Involvement of interaction between RNA and protein in neurodegenerative mechanisms in dementia

• Project/Area Number: 20591407
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Psychiatric science
• Research Institution: Osaka University
• Principal Investigator: TANAKA Toshihisa Osaka University, 大学院・医学系研究科, 講師 (10294068)
• Co-Investigator(Kenkyū-buntansha): TAKEDA Masatoshi 大阪大学, 医学系研究科, 教授 (00179649) ; MORIHARA Takashi 大阪大学, 医学系研究科, 助教 (90403196)
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2009: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2008: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: 老年精神医学 / アルツハイマー病 / 自然免疫 / 老人斑 / 神経原線維変化

Research Abstract

To elucidate involvement of interaction between RNA and protein in neurodegenerative processes, ribotoxic stress was added by oxidative stress, and phosphorylation of tau and activation of JNK and p38 MAPK were revealed. And, TLR-3, an innate immune receptor that can bind to double stranded RNA, was also investigated in disease brain, including Alzheimer disease and amyloid-transgenic mice Tg2576. Expression of TLR-3 was significantly increased in Alzheimer disease and Tg2576, and TLR-3 positive cells were distributed in and around amyloid plaques. In these neurodegenerative processes, oxidation of rRNA or release of RNA from dead cells, might be involved.

Research Products

• [Journal Article] Caffeine Modulates Tau Phosphorylation and Affects Akt Signaling in Postmitotic Neurons. (2011)
  • Author(s): Currais A, Kato K, Canuet L, Ishii R, Tanaka T, Takeda M, Soriano S.
  • Journal Title: J Mol Neurosci. 43(3) Pages: 326-332
  • Peer Reviewed
• [Journal Article] The production ratios of AICDε51 and Aβ42 by intra- membrane proteolysis of βAPP do not always change in parallel. (2010)
  • Author(s): Mori K, Okochi M, Tagami S, Nakayama T, Yanagida K, Kodama TS, Tatsumi S, Fujii K, Tanimukai H, Hashimoto R, Morihara T, Tanaka T, Kudo T, Funamoto S, Ihara Y, Takeda M.
  • Journal Title: Psychogeriatrics. 10(3) Pages: 117-123
  • NAID: 10029771051
  • Peer Reviewed
• [Journal Article] KIBRA genetic polymorphism influences episodic memory in Alzheimer's disease, but does not show association with disease in a Japanese cohort. (2010)
  • Author(s): Hayashi N, Kazui H, Kamino K, Tokunaga H, Takaya M, Yokokoji M, Kimura R, Kito Y, Wada T, Nomura K, Sugiyama H, Yamamoto D, Yoshida T, Currais A, Soriano S, Hamasaki T, Yamamoto M, Yasuda Y, Hashimoto R, Tanimukai H, Tagami S, Okochi M, Tanaka T, Kudo T, Morihara T, Takeda M.
  • Journal Title: Dement Geriatr Cogn Disord. 30(4) Pages: 302-308
  • Peer Reviewed
• [Journal Article] Apolipoprotein E and central nervous system disorders : reviews of clinical findings. (2010)
  • Author(s): Takeda M, Martinez R, Kudo T, Tanaka T, Okochi M, Tagami S, Morihara T, Hashimoto R, Cacabelos R.
  • Journal Title: Psychiatry Clin Neurosci. 4(6) Pages: 592-607
  • Peer Reviewed
• [Journal Article] The production ratios of AICDε51 and Ass42 by intramembrane proteolysis of ssAPP do not always, change in parallel. (2010)
  • Author(s): Mori K, Okochi M, Tagami S, Nakayama T, Yanagida K, Kodama TS, Tatsumi S, Fujii K, Tanimukai H, Hashimoto R, Morihara T, Tanaka T, Kudo T, Funamoto S, Ihara Y, Takeda M.
  • Journal Title: Psychogeriatrics Volume: 10 Pages: 117-1235
  • Peer Reviewed
• [Journal Article] KIBRA genetic polymorphism influences episodic memory in Alzheimer's disease, but does not show association with disease in a Japanese cohort. (2010)
  • Author(s): Hayashi N, Kazui H, Kamino K, Tokunaga H, Takaya M, Yokokoji M, Kimura R, Kito Y, Wada T, Nomura K, Sugiyama H, Yamamoto D, Yoshida T, Currais A, Soriano S, Hamasaki T, Yamamoto M, Yasuda Y, Hashimoto R, Tanimukai H, Tagami S, Okochi M, Tanaka T, Kudo T, Morihara T, Takeda M.
