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Involvement of opioid system in nicotine and alcohol dependence

Research Project

Project/Area Number 20591376
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Psychiatric science
Research InstitutionWakayama Medical University

Principal Investigator

KISHIOKA Shiroh  Wakayama Medical University, 医学部, 教授 (60137255)

Co-Investigator(Kenkyū-buntansha) MAEDA Takehiko  和歌山県立医科大学, 医学部, 准教授 (50271010)
KIGUCHI Norikazu  和歌山県立医科大学, 医学部, 助教 (90433341)
Project Period (FY) 2008 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2008: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Keywordsニコチン / アルコール / オピオイド / コルチコステロン / 依存 / 身体的依存 / 退薬症状 / ナロキソン / 耐性 / 鎮痛 / オピオド / モルヒネ / ナルトレキソン
Research Abstract

In this study, we investigated the role of endogenous opioid system in physical dependence induced by nicotine or alcohol. Treatment of opioid receptor antagonist, naloxone caused withdrawal symptoms in mice administered nicotine twice a day for 5-9 days. Nicotine dependence was suppressed by opioid receptor antagonist, naltrexone. On the other hand, treatment of naloxone caused withdrawal symptoms in mice given water including ethanol (1%). These results suggest that endogenous opioid system plays an important role in physical dependence induced by nicotine or alcohol.

Report

(4 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (64 results)

All 2011 2010 2009 2008 Other

All Journal Article (25 results) (of which Peer Reviewed: 24 results) Presentation (30 results) Book (5 results) Remarks (4 results)

  • [Journal Article] Availability of serum corticosterone level for quantitative evaluation of morphine withdrawal in mice.2011

    • Author(s)
      Ueno K, Maeda T, Kiguchi N, Kobayashi Y, Ozaki M, Kishioka S
    • Journal Title

      Drug Discov.Ther. 5(2)

      Pages: 71-75

    • NAID

      130005054697

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Macrophage inflammatory protein-1 alpha mediates the development of neuropathic pain following peripheral nerve injury through interleukin-1 beta up-regulation.2010

    • Author(s)
      Kiguchi N, Maeda T, Kobayashi Y, Fukazawa Y, Kishioka S
    • Journal Title

      Pain 149(2)

      Pages: 305-315

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Increment of activated serine/threonine protein phosphatase in brain membrane fraction synchronized with antinociceptive effect of morphine in mice.2010

    • Author(s)
      Maeda T, Kiguchi N, Kobayashi Y, Ozaki M, Kishioka S
    • Journal Title

      Biol.Pharm.Bull. 33(6)

      Pages: 1011-1014

    • NAID

      130000247970

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] CC-chemokine MIP-1α in the spinal cord contributes to nerve injury-induced neuropathic pain.2010

    • Author(s)
      Kiguchi N, Kobayashi Y, Maeda T, Saika F, Kishioka S
    • Journal Title

      Neurosci.Lett. 484

      Pages: 17-21

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] 覚せい剤精神病および覚せい剤依存の基礎研究における現状2010

    • Author(s)
      前田武彦
    • Journal Title

      和歌山医学 61(2)

      Pages: 36-41

    • Related Report
      2010 Final Research Report
  • [Journal Article] Macrophage inflammatory protein-1α mediates the development of neuropathic pain following peripheral nerve injury through interleukin-1β up-regulation2010

    • Author(s)
      Kiguchi N, et al.
    • Journal Title

      Pain

      Volume: 149(2) Pages: 305-315

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Increment of activated serine/threonine protein phosphatase in brain membrane fraction synchronized with antinociceptive effect of morphine in mice2010

    • Author(s)
      Maeda T, et al.
    • Journal Title

      Biol.Pharm.Bull.

      Volume: 33(6) Pages: 1011-1014

    • NAID

      130000247970

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] CC-chemokine MIP-1α in the spinal cord contributes to nerve injury-induced neuropathic pain2010

    • Author(s)
      Kiguchi N, et al.
    • Journal Title

      Neurosci.Lett.

