The neural basis of delusional misidentification in dementia with Lewy bodies

• Project/Area Number: 20591413
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Psychiatric science
• Research Institution: Kumamoto University
• Principal Investigator: HASHIMOTO Mamoru Kumamoto University, 医学部附属病院, 講師 (20452881)
• Co-Investigator(Kenkyū-buntansha): IKEDA Manabu 熊本大学, 生命科学研究部, 教授 (60284395)
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000); Fiscal Year 2010: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2009: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2008: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
• Keywords: レビー小体型認知症 / 妄想 / 神経基盤 / 誤認妄想 / 嫉妬妄想 / MRI / 脳血管障害 / Clock Drawing Test / レビー小体型認知症(DLB) / SPECT / Capgras症候群

Research Abstract

In dementia with Lewy bodies (DLB) the prevalence of delusion was higher than that in any other dementia. The principal component analysis for all kinds of delusion in DLB revealed that misidentificational delusion and contents specific delusion such as delusional theft or delusional jealousy might related reciprocally.Furthermore, Alzheimer's disease patients with subcortical ischemic vascular lesionswere significantly more delusional than those without. This result suggests thatsubcortical ischemic vascular lesions may be considered as a risk factor for thedevelopment of delusions in degenerative dementia.

Research Products

• [Journal Article] Neuropsychiatric symptoms of progressive supranuclear palsy in a dementia clinic. (2011)
  • Author(s): Yatabe Y, Hashimoto M, Kaneda K, Honda K, Ogawa Y, Yuki S, Matsuzaki S, Tsuyuguchi A, Kashiwagi H, Ikeda M.
  • Journal Title: Psychogeriatrics 11 Pages: 54-59
  • NAID: 10031165748
• [Journal Article] Neuroanatomy of a neurobehavioral disturbance in the left anterior thalamic infarction. (2011)
  • Author(s): Nishio Y, Hashimoto M, Ishii K, Mori E.
  • Journal Title: J Neurol Neurosurg Psychiatry [Epub ahead of print]
  • Peer Reviewed
• [Journal Article] レビー小体型認知症の薬物療法 (2011)
  • Author(s): 橋本衛
  • Journal Title: 老年精神医学雑誌 22巻 Pages: 176-183
• [Journal Article] BPSDの治療 (2010)
  • Author(s): 橋本衛
  • Journal Title: 日本老年医学会雑誌 47巻 Pages: 294-297
  • NAID: 10027594614
• [Journal Article] 認知症の治療と認知症疾患別のケア～レビー小体型認知症を通して考える～ (2010)
  • Author(s): 橋本衛
  • Journal Title: 九州神経精神医学 56巻 Pages: 11-14
• [Journal Article] 症例からみたDLBの症候学 (2010)
  • Author(s): 橋本衛
  • Journal Title: 老年精神医学雑誌 21巻 Pages: 98-104
• [Journal Article] レビー小体型認知症の薬物療法 (2010)
  • Author(s): 橋本衛
  • Journal Title: 老年精神医学雑誌 Volume: 22 Pages: 176-183
• [Journal Article] 認知症の治療と認知症疾患別のケア～レビー小体型認知症を通して考える～ (2010)
  • Author(s): 橋本衛
  • Journal Title: 九州神経精神医学 Volume: 47 Pages: 11-14
• [Journal Article] 症例からみたDLBの症候学 (2010)
  • Author(s): 橋本衛
  • Journal Title: 老年精神医学雑誌 第21巻増刊号 Pages: 98-104
• [Journal Article] Impact of donepezil hydrochloride on the care burden of family caregivers of patients with Alzheimer's disease. (2009)
