Investigation of schizophrenia and bipolar disorders : Differences and similarities

• Project/Area Number: 20591411
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Psychiatric science
• Research Institution: Kyushu University
• Principal Investigator: ONITSUKA Toshiaki Kyushu University, 大学病院・精神科神経科 (00398059)
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000); Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2009: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2008: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: 統合失調症 / 双極性障害 / 脳磁図 / MRI

Research Abstract

Left hemispheric neuronal deficits in response to speech sounds in patients with schizophrenia compared to healthy subjects and bipolar disorder. Differential hemispheric distribution between patients with schizophrenia and bipolar disorder in auditory sensory gating deficits to speech sounds. Reduced 40 Hz auditory steady-state responses in schizophrenia compared to healthy subjects and bipolar disorder. It may be useful for discrimination of psychiatric deseases to use these neuronal responses.

Research Products

• [Journal Article] Top-down and bottom-up visual information processing of non-social stimuli in high-functioning autism spectrum disorder. (2011)
  • Author(s): Maekawa T, Tobimatsu S, Inada N, Oribe N, Onitsuka T, Kanba S, Kamio T
  • Journal Title: Res Autism Spectr Disord. 5 Pages: 201-209
  • NAID: 120004951562
• [Journal Article] Top-down and bottom-up visual information processing of non-social stimuli in high-functioning autism spectrum disorder. (2011)
  • Author(s): Maekawa T, et al., (5番目)
  • Journal Title: Res Autism Spectr Disord. Volume: 5 Pages: 201-209
  • Peer Reviewed
• [Journal Article] Auditory gating deficit to human voices in schizophrenia : a MEG study. (2010)
  • Author(s): Hirano Y, Hirano S, Maekawa T, Obayashi C, Oribe N, Monji A, Kasai K, Kanba S, Onitsuka T
  • Journal Title: Scbizophr Res. 117 Pages: 61-67
• [Journal Article] Differentiation between bipolar disorder and schizophrenia revealed by neural oscillation to speech sounds : a MEG study. (2010)
  • Author(s): Oribe N, Onitsuka T, Hirano S, Hirano Y, Maekawa T, Obayashi C, Kasai K, Ueno T, Kanba S
  • Journal Title: Bipolar Disord. 12 Pages: 804-812
• [Journal Article] Differentiation between bipolar disorder and schizophrenia revealed by neural oscillation to speech sounds : a MEG study. (2010)
  • Author(s): Oribe N, et al.(last author)
  • Journal Title: Bipolar Disord. Volume: 12 Pages: 804-812
  • Peer Reviewed
• [Journal Article] 気分障害と臨床神経生理学 (2010)
  • Author(s): 中村一太、鬼塚俊明, ほか
  • Journal Title: 最新精神医学 Volume: 15 Pages: 133-139
• [Journal Article] 精神疾患の脳形態画像解析からみた器質的要因 (2010)
  • Author(s): 鬼塚俊明、中村一太, ほか
  • Journal Title: 精神医学 Volume: 52 Pages: 321-328
• [Journal Article] 紡錘状回 (2010)
  • Author(s): 鬼塚俊明
  • Journal Title: 分子精神医学 Volume: 10 Pages: 42-44
• [Journal Article] 内因性精神疾患の神経生理学的研究 (2010)
  • Author(s): 中村一太、鬼塚俊明, ほか
  • Journal Title: 福岡医学雑誌 Volume: 101 Pages: 165-172
• [Journal Article] Auditory gating deficit to human voices in schizophrenia : a MEG study (2010)
  • Author(s): Hirano Y, et al.(last author)
  • Journal Title: Schizophr Res. 117 Pages: 61-67
  • Peer Reviewed
• [Journal Article] Gender difference in right lateral prefrontal hemodynamic response while viewing fearful faces : a multi-channel near-infrared spectroscopy study. (2009)
  • Author(s): Marumo K, Takizawa R, Kawakubo Y, Onitsuka T, Kasai K
  • Journal Title: Neurosci Res. 63 Pages: 89-94
  • NAID: 10027499498
• [Journal Article] Preattentive visual change detection as reflected by the mismatch negativity (MMN)-evidence for amemory-basedprocess. (2009)