      Volume: 484 Pages: 17-21

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The pharmacological mechanisms of electroacupuncture.2009

    • Author(s)
      Fukazawa Y, Maeda T, Kishioka S
    • Journal Title

      Curr.Opin.Investig.Drugs 10(1)

      Pages: 62-69

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Modulation of opioid actions by nitric oxide signaling.2009

    • Author(s)
      Toda N, Kishioka S, Hatano Y, Toda H
    • Journal Title

      Anesthesiology 110(1)

      Pages: 166-181

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Leptin derived from adipocytes in injured peripheral nerves facilitates development of neuropathic pain via macrophage stimulation.2009

    • Author(s)
      Maeda T, Kiguchi N, Kobayashi Y, Ikuta T, Ozaki M, Kishioka S
    • Journal Title

      Proc.Natl.Acad.Sci.USA 106(31)

      Pages: 13076-13081

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Leptin enhances CC-chemokine ligand expression in cultured murine macrophage.2009

    • Author(s)
      Kiguchi N, Maeda T, Kobayashi Y, Fukazawa Y, Kishioka S
    • Journal Title

      Biochem.Biophys.Res.Commun. 384(3)

      Pages: 311-315

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Activation of extracellular signal-regulated kinase in sciatic nerve contributes to neuropathic pain after partial sciatic nerve ligation in mice.2009

    • Author(s)
      Kiguchi N, Maeda T, Kobayashi Y, Fukazawa Y, Kishioka S
    • Journal Title

      Anesth.Analg. 109(4)

      Pages: 1305-1311

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Leptin derived from adipocytes in injured peripheral nerves facilitates development of neuropathic pain via macrophage stimulation2009

    • Author(s)
      Maeda T, Kiguchi N, Kobayashi Y, et al.
    • Journal Title

      Proc.Natl.Acad.Sci.USA 106(31)

      Pages: 13076-13081

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Leptin enhances CC-chemokine ligand expression in cultured murine macrophage2009

    • Author(s)
      Kiguchi N, Maeda T, Kobayashi Y, et al.
    • Journal Title

      Biochem.Biophys.Res.Commun. 384(3)

      Pages: 311-315

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Activation of extracellular signal-regulated kinase in sciatic nerve contributes to neuropathic pain after partial sciatic nerve ligation in mice2009

    • Author(s)
      Kiguchi N, Maeda T, Kobayashi Y, et al.
    • Journal Title

      Anesth.Analg. 109(4)

      Pages: 1305-1311

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The pharmacological mechanisms of electroacupuncture2009

    • Author(s)
      Fukazawa Y, et al.
    • Journal Title

      Current Opinion in Investigational Drugs 10(1)

      Pages: 62-69

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Involvement of spinal Met-enkephalin in nicotine-induced antinociception in mice.2008

    • Author(s)
      Kiguchi N, Maeda T, Tsuruga M, Yamamoto A, Yamamoto C, Ozaki M, Kishioka S
    • Journal Title

      Brain Res. 1189

      Pages: 70-77

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] The critical role of invading peripheral macrophage-derived interleukin-6 in vincristine-induced mechanical allodynia in mice.2008

    • Author(s)
      Kiguchi N, Maeda T, Kobayashi Y, Kondo T, Ozaki M, Kishioka S
    • Journal Title

      Eur.J.Pharmacol. 592(1-3)

      Pages: 87-92

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Up-regulation of tumor necrosis factor-alpha in spinal cord contributes to vincristine-induced mechanical allodynia in mice.2008

    • Author(s)
      Kiguchi N, Maeda T, Kobayashi Y, Kishioka S
    • Journal Title

      Neurosci.Lett. 445

      Pages: 140-143

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Pioglitazone attenuates tactile allodynia and thermal hyperalgesia in mice subjected to peripheral nerve injury.2008

    • Author(s)
      Maeda T, Kiguchi N, Kobayashi Y, Ozaki M, Kishioka S
    • Journal Title

      J.Pharmacol.Sci. 108(3)

      Pages: 341-347

    • NAID

      10024593242

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] The critical role of invading peripheral macrophage-derived interleukin-6 in vincristine-induced mechanical allodynia in mice2008

    • Author(s)
      Kiguchi N, et al.
    • Journal Title

      European Journal of Pharmacology 592(1-3)

      Pages: 87-92

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Up-regulation of tumor necrosis factor-alpha in spinal cord contributes to vincristine-lnduced mechanical allodynia in mice2008

    • Author(s)
      Kiguchi N, et al.
    • Journal Title

      Neuroscience Letters 445

      Pages: 140-143

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Pioglitazone attenuates tactile allodynia and thermal hyperalgesia in mice subjected to peripheral nerve injury2008

    • Author(s)
      Maeda T, et al.
    • Journal Title

      Journal of Pharmacological Sciences 108(3)

      Pages: 341-347

    • NAID

      10024593242

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Pioglitazone attenuates tactile allodynia and microglial activation in mice with peripheral nerve injury2008

