Biological study of socialization deficit and psycho-social intervention in schizophrenia.

• Project/Area Number: 20591392
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Psychiatric science
• Research Institution: University of Toyama
• Principal Investigator: KAWASAKI Yasuhiro University of Toyama, 医学部, 教授 (80242519)
• Co-Investigator(Kenkyū-buntansha): SUZUKI Michio 富山大学, 大学院・医学薬学研究部, 教授 (40236013) ; SUMIYOSHI Tomiki 富山大学, 大学院・医学薬学研究部, 准教授 (80286062) ; NAKAMURA Kazue 富山大学, 大学病院, 助教 (00447658)
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2008: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: 精神生理学 / Schizophrenia / At risk mental state / Early intervention / Magnetic resonance imaging / Event related potential / Magnetic resonanec imaging

Research Abstract

Conventional neuropsychological test battery, magnetic resonance imaging (MRI) and event related potential (ERP) were evaluated from subjects at risk mental state (ARMS), patients with schizophrenia and healthy subjects. The Consultation and Support service in Toyama (CAST) for ARMS was launched by the Toyama University Hospital in cooperation with the Toyama Prefectural Mental Health Centre. Three of 31 clients who met ARMS criteria have subsequently developed a first episode of psychosis. Neuropsychological and ERP evaluation showed that ARMS subjects manifest abnormal profiles intermediate between healthy subjects and schizophrenia patients. Functional-MRI study showed an anomalous amygdala function in the schizophrenia patients. Longitudinal MRI data of the first-episode schizophrenia indicated excessive gray matter decrease in the superior temporal and inferior frontal regions.

Research Products

• [Journal Article] Effect of tandospirone on mismatch negativity and cognitive performance in schizophrenia : A case report. (2010)
  • Author(s): Higuchi Y., Sumiyoshi T., Kawasaki Y., Itoh T., Seo T., Suzuki M.
  • Journal Title: Journal of Clinical Psychopharmacology 30 Pages: 732-4
  • Peer Reviewed
• [Journal Article] An MRI study of the superior temporal subregions in patients with current and past major depression. (2010)
  • Author(s): Takahashi T., Yucel M., Lorenzetti V., Walterfang M., Kawasaki Y., Whittle S., Suzuki M., Pantelis C., Allen N.B.
  • Journal Title: Prog.Neuropsychopharmacol.Biol.Psychiatry 34 Pages: 98-103
  • Peer Reviewed
• [Journal Article] Lack of progressive gray matter reduction of the superior temporal subregions in chronic schizophrenia. (2010)
  • Author(s): Takahashi T., Wood S.J., Kawasaki Y., Suzuki M., Velakoulis D., Pantelis C.
  • Journal Title: Schizophr.Res. 117 Pages: 101-102
  • Peer Reviewed
• [Journal Article] Superior temporal gyrus volume in antipsychotic-naive people at risk of psychosis. (2010)
  • Author(s): Takahashi T., Wood S.J., Yung A.R., Walterfang M., Phillips L.J., Soulsby B., Kawasaki Y., McGorry P.D., Suzuki M., Velakoulis D., Pantelis C.
  • Journal Title: Br.J.Psychiatry 196 Pages: 206-211
  • Peer Reviewed
• [Journal Article] Superior temporal gyrus volume in teenagers with first-presentation borderline personality disorder. (2010)
  • Author(s): Takahashi T., Chanen A.M., Wood S.J., Yucel M., Kawasaki Y., McGorry P.D., Suzuki M., Velakoulis D., Pantelis C.
  • Journal Title: Psychiatry Res.Neuroimaging 182 Pages: 73-76
  • Peer Reviewed
• [Journal Article] Gray matter reduction of the superior temporal gyrus in patients with established bipolar I disorder. (2010)
  • Author(s): Takahashi T., Malhi G.S., Wood S.J., Yucel M., Walterfang M., Kawasaki Y., Suzuki M., Pantelis C.
