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Relationship between awareness of illness and long term outcome in schizophrenia

Research Project

Project/Area Number 20591381
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Psychiatric science
Research InstitutionFujita Health University

Principal Investigator

IWATA Nakao  Fujita Health University, 医学部, 教授 (60312112)

Project Period (FY) 2008 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2008: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords統合失調症 / アドヒアランス / MEMS(Medication Event Monitoring System) / Medication Event Monitoring system / Shared Decision Making / Medication Event Monitoring System / 予後予測因子 / 寛解
Research Abstract

Treatment adherence are pointed out one of important factor for long term outcome in schizophrenia. At the moment, however, no investigation for adherence in real world setting in Japanese medication supply system was performed. In this research, it is the first time in Japan to survey adherence situation by using Medication Monitoring System. As results, adherence decrease immediately after one week discharge, lack of awareness of illness is an estimated factor for poor outcome. Psycho-socio intervention including helping awareness to illness and adherence is more important to improve the outcome of schizophrenia.

Report

(4 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (31 results)

All 2011 2010 2009 2008

All Journal Article (28 results) (of which Peer Reviewed: 22 results) Presentation (3 results)

  • [Journal Article] アドヒアランスの現状・認識とその対応2011

    • Author(s)
      岩田仲生
    • Journal Title

      14(2)

      Pages: 25-28

    • Related Report
      2010 Final Research Report
  • [Journal Article] アドヒアランスの現状・認識とその対応2011

    • Author(s)
      岩田仲生
    • Journal Title

      臨床精神薬理

      Volume: 14(2) Pages: 25-28

    • Related Report
      2010 Annual Research Report
  • [Journal Article] 再発防止を目的とした統合失調症の新しい治療計画 新規持効性注射剤単剤治療と心理教育パッケージ2010

    • Author(s)
      趙岳人、岩田仲生
    • Journal Title

      精神保健 55

      Pages: 36-36

    • Related Report
      2010 Final Research Report
  • [Journal Article] 統合失調症治療における非定型抗精神病薬持効性注射剤の適応と課題2010

    • Author(s)
      岩田仲生
    • Journal Title

      最新精神医学 15(2)

      Pages: 165-175

    • Related Report
      2010 Final Research Report
  • [Journal Article] 説明文書を用いたインフォームド・コンセントが精神疾患患者における抗精神病薬の満足度および服薬態度に及ぼす影響について2010

    • Author(s)
      種村繁人、岩田仲生, 他
    • Journal Title

      臨床精神薬理 13(2)

      Pages: 327-337

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] 再発防止を目的とした統合失調症の新しい治療計画 新規持効性注射剤単剤治療と心理教育パッケージ2010

    • Author(s)
      趙岳人、岩田仲生
    • Journal Title

      精神保健

      Volume: 55 Pages: 36-36

    • Related Report
      2010 Annual Research Report
  • [Journal Article] 統合失調症治療における非定型抗精神病薬持効性注射剤の適応と課題2010

    • Author(s)
      岩田仲生, 他
    • Journal Title

      最新精神医学

      Volume: 15(2) Pages: 165-175

    • Related Report
      2010 Annual Research Report
  • [Journal Article] 説明文書を用いたインフォームド・コンセントが精神疾患患者における抗精神病薬の満足度および服薬態度に及ぼす影響について2010

    • Author(s)
      種村繁人、岩田仲生, 他
    • Journal Title

      臨床精神薬理

      Volume: 13(2) Pages: 327-337

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Serotonin 1A receptor gene is associated with Japanese methamphetamine-induced psychosis patients2010

    • Author(s)
      Kishi T, et al
    • Journal Title

      Neuropharmacology 58

      Pages: 452-456

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] HTR2A is Associated with SSRI Response in Major Depressive Disorder in a Japanese Cohort2009

    • Author(s)
      Kishi T, et al
    • Journal Title

      Neuromolecular Med

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Copy Number Variation in Schizophrenia in the Japanese Population2009

    • Author(s)
      Ikeda M, et al
    • Journal Title

      Biol Psychiatry 67

      Pages: 283-286

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Identification of Novel Candidate Genes for Treatment Response to Risperidone and Susceptibility for Schizophrenia : Integrated Analysis Among Pharmacogenomics, Mouse Expression, and Genetic Case-Control Association Approaches2009

    • Author(s)
      Ikeda M, et al
    • Journal Title

      Biol Psychiatry 67

      Pages: 263-269

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Translin-Associated Factor X Gene(TSNAX)may be Associated with Female major Depressive Disorder in the Japanese Population2009

    • Author(s)
      Okuda A, et al
    • Journal Title

      Neuromolecular Med 12

      Pages: 78-75

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Serotonin 1A receptor gene and major depressive disorder : an association study and meta-analysis2009

    • Author(s)
      Kishi T, et al
    • Journal Title

      J Hum Genet 54

      Pages: 629-633

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Prepulse inhibition of the startle response with chronic schizophrenia : a replication study2009

