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GABAergic system and brain network in Autism spectrum disorder.

Research Project

Project/Area Number 20591394
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Psychiatric science
Research InstitutionKanazawa University

Principal Investigator

KIKUCHI Mitsuru  Kanazawa University, 医学系, 助教 (00377384)

Co-Investigator(Kenkyū-buntansha) HASHIMOTO Takanori  金沢大学, 医学系, 准教授 (40249959)
Co-Investigator(Renkei-kenkyūsha) MUNESUE Toshio  金沢大学, 子どものこころの発達研究センター, 特任准教授 (50293353)
NAGASAWA Tatsuya  金沢大学, 附属病院, 講師 (10334773)
NAKATANI Hideo  金沢大学, 附属病院, 助教 (10452103)
UEDA Humiaki  金沢大学, 附属病院, 講師 (80293356)
RYU Yasuzi  金沢大学, 附属病院, 助教 (50456414)
Project Period (FY) 2008 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000)
Fiscal Year 2009: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2008: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Keywords自閉症スペクトラム障害 / 拡散テンソル解析 / 核磁気共鳴スペクトロスコピー / GABA系機能
Research Abstract

White matter abnormalities can be detected by diffusion tensor imaging (DTI). DTI is a noninvasive MRI technique that is useful for investigating white matter structure, an important aspect of brain connectivity. Autism spectrum disorder (ASD) (n=20) and ASD with bipolar disorder (ASD with BP) (n=4) were compared control subject (n=18). Our results demonstrated that ASD group showed reduced fractional anisotropy (FA) in splenium of corpus callosum, and that ASD with BP group showed reduced FA in superior longitudinal fasciculus. Our results suggested the deviated anatomical brain network in ASD patients.

Report

(4 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (37 results)

All 2011 2010 2009 Other

All Journal Article (20 results) (of which Peer Reviewed: 14 results) Presentation (15 results) Remarks (2 results)

  • [Journal Article] Lamina-Specific Alterations in Cortical GABAA Receptor Subunit Expression in Schizophrenia.2011

    • Author(s)
      Beneyto M, Abbott A, Hashimoto T, Lewis DA.
    • Journal Title

      Cereb Cortex. 21(5)

      Pages: 999-1011

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Reduced acetylchol inesterase activity in the fusiformgyrus in adults with autism spectrum disorders.2011

    • Author(s)
      Suzuki K, Sugihara G, Ouchi Y, Nakamura K, Tsujii M, Futatsubashi M, Iwata Y, Tsuchiya KJ, Matsumoto K, Takebayashi K, Wakuda T, Yoshihara Y, Suda S, Kikuchi M, Takei N, Sugiyama T, Irie T, Mori N.
    • Journal Title

      Arch Gen Psychiatry. 68(3)

      Pages: 306-313

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Hemodynamic responses to visual stimuli in cortex of adults and 3- to 4-year-old children.2011

    • Author(s)
      Remijn GB, Kikuchi M, Yoshimura Y, Shitamichi K, Ueno S, Nagao K, Munesue T, Kojima H, Minabe Y.
    • Journal Title

      Brain Res. 2

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Hemodynamic responses to visual stimuli in cortex of adults and 3-to 4-year-old children2011

    • Author(s)
      Remijn, G.B., et al.
    • Journal Title

      Brain Research

      Volume: 1383 Pages: 242-251

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Nurovascular coupling in the human somatosensory cortex : a single trial study.2010

    • Author(s)
      Kikuchi M, Shitamichi K, Ueno S, Yoshimura Y, Remijn BG, Nagao K, Munesue T, Iiyama K, Tsubokawa T, Haruta Y, Inoue Y, Watanabe K, Hashimoto T, Higashida H, Minabe Y
    • Journal Title

      Neuro Report 21

      Pages: 1106-1110

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Two genetic variants of CD38 in subjects with autism spectrum disorder and controls.2010