  • Journal Title: Dement Geriatr Cogn Disord. Volume: 30 Pages: 302-308
  • Peer Reviewed
• [Journal Article] Depression in the elderly. (2010)
  • Author(s): Takeda M, Tanaka T
  • Journal Title: Geriatr Gerontol Int. Volume: 10 Pages: 277-279
  • NAID: 10027755222
  • Peer Reviewed
• [Journal Article] Apolipoprotein E and central nervous system disorders : reviews of clinical findings. (2010)
  • Author(s): Takeda M, Martinez R, Kudo T, Tanaka T, Okochi M, Tagami S, Morihara T, Hashimoto R, Cacabelos R.
  • Journal Title: Psychiatry Clin Neurosci Volume: 64 Pages: 592-607
  • Peer Reviewed
• [Journal Article] Phosphorylation of tau at Ser214 mediates its interaction with 14-3-3 protein : Implications for the mechanism of tau aggregation. (2009)
  • Author(s): Sadik G, Tanaka T., Kato K, Yanagi K, Morihara T, Takeda M.
  • Journal Title: J Neurochem 108 Pages: 33-43
  • Peer Reviewed
• [Journal Article] Differential interaction and aggregation of 3-repeat and 4-repeat tau isoforms with 14-3-3zeta protein. (2009)
  • Author(s): Sadik G, Tanaka T., Kato K, Yanagi K, Kudo T, Takeda M.
  • Journal Title: Biochem Biophys Res Commun 383(1) Pages: 37-41
  • Peer Reviewed
• [Journal Article] Involvement of puromycine-sensitive aminopeptidase in proteolysis of tau protein in cultured cells, and attenuated proteolysis of FTDP-17 mutant tau. (2009)
  • Author(s): Yanagi K, Tanaka T, Kato K, Sadik G, Morihara T, Kudo T, Takeda M.
  • Journal Title: Psycogeriatrics 9 Pages: 157-166
  • Peer Reviewed
• [Journal Article] Neuroimaging studies in patients with Charles Bonnet Syndrome. (2009)
  • Author(s): Kazui H, Ishii R, Yoshida T, Ikezawa K, Takaya M, Tokunaga H, Tanaka T, Takeda M.
  • Journal Title: Psychogeriatrics 9 Pages: 77-84
  • NAID: 10025638897
  • Peer Reviewed
• [Journal Article] Novel therapeutic strategies for neurodegenerative disease. (2009)
  • Author(s): Tanimukai H, Kudo T, Tanaka T, Grundke-Iqbal I, Iqbal K, Takeda M.
  • Journal Title: Psychogeriatrics 9 Pages: 103-109
  • NAID: 10025639046
  • Peer Reviewed
• [Journal Article] Destruxin E Decreases Beta-Amyloid Generation by Reducing Colocalization of Beta-Amyloid-Cleaving Enzyme 1 and Beta-Amyloid Protein Precursor. (2009)
  • Author(s): Itoh N, Okochi M, Tagami S, Nishitomi K, Nakayama T, Yanagida K, Fukumori A, Jiang J, Mori K, Hosono M, Kikuchi J, Nakano Y, Takinami Y, Dohi K, Nishigaki A, Takemoto H, Minagawa K, Katoh T, Willem M, Haass C, Morihara T, Tanaka T, Kudo T, Hasegawa H, Nishimura M, Sakaguchi G, Kato A, Takeda M.
  • Journal Title: Neurodegener Dis 6 Pages: 230-239
  • Peer Reviewed
• [Journal Article] Prevention of psychiatric illness in the elderly I -Path to Prevention of. (2009)
  • Author(s): Tanaka T, Kazui H, Sadik G, Tanimukai H, Tagami S, Morihara T, Okochi M, Kudo K, Takeda M.