  • Author(s): Hashimoto M, Yatabe Y, Kaneda K, Honda K, Ikeda M.
  • Journal Title: Psychogeriatrics 9 Pages: 196-203
  • NAID: 10027275170
  • Peer Reviewed
• [Journal Article] Neuropsychiatric symptoms in patients with idiopathic normal pressure hydrocephalus. (2009)
  • Author(s): Kito Y, Kazui H, Kubo Y, Yoshida T, Takaya M, Wada T, Nomura K, Hashimoto M, Ohkawa S, Miyake H, Ishikawa M, Takeda M.
  • Journal Title: Behavioural Neurology 21 Pages: 165-174
  • Peer Reviewed
• [Presentation] Delusional thoughts in dementia (2010)
  • Author(s): 橋本衛
  • Organizer: 4^<th> International Congress of Asian Society Against Dementia
  • Place of Presentation: The Grand Bali Beach Sanur-Bali-Indonesia
  • Year and Date: 2010-10-29
• [Presentation] 「奇妙な時計」を描くレビー小体型認知症 アルツハイマー病との比較 (2010)
  • Author(s): 小川雄右、橋本衛、池田学
  • Organizer: 第34回日本神経心理学会
  • Place of Presentation: 京都大学百周年時計台記念館、京都市
  • Year and Date: 2010-09-10
• [Presentation] 変性性認知症と血管性病変の関連(症候学的視点から) (2010)
  • Author(s): 橋本衛
  • Organizer: 第25回日本老年精神医学会
  • Place of Presentation: KKRホテル熊本、熊本市
  • Year and Date: 2010-06-24
• [Presentation] 認知症患者の妄想-認知症専門外来初診患者の検討- (2010)
  • Author(s): 兼田桂一郎、橋本衛
  • Organizer: 第106回日本精神神経学会学術総会
  • Place of Presentation: 広島国際会議場、広島市
  • Year and Date: 2010-05-21
• [Presentation] ワークショップ;4大認知症(AD、FTLD、DLB、VaD)のBPSDと対応「レビー小体型認知症のBPSD」 (2010)
  • Author(s): 橋本衛
  • Organizer: 第29回日本認知症学会
  • Place of Presentation: ウインクあいち、名古屋市
• [Presentation] シンポジウム;変性性認知症と血管性病変の関連(症候学的視点から) (2010)
  • Author(s): 橋本衛
  • Organizer: 第25回日本老年精神医学会
  • Place of Presentation: KKRホテル熊本、熊本市
• [Presentation] 認知症患者の嫉妬妄想についての検討 (2010)
  • Author(s): 小川雄右、橋本衛
  • Organizer: 第25回日本老年精神医学会
  • Place of Presentation: KKRホテル熊本、熊本市
• [Presentation] レビー小体型認知症における後頭葉血流低下の臨床的側面に関する検討 (2009)
  • Author(s): 矢田部裕介、橋本衛
  • Organizer: 第14回日本神経精神医学会
  • Place of Presentation: 仙台国際ホテル、仙台市
  • Year and Date: 2009-11-05
• [Presentation] レビー小体型認知症における後頭葉血流低下の臨床的側面に関する検討 (2009)
  • Author(s): 矢田部裕介, 橋本衛, 白石慎哉, 池田学
  • Organizer: 第14回日本神経精神医学会
  • Place of Presentation: 仙台国際ホテル(仙台)
  • Year and Date: 2009-11-05
• [Presentation] Comparison of sleep talking, sleep behavior and sleep hours in dementia with Lewy bodies and Alzheimer's disease (2009)
  • Author(s): Honda K, Hashimoto M, Yatabe Y, Yuki S, Kaneda K, Ogawa Y, Ikeda M
  • Organizer: The 3^<rd> Congress of Asian Society Against Dementia
  • Place of Presentation: Seoul KyoYuk MunHwa HoeKwan(Seoul Korea)
• [Presentation] 複合的な要因により幻視とカプグラ症候群を呈した非認知症高齢者の1例 (2008)
  • Author(s): 上谷磨紀
  • Organizer: 第61回九州精神神経学会
  • Place of Presentation: 宮崎市JA・AZMホール
  • Year and Date: 2008-10-24
• [Presentation] レビー小体型認知症とアルツハイマー病における睡眠時の言動の比較 (2008)
  • Author(s): 本田和揮
  • Organizer: The Fourth Sleep Symposium in Kansai-Kumamoto
  • Place of Presentation: 熊本県民交流館パレア
  • Year and Date: 2008-08-02