analysis of serotonin transductional dysfunction in autism

• Project/Area Number: 20591398
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Psychiatric science
• Research Institution: Hamamatsu University School of Medicine
• Principal Investigator: ANITHA A.Pillai Hamamatsu University School of Medicine, 子どものこころの発達研究センター, 特任助教 (70377753)
• Co-Investigator(Kenkyū-buntansha): MATSUZAKI Hideo 浜松医科大学, 子どものこころの発達研究センター, 特任准教授 (00334970) ; NAKAMURA Kazuhiko 浜松医科大学, 医学部, 准教授 (80263911) ; TSUJII Masatsugu 中京大学, 現代社会学部, 教授 (20257546) ; SUZUKI Katsuaki 浜松医科大学, 子どものこころの発達研究センター, 特任准教授 (00285040) ; IWATA Keiko 浜松医科大学, 子どものこころの発達研究センター, 特任助教 (30415088) ; IWATA Yasuhide 浜松医科大学, 医学部附属病院, 講師 (10285025) ; MIYACHI Taishi 浜松医科大学, 子どものこころの発達研究センター, 特任助教 (60444345) ; 須田 史朗 浜松医科大学, 子どものこころの発達研究センター, 特任助教 (40432207)
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2008: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
• Keywords: 自閉症 / 中枢神経系 / インテグリンβ3 / セロトニン / インテグリンss3

Research Abstract

We have found serotonin transporter (SERT) binding was significantly lower throughout the brain in autistic individuals compared with healthy controls by PET study. To clalify mechanism underlying, we have analyzed gene and postmortem brain of autistic subjects and the controls. As results, we have found change of SERT-related gene expression in the study. However, there was no difference in SERT expression of postmortem brains between them. Taken together, SERT dysfunction in autistic brain may be caused by intracellular trafficking dysfunction but not expression impairment.

