Neuronal stem cell imaging and analysis of non-human primates brain

• Project/Area Number: 20591404
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Psychiatric science
• Research Institution: Osaka University
• Principal Investigator: MATSUZAKI Hideo Osaka University, 子どものこころの発達研究センター, 特任准教授 (00334970)
• Co-Investigator(Kenkyū-buntansha): IWATA Yasuhide 浜松医科大学, 医学部付属病院, 講師 (10285025) ; NAKAMURA Kazuhiko 浜松医科大学, 医学部, 准教授 (80263911) ; SUDA Shiro 浜松医科大学, 医学部, 助教 (40432207) ; UEKI Takatoshi 浜松医科大学, 医学部, 助教 (60317328) ; IWATA Keiko 浜松医科大学, 子どものこころの発達研究センター, 特任助教 (30415088) ; 山本 茂幸 浜松医科大学, 子どものこころの発達研究センター, 特任助教 (10382201)
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000); Fiscal Year 2010: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2008: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: 神経幹細胞 / 霊長類 / PET / 認知機能

Research Abstract

In this study, we tried to generate recombinant retrovirus or lentivirus vector capable of nhibiting function of neuronal stem cell (NSC) to assess the role of hippocampal neurogenesis in social recognition behavior of non-human primates. This virus vector system may be useful for neurogenesis research as novel tool for NSC-specific gene expression and imaging in vivo.

Research Products

• [Journal Article] Perinatal asphyxia reduces dentate granule cells andExacerbates methamphetamine-induced hyperlocomotion inadulthood. (2008)
  • Author(s): Wakuda T, Matsuzaki H, Suzuki K, Iwata Y, Shinmura C, Suda s, Iwata K, Yamamoto s, Sugihara G, Tsuchiya KJ, Ueki T, Nakamura K, Nakahara D, Takei N, Mori N.
  • Journal Title: PLoS ONE 3
  • Peer Reviewed
• [Journal Article] Irradiation in adulthood as a new model ofschizophrenia. (2008)
  • Author(s): Iwata Y, Suzuki K, Wakuda T, Seki N, Thanseem I, Matsuzaki H, Mamiya T, Ueki T, Mikawa S, Sasaki T, Suda S, Yamamoto s, Tsuchiya KJ, Sugihara G, Nakamura K, Sato K, Takei N, Hashimoto K, Mori N.
  • Journal Title: PLoS ONE 3
  • Peer Reviewed
• [Journal Article] Methamphetamine causes microglial activation in thebrains of human abusers. (2008)
  • Author(s): Sekine Y, Ouchi Y, Sugihara G, Takei N, Yoshikawa E, Nakamura K, Iwata Y, Tsuchiya KJ, Suda S, Suzuki K, Kawai M, Takebayashi K, Yamamoto S, Matsuzaki H, Ueki T, Mori N, Gold MS, Cadet JL.
  • Journal Title: J Neurosci 28 Pages: 5756-5761
  • Peer Reviewed
• [Remarks] ホームページ等