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Oxidative Damage Is Associated with the Onset of Cognitive Impairment in Very Mild Alzheimer's Disease

Research Project

Project/Area Number 20591387
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Psychiatric science
Research InstitutionUniversity of Yamanashi

Principal Investigator

NUNOMURA Akihiko  University of Yamanashi, 大学院・医学工学総合研究部, 准教授 (60241436)

Project Period (FY) 2008 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2008: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords脳神経疾患 / 認知症 / 老化 / 酸化ストレス / アルツハイマー病 / 8-hydroxyguanosine / 核酸 / 免疫細胞化学 / 認知症(痴呆)
Research Abstract

An in situ approach was used to identify an oxidized nucleoside, 8-hydroxyguanosine in the cerebral cortex of postmortem brains. Density measurements of the immunoreactions revealed a modest but statistically significant increase in neuronal RNA oxidation during aging (0.3 to 86 years old). In the subjects with very mild Alzheimer's disease (AD), but not preclinical AD, neurons showed higher burden of oxidized RNA compared to age-matched controls. Prominent levels of neuronal RNA oxidation are associated with the earliest changes marking the onset of cognitive impairment in the prodromal stage of AD.

Report

(4 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (81 results)

All 2011 2010 2009 2008 Other

All Journal Article (46 results) (of which Peer Reviewed: 21 results) Presentation (18 results) Book (13 results) Remarks (4 results)

  • [Journal Article] Mitochondria : a therapeutic target in neurodegeneration.2011

    • Author(s)
      Moreira PI, Zhu X, Nunomura A
    • Journal Title

      Biochim Biophys Acta - Mol Basis Dis 1802

      Pages: 212-220

    • Related Report
      2010 Final Research Report
  • [Journal Article] Intraneuronal amyloid β accumulation and oxidative damage to nucleic acids in Alzheimer disease2010

    • Author(s)
      Nunomura A, Tamaoki T, Tanaka K
    • Journal Title

      Neurobiol Dis 37

      Pages: 731-737

    • Related Report
      2010 Final Research Report
  • [Journal Article] Specific reaction of Met 35 in amyloid β peptide with hypochlorous acid.2010

    • Author(s)
      Nakamura M, Shishido N, Nunomura A
    • Journal Title

      Free Radic Res 44

      Pages: 734-741

    • Related Report
      2010 Final Research Report
  • [Journal Article] Increased iron and free radical generation in preclinical Alzheimer disease and mild cognitive impairment.2010

    • Author(s)
      Smith MA, Zhu X, Nunomura A
    • Journal Title

      J Alzheimers Dis 19

      Pages: 363-372

    • Related Report
      2010 Final Research Report
  • [Journal Article] Oxidative stress in Alzheimer disease : a possibility for prevention.2010

    • Author(s)
      Bonda DJ, Wang X, Nunomura A
    • Journal Title

      Neuropharmacology 59

      Pages: 290-294

    • Related Report
      2010 Final Research Report
  • [Journal Article] Antioxidant approaches for the treatment of Alzheimer's disease.2010

    • Author(s)
      Lee HP, Zhu X, Nunomura A
    • Journal Title

      Expert Rev Neurother 10

      Pages: 1201-1208

    • Related Report
      2010 Final Research Report
  • [Journal Article] Detection and localization of markers of oxidative stress by in situ methods : application in the study of Alzheimer disease2010

    • Author(s)
      Moreira PI, Sayre LM, Nunomura A
    • Journal Title

      Methods Mol Biol 610

      Pages: 419-434

    • Related Report
      2010 Final Research Report
  • [Journal Article] Specific reaction of Met 35 in amyloidβpeptide with hypochlorous acid.2010

    • Author(s)
      Nakamura M, et al.
    • Journal Title

      Free Radical Research

      Volume: 44 Pages: 737-741

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Antioxidant approaches for the treatment of Alzheimer' s disease.2010

    • Author(s)
      Lee HP, et al.
    • Journal Title

      Expert Review of Neurotherapeutics

      Volume: 10 Pages: 1201-1208

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Oxidative stress and its implications for future treatments and management of Alzheimer disease.2010

