Development of methods to promote degradation of amyloid beta

• Project/Area Number: 20591405
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Psychiatric science
• Research Institution: Osaka University
• Principal Investigator: TAGAMI Shinji Osaka University, 大学院・医学系研究科, 助教 (40362735)
• Co-Investigator(Kenkyū-buntansha): OKOCHI Masayasu 大阪大学, 大学院・医学系研究科, 講師 (90335357) ; TAKEDA Masatoshi 大阪大学, 大学院・医学系研究科, 教授 (00179649)
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2008: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: presenilin / gamma secretase / BACE / betaAPP / amyloid beta / Alzheimer disease / アミロイドベータ / アルツハイマー病 / γセクレターゼ / APLP1 / beta APP / MCSF

Research Abstract

Senile plaque is a pathological hallmark of Alzheimer's disease. The major component is amyloid-beta 42 (Aβ42). Inhibition of Aβ42 generation or enhancement of Aβ42 degradation is fundamental approach in developing methods to treat AD. We found that BACE, which sheds beta-amyloid protein precursor (βAPP) to generate CTF-β, cleaves Aβ42 at two sites into species with much less toxicity and hydrophobicity. We also investigated the generation mechanism of Aβ42.

Research Products

• [Journal Article] The production ratios of AICDε51 and Aβ42 by intramembrane proteolysis of βAPP do not always change in parallel. (2010)
  • Author(s): Mori K, Okochi M, Tagami S, Nakayama T, Yanagida K, Kodama TS, Tatsumi S, Fujii K, Tanimukai H, Hashimoto R, Morihara T, Tanaka T, Kudo T, Funamoto S, Ihara Y, Takeda M.
  • Journal Title: Psychogeriatrics 10 Pages: 117-123
  • NAID: 10029771051
  • Peer Reviewed
• [Journal Article] Human B2 inhibitgamma-secretase cleavage of amyloid precursor protein by binding to the presenilin complex. (2010)
  • Author(s): Mitsuishi Y, Hasegawa H, Matsuo A, Araki W, Suzuki T, Tagami S, Okochi M, Takeda M, Roepman R, Nishimura M.
  • Journal Title: J Biol Chem 285 Pages: 14290-14931
  • Peer Reviewed
• [Journal Article] Laughter and humor as complementary and alternative medicines for dementia patients. (2010)
  • Author(s): Takeda M, Hashimoto R, Kudo T, Okochi M, Tagami S, Morihara T, Sadick G, Tanaka T.
  • Journal Title: BMC Complement Altern Med. 10 Pages: 1-7
  • Peer Reviewed
• [Journal Article] (2010)
  • Author(s): Hayashi N, Kazui H, Kamino K, Tokunaga H, Takaya M, Yokokoji M, Kimura R, Kito Y, Wada T, Nomura K, Sugiyama H, Yamamoto D, Yoshida T, Currais A, Soriano S, Hamasaki T, Yamamoto M, Yasuda Y, Hashimoto R, Tanimukai H, Tagami S, Okochi M, Tanaka T, Kudo T, Morihara T, Takeda M.
  • Journal Title: Dement Geriatr Cogn Disord 30 Pages: 302-308
  • Peer Reviewed
• [Journal Article] Apolipoprotein E and central nervous system disorders : reviews of clinical findings. (2010)
  • Author(s): Takeda M, Martinez R, Kudo T, Tanaka T, Okochi M, Tagami S,Morihara T, Hashimoto R, Cacabelos R.
  • Journal Title: Psychiatry Clin Neurosci 64 Pages: 592-607
  • Peer Reviewed
• [Journal Article] The production ratios of AICDε51 and Aβ42 by intramembrane proteolysis of βAPP do not always change in parallel. (2010)
  • Author(s): Mori K, Okochi M, Tagami S, Nakayama T, Yanagida K, Kodama TS, Tatsumi S, Fujii K, Tanimukai H, Hashimoto R, Morihara T, Tanaka T, Kudo T, Funamoto S, Ihara Y, Takeda M.
  • Journal Title: Psychogeriatrics Volume: 10 Pages: 117-123
  • NAID: 10029771051
  • Peer Reviewed
• [Journal Article] Human CRB2 inhibits gamma-secretase cleavage of amyloid precursor protein by binding to the presenilin complex. (2010)
  • Author(s): Mitsuishi Y, Hasegawa H, Matsuo A, Araki W, Suzuki T, Tagami S, Okochi M, Takeda M, Roepman R, Nishimura M.