  • Author(s): Maekawa T, Tobimatsu S, Ogata K, Onitsuka T, Kanba S
  • Journal Title: Neurosci Res. 65 Pages: 107-112
• [Journal Article] Decreased spatial frequency sensitivities for processing faces in male patients with chronic schizophrenia. (2009)
  • Author(s): Obayashi C, Nakashima T, Onitsuka T, Maekawa T, Hirano Y, Hirano S, Oribe N, Kaneko K, Kanba S, Tobimatsu S
  • Journal Title: Clin Neurophysiol. 120 Pages: 1525-1533
• [Journal Article] Abnormal asymmetry of the face N170 repetition effect in male patients with chronic schizophrenia. (2009)
  • Author(s): Onitsuka T, Spencer KM, Lucia LC, Shenton ME, McCarley RW, Niznikiewicz MA
  • Journal Title: Brain Imaging and Behavior 3 Pages: 240-245
• [Journal Article] Locked to stimulation : significance level of the phase-locking factor. (2009)
  • Author(s): Ueno T, Hirano S, Hirano Y, Kanba S, Kobayashi S, Onitsuka T
  • Journal Title: Proc International Cong Imaging Signal Processing IEEE 8 Pages: 4448-4451
• [Journal Article] Locked to stimulation : significance level of the phase-locking factor (2009)
  • Author(s): Ueno T, et al.(last author)
  • Journal Title: Conf Proc Imaging Signal Processing IEEE 8 Pages: 4448-4451
  • Peer Reviewed
• [Journal Article] Abnormal asymmetry of the face N170 repetition effect in male patients with chronic schizophrenia (2009)
  • Author(s): Onitsuka T, et al.
  • Journal Title: Brain Imaging and Behavior 3 Pages: 240-245
  • Peer Reviewed
• [Journal Article] Decreased spatial frequency sensitivities for processing faces in male patients with chronic schizophrenia (2009)
  • Author(s): Obayashi C, et al.(3番目)
  • Journal Title: Clin Neurophysiol 120 Pages: 1525-1533
  • Peer Reviewed
• [Journal Article] Preattentive visual change detection as reflected by the mismatch negativity(MMN)-evidence for a memory-based process (2009)
  • Author(s): Maekawa T, et al.(4番目)
  • Journal Title: Neurosci Res. 65 Pages: 107-112
  • Peer Reviewed
• [Journal Article] Gender difference in right lateral prefrontal hemodynamic response while viewing fearful faces : a multi-channel near-infrared spectroscopy study (2009)
  • Author(s): Marumo K, et al.(4番目)
  • Journal Title: Neurosci Res. 63 Pages: 89-94
  • Peer Reviewed
• [Journal Article] Abnormal neural oscillatory activity to speech sounds in schizophrenia : a MEG study. (2008)
  • Author(s): Hirano S, et al. (全8のlast author)
  • Journal Title: Journal of Neuroscience 28 Pages: 4897-4903
  • Peer Reviewed
• [Journal Article] Auditory sensory gating to human voice : a preliminary MEG study. (2008)
  • Author(s): Hirano Y, et al. (全7の2番目)
  • Journal Title: Psychiatry Research 163 Pages: 4897-4903
  • Peer Reviewed
• [Journal Article] 精神疾患の神経生理学的研究 : 現状と今後の展開 (2008)
  • Author(s): 鬼塚俊明, 上野雄文
  • Journal Title: 臨床精神医学 37 Pages: 1277-1280
• [Journal Article] ミスマッチ陰性電位を用いた統合失調症の視覚情報自動処理過程の検討 (2008)
  • Author(s): 前川敏彦ら(全7の5番目)
  • Journal Title: 臨床脳波 50 Pages: 202-208
  • Peer Reviewed
• [Journal Article] ミスマッチ陰性電位とP300を用いた双極性障害の視覚情報自動処理過程の検討 (2008)
  • Author(s): 角田智哉ら(全9の4番目)
  • Journal Title: 臨床神経生理学 36 Pages: 607-614
  • Peer Reviewed
• [Journal Article] 統合失調症者の社会脳機能-顔・声認知- (2008)
  • Author(s): 鬼塚俊明ら
  • Journal Title: 認知神経科学 10 Pages: 9-14
  • NAID: 130004387872
• [Journal Article] 双極性障害の臨床神経生理学的研究 (2008)
  • Author(s): 前川敏彦, 鬼塚俊明, 神庭重信
  • Journal Title: 臨床精神医学 37 Pages: 1295-1302
• [Presentation] 統合失調症の顔認知障害の神経基盤 (2010)
  • Author(s): 鬼塚俊明
  • Organizer: 第3回発達障害の病態と治療ネットワーク(シンポジスト)
  • Place of Presentation: 北九州市
  • Year and Date: 2010-10-09
