Neural basis of social cognitive impairments in schizophrenia : neuroimaging studies using structural and functional MRI

• Project/Area Number: 20591401
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Psychiatric science
• Research Institution: Kyoto University
• Principal Investigator: MURAI Toshiya Kyoto University, 医学研究科, 教授 (30335286)
• Co-Investigator(Kenkyū-buntansha): FUKUYAMA Hidenao 京都大学, 医学研究科, 教授 (90181297) ; SAWAMOTO Nobukatsu 京都大学, 医学研究科, 助教 (90397547) ; NAMIKI Chihiro 京都大学, 医学研究科, 助教 (40432380)
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2008: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: 神経心理学 / 画像診断学

Research Abstract

Impaired social cognition in schizophrenia is considered as the core contributor in the poor psychosocial functioning of schizophrenia patients. Using structural and functional MRI, we investigated neural bases of social cognitive impairments in schizophrenia. As results, morphological and functional abnormalities in frontal, temporal, and parietal cortices as well as white matter abnormalities were found to be associated with various facets of social cognitive impairments in schizophrenia. These results give us an insight into optimal cognitive rehabilitation in schizophrenia.

Research Products

• [Journal Article] Age-related cortical thinning in schizophrenia. Age-related cortical thinning in schizophrenia. (2011)
  • Author(s): Kubota M, Miyata J, Yoshida H, Hirao K, Fujiwara H, Kawada R, Fujimoto S, Tanaka Y, Sasamoto A, Sawamoto N, Fukuyama H, Murai T.
  • Journal Title: Schizophrenia Research 125 Pages: 21-9
• [Journal Article] Social impairment in schizophrenia revealed by Autistic Quotient correlated with gray matter reduction (2011)
  • Author(s): Sasamoto A, (他7名), Sawamoto N, Fukuyama H, (他1名), Murai T
  • Journal Title: Social Neuroscience Volume: (印刷中)
  • Peer Reviewed
• [Journal Article] Abnormal asymmetry of white matter integrity in schizophrenia revealed by voxelwise diffusion tensor imaging (2011)
  • Author(s): Miyata J, (他8名), Fukuyama H, Sawamoto N, (他1名), Murai T
  • Journal Title: Human Brain Mapping Volume: (印刷中)
  • Peer Reviewed
• [Journal Article] Alexithymia and regional gray matter alterations in schizophrenia (2011)
  • Author(s): Kubota M, (他7名), Sawamoto N, Fukuyama H, (他1名), Murai T
  • Journal Title: Neuroscience Research Volume: (印刷中)
  • Peer Reviewed
• [Journal Article] Age-related cortical thinning in schizophrenia (2011)
  • Author(s): Kubota M, (他8名), Sawamoto N, Fukuyama H, Murai T
  • Journal Title: Schizophrenia Research Volume: 5 Pages: 21-29
  • NAID: 120002723136
  • Peer Reviewed
• [Journal Article] Investigating association of brain volumes with intracranial capacity in schizophrenia. (2010)
  • Author(s): Ueda K, Fujiwara H, Miyata J, Hirao K, Saze T, Kawada R, Fujimoto S, Tanaka Y, Sawamoto N, Fukuyama H, Murai T.
  • Journal Title: Neuroimage 49 Pages: 2503-8
• [Journal Article] Reduced white matter integrity as a neural correlate of social cognition deficits in schizophrenia. (2010)
  • Author(s): Miyata J, Yamada M, Namiki C, Hirao K, Saze T, Fujiwara H, Shimizu M, Kawada R, Fukuyama H, Sawamoto N, Hayashi T, Murai T.
  • Journal Title: Schizophrenia Research 119 Pages: 232-9
  • NAID: 120002383979
• [Journal Article] Reduced white matter integrity as a neural correlate of social cognition deficits in schizophrenia (2010)
  • Author(s): Miyata J, Yamada M, Namiki C, Hirao K, Saze T, Fujiwara H, Shimizu M, Kawada R, Fukuyama H, Sawamoto N, Hayashi T, Murai T
  • Journal Title: Schizophrenia Research
  • NAID: 120002383979
  • Peer Reviewed
• [Journal Article] Investigating association of brain volumes with intracranial capacity in schizophrenia (2010)
  • Author(s): Ueda K, Fujiwara H, Miyata J, Hirao K, Saze T, Kawada R, Fujimoto S, Tanaka Y, Sawamoto N, Fukuyama H, Murai T
  • Journal Title: Neuroimage 49 Pages: 2503-2508
