et al.
    • Organizer
      International Society for Biomedical Research on Alcoholism.
    • Place of Presentation
      Paris
    • Related Report
      2010 Annual Research Report
  • [Presentation] 神経幹細胞移植によるFASDモデルラット「社会脳」再生の試み2010

    • Author(s)
      白坂知彦, 鵜飼渉, 他
    • Organizer
      第10回日本再生医療学会
    • Place of Presentation
      東京
    • Related Report
      2010 Annual Research Report
  • [Presentation] 精神疾患の軽末梢的脳修復-GABAインターニューロン再生と社会コミュニケーションの回復-2009

    • Author(s)
      鵜飼渉, 小野貴文, 白坂知彦, 他
    • Organizer
      第42回精神神経系薬物治療研究報告会
    • Place of Presentation
      大阪
    • Year and Date
      2009-12-04
    • Related Report
      2009 Annual Research Report
  • [Presentation] 攻撃性・衝動性のメカニズムにおける神経新生異常の重要性に関する研究2009

    • Author(s)
      渡邉一平, 鵜飼渉, 小野貴文, 渡邊公彦, 白坂知彦, 橋本恵理, 石井貴男, 館農勝, 齋藤利和
    • Organizer
      第18回神経行動薬理若手研究者の集い
    • Place of Presentation
      横浜
    • Year and Date
      2009-03-19
    • Related Report
      2010 Final Research Report 2009 Annual Research Report
  • [Presentation] (シンポジウム) ストレスによる脳神経回路網変異-障害と修復の分子メカニズム-2009

    • Author(s)
      鵜飼渉, 橋本恵理, 吉永敏弘, 白坂知彦, 石井貴男, 館農勝, 小野貴文, 渡邊公彦, 渡邉一平, 齋藤利和
    • Organizer
      第25回日本ストレス学会学術総会,第27回日本青年期精神療法学会総会合同大会
    • Place of Presentation
      横浜
    • Related Report
      2010 Final Research Report
  • [Presentation] (Workshop) Endoplasmic reticulum stress and neurogenetic dysfunction in psychiatric disorder.2009

    • Author(s)
      鵜飼渉, 橋本恵理, 館農勝, 小野貴文, 渡邊公彦, 渡邉一平, 白坂知彦, 吉永敏弘, 齋藤利和
    • Organizer
      4th CSSI
    • Place of Presentation
      Sapporo, Japan
    • Related Report
      2010 Final Research Report
  • [Presentation] How do ethanol and depression impair neural stem cell? Dysregulation of CREB, NRSF/REST and TLX.2009

    • Author(s)
      石井貴男, 鵜飼渉, 吉永敏弘, 館農勝, 小野貴文, 渡邊公彦, 渡邉一平, 白坂知彦,橋本恵理, 齋藤利和
    • Organizer
      39th SfN
    • Place of Presentation
      Chicago
    • Related Report
      2010 Final Research Report
  • [Presentation] Stem cell therapy as a new treatment strategy for schizophrenia.2009

    • Author(s)
      鵜飼渉, 小野貴文, 橋本恵理, 吉永敏弘, 石井貴男, 渡邊公彦, 渡邉一平, 白坂知彦, 館農勝, 齋藤利和
    • Organizer
      39th SfN
    • Place of Presentation
      Chicago
    • Related Report
      2010 Final Research Report
  • [Presentation] (シンポジウム)末梢サイトカイン変化と精神疾患の病態について2009

    • Author(s)
      鵜飼渉, 小野貴文, 渡邊公彦, 橋本恵理, 吉永敏弘, 石井貴男, 館農勝, 渡邉一平, 白坂知彦, 齋藤利和
    • Organizer
      第52回日本神経科学大会
    • Place of Presentation
      群馬
    • Related Report
      2010 Final Research Report
  • [Presentation] 神経細胞移植は統合失調症の慢性期症状を抑制する2009

    • Author(s)
      小野貴文, 鵜飼渉, 白坂知彦, 吉永敏弘, 橋本恵理, 石井貴男, 館農勝, 渡邊公彦, 渡邉一平, 齋藤利和
    • Organizer
      第52回日本神経科学大会
    • Place of Presentation
      群馬
    • Related Report
      2010 Final Research Report
  • [Presentation] 神経新生の変化における攻撃性・衝動性のメカニズム2009

