Establishing a neuroimaging-based biomarker that aids optimal diagnosis and treatment of mood disorder

• Project/Area Number: 20591378
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Psychiatric science
• Research Institution: The University of Tokyo (2009-2012); Nippon Medical School (2008)
• Principal Investigator: YAHATA Noriaki 東京大学, 医学部附属病院, 特任助教 (70409150)
• Co-Investigator(Kenkyū-buntansha): 大久保 善朗 日本医科大学, 大学院・医学研究科, 教授 (20213663) ; 鈴木 秀典 日本医科大学, 大学院・医学研究科, 教授 (30221328) ; 舘野 周 日本医科大学, 医学部, 講師 (50297917)
• Project Period (FY): 2008 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2009: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2008: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
• Keywords: 脳・神経 / 脳神経疾患 / 薬理学 / ストレス / 精神医学 / 精神疾患 / 脳画像 / 気分障害 / 機能的磁気共鳴撮像法 / 薬理学的fMRI研究

Research Abstract

We aimed to establish a neuroimaging-based biomarker for depression that may help optimizing the treatment of this disorder on an individual basis. We focused on the self-reference task, for which the participants judged whether visually-presented sentences describing adaptive or non-adaptive behaviors in given situations are applicable to the participants themselves. We found that the activity in the medial prefrontal cortex (MPFC) was higher for the patient group when they made judgments on adaptive behaviors, correlating positively with the Hamilton depressive rating scale. We also found that the activity in the MPFC was higher for the healthy control group during their judgments on non-adaptive behaviors, correlating positively with the harm avoidance score in the Temperament and Character Inventory. Collectively, it is suggested that the self-reference task may be a useful state-trait biomarker of mood disorder at the neural network level that may aid diagnosing and determining the kind of treatments for the patients.

Research Products

• [Journal Article] A multimodal approach to investigate biomarkers for psychosis in a clinical setting: the integrative neuroimaging studies in schizophrenia targeting for early intervention and prevention (IN-STEP) project (2013)
  • Author(s): Koike, S., Takano, Y., Iwashiro, N., Satomura, Y., Suga, M., Nagai, T., Natsubori, T., Tada, M., Nishimura, Y., Yamasaki, S., Takizawa, R., Yahata, N., Araki, T., Yamasue, H. & Kasai, K
  • Journal Title: Schizophr Res Volume: 143(1) Issue: 1 Pages: 116-24
  • DOI: 10.1016/j.schres.2012.11.012
  • Peer Reviewed
• [Journal Article] Absence of age-related prefrontal NAA change in adults with autism spectrum disorders (2013)
  • Author(s): Aoki, Y., Abe, O., Yahata, N., Kuwabara, H., Natsubori, T., Iwashiro, N., Takano, Y., Inoue,H., Kawakubo, Y., Gonoi, W., Sasaki, H., Murakami, M., Katsura, M., Nippashi, Y., Takao, H., Kunimatsu, A., Matsuzaki, H., Tsuchiya, K. J., Kato, N., Kasai, K. & Yamasue, H
  • Journal Title: Transl Psychiatry Volume: 2 Issue: 10 Pages: e178-e178
  • DOI: 10.1038/tp.2012.108
  • Peer Reviewed
• [Journal Article] Localized gray matter volume reductions in the pars triangularis of the inferior frontal gyrus in individuals at clinical high-risk for psychosis and first episode for schizophrenia (2012)
  • Author(s): Iwashiro, N., Suga, M., Takano, Y., Inoue, H., Natsubori, T., Satomura, Y., Koike, S., Yahata, N., Murakami, M., Katsura, M., Gonoi, W., Sasaki, H., Takao, H., Abe, O., Kasai, K. & Yamasue, H
  • Journal Title: Schizophr Res Volume: 137(1-3) Issue: 1-3 Pages: 124-31
  • DOI: 10.1016/j.schres.2012.02.024
  • Peer Reviewed
• [Journal Article] ヒト脳画像データベースの構築と統合 (2012)
  • Author(s): 八幡憲明, 笠井清登, 岩坪威
  • Journal Title: 細胞工学 Volume: 31(4) Pages: 486-489
• [Journal Article] ヒト脳画像データベースの構築と統合 (2012)
  • Author(s): 八幡憲明
  • Journal Title: 細胞工学 Volume: 31 Pages: 486-489
• [Journal Article] Cortical blindness caused by hypoxemia following an asthma attack (2011)
  • Author(s): Kunishige, T., Omori, A., Tateno, A., Yahata, N. & Hori, J
  • Journal Title: Jpn J Ophthalmol Volume: 55(5) Issue: 5 Pages: 588-590
  • DOI: 10.1007/s10384-011-0058-7
  • NAID: 10029689298
  • Peer Reviewed
• [Journal Article] Functional magnetic resonance imaging study on the effects of acute single administration of paroxetine on motivation-related brain activity (2011)
  • Author(s): Marutani, T., Yahata, N., Ikeda, Y., Ito, T., Yamamoto, M., Matsuura, M., Okubo, Y., Matsushima, E., Suzuki, H. & Matsuda, T.