• [Presentation] 統合失調症の顔認知障害と社会機能障害の関連 (2010)
  • Author(s): 鬼塚俊明
  • Organizer: 第15回日本認知神経科学会(シンポジスト)
  • Place of Presentation: 松江市
  • Year and Date: 2010-07-17
• [Presentation] The evoked neural oscillations to auditory steady-state stimuli and speech sounds in schizophrenia and bipolar disorder. (2010)
  • Author(s): 鬼塚俊明
  • Organizer: XXVII CINP Congress (Symposium)
  • Place of Presentation: Hong-Kong, China.
  • Year and Date: 2010-06-09
• [Presentation] Auditory steady state responseの左右半球での相違-正常者での予備的研究- (2010)
  • Author(s): 土本利架子, 平野昭吾, 上野雄文, 平野羊嗣, 大林長二, 織部直弥, 中村一太, 福嶋倫子, 鬼塚俊明, 神庭重信
  • Place of Presentation: 福岡市
  • Year and Date: 2010-03-27
• [Presentation] 統合失調症の表情顔に対するERP :空間周波数処理画像を用いたERP後期成分の検討 (2010)
  • Author(s): 大林長二, 鬼塚俊明, 平野羊嗣, 平野昭吾, 織部直弥, 上野雄文, 角田智哉, 土本利架子, 中村一太, 小田祐子, 飛松省三, 神庭重信
  • Place of Presentation: 福岡市
  • Year and Date: 2010-03-27
• [Presentation] β・γ帯域同期活動を指標とした統合失調症の脳機能研究 (2010)
  • Author(s): 織部直弥, 鬼塚俊明, 平野昭吾, 大林長二, 上野雄文, 平野羊嗣, 前川敏彦, 土本利架子, 中村一太, 福嶋倫子, 黒木俊秀, 神庭重信
  • Place of Presentation: 福岡市
  • Year and Date: 2010-03-27
• [Presentation] 統合失調症の音声認知におけるneural oscillation. (2010)
  • Author(s): 平野昭吾, 中村一太, 上野雄文, 平野羊嗣, 織部直弥, 大林長二, 角田智哉, 土本利架子, 福嶋倫子, 小田祐子, 鬼塚俊明, 神庭重信
  • Place of Presentation: 福岡市
  • Year and Date: 2010-03-27
• [Presentation] 社会認知障害の神経基盤 (2010)
  • Author(s): 鬼塚俊明
  • Organizer: 第5回日本統合失調症学会(シンポジスト、オーガナイザー)
  • Place of Presentation: 福岡市
  • Year and Date: 2010-03-26
• [Presentation] 統合失調症者・双極性障害者の神経生理学的研究 (2009)
  • Author(s): 鬼塚俊明
  • Organizer: 第37回日本精神科病院協会精神医学会(シンポジウム, オーガナイザー)
  • Place of Presentation: 高松市
  • Year and Date: 2009-11-13
• [Presentation] Abnormal neural oscillatory activity to speech sounds in schizophrenia : An MEG study (2009)
  • Author(s): 鬼塚俊明, et al.
  • Organizer: 9^<th> World Congress of Biological Psychiatry(Symposium, Co-Chair)
  • Place of Presentation: Paris, France
  • Year and Date: 2009-07-02
• [Presentation] Abnormal neural oscillatory activity to speech sounds in patients with bipolar disorder : a MEG study (2009)
  • Author(s): 鬼塚俊明, et al.
  • Organizer: Fifteenth International Congress on Event-Related Potentials of the Brain(Symposium)
  • Place of Presentation: Indiana, USA
  • Year and Date: 2009-04-22
• [Presentation] 統合失調症者・双極性障害者の共通性・異種性を探る-脳磁図研究 (2008)
  • Author(s): 鬼塚俊明ら
  • Organizer: 第41回精神神経系薬物治療研究報告会
  • Place of Presentation: 大阪府
  • Year and Date: 2008-12-05
• [Presentation] 統合失調症者の表情認知障害-P3aを指標として- (2008)
  • Author(s): 鬼塚俊明
  • Organizer: 第61回九州精神神経学会
  • Place of Presentation: 宮崎県
  • Year and Date: 2008-10-23
• [Presentation] Abnormal neural oscillatory activity to speech sounds in schizophrenia : a MEG study (2008)
  • Author(s): 鬼塚俊明ら
  • Organizer: 第17回箱根精神薬理シンポジウム
  • Place of Presentation: 神奈川県
  • Year and Date: 2008-09-06
• [Presentation] Abnormal asymmetry of the face N170 repetition effect in male patients with chronic schizophrenia (2008)
  • Author(s): 鬼塚俊明ら
  • Organizer: 63^<rd> Annual Scientific Convention & Meeting of Society of Biological Psychiatry
  • Place of Presentation: Washington DC, USA
  • Year and Date: 2008-05-01
• [Book] 誘発電位・事象関連電位と精神疾患(脳科学エッセンシャル-精神疾患の生物学的理解のために(専門医のための精神科臨床リュミエール))(神庭重信・加藤忠史編) (2010)
  • Author(s): 鬼塚俊明
  • Publisher: 中山書店、東京
• [Book] 脳科学エッセンシャル-精神疾患の生物学的理解のために(専門医のための精神科臨床リュミエール) (2010)
  • Author(s): 鬼塚俊明
  • Publisher: 中山書店、東京
• [Book] sMRI-ROI. 精神疾患の脳画像解析・診断学 (2008)
  • Author(s): 鬼塚俊明
  • Total Pages: 127
  • Publisher: 南山堂, 東京
• [Book] MRI. 精神疾患と脳画像 (2008)
  • Author(s): 鬼塚俊明, 重藤寛史
  • Total Pages: 248
  • Publisher: 中山書店, 東京
• [Remarks] ホームページ等
  • URL: http://www.med.kyushu-u.ac.jp/psychiatry/