  • Journal Title: J.Affect.Disord. 123 Pages: 276-282
  • Peer Reviewed
• [Journal Article] A follow-up MRI study of the superior temporal subregions in schizotypal disorder and first-episode schizophrenia. (2010)
  • Author(s): Takahashi T., Suzuki M., Zhou S. Y., Tanino R., Nakamura K., Kawasaki Y., Seto H., Kurachi M.
  • Journal Title: Schizophr.Res. 119 Pages: 65-74
  • Peer Reviewed
• [Journal Article] Differentiation of first-episode schizophrenia patients from healthy controls using ROI-based multiple structural brain variables. (2010)
  • Author(s): Takayanagi Y., Kawasaki Y., Nakamura K., Takahashi T., Orikabe L., Toyoda E., Mozue Y., Sato Y., Itokawa I., Yamasue H., Kasai K., Kurachi M., Okazaki Y., Matsushita M., Suzuki M.
  • Journal Title: Prog.Neuropsychopharmacol.Biol.Psychiatry 34 Pages: 10-17
  • Peer Reviewed
• [Journal Article] Volume reduction and altered sulco-gyral pattern of the orbitofrontal cortex in first-episode schizophrenia. (2010)
  • Author(s): Takayanagi Y., Takahashi T., Orikabe L., Masuda N., Mozue Y., Nakamura K., Kawasaki Y., Itokawa M., Sato Y., Yamasue H., Kasai K., Okazaki Y., Suzuki M.
  • Journal Title: Schizophr.Res. 121 Pages: 55-65
  • Peer Reviewed
• [Journal Article] Volume reduction and altered sulco-gyral pattern of the orbitofrontal cortex in first-episode schizophrenia. (2010)
  • Author(s): Takayanagi Y
  • Journal Title: Schizophr.Res. Volume: 121 Pages: 55-65
  • Peer Reviewed
• [Journal Article] Superior temporal gyrus volume in antipsychotic-naive people at risk of psychosis. (2010)
  • Author(s): Takahashi T
  • Journal Title: Br.J.Psychiatry Volume: 196 Pages: 206-211
  • Peer Reviewed
• [Journal Article] Differentiation of first-episode schizophrenia patients from healthy controls using ROI-based multiple structural brain variables. (2010)
  • Author(s): Takayanagi Y
  • Journal Title: Prog.Neuropsychopharmacol.Biol.Psychiatry Volume: 34 Pages: 10-17
  • Peer Reviewed
• [Journal Article] Progressive gray matter reduction of the superior temporal gyrus during transition to psychosis. (2009)
  • Author(s): Takahashi T., Wood S. J., Yung A.R., Soulsby B., McGorry P.D., Suzuki M., Kawasaki Y., Phillips LJ, Velakoulis D, Pantelis C
  • Journal Title: Arch.Gen.Psychiatry. 66 Pages: 366-376
  • Peer Reviewed
• [Journal Article] Effect of perospirone on P300 electrophysiological activity and social cognition in schizophrenia : a three-dimensional analysis with sloreta. (2009)
  • Author(s): Sumiyoshi T., Higuchi Y., Itch T., Matsui M., Arai H., Suzuki M., Kurachi M., Sumiyoshi C., Kawasaki Y.
  • Journal Title: PsychiatryRes. 172 Pages: 180-183
  • Peer Reviewed
• [Journal Article] An MRI study of the superior temporal subregions in first-episode patients with various psychotic disorders. (2009)
  • Author(s): Takahashi T., Wood S.J., Soulsby B., Kawasaki Y., McGorry P.D., Suzuki M., Velakoulis D., Pantelis C.
  • Journal Title: Schizophr.Res. 113 Pages: 158-166
  • Peer Reviewed
• [Journal Article] The Disrupted-in-Schizophrenia-1 Ser704 Cys polymorphism and brain morphology in schizophrenia. (2009)
  • Author(s): Takahashi T., Suzuki M., Tsunoda M., Maeno N., Kawasaki Y., Zhou S. Y., Hagino H., Niu L., Tsuneki H., Kobayashi S., Sasaoka T., Seto H., Kurachi M., Ozaki N.
