| Budget Amount *help |
¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2009: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2008: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
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| Research Abstract |
This study will be aiming to clarify the pathophysiology of schizophrenia from the view point of neurodevelopmental hypothesis through investigating the brain of animal model and postmortem human brain neuropathologically. As the results, I found the differences of the formation of neuronal fiber and the appearance of neuromodulator protein or neurotransmitter in the brain of model mouse compared to the control. Also, these findings observed in animal model were detected in the brain of schizophrenia. These facts indicated that there existed the neurodevelopmental problem in the pathophysiology of the schizophrenia.
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