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Developmental change of prefrontal function in children with Autism spectrum disorders

Research Project

Project/Area Number 20591391
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Psychiatric science
Research InstitutionThe University of Tokyo

Principal Investigator

WATANABE Keiichiro (2009-2010)  The University of Tokyo, 学生相談ネットワーク本部, 講師 (10323586)

川久保 友紀 (2008)  The University of Tokyo, 医学部附属病院, 特任助教 (40396718)

Co-Investigator(Kenkyū-buntansha) KAWAKUBO Yuki  東京大学, 医学部付属病院, 特任助教 (40396718)
KIM Sooyung  東京大学, 医学部附属病院, 特任助教 (90401108)
渡辺 慶一郎  東京大学, 医学部・附属病院, 特任講師 (10323586)
Co-Investigator(Renkei-kenkyūsha) ISHII Ayaka  東京大学, 医学部付属病院, 助教 (40609020)
KASAI Kiyoto  東京大学, 医学部附属病院, 教授 (80322056)
Project Period (FY) 2008 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Fiscal Year 2010: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2009: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2008: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords発達障害 / 神経心理 / 脳・神経 / 自閉症 / 認知科学
Research Abstract

The aim of this study was exploring the developmental change of prefrontal function in children with autism spectrum disorders (ASD) using the near-infrared spectroscopy. In the typically developing children, the relative change of oxy-hemoglobin was correlated with their age. On the other hand, children with ASD presented the smaller change than age- and IQ-matched typically developing children. Furthermore, there were no correlations between the oxy-hemoglobin and their age.

Report

(4 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (31 results)

All 2011 2010 2009 2008 Other

All Journal Article (14 results) (of which Peer Reviewed: 11 results) Presentation (7 results) Book (5 results) Remarks (1 results) Patent(Industrial Property Rights) (4 results) (of which Overseas: 1 results)

  • [Journal Article] Impaired ability to organize information in individuals with autism spectrum disorders and their siblings.2011

    • Author(s)
      Sumiyoshi C, Kawakubo Y, 他
    • Journal Title

      Neurosci Res 69

      Pages: 252-257

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Task dependent prefrontal dysfunction in persons with Asperger's disorder investigated with multi-channel near-infrared spectroscopy.2011

    • Author(s)
      Iwanami A., Okajima Y, Ota H, Tani M, Yamada T, Hashimoto R, Kanai C, Watanabe H, Yamasue H, Kawakubo Y, Kato N
    • Journal Title

      Research in Autism Spectrum Disorders 5(3)

      Pages: 1187-1193

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Task dependent prefrontal dysfunction in persons with Asperger's disorder investigated with multi-channel near-infrared spectroscopy.2011

    • Author(s)
      Iwanami A, Okajima Y, Ota H, Tani M, Yamada T, Hashimoto R, Kanai C, Watanabe H, Yamasue H, Kawakubo Y, Kato N
    • Journal Title

      Research in Autism Spectrum Disorders

      Volume: 5 Pages: 1187-1193

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Impaired ability to organize information in individuals with autism spectrum disorders and their siblings.2011

    • Author(s)
      Sumiyoshi C, Kawakubo Y, Suga M, Sumiyoshi T, Kasai K
    • Journal Title

      Neurosci Res

      Volume: 69 Pages: 252-257

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] アスペルガー障害の精神生理・神経生理2010

    • Author(s)
      川久保友紀・桑原斉・笠井清登
    • Journal Title

      精神科 16

      Pages: 53-58

    • Related Report
      2010 Final Research Report 2009 Annual Research Report
  • [Journal Article] 発達障害児研究の今:何がどこまで明らかになったのか2009

    • Author(s)
      川久保友紀
    • Journal Title

      学校マネジメント 48

      Pages: 10-13

    • Related Report
      2010 Final Research Report 2009 Annual Research Report
  • [Journal Article] Impaired Prefrontal Hemodynamic Maturation in Autism and Unaffected Siblings2009

    • Author(s)
      Kawakubo Y, Kuwabara H, Watanabe K, et al.
    • Journal Title

      PLoS ONE 4

    • Related Report
      2010 Final Research Report 2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article]2009

    • Author(s)
      川久保友紀・笠井清登
    • Journal Title

      自閉症(星和書店)