  • Journal Title: Psychiatry Clin Neurosci Volume: 65 Issue: 2 Pages: 191-198
  • DOI: 10.1111/j.1440-1819.2011.02189.x
  • Peer Reviewed
• [Journal Article] Functional magnetic resonance imaging study on the effects of acute single administration of paroxetine on motivation-related brain activity. (2011)
  • Author(s): Marutani, T., Yahata, N., Ikeda, Y., Ito, T., Yamamoto, M., Matsuura, M., Okubo, Y., Matsushima, E., Suzuki, H., Matsuda, T.
  • Journal Title: Psychiatry Clin Neurosci. 65 Pages: 191-198
  • Peer Reviewed
• [Journal Article] Functional magnetic resonance imaging study on the effects of acute single administration of paroxetine on motivation-related brain activity. (2011)
  • Author(s): Marutani T
  • Journal Title: Psychiatry and Clinical Neurosciences Volume: 65 Pages: 191-198
  • Peer Reviewed
• [Journal Article] Reduced gray matter volume of pars opercularis is associated with impaired social communication in high-functioning autism spectrum disorders (2010)
  • Author(s): Yamasaki, S., Yamasue, H., Abe, O., Suga, M., Yamada, H., Inoue, H., Kuwabara, H., Kawakubo, Y., Yahata, N., Aoki, S., Kano, Y., Kato, N. & Kasai, K
  • Journal Title: Biol Psychiatry Volume: 68 Issue: 12 Pages: 1141-1147
  • DOI: 10.1016/j.biopsych.2010.07.012
  • Peer Reviewed
• [Journal Article] Auditory load-dependent cerebral activation during the diotic listening task: an fMRI study (2010)
  • Author(s): Ikeda, Y., Yahata, N., Takahashi, H., Koeda, M., Asai, H., Okubo, Y. & Suzuki, H.
  • Journal Title: Neurosci. Res Volume: 67 Issue: 1 Pages: 65-71
  • DOI: 10.1016/j.neures.2010.02.006
  • Peer Reviewed
• [Journal Article] Reduced gray matter volume of pars opercularis is associated with impaired social communication in high-functioning autism spectrum disorders. (2010)
  • Author(s): Yamasaki, S., Yamasue, H., Abe, O., Suga, M., Yamada, H., Inoue, H., Kuwabara, H., Kawakubo, Y., Yahata, N., Aoki, S., Kano, Y., Kato, N., Kasai, K.
  • Journal Title: Biol Psychiatry. 68 Pages: 1141-1147
  • Peer Reviewed
• [Journal Article] Auditory load-dependent cerebral activation during the diotic listening task : an fMRI study. (2010)
  • Author(s): Ikeda, Y., Yahata, N., Takahashi, H., Koeda, M., Asai, H., Okubo, Y., Suzuki, H.
