Neuropathological investigation in the brain of schizophrenia and animal model
| Project/Area Number |
20591400
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Psychiatric science
|
|---|
| Research Institution | Nagoya University |
|---|
Principal Investigator |
IRITANI Shuji Nagoya University, 医学系研究科, 准教授 (60191904)
|
|---|
| Project Period (FY) |
2008 – 2010
|
| Project Status |
Completed (Fiscal Year 2010)
|
| Budget Amount *help |
¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2009: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2008: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
|
|---|
| Keywords | 統合失調症 / モデル動物 / 神経病理 / 免疫組織学 / TH(チロシン水酸化酵素) / VMAT2(Vesicular Monoamine Transporter 2) / 神経病理学 / カルビンディン / チロシン水酸化酵素 |
|---|
| Research Abstract |
This study will be aiming to clarify the pathophysiology of schizophrenia from the view point of neurodevelopmental hypothesis through investigating the brain of animal model and postmortem human brain neuropathologically. As the results, I found the differences of the formation of neuronal fiber and the appearance of neuromodulator protein or neurotransmitter in the brain of model mouse compared to the control. Also, these findings observed in animal model were detected in the brain of schizophrenia. These facts indicated that there existed the neurodevelopmental problem in the pathophysiology of the schizophrenia.
|
Report
(4 results)
Research Products
(22 results)