    • Author(s)
      渡邉一平, 鵜飼渉, 小野貴文, 渡邊公彦, 白坂知彦, 橋本恵理, 石井貴男, 館農勝, 齋藤利和
    • Organizer
      第52回日本神経科学大会
    • Place of Presentation
      群馬
    • Related Report
      2010 Final Research Report 2009 Annual Research Report
  • [Presentation] ヒト脳神経系細胞におけるDNAメチル化解析-全ゲノムメチル化量の定量とメチル化領域の個人間差異の検討-2009

    • Author(s)
      岩本和也, 文東美紀, 上田順子, 中野陽子, 鵜飼渉, 橋本恵理, 齋藤利和, 加藤忠史
    • Organizer
      第31回日本生物学的精神医学会
    • Place of Presentation
      京都
    • Related Report
      2010 Final Research Report 2009 Annual Research Report
  • [Presentation] (Symposium) The stem cell therapy as a possible new treatment for schizophrenia.2009

    • Author(s)
      橋本恵理, 鵜飼渉, 小野貴文, 吉永敏弘, 石井貴男, 館農勝, 渡邊公彦, 齋藤利和
    • Organizer
      第4回日本統合失調症学会
    • Place of Presentation
      大阪
    • Related Report
      2010 Final Research Report
  • [Presentation] (Workshop)Stress responses in diseases : Endoplasmic reticulum stress and neurogenetic dysfunction in psychiatric disorder2009

    • Author(s)
      Ukai W, Hashimoto E, Tateno M, et al.
    • Organizer
      The 4th International Congress on Stress Responses in Biology and Medicine
    • Place of Presentation
      Sapporo, Japan
    • Related Report
      2009 Annual Research Report
  • [Presentation] How do ethanol and depression impair neural stem cell? Dysregulation of CREB, NRSF/REST and TLX2009

    • Author(s)
      Ishii T, Ukai W, Yoshinaga T, et al.
    • Organizer
      The 39th Annual Meeting of Society for Neuroscience
    • Place of Presentation
      Chicago, USA
    • Related Report
      2009 Annual Research Report
  • [Presentation] Stem cell therapy as a new treatment strategy for schizophrenia2009

    • Author(s)
      Ukai W, Ono T, Hashimoto E, et al.
    • Organizer
      The 39th Annual Meeting of Society for Neuroscience
    • Place of Presentation
      Chicago, USA
    • Related Report
      2009 Annual Research Report
  • [Presentation] The change of platelet neurotrophic factors release in depression2009

    • Author(s)
      渡邊公彦, 橋本恵理, 鵜飼渉, et al.
    • Organizer
      The Second World Congress of Asian Psychiatry
    • Place of Presentation
      Taipei, Taiwan
    • Related Report
      2009 Annual Research Report
  • [Presentation] (Symposium)Alcoholism and depression : possible common pathophysiology : Dysregulation of neurogenesis in alcoholism and depression2009

    • Author(s)
      橋本恵理, 石井貴男, 鵜飼渉, et al.
    • Organizer
      The 1st Congress of Asia-Pacific Society of Alcohol and Addiction Research
    • Place of Presentation
      Korea
    • Related Report
      2009 Annual Research Report
  • [Presentation] The stem cell therapy as, a possible new treatment for alcohol induced brain damage2009

    • Author(s)
      Ukai W, Yoshinaga T, Shirasaka T, et al.
    • Organizer
      The 1st Congress of Asia-Pacific Society of Alcohol and Addiction Research
    • Place of Presentation
      Korea
    • Related Report
      2009 Annual Research Report
  • [Presentation] Molecular mechanisms of alcohol-induced neuronal damage to the developing brain : The role of neuron-restrictive silencer factor(NRSF/REST)2009

    • Author(s)
      Tateno M, Ukai W, Ishii T, et al.
    • Organizer
      The 1st Congress of Asia-Pacific Society of Alcohol and Addiction Research
    • Place of Presentation
      Korea
    • Related Report
      2009 Annual Research Report
  • [Presentation] (Symposium)統合失調症は神経発達障害か, 神経変性疾患か? : The stem cell therapy as a possible new treatment for schizophrenia2009

    • Author(s)
      Hashimoto E, Ukai W, Ono T, et al.
    • Organizer
      第4回日本統合失調症学会
    • Place of Presentation
      大阪
    • Related Report
      2009 Annual Research Report
  • [Presentation] 神経細胞移植は統合失調症の慢性期症状を抑制する2009

    • Author(s)
      小野貴文, 鵜飼渉, 白坂知彦, 他
    • Organizer
      第31回日本生物学的精神医学会
    • Place of Presentation
      京都
    • Related Report
      2009 Annual Research Report
  • [Presentation] (日本神経化学会-日本生物学的精神医学会合同シンポシウム)末梢サイトカイン変化と精神疾患の病態について2009