  • Journal Title: Neurosci. Res. 67 Pages: 65-71
  • Peer Reviewed
• [Journal Article] Reduced gray matter volume of pars opercularis is associated with impaired social communication in high-functioning autism spectrum disorders. (2010)
  • Author(s): Yamasaki S
  • Journal Title: Biological Psychiatry Volume: 68 Pages: 1141-1147
  • Peer Reviewed
• [Journal Article] Auditory load-dependent cerebral activation during the diotic listening task : an fMRI study (2010)
  • Author(s): Ikeda Y
  • Journal Title: Neuroscience Research (近刊)
  • Peer Reviewed
• [Journal Article] 統合失調症の進行性脳病態仮説 (2009)
  • Author(s): 高野洋輔,小池進介,八幡憲明,笠井清登
  • Journal Title: 医学のあゆみ Volume: 231(10) Pages: 1034-1039
• [Journal Article] 精神疾患の脳画像データベース構築へ向けて-研究資産としての脳画像 (2009)
  • Author(s): 八幡憲明,根本清貴,山下典生
  • Journal Title: 医学のあゆみ Volume: 231(10) Pages: 991-995
• [Journal Article] 精神療法・心理社会療法の脳基盤-言語による脳機能の自己制御 (2009)
  • Author(s): 福田正人,八幡憲明,須田真史,滝沢龍,亀山正樹
  • Journal Title: 精神科治療学(増刊号) Volume: 24 Pages: 20-23
• [Journal Article] 精神疾患の脳画像データベース構築へ向けて-研究資産としての脳画像 (2009)
  • Author(s): 八幡憲明, 根本清貴, 山下典生
  • Journal Title: 医学のあゆみ 231(10) Pages: 991-995
• [Journal Article] 統合失調症の進行性脳病態仮説 (2009)
  • Author(s): 高野洋輔
  • Journal Title: 医学のあゆみ 231 Pages: 1034-1039
• [Journal Article] 精神疾患の脳画像データベース構築へ向けて-研究資産としての脳画像 (2009)
  • Author(s): 八幡憲明
  • Journal Title: 医学のあゆみ 231 Pages: 991-995
• [Journal Article] 精神療法・心理社会療法の脳基盤-言語による脳機能の自己制御 (2009)
  • Author(s): 福田正人
  • Journal Title: 精神科治療学(増刊号) 24 Pages: 20-23
• [Journal Article] Neural correlates of human virtue judgment (2008)
  • Author(s): Takahashi, H., Kato, M., Matsuura, M., Koeda, M., Yahata, N., Suhara, T. & Okubo, Y
  • Journal Title: Cereb. Cortex Volume: 18 Issue: 8 Pages: 1886-1891
  • DOI: 10.1093/cercor/bhm214
  • Peer Reviewed
• [Journal Article] Brain activations during judgments of positive self-conscious emotion and positive basicemotion: pride and joy (2008)
  • Author(s): Takahashi,H.,Matsuura,M.,Koeda,M., Yahata, N., Suhara, T., Kato, M. & Okubo, Y
  • Journal Title: Cereb. Cortex Volume: 18 Issue: 4 Pages: 898-903
  • DOI: 10.1093/cercor/bhm120
  • Peer Reviewed
• [Journal Article] Brain activations during judgments of positive self-conscious emotion and positive basic emotion : pride and joy. (2008)
  • Author(s): Takahashi, H., Matsuura, M., Koeda, M., Yahata, N., Suhara, T., Kato, M., Okubo, Y.
  • Journal Title: Cereb.Cortex 18 Pages: 898-903
  • Peer Reviewed
• [Journal Article] Brain activations during judgments of positive self-conscious emotion and positive basic emotion: pride and joy (2008)
  • Author(s): Takahashi H
  • Journal Title: Cerebral Cortex 18 Pages: 898-903
  • Peer Reviewed
• [Journal Article] Neural correlates of human virtue judement (2008)
  • Author(s): Takahashi H
  • Journal Title: Cerebral Cortex 18 Pages: 1886-1891
  • Peer Reviewed
• [Presentation] Investigating neural mechanisms that interface between self and others: An fMRI study on the theory of mind and empathy (2011)
  • Author(s): Yahata, N., Yamasue, H., Takano, Y., Kawakubo, Y., Inoue, H., Iwashiro, N., Natsubori, T., Aoki, Y., Takao, H., Gonoi, W., Sasaki, H., Katsura, M., Murakami, M., Kunimatsu, A., Abe, O. & Kiyoto Kasai
  • Organizer: Neuroscience2011.Society for Neuroscience
  • Place of Presentation: Washington DC, USA
  • Year and Date: 2011-11-16
• [Presentation] Investigating neural mechanisms that interface between self and others : An fMRI study on the theory of mind and empathy (2011)