  • Journal Title: J Biol Chem Volume: 285 Pages: 14290-14931
  • Peer Reviewed
• [Journal Article] Laughter and humor as complementary and alternative medicines for dementia patients. (2010)
  • Author(s): Takeda M, Hashimoto R, Kudo T, Okochi M, Tagami S, Morihara T, Sadick G, Tanaka T.
  • Journal Title: BMC Complement Altern Med. Volume: 10 Pages: 1-7
  • Peer Reviewed
• [Journal Article] KIBRA genetic polymorphism influences episodic memory in Alzheimer's disease, but does not show association with disease in a Japanese cohort. (2010)
  • Author(s): Hayashi N, Kazui H, Kamino K, Tokunaga H, Takaya M, Yokokoji M, Kimura R, Kito Y, Wada T, Nomura K, Sugiyama H, Yamamoto D, Yoshida T, Currais A, Soriano S, Hamasaki T, Yamamoto M, Yasuda Y, Hashimoto R, Tanimukai H, Tagami S, Okochi M, Tanaka T, Kudo T, Morihara T, Takeda M.
  • Journal Title: Dement Geriatr Cogn Disord Volume: 30 Pages: 302-308
  • Peer Reviewed
• [Journal Article] Apolipoprotein E and central nervous system disorders : reviews of clinical findings. (2010)
  • Author(s): Takeda M, Martinez R, Kudo T, Tanaka T, Okochi M, Tagami S, Morihara T, Hashimoto R, Cacabelos R.
  • Journal Title: Psychiatry Clin Neurosci Volume: 64 Pages: 592-607
  • Peer Reviewed
• [Journal Article] Analysis of APL1beta28, a surrogate marker for Alzheimer Abeta42, indicates altered precision of gamma-cleavage in the brains of Alzheimer disease patients (2010)
  • Author(s): Okochi, M., Tagami, S., Takeda, M.
  • Journal Title: Neurodegenerative Dis 7 Pages: 42-45
  • Peer Reviewed
• [Journal Article] Takeda, M. Analysis of APL1beta28, a surrogate marker for Alzheimer Abeta42, indicates altered precision of gamma-cleavage in the brains of Alzheimer disease patients (2009)
  • Author(s): Okochi, M., Tagami, S.
  • Journal Title: Neurodegenerative Dis 7 Pages: 42-45
  • Peer Reviewed
• [Journal Article] The 28-amino acid form of an APLP1-derived Ab-like peptide is a surrogate marker for Ab42 production in the central nervous system. (2009)
  • Author(s): Yanagida K, Okochi, M., Tagami S, Nakayama T, Kodama TS, Nishitomi K, Jiang J, Mori K, Tatsumi S, Arai T, Ikeuchi T, Kasuga K, Tokuda T, Kondo M, Ikeda M, Deguchi K, Kazui H, Tanaka T, Morihara T, Hashimoto R, Kudo T, Steiner H, Haass C, Tsuchiya K, Akiyama H, Kuwano R, Takeda M.
  • Journal Title: EMBO Molecular Medicine 1 Pages: 223-235
  • Peer Reviewed
• [Journal Article] Destruxin E Decreases Beta-Amyloid Generation by Reducing Colocalization of Beta-Amyloid-Cleaving Enzyme 1 and Beta-Amyloid Protein Precursor. (2009)
  • Author(s): Itoh N, Okochi, M., Tagami S, Nishitomi K, Nakayama T, Yanagida K, Fukumori A, Jiang J, Mori K, Hosono M, Kikuchi J, Nakano Y, Takinami Y, Dohi K, Nishigaki A, Takemoto H, Minagawa K, Katoh T, Willem M, Haass C, Morihara T, Tanaka T, Kudo T, Hasegawa H, Nishimura M, Sakaguchi G, Kato A, Takeda M.
  • Journal Title: Neurodegenerative Dis 6 Pages: 230-239
  • Peer Reviewed
• [Journal Article] The 28-amino acid form of an APLP1-derived Ab-like peptide is a surrogate marker for Ab42 production in the central nervous system (2009)
  • Author(s): Yanagida K, Okochi, M., Tagami S, Nakayama T, Kodama TS, Nishitomi K, Jiang J, Mori K, Tatsumi S, Arai T, Ikeuchi T, Kasuga K, Tokuda T, Kondo M, Ikeda M, Deguchi K, Kazui H, Tanaka T, Morihara T, Hashimoto R, Kudo T, Steiner H, Haass C, Tsuchiya K, Akiyama H, Kuwano R, Takeda M.