    • Author(s)
      Clark TA, et al.
    • Journal Title

      International Journal of Biological Science

      Volume: 6 Pages: 225-227

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Oxidative stress in Alzheimer disease : a possibility for prevention.2010

    • Author(s)
      Bonda DJ, et al.
    • Journal Title

      Neuropharmacology

      Volume: 59 Pages: 290-294

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 食品・植物由来の抗酸化機能成分による認知症予防.2010

    • Author(s)
      布村明彦, ら.
    • Journal Title

      Geriatric Medicine

      Volume: 48 Pages: 619-626

    • Related Report
      2010 Annual Research Report
  • [Journal Article] 認知症予防の理論:酸化ストレス制御と神経ホルミシス.2010

    • Author(s)
      布村明彦.
    • Journal Title

      日本未病システム学会雑誌

      Volume: 16 Pages: 79-84

    • Related Report
      2010 Annual Research Report
  • [Journal Article] Mitochondria : a therapeutic target in neurodegeneration.2010

    • Author(s)
      Moreira P.I., et al.
    • Journal Title

      Biochimica et Biophysica Acta-Molecular Basis of Disease 1802

      Pages: 212-220

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Detection and localization of markers of oxidative stress by in situ methods : application in the study of Alzheimer disease.2010

    • Author(s)
      Moreira P.I., et al.
    • Journal Title

      Methods in Molecular Biology 610

      Pages: 419-434

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Increased iron and free radical generation in preclinical Alzheimer disease and mild cognitive impairment.2010

    • Author(s)
      Smith M.A., et al.
    • Journal Title

      Journal of Alzheimer's Disease 19

      Pages: 363-372

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Alzheimer病:病因・病態.酸化ストレスの果たす役割.2010

    • Author(s)
      布村明彦, ら.
    • Journal Title

      神経内科 72(Suppl.6)

      Pages: 263-268

    • Related Report
      2009 Annual Research Report
  • [Journal Article] Intraneuronal amyloid β accumulation and oxidative damage to nucleic acids in Alzheimer disease.2010

    • Author(s)
      Nunomura A., et al.
    • Journal Title

      Neurobiology of Disease 37

      Pages: 731-737

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] RNA oxidation in Alzheimer disease and related neurodegenerative disorders.2009

    • Author(s)
      Nunomura A, Hofer T, Moreira PI
    • Journal Title

      Acta Neuropathol 118

      Pages: 151-166

    • Related Report
      2010 Final Research Report
  • [Journal Article] The neuronal expression of MYC causes a neurodegeneration phenotype in a novel transgenic mouse.2009

    • Author(s)
      Lee HG, Casadesus G, Nunomura A
    • Journal Title

      Am J Pathol 174

      Pages: 891-897

    • Related Report
      2010 Final Research Report
  • [Journal Article] Reexamining Alzheimer's disease : evidence for a protective role for amyloid-βprotein precursor and amyloid-β.2009

    • Author(s)
      Castellani RJ, Lee HG, Nunomura A
    • Journal Title

      J Alzheimers Dis 18

      Pages: 447-452

    • Related Report
      2010 Final Research Report
  • [Journal Article] Oxidative stress in Parkinson's disease.2009

    • Author(s)
      Friedlich AL, Smith MA, Nunomura A
    • Journal Title

      Open Pathol J 3

      Pages: 38-42

    • Related Report
      2010 Final Research Report
  • [Journal Article] Natural oxidant balance in Parkinson disease.2009

    • Author(s)
      Perry G, Moreira PI, Nunomura A
    • Journal Title

      Arch Neurol 66

      Pages: 1445-1445

    • Related Report
      2010 Final Research Report
  • [Journal Article] Treatment advances in Alzheimer's disease based on the oxidative stress model.2009

    • Author(s)
      Friedlich AL, Rolston RK, Nunomura A
    • Journal Title

      F1000 Med Rep 1

    • Related Report
      2010 Final Research Report
  • [Journal Article] RNA oxidation in Alzheimer disease and related neurodegenerative disorders.2009