    • Author(s)
      Iwai S, et al.
    • Journal Title

      Drug Discoveries & Therapeutics 2(6)

      Pages: 353-356

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Presentation] Serum corticosterone increase is a useful indicator to quantify the magnitude of naloxone-precipitated morphine withdrawal in mice.2010

    • Author(s)
      Kishioka S, Ueno K, Yamamoto A, Yamamoto C, Kobayashi Y, Kiguchi N, Maeda T
    • Organizer
      Neuroscience 2010
    • Place of Presentation
      San Diego, USA
    • Year and Date
      2010-11-15
    • Related Report
      2010 Final Research Report
  • [Presentation] Serum corticosterone increase is a useful indicator to quantify the magnitude of naloxone-precipitated morphine withdrawal in mice2010

    • Author(s)
      Kishioka S, et al.
    • Organizer
      Neuroscience2010
    • Place of Presentation
      San Diego, USA
    • Year and Date
      2010-11-15
    • Related Report
      2010 Annual Research Report
  • [Presentation] Macrophage inflammatory protein-1α mediates the pathgenesis of neuropathic pain2010

    • Author(s)
      Kiguchi N, et al.
    • Organizer
      Neuroscience2010
    • Place of Presentation
      San Diego, USA
    • Year and Date
      2010-11-14
    • Related Report
      2010 Annual Research Report
  • [Presentation] Leptin and neuropathic pain.2010

    • Author(s)
      Kishioka S, Maeda T
    • Organizer
      Molecular Targets for Novel Pain Therapeutics From basic research to clinical translation
    • Place of Presentation
      Calabria. Italy
    • Year and Date
      2010-09-24
    • Related Report
      2010 Final Research Report
  • [Presentation] Role of macrophage inflammatory protein-1 in the pathogenesis of neuropathic pain.2010

    • Author(s)
      Kiguchi N, Maeda T, Kobayashi Y, Kishioka S
    • Organizer
      Molecular Targets for Novel Pain Therapeutics From basic research to clinical translation
    • Place of Presentation
      Calabria, Italy
    • Year and Date
      2010-09-24
    • Related Report
      2010 Final Research Report
  • [Presentation] Leptin and neuropathic pain2010

    • Author(s)
      Kishioka S, Maeda T
    • Organizer
      Molecular Targets for Novel Pain Therapeutics From basic research to clinical translation
    • Place of Presentation
      Calabria, Italy
    • Year and Date
      2010-09-24
    • Related Report
      2010 Annual Research Report
  • [Presentation] Role of macrophage inflammatory protein-1 in the pathogenesis of neuropathic pain2010

    • Author(s)
      Kiguchi N, et al.
    • Organizer
      Molecular Targets for Novel Pain Therapeutics From basic research to clinical translation
    • Place of Presentation
      Calabria, Italy
    • Year and Date
      2010-09-24
    • Related Report
      2010 Annual Research Report
  • [Presentation] Macrophage inflammatory protein-1α plays a key role in the development of neuropathic pain2010

    • Author(s)
      Kiguchi N, et al.
    • Organizer
      New Perspectives in Neuroscience : Joint Meeting of Young Italian and Japanese Neuroscientists
    • Place of Presentation
      Naples, Italy
    • Year and Date
      2010-09-21
    • Related Report
      2010 Annual Research Report
  • [Presentation] Macropharge inflammatory protein-1α mediates the development of neuropathic pain following peripheral nerve injury2010

    • Author(s)
      木口倫一, 他
    • Organizer
      Neuro2010
    • Place of Presentation
      神戸
    • Year and Date
      2010-09-02
    • Related Report
      2010 Annual Research Report
  • [Presentation] 神経障害性疼痛におけるHMGB1の関与2010

    • Author(s)
      前田武彦, 他
    • Organizer
      第31回鎮痛薬・オピオイドペプチドシンポジウム
    • Place of Presentation
      名古屋
    • Year and Date
      2010-08-27
    • Related Report
      2010 Annual Research Report
  • [Presentation] 神経障害性疼痛形成におけるMIP-2の役割2010

    • Author(s)
      木口倫一, 他
    • Organizer
      第31回鎮痛薬・オピオイドペプチドシンポジウム
    • Place of Presentation
      名古屋
    • Year and Date
      2010-08-27
    • Related Report
      2010 Annual Research Report
  • [Presentation] Nicotine stimulates opioid system through the activation of nicotinic acetylcholine receptor.2010