    • Author(s)
      鵜飼渉, 小野貴文, 渡邊公彦, 他
    • Organizer
      第52回日本神経科学大会
    • Place of Presentation
      群馬
    • Related Report
      2009 Annual Research Report
  • [Presentation] うつ病での血小板BDNFの動き2009

    • Author(s)
      渡邊公彦, 橋本恵理, 鵜飼渉
    • Organizer
      第52回日本神経科学大会
    • Place of Presentation
      群馬
    • Related Report
      2009 Annual Research Report
  • [Presentation] うつ病モデルラットにおける末梢血BDNF変化-血小板BDNF遊離の観点から-2009

    • Author(s)
      渡邊公彦, 鵜飼渉, 石井貴男, 他
    • Organizer
      躁うつ病の薬理・生化学的研究懇話会
    • Place of Presentation
      千歳
    • Related Report
      2009 Annual Research Report
  • [Presentation] (3学会合同シンポジウム)うつ病とアルコール依存症の併存について2009

    • Author(s)
      橋本恵理, 鵜飼渉, 齋藤利和
    • Organizer
      第44回日本アルコール・薬物医学会, 第21回日本アルコール精神医学会, 第12回ニコチン・薬物依存症フォーラム, 合同学術総会
    • Place of Presentation
      横浜
    • Related Report
      2009 Annual Research Report
  • [Presentation] (シンポジウム)アルコールによる脳神経ネットワークの変異:行動変化と分子メカニズムの解析から2009

    • Author(s)
      鵜飼渉, 橋本恵理, 石井貴男, 他
    • Organizer
      第44回日本アルコール・薬物医学会, 第21回日本アルコール精神医学会, 第12回ニコチン・薬物依存症フォーラム, 合同学術総会
    • Place of Presentation
      横浜
    • Related Report
      2009 Annual Research Report
  • [Presentation] 神経幹細胞移植はFASDモデルラットの社会行動異常を改善する2009

    • Author(s)
      白坂知彦, 小野貴文, 鵜飼渉, 他
    • Organizer
      第44回日本アルコール・薬物医学会, 第21回日本アルコール精神医学会, 第12回ニコチン・薬物依存症フォーラム, 合同学術総会
    • Place of Presentation
      横浜
    • Related Report
      2009 Annual Research Report
  • [Presentation] エタノールによる神経幹細胞機能異常における攻撃性・衝動性関連因子の発現変化解析2009

    • Author(s)
      渡邉一平, 鵜飼渉, 小野貴文, 他
    • Organizer
      第44回日本アルコール・薬物医学会, 第21回日本アルコール精神医学会, 第12回ニコチン・薬物依存症フォーラム, 合同学術総会
    • Place of Presentation
      横浜
    • Related Report
      2009 Annual Research Report
  • [Presentation] (シンポジウム)日本における生物学的ストレス研究の紹介:ストレスによる脳神経回路網変異-障害と修復の分子メカニズム-2009

    • Author(s)
      鵜飼渉, 橋本恵理, 吉永敏弘, 他
    • Organizer
      第25回日本ストレス学会学術総会, 第27回日本青年期精神療法学会, 総会合同大会
    • Place of Presentation
      横浜
    • Related Report
      2009 Annual Research Report
  • [Presentation] (シンポジウム) 精神疾患に対する幹細移植療法の可能性に関する研究2008

    • Author(s)
      鵜飼渉, 吉永敏弘, 石井貴男, 橋本恵理, 小野貴文, 館農勝, 渡邉公彦, 渡邉一平, 白坂知彦, 向裕加, 齋藤諭, 齋藤利和
    • Organizer
      第51回日本神経化学会
    • Place of Presentation
      富山
    • Year and Date
      2008-09-12
    • Related Report
      2010 Final Research Report
  • [Presentation] 神経細胞および神経幹細胞ダメージに対する外来性神経幹細胞の効果2008

    • Author(s)
      小野貴文, 鵜飼渉, 石井貴男, 吉永敏弘, 渡邉公彦, 橋本恵理, 渡邉一平, 白坂知彦, 館農勝, 齋藤諭, 齋藤利和
    • Organizer
      第51回日本神経化学会
    • Place of Presentation
      富山
    • Year and Date
      2008-09-12
    • Related Report
      2010 Final Research Report 2008 Annual Research Report
  • [Presentation] 精神疾患に対する幹細胞療法の可能性に関する研究2008