    • Author(s)
      Nunomura A., et al.
    • Journal Title

      Acta Neuropathologica 118

      Pages: 151-166

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 神経ホルミシス (neurohormesis).2009

    • Author(s)
      布村明彦.
    • Journal Title

      老年精神医学雑誌 20

      Pages: 506-507

    • Related Report
      2009 Annual Research Report
  • [Journal Article] Treatment advances in Alzheimer's disease based on the oxidative stress model.2009

    • Author(s)
      Friedlich A.L., et al.
    • Journal Title

      F1000 Medicine Reports 1(Online journal)

      Pages: 5-5

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] アルツハイマー病の生化学バイオマーカー.酸化ストレスマーカー.2009

    • Author(s)
      布村明彦.
    • Journal Title

      Cognition and Dementia 8

      Pages: 27-34

    • Related Report
      2009 Annual Research Report
  • [Journal Article] Reexamining Alzheimer's disease : evidence for a protective role for amyloid-β protein precursor and amyloid-β.2009

    • Author(s)
      Castellani R.J., et al.
    • Journal Title

      Journal of Alzheimer's Disease 18

      Pages: 447-452

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Natural oxidant balance in Parkinson disease.2009

    • Author(s)
      Perry G., et al.
    • Journal Title

      Archives of Neurology 66

      Pages: 1445-1445

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Oxidative stress in Parkinson's disease.2009

    • Author(s)
      Friedlich A.L., et al.
    • Journal Title

      Open Pathology Journal 3

      Pages: 38-42

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] RNA oxidation in Alzheimer disease and related neurodegenerative disorders.2009

    • Author(s)
      Nunomura A., et al.
    • Journal Title

      Acta Neuropathologica Epub ahead of print

      Pages: 1-16

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 軽度認知障害(MCI)発症前後の認知症予防.2009

    • Author(s)
      布村明彦, 玉置寿男
    • Journal Title

      老年精神医学雑誌 20

      Pages: 249-305

    • Related Report
      2008 Annual Research Report
  • [Journal Article] The neuronal expression of MYC causes a neurodegeneration phenotype in a novel transgenic mouse.2009

    • Author(s)
      Lee H. G., et al.
    • Journal Title

      American Journal of Pathology 174

      Pages: 891-897

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] RNA oxidation in neurodegenerative diseases : sublethal damage as a mechanism for chronic degeneration.2008

    • Author(s)
      Nunomura A, Smith MA, Perry G.
    • Journal Title

      Yamanashi Med J 23

      Pages: 75-95

    • NAID

      110007018282

    • Related Report
      2010 Final Research Report
  • [Journal Article] Nucleic acid oxidation in Alzheimer disease.2008

    • Author(s)
      Moreira PI, Nunomura A, Nakamura M
    • Journal Title

      Free Radic Biol Med 44

      Pages: 1493-1505

    • Related Report
      2010 Final Research Report
  • [Journal Article] Phosphorylated tau : toxic, protective, or none of the above.2008

    • Author(s)
      Castellani RJ, Nunomura A, Lee HG
    • Journal Title

      J Alzheimers Dis 14

      Pages: 377-383

    • Related Report
      2010 Final Research Report
  • [Journal Article] Oxidative stress signaling in Alzheimer's disease.2008

    • Author(s)
      Su B, Wang X, Nunomura A
    • Journal Title

      Curr Alzheimer Res 5

      Pages: 525-532

    • Related Report
      2010 Final Research Report
  • [Journal Article] Antioxidant therapy in Alzheimer's disease : theory and practice.2008

    • Author(s)
      Aliev G, Obrenovich ME, Nunomura A
    • Journal Title

      Mini Rev Med Chem 8

      Pages: 1395-1406

    • Related Report
      2010 Final Research Report
  • [Journal Article] RNA oxidation in neurodegenerative diseases : sublethal damage as a mechanism for chronic degeneration.2008

    • Author(s)
      Nunomura A., et al.
    • Journal Title

      Yamanashi Medical Journal 23

      Pages: 75-95

    • NAID

      110007018282

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 酸化ストレス研究からみた認知症予防戦略.2008

    • Author(s)
      布村明彦
    • Journal Title

      Geriatric Medicine 46

      Pages: 1535-1540

    • Related Report
      2008 Annual Research Report
  • [Journal Article] Oxidative stress signaling in Alzheimer's disease2008