      Pages: 112-121

    • Related Report
      2009 Annual Research Report
  • [Journal Article] Association study of the commonly recognized breakpoints in chromosome 15q11-q13 in Japanese autistic patients2008

    • Author(s)
      C.Kato, M.Tochigi, S.Koishi, Y.Kawakubo, K.Yamamoto, H.Matsumoto, O.Hashimoto, S.Y.Kim, K.Watanabe, Y., 他
    • Journal Title

      Pgychiatr Genet 18

      Pages: 133-136

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Associations study of the 15q11-q13 maternal expression domain in Japanese autistic patients2008

    • Author(s)
      C.Kato, M.Tochigi, J.Ohashi, S.Koishi, Y.Kawakubo, K.Yamamoto, H.Matsumoto, O.Hashimoto, S.Y.Kim, K.Watanabe, 他
    • Journal Title

      Am J Med Genet B Neuropsychiatr Genet 147

      Pages: 1008-1012

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] No association between the ryanodine receptor 3 gene and autism in a Japanese population2008

    • Author(s)
      M.Tochigi, C.Kato, J.Ohashi, S.Koishi, Y.Kawakubo,, K.Yamamoto, H.Matsumoto, O.Hashimoto, S.Y.Kim, K.Watanabe, Y.Kmmo, E.
    • Journal Title

      Psychiatry Clin Neurosci 62

      Pages: 341-344

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] No association between the ryanodine receptor 3 gene and autism in a Japanese population2008

    • Author(s)
      M. Tochigi, C. Kato, J. Ohashi, S. Koishi, Y. Kawakubo, K. Yamamoto, H. Matsumoto, O. Hashimoto, S. Y. Kim, K. Watanabe, Y. Kmmo, E.
    • Journal Title

      Psychiatry Clin Neurosci 62

      Pages: 341-344

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Associations study of the 15q11-q13 maternal expression domain in Japanese autistic patients2008

    • Author(s)
      C. Kato, M. Tochigi, J. Ohashi, S. Koishi, Y. Kawakubo, K. Yamamoto, H. Matsumoto, O. Hashimoto, S. Y. Kim, K. Watanabe, Y. Kano, E. Nanba, N. Kato and T.Sasaki
    • Journal Title

      Am J Med Genet B Neuropsychiatr Genet 147

      Pages: 1008-1012

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Association study of the commonly recognized breakpoints in chromosome 15q11-q13 in Japanese autistic patients2008

    • Author(s)
      C. Kato, M. Tochigi, S. Koishi, Y. Kawakubo, K. Yamamoto, H. Matsumoto, 0. Hashimoto, S. Y. Kim, K. Watanabe, Y. Kano, E. Nanba, N. Kato and T. Sasaki
    • Journal Title

      Pgychiatr Genet 18

      Pages: 133-136

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Presentation] AD/HD児童に対する薬物療法による前頭葉機能の変化-DN-CASおよびNIRSを用いた評価2009

    • Author(s)
      川久保友紀
    • Organizer
      第47回日本特殊教育学会
    • Place of Presentation
      宇都宮大学(栃木)
    • Year and Date
      2009-09-21
    • Related Report
      2010 Final Research Report 2009 Annual Research Report
  • [Presentation] AD/HD児童における塩酸メチルフェニデート服用の効果-日本版DN-CAS認知評価システムを用いた認知機能の評価2009

    • Author(s)
      川久保友紀・高橋礼花・桑原斉・渡邊慶一郎・金生由紀子
    • Organizer
      第50回日本児童青年精神医学会
    • Related Report
      2010 Final Research Report
  • [Presentation] 近赤外線スペクトロスコピー(NIRS)を用いた前頭葉機能の発達的変化2008

    • Author(s)
      川久保友紀・笠井清登・稲垣真澄
    • Organizer
      第38回日本臨床神経生理学会
    • Place of Presentation
      神戸国際会議場
    • Year and Date
      2008-11-14
    • Related Report
      2010 Final Research Report
  • [Presentation] 近赤外線スペクトロスコピー(NIRS)を用いた前頭葉機能の発達的変化.2008

    • Author(s)
      川久保友紀・笠井清登・稲垣真澄
    • Organizer
      第38回日本臨床神経生理学会
    • Place of Presentation
      神戸国際会議場
    • Year and Date
      2008-11-14
    • Related Report
      2008 Annual Research Report
  • [Presentation] The broader phenotype in parents of individuals with autism spectrum disorders2008