  • Journal Title: EMBO Molecular Medicine 1 Pages: 223-235
  • Peer Reviewed
• [Journal Article] Destruxin E Decreases Beta-Amyloid Generation by Reducing Colocalization of Beta-Amyloid-Cleaving Enzyme 1 and Beta-Amyloid Protein Precursor (2009)
  • Author(s): Itoh N, Okochi, M., Tagami S, Nishitomi K, Nakayama T, Yanagida K, Fukumori A, Jiang J, Mori K, Hosono M, Kikuchi J, Nakano Y, Takinami Y, Dohi K, Nishigaki A, Takemoto H, Minagawa K, Katoh T, Willem M, Haass C, Morihara T, Tanaka T, Kudo T, Hasegawa H, Nishimura M, Sakaguchi G, Kato A, Takeda M.
  • Journal Title: Neurodegenerative Dis 6 Pages: 230-239
  • Peer Reviewed
• [Journal Article] Amyloid-beta 42 generating process may have a biological re inegulatin of Notch signaling Jpn. (2008)
  • Author(s): Tagami S., Okochi M., Fukumori A., Takeda M.
  • Journal Title: J.Neuropsychopharmacology 28 Pages: 177-183
  • Peer Reviewed
• [Journal Article] Fulminant case of Guillain-Barre syndrome with poor recovery and depression after Haemophilus influenzae infection. (2008)
  • Author(s): Tagami S., Susuki K., Takeda M., Koga M.
  • Journal Title: Psychiatry and Clinical Neuroscience 62 Pages: 487-487
  • Peer Reviewed
• [Journal Article] Macrophage colony stimulating factor is associated with excretion of amyloid- peptides from cerebrospinal fluid to peripheral blood. (2008)
  • Author(s): Jiang J., Okochi M., Tagami S., Nishitomi K., Yanagida K., Nakayama T., Tatsumi K.,Mori K., Takeda M.
  • Journal Title: Psychogeriatrics 8 Pages: 188-195
  • Peer Reviewed
• [Journal Article] Impaired prepulse inhibition and habituation of acoustic startle response in Japanese patients with schizophrenia. (2008)
  • Author(s): Takahashi H, Iwase M, Ishii R, Ohi K, Fukumoto M, Azechi M, Ikezawa K, Kurimoto R, Canuet L, Nakahachi T, Iike N, Tagami S, Morihara T, Okochi M, Tanaka T, Kazui H, Yoshida T, Tanimukai H, Yasuda Y, Kudo T, Hashimoto R, Takeda M.
  • Journal Title: Neurosci Res 62 Pages: 187-194
  • Peer Reviewed
• [Journal Article] Amyloid-beta 42 generating process may have a biologicalrole in regulation of Notch signaling intensity (2008)
  • Author(s): Tagami S., Okochi M., Fukumori A., Takeda M
  • Journal Title: Jpn. J. Neuropsychopharmacology 28 Pages: 177-183
  • Peer Reviewed
• [Journal Article] Fulminant case of Guillain-Barre syndrome with poor recovenpression after Haemophilus influenzae infection (2008)
  • Author(s): Tagami S., Susuki K., Takeda M., Koga M
  • Journal Title: Psychiatry and Clinical Neuroscience 62 Pages: 487-487
  • Peer Reviewed
• [Journal Article] Macrophage colony stimulating factor is associated with exeretion of amyloid-peptides from cerebrospinal fluid to peripheral blood (2008)
  • Author(s): Jiang J., Okochi M., Tagami S., Nishitomi K., Yanagida K., Nakayama T., Tatsumi K., Mori K., Takeda M
  • Journal Title: Psychogeriatrics 8 Pages: 188-195
  • Peer Reviewed
• [Journal Article] Impaired prepulse inhibition and habituation of acoustic startle response in Japanese patients with schizophrenia (2008)
  • Author(s): Takahashi H, Iwase M, Ishii R, 0hi K, Fukumoto M, Azechi M, Ikezawa K, Kurimoto R, Canuet L, Nakahachi T, like N, Tagami S, Morihara T, Okochi M, Tanaka T, Kazui H, Yoshida T, Tanimukai H, Yasuda Y, Kudo T, Hashimoto R, Takeda M
  • Journal Title: Neurosci Res 62 Pages: 187-194
  • Peer Reviewed
• [Journal Article] Difficulty identifying spinocerebellar ataxia 17 from precedingric symptoms (2008)
  • Author(s): Ohi K, Hashimoto R, Sugai F, Yasuda Y, Tagami s, Takamura H, Morihara T, Okochi M, Tanaka T, Kudo T, Sakoda s, Takeda M
