Research on pathophysiology and mechanisms to develop carbonyl stress-related schizophrenia
| Project/Area Number |
20591383
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Psychiatric science
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| Research Institution | Tokyo Metropolitan Organization for Medical Research |
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Principal Investigator |
ARAI Makoto Tokyo Metropolitan Organization for Medical Research, 東京都精神医学総合研究所, 主席研究員 (80356253)
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| Co-Investigator(Kenkyū-buntansha) |
ITOKAWA Masanari 財団法人東京都医学研究機構, 東京都精神医学総合研究所, プロジェクトリーダー(参事) (40332324)
OKAZAKI Yuji 財団法人東京都医学研究機構, 東京都精神医学総合研究所, 客員研究員 (40010318)
MIYATA Toshio 東北大学, 大学院・医学系・研究科・付属創生応用医学研究センター, センター長(教授) (10222332)
YOHSIKAWA Takeo 独立行政法人理化学研究所, 分子精神科学研究チーム, チームリーダー (30249958)
OHNISHI Tetsuo 独立行政法人理化学研究所, 分子精神科学研究チーム, 研究員 (80373281)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2009: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2008: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Keywords | 統合失調症 / カルボニルストレス / 酸化ストレス / 遺伝子変異 / グリオキサラーゼ / ビタミン / ストレス / ゲノム / 遺伝子 / 脳・神経 / 遺転子 |
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| Research Abstract |
Accumulation of advanced glycation end products, including pentosidine, results from "carbonyl stress," a state featuring an increase in reactive carbonyl compounds and their attendant protein modifications. We found a cross-sectional link, albeit incomplete, between glyoxalase I defect?elicited carbonyl stress and a subgroup of patients with schizophrenia. Thus, agents such as pyridoxamine able to inhibit advanced glycation end product formation or entrap reactive carbonyl compounds may also prove to be of therapeutic value.
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Report
(4 results)
Research Products
(87 results)
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[Journal Article] Enhanced Carbonyl Stress in a Subpopulation of Schizophrenia.2010
Author(s)
Arai M, Yuzawa H, Nohara I, Ohnishi T, Obata N, Iwayama Y, Haga S, Toyota T, Ujike H, Arai M, Ichikawa T, Nishida A, Tanaka Y, Furukawa A, Aikawa Y, Kuroda O, Niizato K, Izawa R, Nakamura K, Mori N, Matsuzawa D, Hashimoto K, Iyo M, Sora I, Matsushita M, Okazaki Y, Yoshikawa T, Miyata T, Itokawa M.
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Journal Title
Arch Gen Psychiatry. 67(6)
Pages: 589-597
NAID
Related Report
Peer Reviewed
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