    • Author(s)
      Su B., et al.
    • Journal Title

      Current Alzheimer Research 5

      Pages: 523-532

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Antioxidant therapy in Alzheimer's disease : theory and practice.2008

    • Author(s)
      Aliev G., et al.
    • Journal Title

      Mini-Reviews in Medicinal chemistry 8

      Pages: 1395-1406

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Sublethal RNA oxidation as a mechanism for neurodegenerative disease.2008

    • Author(s)
      Castellani R. J., et al.
    • Journal Title

      International Journal of Molecular Sciences 9

      Pages: 789-806

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Phosphorylated tau : toxic, protective, or none of the above.2008

    • Author(s)
      Castellani R. J., et al.
    • Journal Title

      Journal of Alzheimer's Disease 14

      Pages: 377-383

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Nucleic acid oxidation in Alzheimer disease.2008

    • Author(s)
      Moreira P. I., et al.
    • Journal Title

      Free Radical Biology and Medicine 44

      Pages: 1493-1505

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Presentation] Intracellular amyloid-β is a consistent feature of hippocampal neurons and unrelated to age or Alzheimer disease.2010

    • Author(s)
      Blair JA, et al.
    • Organizer
      Microscopy Society of Northeastern Ohio Fall Meeting 2010
    • Place of Presentation
      Akron, USA
    • Year and Date
      2010-11-04
    • Related Report
      2010 Final Research Report
  • [Presentation] Intracellular amyloid-βis a consistent feature of hippocampal neurons and unrelated to age or Alzheimer disease.2010

    • Author(s)
      Blair JA, et al.
    • Organizer
      Microscopy Society of Northeastern Ohio Fall Meeting 2010
    • Place of Presentation
      Akron, USA
    • Year and Date
      2010-11-04
    • Related Report
      2010 Annual Research Report
  • [Presentation] アルツハイマー病とパーキンソン病における酸化ストレスの役割2010

    • Author(s)
      布村明彦
    • Organizer
      J-CAN 2010(Japanese Consortium for Age-related Neurodegenerative Disorders)
    • Place of Presentation
      東京
    • Year and Date
      2010-08-28
    • Related Report
      2010 Final Research Report
  • [Presentation] アルツハイマー病とパーキンソン病における酸化ストレスの役割2010

    • Author(s)
      布村明彦.
    • Organizer
      J-CAN 2010 (Japanese Consortium for Age-related NeurodegenerativeDisorders)
    • Place of Presentation
      東京
    • Year and Date
      2010-08-28
    • Related Report
      2010 Annual Research Report
  • [Presentation] Alzheimer disease neuropathology is pathognomonic but not pathogenic.2010

    • Author(s)
      Castellani RJ, et al.
    • Organizer
      The 4th World Congress on Controversies in Neurology (CONy)
    • Place of Presentation
      Barcelona, Spain
    • Related Report
      2010 Final Research Report
  • [Presentation] Alzheimer disease neuropathology is pathognomonic but not pathogenic.2010

    • Author(s)
      Castellani RJ, et al.
    • Organizer
      The 4^<th> World Congress on Controversies in Neurology (CONy)
    • Place of Presentation
      Barcelona, Spain
    • Related Report
      2010 Annual Research Report
  • [Presentation] 酸化ストレスと神経ホルミシスの観点から見た認知症予防2009

    • Author(s)
      布村明彦
    • Organizer
      第16回日本未病システム学会
    • Place of Presentation
      大阪
    • Year and Date
      2009-10-31
    • Related Report
      2010 Final Research Report
  • [Presentation] 酸化ストレスと神経ホルミシスの観点から見た認知症予防.2009

    • Author(s)
      布村明彦.
    • Organizer
      第16回日本未病システム学会
    • Place of Presentation
      大阪
    • Year and Date
      2009-10-31
    • Related Report
      2009 Annual Research Report
  • [Presentation] 酸化ストレス制御と神経ホルミシス:認知症予防のストラテジー2009