    • Author(s)
      Kishioka S, Ueno K, Yamamoto C, Yamamoto A, Saika F, Iwai S, Kobayashi Y, Kiguchi N, Maeda T
    • Organizer
      The International Narcotics Research Conference 2010
    • Place of Presentation
      Malmo, Sweden
    • Year and Date
      2010-07-13
    • Related Report
      2010 Final Research Report
  • [Presentation] Nicotine stimulates opioid system through the activation of nicotinic acetylcholine receptor2010

    • Author(s)
      Kishioka S, et al.
    • Organizer
      The International Narcotics Research Conference 2010
    • Place of Presentation
      Malmo, Sweden
    • Year and Date
      2010-07-12
    • Related Report
      2010 Annual Research Report
  • [Presentation] HMGB1によるレプチンシグナル活性化は神経障害性疼痛の形成に関与する2010

    • Author(s)
      前田武彦, 木口倫一, 小林悠佳, 岸岡史郎
    • Organizer
      第83回日本薬理学会年会
    • Place of Presentation
      大阪
    • Related Report
      2009 Annual Research Report
  • [Presentation] Development of tolerance to nicotine-induced corticosterone increase and antinociception in mice.2009

    • Author(s)
      Kishioka S, Ueno K, Yamamoto C, Yamamoto Y, Saika F, Iwai S, Kobayashi Y, Kiguchi N, Maeda T
    • Organizer
      The 1^<st> meeting of the Asian College of Neuropsychopharmacology
    • Place of Presentation
      Kyoto
    • Year and Date
      2009-11-14
    • Related Report
      2010 Final Research Report
  • [Presentation] Inhibition of morphine tolerance under the several pain conditions in mice.2009

    • Author(s)
      Iwai S, Kiguchi N, Kobayashi Y, Maeda T, Kishioka S
    • Organizer
      The 1^<st> meeting of the Asian College of Neuropsychopharmacology
    • Place of Presentation
      Kyoto
    • Year and Date
      2009-11-14
    • Related Report
      2010 Final Research Report
  • [Presentation] Involvement of endogenous opioid system in the development of physical dependence on nicotine in mice.2009

    • Author(s)
      Kishioka S, Ueno K, Yamamoto C, Maeda T, Kiguchi N, Kobayashi Y, Fukazawa Y
    • Organizer
      The International Narcotics Research Conference 2009
    • Place of Presentation
      Portland, Oregon
    • Year and Date
      2009-07-15
    • Related Report
      2010 Final Research Report
  • [Presentation] Adipokines regulate development of neuropathic pain.2009

    • Author(s)
      Maeda T, Kishioka S
    • Organizer
      第82回日本薬理学会年会
    • Place of Presentation
      横浜
    • Year and Date
      2009-03-18
    • Related Report
      2010 Final Research Report
  • [Presentation] Involvement of endogenous opioid system in nicotine-induced antinociception and physical dependence in mice.2009

    • Author(s)
      Kobayashi Y, Ueno K, Kiguchi N, Maeda T, Yamamoto C, Kishioka S
    • Organizer
      第82回日本薬理学会年会
    • Place of Presentation
      横浜
    • Year and Date
      2009-03-16
    • Related Report
      2010 Final Research Report
  • [Presentation] 神経障害性疼痛におけるMIP-Iαの関与2009

    • Author(s)
      木口倫一, 他
    • Organizer
      第82回日本薬理学会年会
    • Place of Presentation
      横浜
    • Related Report
      2008 Annual Research Report
  • [Presentation] アディポカインは神経障害性疼痛の形成を調節する2009

    • Author(s)
      前田武彦, 他
    • Organizer
      第82回日本薬理学会年会
    • Place of Presentation
      横浜
    • Related Report
      2008 Annual Research Report
  • [Presentation] ニコチンの抗侵害刺激効果および身体依存形成能における内因性オピオイド系の関与2009

    • Author(s)
      小林悠佳, 他
    • Organizer
      第82回日本薬理学会年会
    • Place of Presentation
      横浜
    • Related Report
      2008 Annual Research Report
  • [Presentation] Effects of peroxisome proliferator-activated receptor gamma agonist on the neuropathic pain induced by partial sciatic nerve ligation in mice.2008

    • Author(s)
      Kishioka S, Maeda T, Kiguchi N, Kobayashi Y
    • Organizer
      Japan-China Medical Workshop on Drug Discoveries and Therapeutics 2008
    • Place of Presentation
      Tokyo
    • Year and Date
      2008-09-29
    • Related Report
      2010 Final Research Report
  • [Presentation] The activation of peroxisome proliferator-activated receptor gamma (PPARγ) suppresses the neuropathic pain due to partial sciatic nerve ligation in mice.2008

