| Project/Area Number |
20591414
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Psychiatric science
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| Research Institution | Kumamoto University |
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Principal Investigator |
IKEDA Manabu Kumamoto University, 大学院・生命科学研究部, 教授 (60284395)
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| Co-Investigator(Kenkyū-buntansha) |
HASHIMOTO Mamoru 熊本大学, 医学部附属病院, 助教 (20452881)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2009: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2008: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
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| Keywords | 常同行動 / FTD / 神経基盤 / 統計画像解析 / SPECT / 食行動 / Semantic Dementia / Progressive supranuclear palsy / Semantic dementia |
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| Research Abstract |
Recently, the relationship between Progressive supranuclear palsy (PSP) and frontotemporal dementia (FTD) has been recognized, which includes clinical, pathological, biochemical and genetic features. However, there have been few studies that directly compared neuropsychiatric symptoms between PSP and FTD. The aim of the present study was to investigate comprehensive psychiatric and behavioral symptoms in PSP and compared them with those in FTD. Patients with PSP (n=10) and FTD (n=13) were selected on the basis of inclusion/exclusion criteria from a consecutive series in the dementia clinic of Kumamoto University Hospital. We assessed their comprehensive neuropsychiatric features by using the Neuropsychiatric Inventory (NPI), the Stereotypy Rating Inventory (SRI) and a specific antisocial behavior checklist. There were no significant differences in the total NPI and NPI subscale scores between the two groups. Both groups showed quite asimilar pattern in the features of neuropsychiatric symptoms : apathy showed the highest score, followed by aberrant motor behavior and disinhibition.
The PSP group was significantly lower in the total SRI and eating and cooking behavior scores than those in the FTD group. The prevalence of antisocial behaviors in PSP (50%) was equal to those in the FTD group (46%). We hypothesize that the stereotypic behaviors reflect the involvement of specific neural substrate in FTD-namely, the ventral frontal lobe, the temporal pole, and the amygdala.
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