  • Journal Title: Dementia- Psychogeriatrics 9 Pages: 111-115
  • Peer Reviewed
• [Journal Article] Prevention of psychiatric illness in the elderly I -Path to Prevention of Dementia- (2009)
  • Author(s): Tanaka T, Kazui H, Sadik G, Tanimukai H, Tagami S, Morihara T, Okochi M, Kudo K, Takeda M.
  • Journal Title: Psychogeriatrics 9 Pages: 111-115
  • NAID: 10027274850
  • Peer Reviewed
• [Journal Article] Phosphorylation of tau at Ser214 mediates its interaction with 14-3-3 protein : Implications for the mechanism of tau aggregation (2009)
  • Author(s): Sadik G, Tanaka T., Kato K, Yanagi K, Morihara T, Takeda M
  • Journal Title: J Neurochem 108 Pages: 33-43
  • Peer Reviewed
• [Journal Article] Differential interaction and aggregation of 3-repeat and 4-repeat tau isoforms with 14-3-3zeta protein (2009)
  • Author(s): Sadik G, Tanaka T., Kato K, Yanagi K, Kudo T, Takeda M
  • Journal Title: Biochem Biophys Res Commun 383 Pages: 37-41
  • Peer Reviewed
• [Journal Article] Involvement of puromycine-sensitive aminopeptidase in proteolysis of tau protein in cultured cells, and attenuated proteolysis of FTDP-17 mutant tau (2009)
  • Author(s): Yanagi K, Tanaka T, Kato K, Sadik G, Morihara T, Kudo T, Takeda M
  • Journal Title: Psychogeriatrics 9 Pages: 157-166
  • Peer Reviewed
• [Journal Article] Neuroimaging studies in patients with Charles Bonnet Syndrome (2009)
  • Author(s): Kazui H, Ishii R, Yoshida T, Ikezawa K, Takaya M, Tokunaga H, Tanaka T, Takeda M.
  • Journal Title: Psychogeriatrics 9 Pages: 77-84
  • NAID: 10025638897
  • Peer Reviewed
• [Journal Article] Novel therapeutic strategies for neurodegenerative disease (2009)
  • Author(s): Tanimukai H, Kudo T, Tanaka T, Grundke-Iqbal I, Iqbal K, Takeda M
  • Journal Title: Psychogeriatrics 9 Pages: 103-109
  • NAID: 10025639046
  • Peer Reviewed
• [Journal Article] The 28-amino acid form of an APLP1-derived Ass-like peptide is a surrogate marker for Ass42 production in the central nervous system (2009)
  • Author(s): Yanagida K, Okochi M, Tagami S, Nakayama T, Kodama T, Nishitomi K, Jiang J, Mori K, Tatsumi S, Arai T, Ikeuchi T, Kasuga K, Tokuda T, Kondo M, Ikeda M, Deguchi K, Kazui H, Tanaka T, Morihara T, Hashimoto R, Kudo T, Steiner H, Haass C, Tsuchiya K, Akiyama H, Kuwano R, Takeda M.
  • Journal Title: EMBO Molecular Medicine 1 Pages: 223-235
  • Peer Reviewed
• [Journal Article] Phosphorylation of tau at Ser214 mediates its interaction with 14-3-3 protein : implications for the mechanism of tau aggregation. (2009)
  • Author(s): Sadik G, Tanaka T, Kato K, Yamamori H, Nessa BN, MoriharaT, Takeda M.
  • Journal Title: J Neurochem 108 Pages: 33-43
  • Peer Reviewed
• [Journal Article] Involvement of puromycin -sensitive aminopeptidase in proteolysis of tau protein in cultured cells, and attenuated proteolysis of FTDP-17 mutant tau. (2009)
  • Author(s): Yanagi K, Tanaka T, Kato K, Sadik G, Morihara T, Takeda M.
  • Journal Title: Psycogeriatrics 9(未定)
  • Peer Reviewed
• [Journal Article] Processes of β-amyloid and intracellular cytoplasmic domain generation by presenilin/γ-Secretase. (2008)
  • Author(s): Tagami S., Okochi M., Fukumori A., Jingwei J., Yanagida K., Nakayama T., Morihara T., Tanaka T., Kudo T., Takeda M.