    • Author(s)
      Munesue T, Yokoyama S, Nakamura K, Anitha A, Yamada K, Hayashi K, Asaka T, Liu HX, Jin D, Koizumi K, Islam MS, Huang JJ, Ma WJ, Kim UH, Kim SJ, Park K, Kim D, Kikuchi M, Ono Y, Nakatani H, Suda S, Miyachi T, Hirai H, Salmina A, Pichugina YA, Soumarokov AA, Takei N, Mori N, Tsujii M, Sugiyama T, Yagi K, Yamagishi M, Sasaki T, Yamasue H, Kato N, Hashimoto R, Taniike M, Hayashi Y, Hamada J, Suzuki S, Ooi A, Noda M, Kamiyama Y, Kido MA, Lopatina O, Hashii M, Amina S, Malavasi F, Huang EJ, Zhang J, Shimizu N, Yoshikawa T, Matsushima A, Minabe Y, Higashida H.
    • Journal Title

      Neurosci Res. 67(2)

      Pages: 181-191

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Oxytocin signal and social behaviour : comparison among adult and infant oxytocin, oxytocin receptor and CD38 gene knockout mice.2010

    • Author(s)
      Higashida H, Lopatina O, Yoshihara T, Pichugina YA, Soumarokov AA, Munesue T, Minabe Y, Kikuchi M, Ono Y, Korshunova N, Salmina AB.
    • Journal Title

      J Neuroendocrinol. 22(5)

      Pages: 373-379

    • NAID

      120002561624

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Smaller insula and inferior frontal volumes in young adults with pervasive developmental disorders.2010

    • Author(s)
      Kosaka H, Omori M, Munesue T, Ishitobi M, Matsumura Y, Takahashi T, Narita K, Murata T, Saito DN, Uchiyama H, Morita T, Kikuchi M, Mizukami K, Okazawa H, Sadato N, Wada Y.
    • Journal Title

      Neuroimage. 50(4)

      Pages: 1357-1363

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Neurovascular coupling in the human somatosensory cortex : a single trial study.2010

    • Author(s)
      Kikuchi, M., et al.
    • Journal Title

      NeuroReport

      Volume: 21 Pages: 1106-1110

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Oxytocin signal and social behaviour : comparison among adult and in fant oxytocin, oxytocin receptor and CD38 gene knockout mice.2010

    • Author(s)
      Higashida, H., et al.
    • Journal Title

      J Neuroendocrinol

      Volume: 22 Pages: 373-379

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Two genetic variants of CD38 in subjects with autism spectrum disorder and controls.2010

    • Author(s)
      Munesue, T., et al.
    • Journal Title

      Neurosci Res

      Volume: 67 Pages: 181-191

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Attentional engagement to sound : cortical hemodynamics assessed with near-infrared spectroscopy.2010

    • Author(s)
      Remijn, G.B., et al.
    • Journal Title

      Proceedillgs of the Acoustical Society of Japan

      Volume: 146 Pages: 807-809

    • Related Report
      2010 Annual Research Report
  • [Journal Article] 子どものこころの生理学:バンビプランの紹介2010

    • Author(s)
      菊知充、三辺義雄
    • Journal Title

      脳21

      Volume: 13 Pages: 146-150

    • Related Report
      2010 Annual Research Report
  • [Journal Article] Heart rate variability in drug-naive patients with panic disorder and major depressive disorder.2009

    • Author(s)
      Kikuchi M, Hanaoka A, Kidani T, Remijn GB, Minabe Y, Munesue T, Koshino Y.
    • Journal Title

      Prog Neuropsychopharmacol Biol Psychiatry. 33(8)

      Pages: 1474-1478

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Altered markers of tonic inhibition in the dorsolateral prefrontal cortex of subjects with schizophrenia.2009

    • Author(s)
      Maldonado-Aviles JG, Curley AA, Hashimoto T, Morrow AL, Ramsey AJ, O'Donnell P, Volk DW, Lewis DA.
    • Journal Title

      Am J Psychiatry. 166(4)

      Pages: 450-459

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Age-related variation in EEG complexity to photic stimulation : a multiscale entropy analysis.2009

    • Author(s)
      Takahashi T, Cho RY, Murata T, Mizuno T, Kikuchi M, Mizukami K, Kosaka H, Takahashi K, Wada Y.
    • Journal Title