    • Author(s)
      鵜飼渉, 他
    • Organizer
      第51回日本神経化学会
    • Place of Presentation
      富山
    • Year and Date
      2008-09-12
    • Related Report
      2008 Annual Research Report
  • [Presentation] DNA methylation analysis in the human brain : separation of neuronal and non-neuronal nuclei by cell sorting.2008

    • Author(s)
      Bundo M, Iwamoto K, Nakano Y, Ueda J, Ukai W, Hashimoto E, Saito T, Kato T
    • Organizer
      16th WCPG
    • Place of Presentation
      Osaka Japan
    • Related Report
      2010 Final Research Report
  • [Presentation] DNA methylation analysis in the human brain : promoter tilling array analysis of neuronal and non-neuronal nuclei.2008

    • Author(s)
      Iwamoto K, Bundo M, Ueda J, Nakano Y, Ukai W, Hashimoto E, Saito T, Kato T
    • Organizer
      16th WCPG
    • Place of Presentation
      Osaka Japan
    • Related Report
      2010 Final Research Report
  • [Presentation] 胎児期アルコール曝露モデルに対する神経幹細胞移植の試み2008

    • Author(s)
      吉永敏弘, 石井貴男, 鵜飼渉, 館農勝, 小野貴文, 渡邊公彦, 渡邉一平, 白坂知彦, 齋藤諭, 橋本恵理, 齋藤利和
    • Organizer
      第18回日本臨床精神神経薬理学会 第38回日本神経精神薬理学会合同年会
    • Place of Presentation
      東京
    • Related Report
      2010 Final Research Report
  • [Presentation] (Symposium) Neuroprotective effects on atypical antipsychotics against ER stress-induced cell damage.2008

    • Author(s)
      Tateno M, Kurosawa S, Ukai W, Hashimoto E, Ishii T, Yoshinaga T, Saito S. Saito T
    • Organizer
      2nd WFSBP
    • Place of Presentation
      Toyama, Japan
    • Related Report
      2010 Final Research Report
  • [Presentation] (Symposium) translational research of repairing therapy for the damaged brain by ethanol.2008

    • Author(s)
      Ishii T, Yoshinaga T, Ukai W, Hashimoto E, Tateno M, Ono T, Watanabe K, Saito S. Saito T
    • Organizer
      2nd WFSBP
    • Place of Presentation
      Toyama, Japan
    • Related Report
      2010 Final Research Report
  • [Presentation] (Symposium) New potential therapy of neural stem cell transplantation for repairing alcohol-induced brain damage.2008

    • Author(s)
      齋藤利和, 橋本恵理, 鵜飼渉, 吉永敏弘, 石井貴男, 館農勝, 小野貴文, 渡邊公彦, 齋藤諭
    • Organizer
      16th CINP
    • Place of Presentation
      Munich, Germany
    • Related Report
      2010 Final Research Report
  • [Presentation] Possible new treatment of schizophrenia : A combined therapy of cells and drugs.2008

    • Author(s)
      鵜飼渉, 橋本恵理, 吉永敏弘, 石井貴男, 館農勝, 小野貴文, 渡邊公彦, 齋藤諭, 齋藤利和
    • Organizer
      16th CINP
    • Place of Presentation
      Munich, Germany
    • Related Report
      2010 Final Research Report
  • [Presentation] Possible new treatment of schizophrenia : a combined therapy of cells and drugs2008

    • Author(s)
      Ukai W, et al.
    • Organizer
      16th Collegium Internationale Neuro-Psycho pharmacologicum
    • Place of Presentation
      Munich
    • Related Report
      2008 Annual Research Report
  • [Presentation] The influence of antidepressants on the neurotrophic factors in platelets2008

    • Author(s)
      Watanabe K, et al.
    • Organizer
      The 11th Congress of the ASEAN Federati on for Psychiatry and Mental Health
    • Place of Presentation
      Bangkok
    • Related Report
      2008 Annual Research Report
  • [Book] 脳科学エッセンシャル-精神疾患の生物学的理解のために.専門医のための精神科臨床リュミエール162010

    • Author(s)
      橋本恵理, 他
    • Publisher
      中山書店
    • Related Report
      2010 Annual Research Report
  • [Book] 精神神経疾患死後脳研究と献体プログラム.ブレインバンクが拓く精神疾患研究2010

    • Author(s)
      橋本恵理, 他
    • Publisher
      新興医学出版社
    • Related Report
      2010 Annual Research Report
  • [Remarks] ホームページ等

    • Related Report
      2010 Final Research Report

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Published: 2008-04-01   Modified: 2016-04-21  

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