Research Products

• [Journal Article] Replication study of Japanese cohorts supports the role of STX1A in autism susceptibility. (2011)
  • Author(s): Nakamura K, Iwata Y, Anitha A, Miyachi T, Toyota T, Yamada S, Tsujii M, Tsuchiya KJ, Iwayama Y, Yamada K, Hattori E, Matsuzaki H, Matsumoto K, Suzuki K, et al.
  • Journal Title: Prog Neuropsychopharmacol Biol Psychiatry 35(2) Pages: 454-458
• [Journal Article] Replication study of Japanese cohorts supports the role of STX1A in autism susceptibility. (2011)
  • Author(s): Nakamura K, Iwata Y, Anitha A, Miyachi T, Toyota T, Yamada S, Tsujii M, Tsuchiya KJ, Iwayama Y, Yamada K, Hattori E, Matsuzaki H, Matsumoto K, Suzuki K, Suda S, Takebayashi K, Takei N, Ichikawa H, Sugiyama T, Yoshikawa T, Mori N.
  • Journal Title: Prog Neuropsychopharmacol Biol Psychiatry Volume: 35(2) Pages: 454-458
  • Peer Reviewed
• [Journal Article] Further evidence for the role of MET in autism susceptibility. (2010)
  • Author(s): Thanseem I, Nakamura K, Miyachi T, Toyota T, Yamada S, Tsujii M, Tsuchiya KJ, Anitha A, Iwayama Y, Yamada K, Hattori E, Matsuzaki H, Matsumoto K, Iwata Y, Suzuki K, et al.
  • Journal Title: Neurosci Res. 68(2) Pages: 137-141
• [Journal Article] Brain Serotonin and Dopamine Transporter Bindings in Adults with High-Functioning Autism. (2010)
  • Author(s): Nakamura K, Sekine Y, Ouchi Y, Tsujii M, Yoshikawa E, Futatsubashi M, Tsuchiya KJ, Sugihara G, Nishimura K, Takebayashi K, Kawai M, Iwata Y, Suzuki K, Suda S, Matsuzaki H, et al.
  • Journal Title: Arch.Gen.Psychiatry. 67(1) Pages: 59-68
• [Journal Article] Genetic analyses of Roundabout (ROBO) axon guidance receptors in autism. (2008)
  • Author(s): Anitha A, Nakamura K, Yamada K, Suda S, Thanseem I, Tsujii M, Iwayama Y, Hattori E, Toyota T, Miyachi T, Iwata Y, Suzuki K, Matsuzaki H, et al.
  • Journal Title: Am J Med Genet B Neuropsychiatr Genet. 147B(7) Pages: 1019-1027
• [Journal Article] Genetic and expression analyses reveal elevated expression of syntaxin 1A (STX1A) in high functioning autism. (2008)
  • Author(s): Nakamura K, Anitha A, Yamada K, Tsujii M, Iwayama Y, Hattori E, Toyota T, Suda S, Takei N, Iwata Y, Suzuki K, Matsuzaki H, et al.
  • Journal Title: Int J Neuropsychopharmacol. 2 Pages: 1-12
• [Journal Article] Genetic analyses of Roundabout (ROBO)axon guidance receptors in autism. (2008)
  • Author(s): Anitha A, et al.
  • Journal Title: American Journal of Medical Genetics part B-Neuropsychiatric Genetics 147B Pages: 1019-1027
  • Peer Reviewed
• [Journal Article] Genetic and expression analyses reveal elevated expression of syntaxin 1A(STXIA) in high functioning autism. (2008)
  • Author(s): Nakamura K, et al.
  • Journal Title: International Journal of Neuropsychopharmacology 11 Pages: 1073-1084
  • Peer Reviewed
• [Journal Article] Gene and expression analyses reveal enhanced expression of pericentrin 2 (PCNT2)in bipolar disorder. (2008)
  • Author(s): Anitha A, et al.
  • Journal Title: Biological Psychiatry 63 Pages: 678-685
  • Peer Reviewed
• [Presentation] Brain serotonin and dopamine transporter bindings in adults with autism. (2010)
  • Author(s): Nakamura K, Iwata Y, Mori N, Sugihara G, Ouchi Y, Tsujii M, Sugiyama T, Tsuchiya KJ, Suzuki K, Matsuzaki H, Suda S, Takei N.
  • Organizer: The Society for Neuroscience 40th annual meeting
  • Place of Presentation: San Diego, USA.
  • Year and Date: 2010-11-16
• [Presentation] Brain Serotonin and Dopamine Transporter Bindings in Adults with Autism. (2010)
  • Author(s): Nakamura K, Ouchi Y, Tsujii M, Tsuchiya KJ, Sugihara G, Iwata Y, Suzuki K, Matsuzaki H, et al.
  • Organizer: The 9th annual International Meeting for Autism Research
  • Place of Presentation: Philadelphia, USA
  • Year and Date: 2010-05-21
• [Presentation] Serotonin related gene expression changes in subjects with autism : A postmortem brain study. (2009)
  • Author(s): Suda S, Iwata K, Anitha A, Thanseem I, Matsuzaki H, Kameno Y, Nakamura K, Mori N, Takei N.
  • Organizer: The Society for Neuroscience 39th annual meeting
  • Place of Presentation: Chicago, USA
  • Year and Date: 2009-10-19
• [Presentation] Serotonin related gene expression changes in subjects with autism : A postmortem brain study (2009)
  • Author(s): Suda S, Iwata K, Anitha A, Thanseem I, Matsuzaki H, Kameno Y, Nakamura K, Mori N, Takei N.
  • Organizer: The Society for Neuroscience 39th annual meeting
  • Place of Presentation: Chicago, USA
  • Year and Date: 2009-10-19
• [Presentation] Genetic and Expression Analyses of Serotonergic Factors in Autism. (2009)
  • Author(s): Nakamura K, Miyachi T, Anitha A, Tsujii M, Suda S, Thanseem I, Tsuchiya K, Matsuzaki H, et al.
  • Organizer: The 8th Annual International Meeting For Autism Research
  • Place of Presentation: Chicago
• [Presentation] Serotonin transporter and serotonin related gene expression in autism. (2008)
  • Author(s): Suda S, Iwata K, Anitha A, Thanseem I, Nakamura K, Matsuzaki H, Iwata Y, Yamamoto S, Suzuki K, et al.
  • Organizer: The 38th annual meeting of the Society for Neuroscience
  • Place of Presentation: Washington
  • Year and Date: 2008-11-17
• [Presentation] Gene and expression analyses reveal elevated expression of syntaxin 1A in high functioning autism (2008)
  • Author(s): Anitha A, et al.
  • Organizer: XVIth World Congress on Psychiatric Genetics
  • Place of Presentation: 大阪
  • Year and Date: 2008-10-11
• [Presentation] Genetic analyses of serotonergic factors in autism. (2008)
  • Author(s): Matsuzaki H, Nakamura K, Tsujii M, Anitha A, et al.
  • Organizer: The 7th annual International Meeting for Autism Research
  • Place of Presentation: London, UK
• [Remarks] ホームページ等