  • Journal Title: Psychiatry Res. 172 Pages: 128-135
  • Peer Reviewed
• [Journal Article] Progressive gray matter reduction of the superior temporal gyrus during transition to psychosis. (2009)
  • Author(s): Takahashi T, Wood SJ, Yung AR, Soulsby B, McGorry PD, Suzuki M, Kawasaki Y, Phillips LJ, Velakoulis D, Pantelis C.
  • Journal Title: Arch Gen Psychiatry 66 Pages: 366-376
  • Peer Reviewed
• [Journal Article] Effect of perospirone on P300 electrophysiological activity and social cognition in schizophrenia : a three-dimensional analysis with sloreta. (2009)
  • Author(s): Sumiyoshi T, Higuchi Y, Itoh T, Matsui M, Arai H, Suzuki M, Kurachi M, Sumiyoshi C, Kawasaki Y.
  • Journal Title: Psychiatry Res 172 Pages: 180-183
  • Peer Reviewed
• [Journal Article] The Disrupted-in-Schizophrenia-1 Ser704Cys polymorphism and brain morphology in schizophrenia. (2009)
  • Author(s): Takahashi T, Suzuki M, Tsunoda M, Maeno N, Kawasaki Y, Zhou SY, Hagino H, Niu L, Tsuneki H, Kobayashi S, Sasaoka T, Seto H, Kurachi M, Ozaki N.
  • Journal Title: Psychiatry Res 172 Pages: 128-135
  • Peer Reviewed
• [Journal Article] Anomalous cerebral asymmetry in patients with schizophrenia demonstrated by voxel-based morphometry. (2008)
  • Author(s): Kawasaki Y., Suzuki M., Takahashi T., Nohara S., McGuire P., Seto H., Kurachi M.
  • Journal Title: Biol.Psychiatry. 63 Pages: 793-800
  • Peer Reviewed
• [Journal Article] The relationship between prefrontal brain volume and characteristics of memory strategy in schizophrenia spectrum disorders. (2008)
  • Author(s): Matsui M., Suzuki M., Zhou S. Y., Takahashi T., Kawasaki Y., Yuuki H., Kato K., Kurachi M.
  • Journal Title: Prog.Neuropsychopharmacol.Biol.Psychiatry. 32 Pages: 1854-1862
  • Peer Reviewed
• [Journal Article] Prevalence and length of the adhesio interthalamica in schizophrenia spectrum disorders. (2008)
  • Author(s): Takahashi T., Suzuki M., Zhou S.Y., Nakamura K., Tanino R., Kawasaki Y., Seal M.L., Seto H., Kurachi M.
  • Journal Title: Psychiatry Res. 164 Pages: 90-94
  • Peer Reviewed
• [Journal Article] The association of genotypic combination of the DRD3 and BDNF polymorphisms on the adhesio interthalamica and medial temporal lobe structures. (2008)
  • Author(s): Takahashi T., Suzuki M., Tsunoda M., Kawamura Y., Takahashi N., Maeno N., Kawasaki Y., Zhou S.Y., Hagino H., Niu L., Tsuneki H., Kobayashi S., Sasaoka T., Seto H., Kurachi M., Ozaki N.
  • Journal Title: Prog.Neuropsychopharmacol.Biol.Psychiatry. 32 Pages: 1236-1242
  • Peer Reviewed
• [Journal Article] Association between the brain-derived neurotrophic factor Val66Met polymorphism and brain morphology in a Japanese sample of schizophrenia and healthy comparisons. (2008)
  • Author(s): Takahashi T., Suzuki M., Tsunoda M., Kawamura Y., Takahashi N., Tsuneki H., Kawasaki Y., Zhou S. Y., Kobayashi S., Sasaoka T., Seto H., Kurachi M., Ozaki N.
