| Project/Area Number |
20591382
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Psychiatric science
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| Research Institution | National Institute of Radiological Sciences |
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Principal Investigator |
TAKANO Harumasa National Institute of Radiological Sciences, 分子イメージング研究センター, 研究員 (30348792)
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| Co-Investigator(Renkei-kenkyūsha) |
TAKAHASHI Hidehiko 独立行政法人放射線医学総合研究所, 分子イメージング研究センター, 客員研究員 (60415429)
ITO Hiroshi 独立行政法人放射線医学総合研究所, 分子イメージング研究センター, チームリーダー (20360357)
SUHARA Tetsuya 独立行政法人放射線医学総合研究所, 分子イメージング研究センター, グループリーダー (90216490)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2009: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2008: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
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| Keywords | 脳・神経 / セロトニン / 脳画像 / 放射線 / うつ病 |
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| Research Abstract |
We performed positron emission tomography study on serotonin transporter (5HTT) and serotonin 1A receptor (5HT 1A) in healthy subjects. High binding of 5HTT was observed in the striatum, raphe nucleus, and thalamus, whereas low binding in the cerebral cortex. In contrast, high binding of 5HT1A was observed in the hippocampus, cerebral cortex, and raphe nucleus, moderate binding in the cerebral cortex, raphe nucleus, and striatum, and low binding in the thalamus. Furthermore, negative correlations in binding between 5HTT and 5HT1A were observed in some brain regions.
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