      Clin Neurophysiol. 120

      Pages: 476-483

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Bambi plan : project for the early detection of autism spectrum disorder using a NIRS/MEG integrated device2009

    • Author(s)
      Mitsuru Kikuchi, Toshio Munesue, Koichi Iiyama, Gerard B.Remijn, Yoshio Minabe
    • Journal Title

      Journal of Brain Science 5

      Pages: 56-60

    • NAID

      10028270193

    • Related Report
      2009 Annual Research Report
  • [Journal Article] 発達障害と臨床神経生理2009

    • Author(s)
      菊知充, 吉村優子
    • Journal Title

      最新精神医学 15

      Pages: 141-146

    • Related Report
      2009 Annual Research Report
  • [Journal Article] 情動の脳内機構 : 共感・愛着 ―自閉症スペクトラムから―2009

    • Author(s)
      東田陽博, 菊知充, 棟居俊夫
    • Journal Title

      BRAIN MEDICAL 21

      Pages: 47-54

    • Related Report
      2009 Annual Research Report
  • [Journal Article] 自閉症の脳イメージング2009

    • Author(s)
      中村和彦, 菊知充
    • Journal Title

      精神科 14

      Pages: 112-120

    • Related Report
      2008 Annual Research Report
  • [Presentation] Advantages and pitfalls of segmentation methods using texture, anatomical features, and VBM on brain MR images.2010

    • Author(s)
      Hayashi, N Sanada, S Miyati T, 鈴木道雄, 菊知充, Matsui O, 三邉義雄, Yamamoto T, Minehiro K, Sakuta K, Takanaga M, Kawashima H
    • Organizer
      Radiological Society of North America 2010 96th Scientific Assembly and Annual Meeting
    • Place of Presentation
      McCormick Place, Chicago (USA)
    • Year and Date
      2010-11-30
    • Related Report
      2010 Final Research Report
  • [Presentation] Advantages and pitfalls of segmentation methods using texture, anatomical features, and VBM on brain MR images.2010

    • Author(s)
      Hayashi, N., et al.
    • Organizer
      Radiological Society of North America 2010 96th Scientific Assembly and Annual Meeting
    • Place of Presentation
      McCormick PlaceChicago(USA)
    • Year and Date
      2010-11-30
    • Related Report
      2010 Annual Research Report
  • [Presentation] 子どもに優しい脳発達研究2010

    • Author(s)
      菊知充
    • Organizer
      第1回金沢大学子どものこころサミット
    • Place of Presentation
      金沢大学病院「宝ホール」金沢市(石川県)
    • Year and Date
      2010-11-26
    • Related Report
      2010 Annual Research Report
  • [Presentation] 子どもに優しい脳発達研究プロジェクト:バンビプラン2010

    • Author(s)
      菊知充、渡邊克巳、鈴木道雄、春田康博、井上芳浩、三邉義雄
    • Organizer
      第19回海馬と高次脳機能学会
    • Place of Presentation
      金沢湯涌創作の森「交流研修棟」(石川県)
    • Year and Date
      2010-11-20
    • Related Report
      2010 Final Research Report
  • [Presentation] 子どもに優しい脳発達研究プロジェクト:バンビプラン2010

    • Author(s)
      菊知充
    • Organizer
      第19回海馬と高次脳機能学会
    • Place of Presentation
      湯涌創作の森金沢市(石川県)
    • Year and Date
      2010-11-20
    • Related Report
      2010 Annual Research Report
  • [Presentation] Auditory evoked response of speech stimuli in 3-to 4-year-old children : a magnetoencephalography study.2010

    • Author(s)
      Yoshimura Y.菊知充, Shitamichi, K., Ueno, S., Nagao, K., Minabe Y.
    • Organizer
      International Congress of Clinical Neurophysiology (ICCN2010)
    • Place of Presentation
      神戸国際会議場神戸市(兵庫県)
    • Year and Date
      2010-11-01
    • Related Report
      2010 Final Research Report
  • [Presentation] Correlations between the development of cognitive functions and spontaneous MEG responses of healthy 3- to 4-year-old infants.2010

