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Neuronal stem cell imaging and analysis of non-human primates brain

Research Project

Project/Area Number 20591404
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Psychiatric science
Research InstitutionOsaka University

Principal Investigator

MATSUZAKI Hideo  Osaka University, 子どものこころの発達研究センター, 特任准教授 (00334970)

Co-Investigator(Kenkyū-buntansha) IWATA Yasuhide  浜松医科大学, 医学部付属病院, 講師 (10285025)
NAKAMURA Kazuhiko  浜松医科大学, 医学部, 准教授 (80263911)
SUDA Shiro  浜松医科大学, 医学部, 助教 (40432207)
UEKI Takatoshi  浜松医科大学, 医学部, 助教 (60317328)
IWATA Keiko  浜松医科大学, 子どものこころの発達研究センター, 特任助教 (30415088)
山本 茂幸  浜松医科大学, 子どものこころの発達研究センター, 特任助教 (10382201)
Project Period (FY) 2008 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2010: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2008: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords神経幹細胞 / 霊長類 / PET / 認知機能
Research Abstract

In this study, we tried to generate recombinant retrovirus or lentivirus vector capable of nhibiting function of neuronal stem cell (NSC) to assess the role of hippocampal neurogenesis in social recognition behavior of non-human primates. This virus vector system may be useful for neurogenesis research as novel tool for NSC-specific gene expression and imaging in vivo.

Report

(4 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (4 results)

All 2008 Other

All Journal Article (3 results) (of which Peer Reviewed: 3 results) Remarks (1 results)

  • [Journal Article] Perinatal asphyxia reduces dentate granule cells andExacerbates methamphetamine-induced hyperlocomotion inadulthood.2008

    • Author(s)
      Wakuda T, Matsuzaki H, Suzuki K, Iwata Y, Shinmura C, Suda s, Iwata K, Yamamoto s, Sugihara G, Tsuchiya KJ, Ueki T, Nakamura K, Nakahara D, Takei N, Mori N.
    • Journal Title

      PLoS ONE 3

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Irradiation in adulthood as a new model ofschizophrenia.2008

    • Author(s)
      Iwata Y, Suzuki K, Wakuda T, Seki N, Thanseem I, Matsuzaki H, Mamiya T, Ueki T, Mikawa S, Sasaki T, Suda S, Yamamoto s, Tsuchiya KJ, Sugihara G, Nakamura K, Sato K, Takei N, Hashimoto K, Mori N.
    • Journal Title

      PLoS ONE 3

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Methamphetamine causes microglial activation in thebrains of human abusers.2008

    • Author(s)
      Sekine Y, Ouchi Y, Sugihara G, Takei N, Yoshikawa E, Nakamura K, Iwata Y, Tsuchiya KJ, Suda S, Suzuki K, Kawai M, Takebayashi K, Yamamoto S, Matsuzaki H, Ueki T, Mori N, Gold MS, Cadet JL.
    • Journal Title

      J Neurosci 28

      Pages: 5756-5761

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Remarks] ホームページ等

    • Related Report
      2010 Final Research Report

URL: 

Published: 2008-04-01   Modified: 2016-04-21  

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