  • Journal Title: Neurodegenerative Dis 5 Pages: 160-162
  • Peer Reviewed
• [Journal Article] Post-marketing surveillance of donepezil hydrochloride in Japanese patients with Alzheimer's disease with behavioral and psychological symptoms of dementia (BPSD). (2008)
  • Author(s): Tanaka T., Kazui H., Tanimukai H., Morihara H., Sadik G., Kudo T., Takeda M.
  • Journal Title: Psycogeriatrics 8 Pages: 114-123
  • Peer Reviewed
• [Journal Article] Dynamin 2 gene is a novel susceptibility gene for late-onset Alzheimer disease in non-APOE-epsilon4 carriers. (2008)
  • Author(s): Aidaralieva NJ, Kamino K, Kimura R, Yamamoto M, Morihara T, Kazui H, Hashimoto R, Tanaka T, Kudo T, Kida T, Okuda J, Uema T, Yamagata H, Miki T, Akatsu H, Kosaka K, Takeda M.
  • Journal Title: J Hum Genet. 53 Pages: 296-302
  • Peer Reviewed
• [Journal Article] Mild Cognitive Impairment (MCI) and Subjective Cognitive (2008)
  • Author(s): Takeda M, Morihara T, Okochi M, Sadik G, Tanaka T.
  • Journal Title: Impairment (SCI) Psycogeriatrics 8 Pages: 155-160
  • Peer Reviewed
• [Journal Article] The 13th congress of IPA and recent expansion of researches into psychogeriatric (2008)
  • Author(s): Tanaka T., Tomioka M., Sadik G, Takeda M.
  • Journal Title: Psycogeriatrics 8 Pages: 1-3
  • Peer Reviewed
• [Journal Article] Post-marketing surveillance. of donepezil hydrochloride in Japanese patients withAlzheimer's disease with behavioral and psychological symptoms of dementia(BPSD). (2008)
  • Author(s): Tanaka T., Kazui H., Tanimukai H., Morihara H., Sadik G., Kudo T., Takeda M.
  • Journal Title: Psycogeriatrics 8 Pages: 114-123
  • Peer Reviewed
• [Journal Article] Mild Cognitive Impairment (MCI)and Subjective Cognitive Impairment (SCI) (2008)
  • Author(s): Takeda M, Morihara T, Okochi M, Sadik G, Tanaka T
  • Journal Title: Psycogeriatrics 8 Pages: 155-160
  • Peer Reviewed
• [Journal Article] Processes of beta-amyloid and intracellular cytoplasmic domain generation bypresenilin/gamma-secretase. (2008)
  • Author(s): Tagami s, Okochi M, Fukumori A, Jiang J, Yanagida K, Nakayama T, Morihara T, Tanaka T, Kudo T, Takeda M.
  • Journal Title: Neurodegener Dis 5 Pages: 160-162
  • Peer Reviewed
• [Presentation] 主観的認知機能障害(SCI)から軽度認知機能障害(MCI)へ、シンポジウム 認知症の早期診断を多角的に考える (2010)
  • Author(s): 田中稔久
  • Organizer: アルツハイマー病研究会 第11回学術シンポジウム
  • Place of Presentation: 東京(招待講演)
  • Year and Date: 2010-04-17
• [Presentation] PIB-PET images, compared with MR, FDG-PET, IMP-SPECT images, of a patient with Alzheimer's disease with presenilin-1 mutation (Met233Leu) showing a new phenotype. (2010)
  • Author(s): Takaya M, Tanaka T, Ataka S, Shimada H, Morihara T, Miki T, Kazui H, Takeda M
  • Organizer: The 13^<th> International Conference on Alzheimer Disease and related disorders
  • Place of Presentation: Hawaii, U.S.A.
• [Presentation] Identification of a gene which controls Abeta accumulation using App Tg mice with mixed genetic background (2010)
  • Author(s): Morihara T, Hayashi N, Yokokoji M, Fukusyo E, Tanimukai H, Tagami S, Okochi M, Tanaka T, Kudo T, Takeda M
  • Organizer: The 13^<th> International Conference on Alzheimer Disease and related disorders
  • Place of Presentation: Hawaii, U.S.A.