    • Author(s)
      Nagao, K. Kikuchi, M. , oshimura Y., Shitamichi, K., Ueno, S. Minabe Y.
    • Organizer
      International Congress of Clinical Neurophysiology (ICCN2010)
    • Place of Presentation
      神戸国際会議場神戸市(兵庫県)
    • Year and Date
      2010-11-01
    • Related Report
      2010 Final Research Report
  • [Presentation] Auditory evoked response of speech stimuli in 3- to 4-year-old children : a magnetoencephalography study.2010

    • Author(s)
      Yoshimura Y., et al.
    • Organizer
      International Congress of Clinical Neurophysiology(ICCN2010)
    • Place of Presentation
      神戸国際会議場神戸市(兵庫県)
    • Year and Date
      2010-11-01
    • Related Report
      2010 Annual Research Report
  • [Presentation] Correlations between the development of cognitive functions and spontaneous MEG responses of healthy 3- to 4-year-old infants.2010

    • Author(s)
      Nagao, K., et al.
    • Organizer
      International Congress of Clinical Neurophysiology(ICCN2010)
    • Place of Presentation
      神戸国際会議場神戸市(兵庫県)
    • Year and Date
      2010-11-01
    • Related Report
      2010 Annual Research Report
  • [Presentation] NIRS-measurements of cortical hemodynamic activity in adults and preschool infants in response to static and motion stimuli.2010

    • Author(s)
      Remijn, G.B., Kikuchi, M., Yoshimura, Y., Shitamichi, K., Ueno, S.,Nagao, K., Kojima, H., Minabe Y.
    • Organizer
      International Congress of Clinical Neurophysiology (ICCN2010)
    • Place of Presentation
      神戸国際会議場神戸市(兵庫県)
    • Year and Date
      2010-10-29
    • Related Report
      2010 Final Research Report
  • [Presentation] NIRS-measurements of cortical hemodynamic activity in adults and preschool infants in response to static and motion stimuli.2010

    • Author(s)
      Remijn, G.B., et al.
    • Organizer
      International Congress of Clinical Neurophysiology(ICCN2010)
    • Place of Presentation
      神戸国際会議場神戸市(兵庫県)
    • Year and Date
      2010-10-29
    • Related Report
      2010 Annual Research Report
  • [Presentation] バンビプランの紹介-広汎性発達障害の診断・治療・経過観察総合システムの開発-2010

    • Author(s)
      菊知充
    • Organizer
      第173回北陸精神神経学会
    • Place of Presentation
      金沢都ホテル(石川県)
    • Year and Date
      2010-06-21
    • Related Report
      2010 Final Research Report
  • [Presentation] シンポジウム『子どものこころの脳科学-大阪大学・浜松医科大学・金沢大学連合大学院発足を記念して-』:バンビプランの紹介2010

    • Author(s)
      菊知充、三邉義雄
    • Organizer
      第36回日本脳科学会
    • Place of Presentation
      金沢大学医学部記念館(石川県)
    • Year and Date
      2010-06-12
    • Related Report
      2010 Final Research Report
  • [Presentation] バンビプランの紹介 ―広汎性発達障害の診断・治療・経過観察総合システムの開発―2009

    • Author(s)
      菊知充
    • Organizer
      第173回北陸精神神経学会
    • Place of Presentation
      金沢都ホテル (石川県)
    • Year and Date
      2009-06-21
    • Related Report
      2009 Annual Research Report
  • [Presentation] シンポジウム『子どものこころの脳科学―大阪大学・浜松医科大学・金沢大学連合大学院発足を記念して―』: バンビプランの紹介2009

    • Author(s)
      菊知充
    • Organizer
      第36回日本脳科学会
    • Place of Presentation
      金沢大学医学部記念館 (石川県)
    • Year and Date
      2009-06-12
    • Related Report
      2009 Annual Research Report
  • [Remarks]

    • URL

      http://bambiplan.w3.kanazawa-u.ac.jp/

    • Related Report
      2010 Annual Research Report
  • [Remarks]

    • URL

      http://kokorosummit.w3.kanazawa-u.ac.jp/program.html

    • Related Report
      2010 Annual Research Report

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Published: 2008-04-01   Modified: 2016-04-21  

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