    • Author(s)
      Moriwaki M, et al
    • Journal Title

      Neurosci Res 65

      Pages: 259-262

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Orphan Nuclear Receptor Rev-erb Alpha Gene(NR1D1)and Fluvoxamine Response in Major Depressive Disorder in the Japanese Population2009

    • Author(s)
      Kishi T, et al
    • Journal Title

      Neuropsychobiology 59

      Pages: 234-238

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Risk factors for obstructive sleep apnea syndrome screening in mood disorder patients2009

    • Author(s)
      Hattori M, et al
    • Journal Title

      Psychiatry Clin Neurosci 63

      Pages: 385-391

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Possible association of prokineticin 2 receptor gene(PROKR2)with mood disorders in the Japanese population2009

    • Author(s)
      Kishi T, et al
    • Journal Title

      Neuromolecular Med 11

      Pages: 114-122

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Analysis of 10 independent samples provides evidence for association between schizophrenia and a SNP flanking fibroblast growth factor receptor 2.2009

    • Author(s)
      O'Donovan MC, et al.
    • Journal Title

      Mol Psychiatry. 14

      Pages: 30-36

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Association study of the calcineurin A gamma subunit gene (PPP3CC) and methamphetamine-use disorder in a Japanese population.2008

    • Author(s)
      Kinoshita Y, et al.
    • Journal Title

      Ann N Y Acad Sci. 1139

      Pages: 57-62

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Glutamate cysteine ligase modifier (GCLM) subunit gene is not associated with methamphetamine-use disorder or schizophrenia in the Japanese population.2008

    • Author(s)
      Kishi T, et al.
    • Journal Title

      Ann N Y Acad Sci. 1139

      Pages: 63-69

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Alpha4 and beta2 subunits of neuronal nicotinic acetylcholine receptor genes are not associated with methamphetamine-use disorder in the Japanese population.2008

    • Author(s)
      Kishi T, et al.
    • Journal Title

      Ann N Y Acad Sci. 1139

      Pages: 70-82

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Prostate apoptosis response 4 gene is not associated with methampheta mine-use disorder in the Japanese population.2008

    • Author(s)
      Kishi T, et al.
    • Journal Title

      Ann N Y Acad Sci. 1139

      Pages: 83-88

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Variants of dopamine and serotonin candidate genes as predictors of response to risperidone treatment in first-episode schizophrenia.2008

    • Author(s)
      Ikeda M, et al.
    • Journal Title

      Pharmacogenomics. 10

      Pages: 1437-43

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Association analysis of nuclear receptor Rev-erb alpha gene (NR1D1) with mood disorders in the Japanese population.2008

    • Author(s)
      Kishi T, et al.
    • Journal Title

      Neurosci Res. 62

      Pages: 211-215

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] dentification of loci associated with schizophrenia by genome-wide association and follow-up.2008

    • Author(s)
      O'Donovan MC, et al.
    • Journal Title

      Nat Genet. 40

      Pages: 1053-55

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Identification of YWHAE, a gene encoding 14-3-3epsilon, as a possible susceptibility gene for schizophrenia.2008

    • Author(s)
      Ikeda M, et al.
    • Journal Title

      Hum Mol Genet. 17

      Pages: 3312-22

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Genetic association analysis of tagging SNPs in alpha4 and beta2 subunits of neuronal nicotinic acetylcholine receptor genes (CHRNA4 and CHRNB2) with schizophrenia in the Japanese population2008

    • Author(s)
      Kishi T, et al.
    • Journal Title

      J Neural Transm. 115

      Pages: 1457-61

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Presentation] 統合失調症患者におけるリスペリドン持効性注射剤に関する受け入れ調査2010

    • Author(s)
      亀井浩之、岩田仲生, 他
    • Organizer
      第20回日本臨床精神神経薬理学会
    • Place of Presentation
      仙台国際センター(宮城県)
    • Year and Date
      2010-09-16
    • Related Report
      2010 Annual Research Report 2010 Final Research Report
  • [Presentation] 統合失調症に対する「リスペリドン持効性注射剤(RLAI)と心理教育テキスト(COMPASS)」パッケージ治療の有効性2010

    • Author(s)
      趙岳人、岩田仲生, 他
    • Organizer
      第20回日本臨床精神神経薬理学会
    • Place of Presentation
      仙台国際センター(宮城県)
    • Year and Date
      2010-09-16
    • Related Report
      2010 Annual Research Report 2010 Final Research Report
  • [Presentation] Association study of schizophrenia in Japanese population2008

    • Author(s)
      Iwata N.
    • Organizer
      XVIth World Congress on Psychiatric Genetics
    • Place of Presentation
      Osaka, Japan
    • Year and Date
      2008-10-14
    • Related Report
      2008 Annual Research Report

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Published: 2008-04-01   Modified: 2016-04-21  

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