  • Author(s): Yahata N
  • Organizer: Neuroscience 2011 (Society for Neuro science)
  • Place of Presentation: Washington DC, USA
  • Year and Date: 2011-11-16
• [Presentation] Understanding attention-deficit hyperactivity disorder through the reward system. Neuro2011 (2011)
  • Author(s): Yahata,N
  • Organizer: 第34回日本神経科学大会
  • Place of Presentation: 横浜
  • Year and Date: 2011-09-16
• [Presentation] Understanding attention-deficit hyperactivity disorder through the reward system (2011)
  • Author(s): Yahata N
  • Organizer: 第34回日本神経科学大会
  • Place of Presentation: 横浜
  • Year and Date: 2011-09-16
• [Presentation] 報酬系を通した注意欠如多動性障害の病態理解:fMRI研究.シンポジウム8・神経経済学と生物学的精神医学の融合 (2011)
  • Author(s): 八幡憲明
  • Organizer: 第33回日本生物学的精神医学会
  • Place of Presentation: 東京
  • Year and Date: 2011-05-22
• [Presentation] 報酬系を通した注意欠如多動性障害の病態理解:fMRI研究 (2011)
  • Author(s): 八幡憲明
  • Organizer: 第33回日本生物学的精神医学会
  • Place of Presentation: 東京
  • Year and Date: 2011-05-22
• [Presentation] 統合失調症患者における対人認知障害～心の理論・共感性のFunctional MRI 研究～ (2010)
  • Author(s): 八幡憲明
  • Organizer: 第40回日本臨床神経生理学会学術大会
  • Place of Presentation: 神戸
  • Year and Date: 2010-11-02
• [Presentation] 統合失調症患者における対人認知障害～心の理論・共感性のFunctional MRI研究～ (2010)
  • Author(s): 八幡憲明
  • Organizer: 第40回日本臨床神経生理学会学術大会
  • Place of Presentation: 神戸
  • Year and Date: 2010-11-02
• [Presentation] Sexually-Dimorphic Neural Basis of Empathy: an fMRI study. Neuro2010 (2010)
  • Author(s): Takano, Y., Yamasue, H., Yahata, N., Hashimoto, R., Gonoi, W., Sasaki, H., Takao, H.,Natsubori, T., Iwashiro, N., Inoue, H., Takei, K., Abe, O. & Kasai, K
  • Organizer: 第33回日本神経科学大会
  • Place of Presentation: 神戸
  • Year and Date: 2010-09-04
• [Presentation] Sexually-Dimorphic Neural Basis of Empathy : an fMRI study. (2010)
  • Author(s): Takano Y
  • Organizer: 第33回日本神経科学大会
  • Place of Presentation: 神戸
  • Year and Date: 2010-09-04
• [Presentation] Investigating neural mechanisms that interface between self and others: an fMRI study on the theory of mind and empathy. Neuro2010 (2010)
  • Author(s): Yahata, N
  • Organizer: 第33回日本神経科学大会
  • Place of Presentation: 神戸
  • Year and Date: 2010-09-03
• [Presentation] Repetition suppression of theory of mind: Functional imaging evidence for domain-specific and domain-general elements of the mentalizing system. Neuro2010 (2010)
  • Author(s): Cohen, A. S., Grafton, S. T., Miller, M. B., Kato, N., Hashimoto, R., Yahata, N. & German, T. C.
  • Organizer: 第33回日本神経科学大会
  • Place of Presentation: 神戸
  • Year and Date: 2010-09-03
• [Presentation] Investigating neural mechanisms that interface between self and others : an fMRI study on the theory of mind and empathy. Neuro2010 (2010)
  • Author(s): Yahata, N.
  • Organizer: 第33回日本神経科学大会
  • Place of Presentation: 神戸
  • Year and Date: 2010-09-03
• [Presentation] Investigating neural mechanisms that interface between self and others : an fMRI study on the theory of mind and empathy. (2010)
  • Author(s): Yahata N
  • Organizer: 第33回日本神経科学大会
  • Place of Presentation: 神戸
  • Year and Date: 2010-09-03
• [Presentation] Repetition suppression of theory of mind : Functional imaging evidence for domain-snecific and domain-general elements of the mentalizing system. (2010)
  • Author(s): Cohen A
  • Organizer: 第33回日本神経科学大会
  • Place of Presentation: 神戸
  • Year and Date: 2010-09-03
• [Presentation] 自尊心の神経基盤の探索:機能的MRIによる検討 (2010)
  • Author(s): 藤澤洋輔,八幡憲明,野守美千子,神山貴弘,舘野周,川島義高,森田健太郎,増岡孝浩,大久保善朗