  • Peer Reviewed
• [Journal Article] Reduced white matter integrity correlated with cortico-subcortical gray matter deficits in schizophrenia. (2009)
  • Author(s): Miyata J, Hirao K, Namiki C, Fujiwara H, Shimizu M, Fukuyama H, Sawamoto N, Hayashi T, Murai T.
  • Journal Title: Schizophrenia Research 111 Pages: 78-85
• [Journal Article] Brain volume and dysexecutive behavior in schizophrenia. (2009)
  • Author(s): Kawada R, Yoshizumi M, Hirao K, Fujiwara H, Miyata J, Shimizu M, Namiki C, Sawamoto N, Fukuyama H, Hayashi T, Murai T.
  • Journal Title: Prog Neuropsychopharmacol Biol Psychiatry 33 Pages: 1255-60
• [Journal Article] Brain volume and dysexecutive behavior in schizophrenia (2009)
  • Author(s): Kawada R, Yoshizumi M, Hirao K, Fujiwara H, Miyata J, Shimizu M, Namiki C, Sawamoto N, Fukuyama H, Hayashi T, Murai T
  • Journal Title: Prog Neuropsychopharmacol Biol Psychiatry 33 Pages: 1255-1260
  • Peer Reviewed
• [Journal Article] Reduced white matter integrity correlated with cortico-subcortcal gray matter deficits in schizophrenia (2009)
  • Author(s): Miyata J, Hirao K, Namiki C, Fujiwara H, Shimizu M, Fukuyama H, Sawamoto N, Hayashi T, Murai T.
  • Journal Title: Schizophrenia Research
  • Peer Reviewed
• [Journal Article] Social impairment in schizophrenia revealed by Autistic Quotient correlated with gray matter reduction.
  • Author(s): Sasamoto A, Miyata J, Hirao K, Fujiwara H, Kawada R, Fujimoto S, Tanaka Y, Kubota M, Sawamoto N, Fukuyama H, Takahashi H, Murai T.
  • Journal Title: Social Neuroscience. in press
• [Journal Article] Abnormal asymmetry of white matter integrity in schizophrenia revealed by voxelwise diffusion tensor imaging.
  • Author(s): Miyata J, Sasamoto A, Koelkebeck K, Hirao K, Ueda K, Kawada R, Fujimoto S, Tanaka Y, Kubota M, Fukuyama H, Sawamoto N, Takahashi H, Murai T.
  • Journal Title: Human Brain Mapping. in press
• [Journal Article] Alexithymia and regional gray matter alterations in schizophrenia.
  • Author(s): Kubota M, Miyata J.Hirao K, Fujiwara H, Kawada R, Fujimoto S, Tanaka Y, Sasamoto A, Sawamoto N, Fukuyama H, Takahashi H, Murai T.
  • Journal Title: Neuroscience Research. in press
• [Presentation] Abnormal white matter asymmetry in schizophrenia demonstrated by tract-based spatial statistics. (2010)
  • Author(s): Miyata J, Sasamoto A, Koelkebeck K, Kawada R, Kubota M, Sawamoto N, Fukuyama H, Murai T.
  • Organizer: 16th Annual Meeting of the Organization for Human Brain Mapping
  • Place of Presentation: Barcelona, Spain
• [Presentation] Regional white matter integrity reductions correlate with cortico-subcortical gray matter reductions and social cognition ability in schizophrenia. (2009)
  • Author(s): Miyata J, Hirao K, Yamada M, Namiki C, Fujiwara H, Shimizu M, Fukuyama H, Sawamoto N, Hayashi T, Murai T.
  • Organizer: 15th Annual Meeting of the Organization for Human Brain Mapping
  • Place of Presentation: San Francisco, California.
• [Presentation] Regional white matter integrity reductions correlate with cortico-subcortical gray matter reductions and social cognition ability in schizophrenia (2009)
  • Author(s): Miyata J, Hirao K, Yamada M, Namiki C, Fujiwara H, Shimizu M, Fukuyama H, Sawamoto N, Hayashi T, Murai T
  • Organizer: 15th Annual Meeting of the Organization for Human Brain Mapping
  • Place of Presentation: San Francisco, California U.S.A.
• [Presentation] Transkulturelle Aspekte der Mentalisierung bei Schizophrenien (2008)
  • Author(s): Kolkebeck K, Hirao K, Saze T, Miyata J, Kawada R, Ohrmann P, Pedersen A, Bauer J, Brandt M, Arolt V, Murai T.
  • Organizer: DGPPN Konress 2008
  • Place of Presentation: Berlin
  • Year and Date: 2008-11-26
• [Presentation] Tractography assisted callosal parcellation : its impact on schizophrenia study (2008)
  • Author(s): Miyata J, Murai T
  • Organizer: 2nd WFSBP Asia-Pacific Congress
  • Place of Presentation: Toyama