    • Author(s)
      Kawakubo Y, Kuwabara H, Kasai K
    • Organizer
      7th Annual international meeting for autism research (IMFAR).
    • Place of Presentation
      London
    • Year and Date
      2008-05-15
    • Related Report
      2010 Final Research Report
  • [Presentation] The broader phenotype in parents of individuals with autism spectrum disorders2008

    • Author(s)
      Kawakubo Y, Kuwabara H, Kasai K
    • Organizer
      7th Annual international meeting for autism research(IMFAR)
    • Place of Presentation
      London
    • Year and Date
      2008-05-15
    • Related Report
      2008 Annual Research Report
  • [Presentation] Electrophysiological abnormalities of spatial attention in adults with autism during the gap overlap task.2008

    • Author(s)
      川久保友紀
    • Organizer
      The 7^<th> International conference of attention
    • Place of Presentation
      Allahabad, India
    • Related Report
      2010 Final Research Report
  • [Book] 臨床精神医学講座(第4章;広汎性発達障害・自閉症関連検査)2010

    • Author(s)
      川久保友紀・金生由紀子
    • Publisher
      中山書店
    • Related Report
      2010 Final Research Report
  • [Book] 「広汎性発達障害・自閉症関連検査」精神科診療データブック((編)松下正明、中根允文、浅井昌弘)2010

    • Author(s)
      川久保友紀・金生由紀子
    • Publisher
      中山書店
    • Related Report
      2010 Annual Research Report
  • [Book] 自閉症2009

    • Author(s)
      川久保友紀・笠井清登
    • Publisher
      星和書店
    • Related Report
      2010 Final Research Report
  • [Book] 精神疾患とNIRS(福田正人 編)(III.精神疾患への応用1.統合失調症・自閉症の前頭葉機能障害とNIRSの臨床応用)2009

    • Author(s)
      滝沢龍、川久保友紀、桑原斉、笠井清登
    • Publisher
      中山書店
    • Related Report
      2010 Final Research Report
  • [Book] 臨床精神医学講座(第4章;広汎性発達障害・自閉症関連検査)

    • Author(s)
      川久保友紀・金生由紀子
    • Publisher
      中山書店(印刷中)(掲載確定)
    • Related Report
      2008 Annual Research Report
  • [Remarks] ホームページ等

    • URL

      http://childpsy.umin.jp/index.html

    • Related Report
      2010 Final Research Report
  • [Patent(Industrial Property Rights)] Stimulation subject presentation device for living body optical measurement apparatus and method for presenting stimulation subject2011

    • Inventor(s)
      笠井清登, Takizawa R, 川久保友紀, 高橋礼花, Kuwabara H, Kawasaki S, Ichikawa N
    • Industrial Property Rights Holder
      Hitachi medical co.
    • Acquisition Date
      2011-02-18
    • Related Report
      2010 Final Research Report
  • [Patent(Industrial Property Rights)] Stimulation subject presentation device for living body optical measurement apparatus and method for presenting stimulation subject2011

    • Inventor(s)
      Kasai K, Takizawa R, Kawakubo Y, Takahashi A, Kuwabara H, Kawasaki S, Ichikawa N
    • Industrial Property Rights Holder
      Hitachi medical co.
    • Filing Date
      2011-02-18
    • Related Report
      2010 Annual Research Report
    • Overseas
  • [Patent(Industrial Property Rights)] 生体光計測装置における刺激課題呈示装置及び刺激課題呈示方法2008

    • Inventor(s)
      高橋礼花、川久保友紀、滝沢龍、桑原斉、笠井清登、川崎真護、市川祝善
    • Industrial Property Rights Holder
      日立メディコ
    • Filing Date
      2008-06-12
    • Related Report
      2010 Final Research Report
  • [Patent(Industrial Property Rights)] 主体光計測装置における刺激課題呈示装置及び刺激課題呈示方法2008

    • Inventor(s)
      高橋礼花、川久保友紀、滝沢龍、桑原斉、笠井清登
    • Industrial Property Rights Holder
      日立メディコ
    • Industrial Property Number
      2008-146721
    • Filing Date
      2008-06-12
    • Related Report
      2008 Annual Research Report

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Published: 2008-04-01   Modified: 2016-04-21  

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