  • Journal Title: Psychiatry and Clinical Neuroscience 62 Pages: 625-625
  • Peer Reviewed
• [Journal Article] 0
• [Presentation] アルツハイマー病の発症予期診断バイオマーカー開発を目的とした脳脊髄液中のペプチド解析amyloid beta42のサロゲートマーカー (2010)
  • Author(s): 田上真次, 柳田寛太, 児玉高志, 佐野聖三, 朝長毅, 武田雅俊, 大河内正康
  • Organizer: APL1beta 28について日本ヒトプロテオーム機構第8回大会
  • Place of Presentation: 東京ボイホテル東急
• [Presentation] Analysis of CSF of patients suffering from PS1-mutated familial AD indicates that the level of Abeta42 generation does not increase in brain of these patients. (2010)
  • Author(s): Tagami S, Okochi M, Yanagida K, Kodama T, Takeda M
  • Organizer: 第53回日本神経化学会(神戸)大会Neuro2010
  • Place of Presentation: 神戸コンボンションセンター
• [Presentation] 末梢血中のamyloid beta42のサロゲートマーカー開発について (2010)
  • Author(s): 田上真次, 大河内正康, 児玉高志, 柳田寛太, 佐野聖三, 朝長毅, 武田雅俊
  • Organizer: 第29回日本認知症学会学術集会
  • Place of Presentation: 名古屋市ウインク愛知
• [Presentation] The Rato of Cs Apl1eta28, a Surrogate Marker for Abeta42, Increases Beore Onset of Sporadic Alzheimer'S Disease, Alzheimer's Assoiation. (2010)
  • Author(s): Okochi M, Tagami S, Yanagida K, Takeda M.
  • Organizer: Internional Conference on Alzheimer's Disease 2010
  • Place of Presentation: Honolulu Hawaii U.S.A Tagami
• [Presentation] アルツハイマー病の発症予期診断バイオマーカー開発を目的とした脳脊髄液中のペプチド解析 amyloid beta42のサロゲートマーカー、APL1beta28について (2010)
  • Author(s): 田上真次, 柳田寛太, 児玉高志, 佐野聖三, 朝長毅, 武田雅俊, 大河内正康
  • Organizer: 日本ヒトプロテオーム機構第8回大会
  • Place of Presentation: 東京ベイホテル東急
• [Presentation] Analysis of CSF of patients suffering from PS1-mutated familial AD indicates that the level of Abeta42 generation does not increase in brain of these patients (2010)
  • Author(s): Tagami S, Okochi M, Yanagida K, Kodama T, Takeda M
  • Organizer: 第53回日本神経化学会(神戸)大会Neuro2010
  • Place of Presentation: 神戸コンベンションセンター
• [Presentation] The Ratio of Csf Apl1beta28, a Surrogate Marker for Abeta42, Increases Before Onset of Sporadic Alzheimer'S Disease (2010)
  • Author(s): Okochi M, Tagami S, Yanagida K, Takeda M
  • Organizer: Alzheimer's Association International Conference o Alzheimer's Disease 2010
  • Place of Presentation: Honolulu Hawaii U.S.A
• [Presentation] Overproduction of Aβ42 may not occur even in brain of PS1 familial AD patients in which tremendous amounts of Aβ42 accumulate in cotton wool plaques. (2009)
  • Author(s): 田上真次, 大河内正康, 武田雅俊
  • Organizer: 第28回日本認知症学会
  • Place of Presentation: 仙台、東北大学百周年記念会館
  • Year and Date: 2009-11-20
• [Presentation] Overproduction of Aβ42 may not occur even in brain of PS1 familial AD patients in which tremendous amounts of Aβ42 accumulate in cotton wool plaques. -Aβ40 is "good" and Aβ42 is "bad"? (2009)
  • Author(s): 田上真次, 大河内正康, 武田雅俊
  • Organizer: 第28回日本認知症学会
  • Place of Presentation: 仙台, 東北大学百周年記念会館
  • Year and Date: 2009-11-20
• [Presentation] 家族性アルツハイマー病の発症機序において、脳内アミロイドβ42の産生増大は本当に起こっているか? (2009)
  • Author(s): 田上真次, 大河内正康, 柳田寛太, 中山泰亮, 児玉高志, 辰巳真一, 森康治, 武田雅俊
  • Organizer: 第16回未病システム学会総会
  • Place of Presentation: 千里ライフサイエンスセンター
  • Year and Date: 2009-10-31
• [Presentation] 病的に低下したNotchシグナルを是正する新たな方法の開発について (2009)
  • Author(s): 田上真次, 大河内正康
  • Organizer: 第4回Notch研究会
  • Place of Presentation: 国立遺伝学研究所講堂
  • Year and Date: 2009-07-30
• [Presentation] 病的に低下した Notch シグナルを是正する新たな方法の開発について (2009)
  • Author(s): 田上真次, 大河内正康
  • Organizer: 第4回 Notch 研究会
  • Place of Presentation: 国立遺伝学研究所講堂
  • Year and Date: 2009-07-30
• [Presentation] Analysis of an Aβ-like peptide in human CSF to address how the cleavage precision of presenilin/γ-secase iltered in PS1 familiaAD pats. (2009)
  • Author(s): S, Okochi M, Takeda M.