  • Year and Date: 2008-09-11
• [Presentation] Brain volume and frontal systems behavior in schizophrenia (2008)
  • Author(s): Kawada R, Yoshizumi M, Hirao K, Fujiwara H, Miyata J, Shimizu M, Namiki C, Sawamoto N, Fukuyama H, Hayashi T, Murai T.
  • Organizer: 2nd WFSBP Asia-Pacific Congress
  • Place of Presentation: Toyama
  • Year and Date: 2008-09-11
• [Presentation] Female specific anterior cingulate abnormalities and empathic disabilities in schizophrenia (2008)
  • Author(s): Fujiwara H, Shimizu M, Hirao K, Miyata J, Sawamoto N, Fukuyama H, Hayashi T, Murai T.
  • Organizer: 2nd WFSBP Asia-Pacific Congress
  • Place of Presentation: Toyama
  • Year and Date: 2008-09-11
• [Presentation] Abnormal Gyrification and Brain Volume Reduction in Schizophrenia (2008)
  • Author(s): Saze T, Hirao K, Miyata J, Fujiwara H, Shimizu M, Namiki C, Sawamoto N, Fukuyama H, Hayashi T, Murai T.
  • Organizer: 2nd WFSBP Asia-Pacific Congress
  • Place of Presentation: Toyama
  • Year and Date: 2008-09-11
• [Presentation] Affective mentalizing and frontotemporal pathology in schizophrenia (2008)
  • Author(s): Hirao K, Miyata J, Namiki C, Yamada M, Murai T.
  • Organizer: 9th International Congress
  • Place of Presentation: Montreal
  • Year and Date: 2008-07-25
• [Presentation] 39) Investigation of theory of mind abilities combining functional magnetic resonance imaging (fMRI) and diffusion tensor imaging (DTI) in a Japanese sample of schizophrenia patients (2008)
  • Author(s): Koelkebeck K, Hirao K, Saze T, Miyata J, Kawada R, Ohrmann P, Bauer J, Pedersen A, Murai T.
  • Organizer: 1st Schizophrenia International Research Society Conference
  • Place of Presentation: Venice
  • Year and Date: 2008-06-21
• [Presentation] Midline and medial thalamic structures in patients with schizophrenia : an MRI study (2008)
  • Author(s): Shimizu M, Fujiwara H, Hirao K, Namiki C, Fukuyama H, Hayashi T, Murai T.
  • Organizer: 1st Schizophrenia International Research Society Conference
  • Place of Presentation: Venice
  • Year and Date: 2008-06-21
• [Presentation] Investigation of theory of mind abilities combining functional magnetic resonance imaging (fMRI) and diffusion tensor imaging (DTI) in a Japanese sample of schizophrenia patients. (2008)
  • Author(s): Koelkebeck K, Hirao K, Saze T, Miyata J, Kawada R, Ohrmann P, Bauer J, Pedersen A, Murai T.
  • Organizer: 1st Schizophrenia International Research Society Conference
  • Place of Presentation: Venice
• [Presentation] Midline and medial thalamic structures in patients with schizophrenia : an MRI study. (2008)
  • Author(s): Shimizu M, Fujiwara H, Hirao K, Namiki C, Fukuyama H, Hayashi T, Murai T.
  • Organizer: 1st Schizophrenia International Research Society Conference
  • Place of Presentation: Venice
• [Presentation] Affective mentalizing and frontotemporal pathology in schizophrenia. (2008)
  • Author(s): Hirao K, Miyata J, Namiki C, Yamada M, Murai T.
  • Organizer: 9th International Congress
  • Place of Presentation: Montreal
• [Presentation] Brain volume and frontal systems behavior in schizophrenia. (2008)
  • Author(s): Kawada R, Yoshizumi M, Hirao K, Fujiwara H, Miyata J, Shimizu M, Namiki C, Sawamoto N, Fukuyama H, Hayashi T, Murai T.
  • Organizer: 2nd WFSBP Asia-Pacific Congress
  • Place of Presentation: Toyama
• [Presentation] Female specific anterior cingulate abnormalities and empathic disabilities in schizophrenia. (2008)
  • Author(s): Fujiwara H, Shimizu M, Hirao K, Miyata J, Sawamoto N, Fukuyama H, Hayashi T, Murai T.
  • Organizer: 2nd WFSBP Asia-Pacific Congress
  • Place of Presentation: Toyama
• [Presentation] Abnormal Gyrification and Brain Volume Reduction in Schizophrenia. (2008)
  • Author(s): Saze T, Hirao K, Miyata J, Fujiwara H, Shimizu M, Namiki C, Sawamoto N, Fukuyama H, Hayashi T, Murai T.
  • Organizer: 2nd WFSBP Asia-Pacific Congress
  • Place of Presentation: Toyama