| Project/Area Number |
20591393
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Psychiatric science
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| Research Institution | University of Toyama |
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Principal Investigator |
SUZUKI Michio 富山大学, 大学院・医学薬学研究部(医学), 教授 (40236013)
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| Co-Investigator(Kenkyū-buntansha) |
KAWASKI Yasuhiro 富山大学, 附属病院, 講師 (80242519)
SUMIYOSHI Tomiki 富山大学, 大学院・医学薬学研究部(医学), 准教授 (80286062)
NAKAMURA Kazue 富山大学, 附属病院, 助教 (00447658)
KURACHI Masayoshi 富山大学, 大学院・医学薬学研究部(医学), 名誉教授 (80019603)
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| Project Period (FY) |
2008 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2011: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2010: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2009: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2008: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Keywords | 精神生理学 / 統合失調症 / 機能的磁気共鳴画像 / ミラーニューロンシステム / 社会脳 / 自己 / 他者 / 自己意識 / 拡散テンソル画像 / fractional anisotropy / 陰性症状 |
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| Research Abstract |
A diffusion tensor imaging(DTI) study revealed disturbed white matter integrity in bundles connecting the frontal lobe with the thalamus and temporal lobe, a part of which is suggested to implicate the negative symptoms in schizophrenia. A functional magnetic resonance imaging(fMRI) study using self-and other-evaluation tasks demonstrated functional abnormalities in the prefrontal cortex, cerebral midline stuructures, and inferior parietal lobule, which provide evidence for neural basis of deficits in self-awareness in schizophrenia. A structural MRI study in patients with early phase of psychosis suggested the implication of the anterior cingulate cortex in manifestation of overt psychosis in schizophrenia.
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