  • Organizer: InternationalConferenc on Alzheimer's Disease (ICAD)
  • Place of Presentation: Messe Wien Exhibition and Congress Center Vienna, Austria
• [Presentation] Analysis of an Aβ-like peptide in human CSF to address how the cleavage precision of presenilin/γ-secretase is altered in PS1 familial AD patients (2009)
  • Author(s): 田上真次, 大河内正康, 武田雅俊
  • Organizer: International Conference on Alzheimer's Disease (ICAD)
  • Place of Presentation: Messe Wien Exhibition and Congress Center Vienna, Austria
• [Presentation] Relation between preseniln/γ -secretase modulators and Notch signaling intensity. (2008)
  • Author(s): Tagami S, Okochi M, Yanagida K, Nakayama T, Kodama T, Tatsumi S, Jiang J, Mori KSakaguchi G, Kato A, Hasegawa H, Nishimra M, Takeda M.
  • Organizer: 第27回日本認知症学会
  • Place of Presentation: 群馬県前橋テルサ
  • Year and Date: 2008-10-10
• [Presentation] Relation between presenilin/r-secretase modulators and Notchsignaling intensity (2008)
  • Author(s): Tagami s, Okochi M, Yanagida K, Nakayama T, Kodama T, Tatsumi s, Jiang J, Mori KSakaguchi G, KatoA, Hasegawa H, NishimuraM, Takeda M
  • Organizer: 第27回日本認知症学会
  • Place of Presentation: 群馬県前橋テルサ
  • Year and Date: 2008-10-10
• [Presentation] アルツハイマー病の病原性物質であるAβ42」を産生する仕組みには「細胞の分化に必須のNotchシグナル強度」を調節する生理作用がある (2008)
  • Author(s): 田上真次, 大河内正康, 武田雅俊
  • Organizer: 第51回日本神経化学大会シンポジウム8アルツハイマー病の神経化学
  • Place of Presentation: 富山国際会議場
  • Year and Date: 2008-09-12
• [Presentation] 「アルツハイマー病の病原性物質であるAβ42」を産生する仕組みには「細胞の分化に必須のNotchシグナル強度」を調節する生理作用がある-Aβ42産生抑制薬の開発時に予想される問題点とその解決法の模索 (2008)
  • Author(s): 田上真次 大河内正康武田雅俊
  • Organizer: 第51回日本神経化学大会 シンポジウム8アルツハイマー病の神経化学
  • Place of Presentation: 富山国際会議場
  • Year and Date: 2008-09-12
• [Presentation] プレセニリンフセクレターゼ修飾薬の生理活性について (2008)
  • Author(s): 田上真次 大河内正康武田雅俊
  • Organizer: 第51回日本神経化学大会
  • Place of Presentation: 富山国際会議場
  • Year and Date: 2008-09-12
• [Presentation] Notch signaling can be up-regulated through modification of presenilin/γ-secretase-mediated S3 cleavage. (2008)
  • Author(s): Tagami, S., Okochi, M., Takeda, M.
  • Organizer: The 31th Annual Meeting of the Japan Neuroscience Society
  • Place of Presentation: 東京国際会議場
  • Year and Date: 2008-07-30
• [Presentation] Changes in the cleavage preision of presenilin/γ-secretase regulate Notch signalingtensity. (2008)
  • Author(s): Tagami, S., Okochi, M., Takeda, M.