  • Organizer: 第7回日本うつ病学会総会
  • Place of Presentation: 金沢
  • Year and Date: 2010-06-11
• [Presentation] SSRI,プラセボが報酬予測に与える影響 (2009)
  • Author(s): 丸谷俊之,八幡憲明,池田裕美子,山本愛実,伊藤岳人,松浦雅人,松島英介,鈴木秀典,松田哲也
  • Organizer: 第39回臨床神経生理学会
  • Place of Presentation: 小倉
  • Year and Date: 2009-11-20
• [Presentation] SSRI,プラセボが報酬予測に与える影響 (2009)
  • Author(s): 丸谷俊之
  • Organizer: 第39回臨床神経生理学会
  • Place of Presentation: 北九州
  • Year and Date: 2009-11-20
• [Presentation] プラセボがヒト情動機構に及ぼす効果の検討:fMRI研究 (2009)
  • Author(s): 八幡憲明,新貝慈利,舘野周,鈴木秀典,大久保善朗
  • Organizer: 第32回日本神経科学大会
  • Place of Presentation: 名古屋
  • Year and Date: 2009-09-18
• [Presentation] 両耳同音聴課題を用いた聴覚性選択的注意:fMRI研究 (2009)
  • Author(s): 池田裕美子,八幡憲明,高橋英彦,肥田道彦,大久保善朗,鈴木秀典
  • Organizer: 第32回日本神経科学大会
  • Place of Presentation: 名古屋
  • Year and Date: 2009-09-18
• [Presentation] 抗不安薬ならびにプラセボがヒト情動機構に及ぼす効果の検討～薬理学的fMRI研究～ (2009)
  • Author(s): 八幡憲明,新貝慈利,舘野周,肥田道彦,小川耕平,田渕隆,鈴木秀典,大久保善朗
  • Organizer: 第31回日本生物学的精神医学会
  • Place of Presentation: 京都
  • Year and Date: 2009-04-25
• [Presentation] 統合失調症患者における他者の感情理解の脳基盤 (2009)
  • Author(s): 高野洋輔,山末英典,橋本龍一郎,八幡憲明,阿部修,武井邦夫,高尾英正,青木茂樹,笠井清登
  • Organizer: 第31回日本生物学的精神医学会
  • Place of Presentation: 京都
  • Year and Date: 2009-04-25
• [Presentation] Modulation of the human emotional system by subacute fatigue load: an fMRI study (2008)
  • Author(s): Yahata, N., Sasaki, T., Matsumoto, S.,Matsuda, T., Suzuki, H., Okubo, Y., Sakai, K
  • Organizer: Neuroscience 2008. Society for Neuroscience
  • Place of Presentation: Washington DC, USA
  • Year and Date: 2008-11-16
• [Presentation] Modulation of the human emotional system by subacute fatigue load : an fMRI study. (2008)
  • Author(s): Yahata, N., Sasaki, T., Matsumoto, S., Matsuda, T., Suzuki, H., Okubo, Y., Sakai, K.
  • Organizer: Neuroscience 2008. Society for Neuroscience.
  • Place of Presentation: Washington DC, USA
  • Year and Date: 2008-11-16
• [Presentation] Modulation of the human emotional system by subacute fatigue load: an fMRI study (2008)
  • Author(s): Yahata N
  • Organizer: Neuroscience 2008 (the 38th annual meeting of the Society for Neuroscience)
  • Place of Presentation: Washington DC, USA
  • Year and Date: 2008-11-16
• [Presentation] Neural Activities Underlying Self-Esteem in Healthy Adults: An fMRI Study (2008)
  • Author(s): Tateno A
  • Organizer: 第2回アジア・太平洋生物学的精神医学会第30回日本生物学的精神医学会(合同学会)
  • Place of Presentation: 富山
  • Year and Date: 2008-09-13
• [Presentation] Effects of subacute fatigue load on the human emotional system: an fMRI study (2008)
  • Author(s): Yahata N
  • Organizer: 第31回日本神経科学大会
  • Place of Presentation: 東京
  • Year and Date: 2008-07-10
• [Presentation] Neural activities underlying self-esteem in healthy adults: An fMRI study (2008)
  • Author(s): Tateno, A., Yahata, N., Morita, K., Masuoka, T. & Okubo, Y
  • Organizer: 2nd WFSBP Asia-Pacific Congress and 30th Annual Meeting of JSBP
  • Place of Presentation: Toyama, Japan
• [Presentation] Effects of subacute fatigue load on the human emotional system: an fMRI study. Neuroscience 2008 (2008)
  • Author(s): Yahata, N., Sasaki, T., Matsumoto, S., Matsuda, T., Suzuki, H., Okubo, Y. & Sakai, K
  • Organizer: 第31回日本神経科学大会
  • Place of Presentation: 東京
• [Book] 前頭前野内側皮質MPFCの構造と機能. 福田正人・鹿島晴雄編. 専門医のための精神科臨床リュミエール第III期・第21巻『前頭葉でわかる精神疾患の臨床』 (2010)
  • Author(s): 八幡憲明
  • Publisher: 中山書店
• [Book] 前頭葉でわかる精神疾患の臨床(専門医のための精神科臨床リュミエール・第21巻) (2010)
  • Author(s): 八幡憲明
  • Publisher: 中山書店