    • Author(s)
      布村明彦
    • Organizer
      第24回日本老年精神医学会
    • Place of Presentation
      横浜
    • Year and Date
      2009-06-19
    • Related Report
      2010 Final Research Report
  • [Presentation] 酸化ストレス制御と神経ホルミシス : 認知症予防のストラテジー2009

    • Author(s)
      布村明彦.
    • Organizer
      第24回日本老年精神学会
    • Place of Presentation
      横浜
    • Year and Date
      2009-06-19
    • Related Report
      2009 Annual Research Report
  • [Presentation] アンチエイジングと認知症予防-酸化ストレス研究からの展望-2009

    • Author(s)
      布村明彦
    • Organizer
      第9回日本抗加齢医学会
    • Place of Presentation
      東京
    • Year and Date
      2009-05-28
    • Related Report
      2010 Final Research Report
  • [Presentation] アンチエイジングと認知症予防 -酸化ストレス研究からの展望-2009

    • Author(s)
      布村明彦.
    • Organizer
      第9回日本抗加齢医学会
    • Place of Presentation
      東京
    • Year and Date
      2009-05-28
    • Related Report
      2009 Annual Research Report
  • [Presentation] アミロイドベータペプチドと次亜塩素酸およびタウリンクロラミンとの反応2009

    • Author(s)
      宍戸直美, ら
    • Organizer
      第82回日本生化学会
    • Place of Presentation
      神戸
    • Related Report
      2010 Final Research Report
  • [Presentation] Pleuripotent treatments for pleuripotent mechanisms in Alzheimer disease : lessons from nature.2009

    • Author(s)
      Smith M.A., et al.
    • Organizer
      22nd Biennial Meeting of the International Society for Neurochemistry /Asian-Pacific Society for Neurochemistry
    • Place of Presentation
      Busan, South Korea
    • Related Report
      2010 Final Research Report
  • [Presentation] Specific reaction of Met 35 in amyloid beta peptide with hypochlorous acid.2009

    • Author(s)
      布村明彦, et al.
    • Organizer
      6th International Human Peroxidase Meeting
    • Place of Presentation
      Chapel Hill, North Carolina, USA
    • Related Report
      2010 Final Research Report 2009 Annual Research Report
  • [Presentation] Pleuripotent treatments for pleuripotent mechanisms in Alzheimer disease : lessons from nature.2009

    • Author(s)
      Smith M.A., et al.
    • Organizer
      22nd Biennial Meeting of the International Society for Neurochemistry/Asian-Pacific Society for Neurochemistry
    • Place of Presentation
      Busan, South Korea
    • Related Report
      2009 Annual Research Report
  • [Presentation] 酸化ストレスと神経ホルミシス:認知症予防のキーワード2008

    • Author(s)
      布村明彦
    • Organizer
      第31回日本神経科学大会Neuroscience
    • Place of Presentation
      東京
    • Year and Date
      2008-07-11
    • Related Report
      2010 Final Research Report
  • [Presentation] 酸化ストレスと神経ホルミシス : 認知症予防のキーワード.2008

    • Author(s)
      布村明彦
    • Organizer
      第31回日本神経科学大会Neuroscience 2008
    • Place of Presentation
      東京国際フォーラム
    • Year and Date
      2008-07-11
    • Related Report
      2008 Annual Research Report
  • [Book] Emerging Drugs and Targets for Alzheimer's Disease(Targetting oxidative mechanisms in Alzheimer disease. Vol. 2)(Martinez A (Ed))2010

    • Author(s)
      Lee HP, Rolston RK, Nunomura A
    • Publisher
      RSC Publishing, London
    • Related Report
      2010 Final Research Report
  • [Book] Metals and Neurodegeneration.(Iron-mediated neurotoxicity in Alzheimer disease : causes, consequences, and future therapeutic directions)(Huang S (Ed)2010

    • Author(s)
      Stone JG, Nunomura A, Hayashi T
    • Publisher
      Research Signpost, Kerala, India
    • Related Report
      2010 Final Research Report
  • [Book] Metals and Neurodegeneration2010