• [Presentation] アポトーシス阻害蛋白XIAPのPKCによるリン酸化を介した細胞死抑性メカニズムの解析 (2010)
  • Author(s): 加藤希世子、田中稔久、Golam Sadik、Antonio Currais、柳健太郎、馬場都、丸山大輔、武田雅俊
  • Organizer: 第29回日本認知症学会
  • Place of Presentation: 愛知県名古屋市
• [Presentation] PIB-PET images, compared with MR, FDG-PET, and IMP-SPECT images, of a patient with Alzheimer's disease with presenilin-1 mutation (Met233Leu) showing a new phenotype (2010)
  • Author(s): Takaya M, Tanaka T, Ataka S, Shimada H, Morihara T, Miki T, Kazui H, Takeda M.
  • Organizer: The 13^<th> International Conference on Alzheimer Disease and related disorders
  • Place of Presentation: Hawaii, USA.
• [Presentation] Identification of a gene which controls Abeta accumulation using App Tg mice with mixed genetic background (2010)
  • Author(s): Morihara T, Hayashi N, Yokokoji M, Fukusyo E, Tanimukai H, Tagami S, Okochi M, Tanaka T, Kudo T, Takeda M.
  • Organizer: The 13^<th> International Conference on Alzheimer Disease and related disorders
  • Place of Presentation: Hawaii, USA.
• [Presentation] アポトーシス阻害蛋白XIAPのPKCによるリン酸化を介した細胞死抑性メカニズムの解析 (2010)
  • Author(s): 加藤希世子、田中稔久、Golam Sadik, Antonio Currais、柳健太郎、馬場都、丸山大輔、武田雅俊
  • Organizer: 第29回日本認知症学会
  • Place of Presentation: 名古屋市
• [Presentation] タウの病理-運動ニューロン疾患を呈する前頭側頭型認知症の分子病態 (2009)
  • Author(s): 田中稔久
  • Organizer: 第19回神経科学の基礎と臨床
  • Place of Presentation: 千里ライフサイエンスセンター(大阪市)
  • Year and Date: 2009-12-19
• [Presentation] タウの病理―運動ニューロン疾患を呈する前頭側頭型認知症の分子病態 (2009)
  • Author(s): 田中稔久
  • Organizer: 第19回神経科学の基礎と臨床
  • Place of Presentation: 大阪
  • Year and Date: 2009-12-19
• [Presentation] FTDP-17タウ変異によるタウ蛋白代謝過程の変化 (2009)
  • Author(s): 田中稔久、柳健太郎、Golam Sadik, 加藤希世子, 馬場都、武田雅俊
  • Organizer: 日本老年医学会:第20回近畿地方会
  • Place of Presentation: 新大阪チサンホテル(大阪市)
  • Year and Date: 2009-12-01
• [Presentation] タウ蛋白とその他の生化学マーカー「ADの診断を中心に」、シンポジウム 認知症の診断 -この10年とこれから- (2009)
  • Author(s): 田中稔久
  • Organizer: アルツハイマー病研究会 第10回学術シンポジウム
  • Place of Presentation: 東京
  • Year and Date: 2009-04-18
• [Presentation] 14-3-3 protein differentially interacts with 3-repeat and 4-repeat tau. (2009)
  • Author(s): Tanaka T, Sadik G, Kato K, Yanagi K, Takeda M
  • Organizer: The 12th International Conference on Alzheimer Disease and related disorders.
  • Place of Presentation: Vienna, Austria.
• [Presentation] Attenuated proteolysis of FTDP-17 mutant tau in cultured cells and involvement of increased phosphorylation of tau. (2009)
  • Author(s): Tanaka T, Kato K, Yanagi K, Sadik G, Takeda M
  • Organizer: The 14th Congress of the International Psychogeriatrics Association.