    • Author(s)
      Maeda T, Kishioka S
    • Organizer
      XI Workshop on Apoptosis in Biology and Medicine
    • Place of Presentation
      Sendai
    • Year and Date
      2008-09-13
    • Related Report
      2010 Final Research Report
  • [Presentation] レプチンの神経因性疼痛増悪作用のメカニズム解明2008

    • Author(s)
      前田武彦, 他
    • Organizer
      第113回日本薬理学会近畿部会
    • Place of Presentation
      岡山
    • Related Report
      2008 Annual Research Report
  • [Presentation] 坐骨神経部分結紮モデルマウスにおける CCケモカインリガンドおよびその受容体発現増加2008

    • Author(s)
      木口倫一, 他
    • Organizer
      第31回日本神経科学大会
    • Place of Presentation
      東京
    • Related Report
      2008 Annual Research Report
  • [Presentation] 神経因性疼痛行動に及ぼすケモカインCCL3/MIP-lαの影響2008

    • Author(s)
      木口倫一, 他
    • Organizer
      第29回鎮痛薬・オピオイドペプチドシンポジウム
    • Place of Presentation
      富山
    • Related Report
      2008 Annual Research Report
  • [Presentation] アディポサイトカインによるアロディニア形成の調節2008

    • Author(s)
      前田武彦, 他
    • Organizer
      第29回鎮痛薬・オピオイドペプチドシンポジウム
    • Place of Presentation
      富山
    • Related Report
      2008 Annual Research Report
  • [Presentation] Involvement of CC chemokine ligand 3 (CCL3)and 4 (CCL4)in nerve injury-induced neuropathic pain2008

    • Author(s)
      Kiguchi N, et al.
    • Organizer
      XI Workshop on Apoptosis in Biology and Medicine
    • Place of Presentation
      Sendai, Japan
    • Related Report
      2008 Annual Research Report
  • [Presentation] The activation of peroxisome proliferator-activated receptor gamma (PPARγ) suppresses the neuropathic pain due to partial sciatic nerve ligation in mice2008

    • Author(s)
      Maeda T, et al.
    • Organizer
      XI Workshop on Apoptosis in Biology and Medicine
    • Place of Presentation
      Sendai, Japan
    • Related Report
      2008 Annual Research Report
  • [Book] Chapter 13 PPAR and Pain 852009

    • Author(s)
      前田武彦, 岸岡史郎
    • Publisher
      Int.Rev.Neurobiol
    • Related Report
      2010 Final Research Report
  • [Book] Chapter 14 Involvement of inflammatory mediators in neuropathic pain caused by vincristine 852009

    • Author(s)
      Kiguchi N, Maeda T, Kobayashi Y, Saika F, Kishioka S
    • Publisher
      Int.Rev.Neurobiol
    • Related Report
      2010 Final Research Report
  • [Book] エッセンシャル神経科学(シナプス伝達(分担訳),第II部ニューロン)(前田正信監訳)2008

    • Author(s)
      前田武彦, 岸岡史郎
    • Publisher
      丸善
    • Related Report
      2010 Final Research Report
  • [Book] エッセンシャル神経科学(神経伝達物質(分担訳),第II部ニューロン)(前田正信監訳)2008

    • Author(s)
      岸岡史郎
    • Publisher
      丸善
    • Related Report
      2010 Final Research Report
  • [Book] エッセンシャル神経科学(分担訳)2008

    • Author(s)
      岸岡史郎, 他
    • Total Pages
      574
    • Publisher
      丸善
    • Related Report
      2008 Annual Research Report
  • [Remarks] ホームページ等

    • URL

      http://www.wakayama-med.ac.jp/dept/igakubu/160416/index.html

    • Related Report
      2010 Final Research Report
  • [Remarks]

    • URL

      http://www.wakayama-med.ac.jp/dept/igakubu/160416/index.html

    • Related Report
      2010 Annual Research Report
  • [Remarks]

    • URL

      http://www.wakayama-med.ac.jp/dept/igakubu/160416/index.html

    • Related Report
      2009 Annual Research Report
  • [Remarks]

    • URL

      http://www.wakayama-med.ac.jp/dept/igakubu/160416/index.html

    • Related Report
      2008 Annual Research Report

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Published: 2008-04-01   Modified: 2016-04-21  

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