  • Journal Title: Neurosci.Lett. 435 Pages: 34-39
  • Peer Reviewed
• [Journal Article] Electrophysiological basis for the ability of olanzapine to improve verbal memory and functional outcome in patients with schizophrenia : a LORETA analysis of P300. (2008)
  • Author(s): Higuchi Y., Sumiyoshi T., Kawasaki Y., Matsui M., Arai H., Kurachi M.
  • Journal Title: Schizophr.Res. 101 Pages: 320-330
  • Peer Reviewed
• [Journal Article] Association between absence of the adhesio interthalamica and amygdala volume in schizophrenia. (2008)
  • Author(s): Takahashi T., Suzuki M., Nakamura K., Tanino R., Zhou S. Y., Hagino H., Niu L., Kawasaki Y., Seto H., Kurachi M.
  • Journal Title: Psychiatry Res. 162 Pages: 101-111
  • Peer Reviewed
• [Journal Article] Anomalous cerebral asymmetry in patients with schizophrenia demonstrated by voxel-based morphometry. (2008)
  • Author(s): Kawasaki Y., Suzuki M., Takahashi T., Nohara S, McGuire P. K., Seto H., Kurachi M.
  • Journal Title: Biol Psychiatry 63 Pages: 793-800
  • Peer Reviewed
• [Journal Article] Association between absence of the adhesio interthalamica and amygdala volume in schizophrenia. (2008)
  • Author(s): Takahashi T., Suzuki M., Nakamura K., Tanino R., Zhou S. -Y., Hagino H., Niu L., Kawasaki Y., Seto H., Kurachi M.
  • Journal Title: Psychiatry Res. Neuroimaging 162 Pages: 101-111
  • Peer Reviewed
• [Presentation] Longitudinal voxel-based morphometry to evaluate progressive gray matter changes in first-episode schizophrenia. (2010)
  • Author(s): Kawasaki Y.
  • Organizer: 7th international conference on early psychosis
  • Place of Presentation: Amsterdam, Netherland.
  • Year and Date: 2010-11-30
• [Presentation] Longitudinal voxel-based morphometric study to evaluate progressive gray mater changes in first-episode schizophrenia. (2010)
  • Author(s): Kawasaki Y
  • Organizer: 2nd Schizophrenia International Research Society
  • Place of Presentation: Florence, Italy.
  • Year and Date: 2010-04-12
• [Presentation] Diminished limbic activation associated with face perception in patients with schizophrenia (2010)
  • Author(s): Kawasaki Y., Furuichi A., Nakamura K., Suzuki M.
  • Organizer: 18th European Congress of Psychiatry
  • Place of Presentation: Munich, Germany
  • Year and Date: 2010-03-02
• [Presentation] Longitudinal voxel-based morphometry to evaluate progressive gray matter changes in first-episode schizophrenia. (2010)
  • Author(s): Kawasaki Y., Suzuki M., Takahashi T., Kido M., Nakamura K.
  • Organizer: 7th international conference on early psychosis
  • Place of Presentation: Amsterdam
• [Presentation] Longitudinal voxel-based morphometric study to evaluate progressive gray mater changes in first-episode schizophrenia. (2010)
  • Author(s): Kawasaki Y., Kido M., Takahashi T., Nakamura K., Suzuki M.
  • Organizer: 2nd Schizophrenia International Research Society Conference
  • Place of Presentation: Florence, Italy
• [Presentation] A functional MRI study of face perception in patients with Schizophrenia (2009)
  • Author(s): Kawasaki Y, Furuichi A, Nakamura K, Suzuki M
  • Organizer: 9th World Federation of Biological Psychiatry
  • Place of Presentation: 国際会議場(パリ)
  • Year and Date: 2009-06-02
• [Presentation] Effect of perospirone on P300 electrophysiological activity and social cognition in schizophrenia : A three-dimensional analysis with sLORETA (2009)
  • Author(s): Sumiyoshi T, Higuchi Y, Itoh T, Matsui M, Arai H, Suzuki M, Sumiyoshi C, Kawasaki Y
  • Organizer: 9th World Federation of Biological Psychiatry
  • Place of Presentation: 国際会議場(パリ)
  • Year and Date: 2009-06-01
• [Presentation] VBMによる形態脳画像研究(シンポジウム:統合失調症の神経画像研究・アップデート) (2009)
  • Author(s): 川崎康弘
  • Organizer: 第31回日本生物学的精神医学会
  • Place of Presentation: 国際会議場(京都)
  • Year and Date: 2009-04-23
• [Presentation] A functional MRI study of face perception in patients with Schizophrenia. (2009)
  • Author(s): Kawasaki Y., Furuichi A., Nakamura K., Suzuki M.
