| Project/Area Number |
20591376
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Psychiatric science
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| Research Institution | Wakayama Medical University |
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Principal Investigator |
KISHIOKA Shiroh Wakayama Medical University, 医学部, 教授 (60137255)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
MAEDA Takehiko 和歌山県立医科大学, 医学部, 准教授 (50271010)
KIGUCHI Norikazu 和歌山県立医科大学, 医学部, 助教 (90433341)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
|
| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2008: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
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| Keywords | ニコチン / アルコール / オピオイド / コルチコステロン / 依存 / 身体的依存 / 退薬症状 / ナロキソン / 耐性 / 鎮痛 / オピオド / モルヒネ / ナルトレキソン |
|---|
| Research Abstract |
In this study, we investigated the role of endogenous opioid system in physical dependence induced by nicotine or alcohol. Treatment of opioid receptor antagonist, naloxone caused withdrawal symptoms in mice administered nicotine twice a day for 5-9 days. Nicotine dependence was suppressed by opioid receptor antagonist, naltrexone. On the other hand, treatment of naloxone caused withdrawal symptoms in mice given water including ethanol (1%). These results suggest that endogenous opioid system plays an important role in physical dependence induced by nicotine or alcohol.
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