| Project/Area Number |
20591398
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Psychiatric science
|
|---|
| Research Institution | Hamamatsu University School of Medicine |
|---|
Principal Investigator |
ANITHA A.Pillai Hamamatsu University School of Medicine, 子どものこころの発達研究センター, 特任助教 (70377753)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
MATSUZAKI Hideo 浜松医科大学, 子どものこころの発達研究センター, 特任准教授 (00334970)
NAKAMURA Kazuhiko 浜松医科大学, 医学部, 准教授 (80263911)
TSUJII Masatsugu 中京大学, 現代社会学部, 教授 (20257546)
SUZUKI Katsuaki 浜松医科大学, 子どものこころの発達研究センター, 特任准教授 (00285040)
IWATA Keiko 浜松医科大学, 子どものこころの発達研究センター, 特任助教 (30415088)
IWATA Yasuhide 浜松医科大学, 医学部附属病院, 講師 (10285025)
MIYACHI Taishi 浜松医科大学, 子どものこころの発達研究センター, 特任助教 (60444345)
須田 史朗 浜松医科大学, 子どものこころの発達研究センター, 特任助教 (40432207)
|
|---|
| Project Period (FY) |
2008 – 2010
|
| Project Status |
Completed (Fiscal Year 2010)
|
| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2008: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
|
|---|
| Keywords | 自閉症 / 中枢神経系 / インテグリンβ3 / セロトニン / インテグリンss3 |
|---|
| Research Abstract |
We have found serotonin transporter (SERT) binding was significantly lower throughout the brain in autistic individuals compared with healthy controls by PET study. To clalify mechanism underlying, we have analyzed gene and postmortem brain of autistic subjects and the controls. As results, we have found change of SERT-related gene expression in the study. However, there was no difference in SERT expression of postmortem brains between them. Taken together, SERT dysfunction in autistic brain may be caused by intracellular trafficking dysfunction but not expression impairment.
|