    • Author(s)
      Stone JG, et al.
    • Total Pages
      285
    • Publisher
      Research Signpost (Kerala, India)
    • Related Report
      2010 Annual Research Report
  • [Book] Emerging Drugs and Targets for Alzheimer's Disease. Vol.2 : Neuronal Plasticity, Neuronal Protection and other Miscellaneous Strategies2010

    • Author(s)
      Lee H.P., et al.
    • Total Pages
      242
    • Publisher
      RSC Publishing (London)
    • Related Report
      2009 Annual Research Report
  • [Book] Current Hypotheses and Research Milestones in Alzheimer's Disease(Neurofibrillary tangle formation as a protective response to oxidative stress in Alzheimer's disease)(Maccioni RB, Perry G (Eds))2009

    • Author(s)
      Nunomura A, Takeda A, Moreira PI
    • Publisher
      Springer Science, New York, NY
    • Related Report
      2010 Final Research Report
  • [Book] からだと酸素の事典,酸素ダイナミクス研究会(アルツハイマー病と酸素ストレス)(編集責任者:田村守(編))2009

    • Author(s)
      布村明彦
    • Publisher
      朝倉書店, 東京
    • Related Report
      2010 Final Research Report
  • [Book] からだと酸素の事典2009

    • Author(s)
      布村明彦.
    • Total Pages
      596
    • Publisher
      朝倉書店 (東京)
    • Related Report
      2009 Annual Research Report
  • [Book] Current Hypotheses and Research Milestones in Alzheimer's Disease2009

    • Author(s)
      Nunomura A., et al.
    • Total Pages
      264
    • Publisher
      Springer Science+Business Media (New York)
    • Related Report
      2009 Annual Research Report
  • [Book] Oxidative Neural Injury (Series : Contemporary Clinical Neuroscience)2009

    • Author(s)
      Moreira P.I., et al.
    • Total Pages
      218
    • Publisher
      Humana Press (New York)
    • Related Report
      2009 Annual Research Report
  • [Book] Advances in Alzheimer's and Parkinson's Disease : Insights, Progress, and Perspectives(The role of oxidative insult and neuronal survival in chronic neurodegenerative diseases)(Fisher A, Memo M, Stocchi F, Hanin I (Eds))2008

    • Author(s)
      Nunomura A, Moreira PI, Zhu X
    • Publisher
      Springer, New York, NY
    • Related Report
      2010 Final Research Report
  • [Book] 酸化ストレスと老化.老年医学の基礎と臨床I(老化とその制御.老化はなぜ起こるか)(大内尉義(編),浦上克哉(監))2008

    • Author(s)
      布村明彦
    • Publisher
      ワールドプランニング, 東京
    • Related Report
      2010 Final Research Report
  • [Book] 老年医学の基礎と臨床I-認知症を理解するための基礎知識-.2008

    • Author(s)
      布村明彦
    • Total Pages
      510
    • Publisher
      ワールドプランニング(東京)
    • Related Report
      2008 Annual Research Report
  • [Book] Pharmacological Mechanisms in Alzheimer's Therapeutics.2008

    • Author(s)
      Moreira P. I., et al.
    • Total Pages
      319
    • Publisher
      Springer (New York)
    • Related Report
      2008 Annual Research Report
  • [Remarks] ホームページ

    • URL

      http://erdb.yamanashi.ac.jp/rdb/A_DispInfo.Scholar?ID=7A340E6805978836

    • Related Report
      2010 Final Research Report
  • [Remarks]

    • URL

      http://erdb.yamanashi.ac.jp/rdb/A_DispInfo.Scholar?ID=7A340E6805978836

    • Related Report
      2010 Annual Research Report
  • [Remarks]

    • URL

      http://erdb.yamanashi.ac.jp/rdb/A_DispInfo.Scholar?ID=7A340E6805978836

    • Related Report
      2009 Annual Research Report
  • [Remarks]

    • URL

      http://erdb.yamanashi.ac.jp/rdb/A_DispInfo.Scholar?ID=7A340E6805978836

    • Related Report
      2008 Annual Research Report

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Published: 2008-04-01   Modified: 2016-04-21  

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