  • Organizer: The 11th International Conference on Alzheimer's disease and Related Disorders
  • Place of Presentation: McCormick Place, Chicago, USA
  • Year and Date: 2008-07-30
• [Presentation] Changes in the cleavage precision of presenilin/r-secretase regulate Notch signaling intensity (2008)
  • Author(s): Tagami, s., Okochi, M., Takeda, M
  • Organizer: The llth International Conference on Alzheimer's disease and Related Disorders
  • Place of Presentation: McCormick Place, Chicago, USA
  • Year and Date: 2008-07-30
• [Presentation] Notch signaling can be up-regulated through modification ofpresenilin/r-secretase-mediated S3 cleavage (2008)
  • Author(s): Tagami, s., Okochi, M., Takeda, M
  • Organizer: The 31th Annual Meeting of the Japan Neuroscience Society
  • Place of Presentation: 東京国際会議場
  • Year and Date: 2008-07-10
• [Book] 老年期うつ病家庭医学大全科 (2010)
  • Author(s): 田上真次, 武田雅俊
  • Publisher: 法研
• [Book] 興奮・暴力疾患と治療III (2010)
  • Author(s): 田上真次, 武田雅俊
  • Total Pages: 217
  • Publisher: 南江堂
• [Book] 神経内科第72巻特別増刊号認知症診断マニュアル総論的事項-アルツハイマー病の病理過程の理解と治療薬開発(Aβカスケード、神経栄養因子、神経伝達物質) (2010)
  • Author(s): 田上真次, 大河内正康, 武田雅俊
  • Publisher: 科学評論者
• [Book] 新老年学第3版アルツハイマー型認知症 (2010)
  • Author(s): 田上真次, 大河内正康, 武田雅俊
  • Publisher: 東京大学出版会
• [Book] 老年期うつ病 家庭医学大全科 (2010)
  • Author(s): 田上真次, 武田雅俊
  • Publisher: 法研
• [Book] 興奮・暴力 疾患と治療III (2010)
  • Author(s): 田上真次, 武田雅俊
  • Total Pages: 217
  • Publisher: 南江堂
• [Book] 神経内科 第72巻特別増刊号 認知症診断マニュアル総論的事項-アルツハイマー病の病理過程の理解と治療薬開発 (Aβカスケード、神経栄養因子、神経伝達物質) (2010)
  • Author(s): 田上真次, 大河内正康, 武田雅俊
  • Total Pages: 5
  • Publisher: 科学評論者
• [Book] 新老年学 第3版アルツハイマー型認知症 (2010)
  • Author(s): 田上真次, 大河内正康, 武田雅俊
  • Total Pages: 9
  • Publisher: 東京大学出版会
• [Book] Psychiatry Today, No. 25 Alzheimer's Association 2009 International Conference on Alzheimer's disease (ICAD2009) に参加して (2010)
  • Author(s): 田上真次
  • Total Pages: 1
  • Publisher: Psychiatry Today
• [Book] プレセニリンγセクレターゼによる切断の多様性とその変化について (2008)
  • Author(s): 田上真次, 大河内正康, 福森亮雄, 武田雅俊
  • Publisher: 分子精神医学先端医学社
• [Book] プレセニリンγセクレターゼによる切断の多様性とその変化について (2008)
  • Author(s): 田上真次 大河内正康 福森亮雄武田雅俊
  • Total Pages: 4
  • Publisher: 分子精神医学先端医学社
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  • URL: http://www.osaka-u.ac.jp/en/research/annual-report/volume-9/100_select_paper/biology02.html
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• [Patent(Industrial Property Rights)] プレセニリンγセクレターゼによるアルツハイマー病アミロイドの分解アッセイ法 (2010)
  • Inventor(s): 大河内正康, 田上真次, 武田雅俊, 西冨晃平
  • Industrial Property Rights Holder: 大河内正康, 田上真次, 武田雅俊, 西冨晃平
  • Filing Date: 2010-10-18
• [Patent(Industrial Property Rights)] プレセニリンγセクレターゼによるアルツハイマー病アミロイドの分解アッセイ法 (2010)
  • Inventor(s): 大河内正康、田上真次、武田雅俊、西冨晃平
  • Industrial Property Rights Holder: 大河内正康、田上真次、武田雅俊、西冨晃平
  • Filing Date: 2010-10-18
  • Overseas