  • Organizer: 9th World Congress of Biological Psychiatry
  • Place of Presentation: Paris, France
• [Presentation] A functional MRI study of emotion processing in patients with schizophrenia. (2009)
  • Author(s): Kawasaki Y., Furuichi A., Nakamura K., Suzuki M.
  • Organizer: Cognition Satellite Meeting ICOSR
  • Place of Presentation: San Diego, U.S.A.
• [Presentation] Early detection and intervention proect for young pople at risk for developing psychosis in Toyama. (2009)
  • Author(s): Kawasaki Y., Suzuki M., Sumiyoshi T., Takahashi T., Nishiyama S., Matsui M., Kurachi M., Kazukawa S.
  • Organizer: 4th Annual Meeting of Japanese Society f Schizophrenia Research
  • Place of Presentation: Osaka
• [Presentation] A functional MRI study of face perception in patients with schizophrenia. (2009)
  • Author(s): Kawasaki Y, Furuichi A, Nakamura K, Suzuki M.
  • Organizer: International Congress-Emory University Cognition Satellite Meeting
  • Place of Presentation: San Diego, USA.
• [Presentation] Voxel-Based Morphometry Evaluating Gray Matter Asymmetry in Patients with Schizophrenia. (2008)
  • Author(s): Kawasaki Y., Suzuki M., Takahashi T., Sumiyoshi T., McGuire P., Kurachi M.
  • Organizer: 10th Biennial Australasian Schizophrenia Conference
  • Place of Presentation: Lorne, Australia
  • Year and Date: 2008-10-23
• [Presentation] Voxel-Based Morphometry Evaluating Gray Matter Asymmetry in Patients with Schizophrenia. (2008)
  • Author(s): Kawasaki Y, Suzuki M, Takahashi T, Sumiyoshi T, McGuire P, Kurachi M
  • Organizer: 10th Australasian Schizophrenia Conference
  • Place of Presentation: Lorne, Australia
  • Year and Date: 2008-10-23
• [Presentation] Early detection and intervention project for young people at risk for developing psychosis in Toyama. (2008)
  • Author(s): Kawasaki Y., Suzuki M., Takahashi T., Sumiyoshi T., Nishiyama S., Matsui M., Kurachi M., Kazukawa S.
  • Organizer: 21st October the 6th International Conference on Early Psychosis
  • Place of Presentation: Melbourne, Australia
  • Year and Date: 2008-10-21
• [Presentation] Early detection and intervention project for young people at risk for developing psychosis in Toyama. (2008)
  • Author(s): Kawasaki Y, Suzuki M, Takahashi T, Sumiyoshi T, Nishiyama S, Matsui M, Kurachi M, Kazukawa S
  • Organizer: 6th International Conference on Early Psychosis
  • Place of Presentation: Melbourne, Australia
  • Year and Date: 2008-10-21
• [Presentation] Structural Neuroimaging as a Biomarker for Schizophrenia. : Novel Biomarkers for Schizophrenia and Depressive Disorders. (2008)
  • Author(s): Kawasaki Y.
  • Organizer: The 2nd WFSBP Asia-Pacific Congress and 30th Annual Meeting of JSBP(In symposium (organized and chaired by Kozima T and Kawasaki Y.))