  • Place of Presentation: Montreal, Canada
• [Presentation] 培養細胞におけるタウ蛋白の分解におけるpuromycin感受性アミノペプチダーゼの関与 (2009)
  • Author(s): 田中稔久、柳健太郎、Golam Sadik, 加藤希世子、武田雅俊
  • Organizer: 第28回日本認知症学会
  • Place of Presentation: 宮城県仙台市
• [Presentation] 14-3-3 protein differentially interacts with 3-repeat and 4-repeat tau (2009)
  • Author(s): 田中稔久, Golam Sadik, 加藤希世子, 柳健太郎, 武田雅俊
  • Organizer: The 12^<th> International Conference on Alzheimer Disease and related disorders
  • Place of Presentation: Vienna, Austria
• [Presentation] Attenuated proteolysis of FTDP-17 mutant tau in cultured cells and involvement of increased phosphorylation of tau (2009)
  • Author(s): 田中稔久, 加藤希世子, 柳健太郎, Golam Sadik, 武田雅俊
  • Organizer: The 14^<th> Congress of the International Psychogeriatrics Association
  • Place of Presentation: Montreal, Canada
• [Presentation] 培養細胞におけるタウ蛋白の分解における puromycin 感受性アミノペプチダーゼの関与 (2009)
  • Author(s): 田中稔久, 柳健太郎, Golam Sadik, 加藤希世子, 武田雅俊
  • Organizer: 第28回日本認知症学会
  • Place of Presentation: 仙台市
• [Presentation] 14-3-3 Protein Exhibits Strong Affinity for 3-repeat Tau and Increases Its Filament Formation. (2008)
  • Author(s): Sadik G, Tanaka T, Kato K, Yanagi K, Takeda M
  • Organizer: The 11^<th> International Conference on Alzheimer Disease and related disorders
  • Place of Presentation: Chicago, U.S.A.
• [Presentation] Involvement of tauprotein in neurodegeneration (2008)
  • Author(s): Tanaka T, Sadik G, Kato K, Yanagi K, Takeda M
  • Organizer: 第51回日本神経化学大会
  • Place of Presentation: 富山
• [Presentation] 14-3-3 differentially induces 3-repeat and 4-repeat tau aggregation (2008)
  • Author(s): Sadik G, Tanaka T, Kato K, YanagiK, Takeda M
  • Organizer: 第51回日本神経化学大会
  • Place of Presentation: 富山
• [Presentation] GSK3抑制によるカスペース阻害因子XIAPの亢進機序について (2008)
  • Author(s): 加藤希世子、田中稔久、Golam Sadik, 柳健太郎、武田雅俊
  • Organizer: 第27回日本認知症学会
  • Place of Presentation: 群馬県前橋市
• [Presentation] 14-3-3 Protein is a potential candidate inducer for fibrillization of 3-repeat Tau Soociety for Neuroscience (2008)
  • Author(s): Sadik G, Tanaka T, Kato K, Kentaro Yanagi, Takeda M
  • Organizer: the 38^<th> Annual Meeting
  • Place of Presentation: Washington
• [Presentation] 14-3-3 Protein Exhibits Strong Affinity for 3-repeat Tau and Increases ItsFilament Formation (2008)
  • Author(s): Sadik G, Tanaka T, Kato K, Yanagi K, Takeda M
  • Organizer: The nth international conference on Alzheimerdisease and related disorders
  • Place of Presentation: Chicago USA
• [Presentation] Involvement of tau protein in neurodegeneration (2008)
  • Author(s): Tanaka T, Sadik G, Kato K, Yanagi K, Takeda M
  • Organizer: 第51回神経化学大会
  • Place of Presentation: 富山
• [Presentation] 14-3-3 differentially induces 3-repeat and 4-repeat tau aggregation (2008)
  • Author(s): Sadik G, Tanaka T, Kato K, Yanagi K, Takeda M
  • Organizer: 第51回神経化学大会
  • Place of Presentation: 富山
• [Presentation] GSK3抑制によるカスペース阻害因子XIAPの亢進機序について (2008)
  • Author(s): 加藤希世子, 田中稔久, GolamSadik, 柳健太郎, 武田雅俊
  • Organizer: 第27回日本認知症学会学術集会
  • Place of Presentation: 前橋
• [Presentation] 14-3-3 Protein Exhibits Strong Affinity for 3-repeat Tau and Increases ItsFilament Formation (2008)
  • Author(s): Sadik G, Tanaka T, Kato K, Yanagi K, Takeda M
  • Organizer: Soociety for Neuroscience the 38th Annual Meeting
  • Place of Presentation: Washington, U. S. A.
• [Book] 新老年学(第3版)(「高齢者の幻覚・妄想」) (2010)
  • Author(s): 田中稔久
  • Publisher: 東京大学出版会