  • Place of Presentation: Toyama
• [Presentation] Anomalous cerebral asymmetry in patients with schizophrenia demonstrated by voxel-based morphometry. (2008)
  • Author(s): Kawasaki Y., Suzukil M., Takahashi T, Nohara S., Nakamura K., Kurachi M.
  • Organizer: 1st Schizophrenia International Research Society Conference
  • Place of Presentation: Venice
• [Presentation] Anomalous cerebral asynmetry in patients with schizophrenia demonstrated by voxel-based morphometry. (2008)
  • Author(s): Kawasaki Y, Suzukil M, Takahashi T, Nohara S, Nakamura K, Kurachi M
  • Organizer: Schizophrenia International Research Society Conference
  • Place of Presentation: Venice, Italia
• [Presentation] Structural Neuroimaging as a Biomarker for Schizophrenia. (2008)
  • Author(s): Kawasaki Y.
  • Organizer: 2nd WFSBP Asia-Pacific Congress & 30th JSBP
  • Place of Presentation: Toyama, Japan
• [Book] 早期精神病の診断と治療(ヘンリーJ.ジャクソン,バトリックD.マクゴーリ編,水野雅文他監訳)(精神病未治療期間:定義,測定および転帰との関連) (2010)
  • Author(s): 住吉太幹,川崎康弘,鈴木道雄
  • Publisher: 医学書院,東京
• [Book] 画像検査CT-MRI(精神科臨床評価検査法マニュアル) (2010)
  • Author(s): 川崎康弘
  • Total Pages: 863
  • Publisher: アークメディア
• [Book] Social Interactions in the 21st Century(Heatherton A.T.and Walcott V.A.(Eds).)(Social interaction deficits in schizophrenia-spectrum disorders and pharmacologic intervention) (2009)
  • Author(s): Sumiyoshi T., Matsuoka T., Tanaka K., Bubenikowa-Valesova V.
  • Publisher: Nova Science Publishers Inc., Hauppauge, NY, USA
• [Book] 精神疾患と認知機能(精神疾患と認知機能研究会編)(認知機能をどう捉え,評価するのかA.検査法 V.画像) (2009)
  • Author(s): 川崎康弘,鈴木道雄
  • Publisher: 新興医学出版,東京
• [Book] 「生体の科学」増大特集-神経伝達に関与する物質(伊藤正男,野々村禎昭,藤田道也編)(統合失調症の認知機能障害における5-HT受容体の役割) (2009)
  • Author(s): 住吉太幹
  • Publisher: 金原一郎記念医学医療振興財団,東京
• [Book] 標準精神医学(野村総一郎ほか編)(統合失調症) (2009)
  • Author(s): 鈴木道雄
  • Publisher: 医学書院,東京
• [Book] 精神科専門医のためのプラクティカル精神医学(山内俊雄総編集)(精神病性障害) (2009)
  • Author(s): 鈴木道雄
  • Publisher: 中山書店,東京
• [Book] レジリアンス-現代精神医学の新しいパラダイム-(加藤敏,八木剛平編)(脳画像からみた統合失調症の顕在発症防御機構) (2009)
  • Author(s): 鈴木道雄
  • Publisher: 金原出版,東京
• [Book] 精神疾患の脳画像解析・診断学(平安良雄,笠井清登編)(脳画像検査の臨床応用) (2008)
  • Author(s): 川崎康弘,鈴木道雄
  • Publisher: 南山堂,東京
• [Book] 専門医のための精神科臨床リュミエール2.精神疾患と脳画像(福田正人編)(統合失調症の脳構造診断の実用化) (2008)
  • Author(s): 鈴木道雄
  • Publisher: 中山書店,東京
• [Book] 専門医のための精神科臨床リュミエール5.統合失調症の早期診断と早期介入(水野雅文編)(前駆期における生物学的診断) (2008)
  • Author(s): 鈴木道雄
  • Publisher: 中山書店,東京
• [Remarks] ホームページ等
• [Remarks] こころのリスク相談事業
  • URL: http://www.med.u-toyama.ac.jp/neuropsychiatry/index-kokoro.html