Relationship between the effectiveness of repetitive transcranial magnetic stimulation (rTMS) and brain images in the treatment for major depression.

• Project/Area Number: 20591416
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Psychiatric science
• Research Institution: Wakayama Medical University
• Principal Investigator: SHINOSAKI Kazuhiro Wakayama Medical University, 医学部, 教授 (40215984)
• Co-Investigator(Kenkyū-buntansha): UKAI Satoshi 和歌山県立医科大学, 医学部, 准教授 (80324763) ; TSUJI Tomikimi 和歌山県立医科大学, 医学部, 講師 (10347586) ; KOSE Asami 和歌山県立医科大学, 医学部, 助教 (10405425) ; UEYAMA Eiko 和歌山県立医科大学, 医学部, 助教 (40405444) ; SYOUYAMA Masaru 和歌山県立医科大学, 医学部, 助教 (70364081) ; OKUMURA Masatoshi 和歌山県立医科大学, 医学部, 助教 (00464678) ; YAMAMOTO Masahiro 和歌山県立医科大学, 医学部, 助教 (80423937) ; IWATANI Jun 和歌山県立医科大学, 医学部, 学内助教 (60458057)
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000); Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2009: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2008: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: 反復経頭蓋磁気刺激 / 脳血流シンチグラム / MRI画像 / うつ病 / 気分障害

Research Abstract

【Study1】The aim of this study was to examine chronic rTMS effects on hippocampal neurogenesis in rats. In the rTMS-treated group, BrdU-positive cells were significantly increased in the dentate gyrus. Our results suggest that hippocampal neurogenesis might be involved in the antidepressant effects of chronic rTMS.
【Study2】Using a responder and a non-responder of repetitive transcranial magnetic stimulation (rTMS) for depression, pre-treatment Cg25 perfusion was higher and was decreased after treatment in the responder. Our results suggest that rTMS treatment response may be related to pre-treatment Cg25 activity and modulation of the Cg25.

Research Products

• [Journal Article] Chronic repetitive transcranial magnetic stimulation increases hippocampal neurogenesis in rats (2011)
  • Author(s): Eiko Ueyama, Satoshi Ukai, Asao Ogawa, Masakiyo Yamamoto, Shunsuke Kawaguchi, Ryouhei Ishii, Kazuhiro Shinosaki
  • Journal Title: Psychiatry and Clinical Neurosciences 65 Pages: 77-81
  • Peer Reviewed
• [Journal Article] Chronic repetitive transcranial magnetic stimulation increases hippocampal neurogenesis in rats (2011)
  • Author(s): Eiko Ueyama, Satoshi Ukai, Asao Ogawa, Masakiyo Yamamoto, Shunsuke Kawaguchi, Ryouhei Ishii, Kazuhiro Shinosaki
  • Journal Title: Psychiatry and Clinical Neurosciences Volume: 65 Pages: 77-81
  • Peer Reviewed
• [Journal Article] Evaluation of regional cerebral blood flow in a patient with musical hallucinations. (2010)
  • Author(s): Masaru Shoyama, Satoshi Ukai, Yuji Kitabata, Masahiro Yamamoto, Masatoshi Okumura, Asami Kose, Tomikimi Tsuji, Kazuhiro Shinosaki
  • Journal Title: Neurocase 16 Pages: 1-6
  • Peer Reviewed
• [Journal Article] 精神疾患に対する反復経頭蓋磁気刺激治療 (2010)
  • Author(s): 鵜飼聡, 辻富基美, 篠崎和弘
  • Journal Title: 臨床脳波 52 Pages: 213-220
• [Journal Article] 双極性うつ状態に対する経頭蓋連続磁気刺激治療 (2010)
  • Author(s): 辻富基美、鵜飼聡、篠崎和弘
  • Journal Title: 臨床脳波 51 Pages: 701-707
• [Journal Article] 精神疾患に対する反復経頭蓋磁気刺激治療 (2010)
  • Author(s): 鵜飼聡, 辻富基美, 篠崎和弘
  • Journal Title: 臨床脳波 Volume: 52 Pages: 213-220
• [Journal Article] Evaluation of regional cerebral blood flow in a patient with musical hallucinations. (2010)
  • Author(s): Masaru Shoyama, Satoshi Ukai, Yuji Kitabata, Masahiro Yamamoto, Masatoshi Okumura, Asami Rose, Tomikimi Tsuji, Kazuhiro Shinosaki
  • Journal Title: Neurocase Volume: 16 Pages: 1-6
  • Peer Reviewed
• [Journal Article] 双極性うつ状態に対する経頭蓋連続磁気刺激治療 (2010)
  • Author(s): 辻富基美、鵜飼聡、篠崎和弘
  • Journal Title: 臨床脳波 Volume: 51 Pages: 701-707
• [Journal Article] 双極性うつ状態に対する経頭蓋連続磁気刺激治療 (2010)
  • Author(s): 辻富基美, 鵜飼聡, 篠崎和弘
  • Journal Title: 臨床脳波 51 Pages: 701-707
• [Presentation] r-TMS/m-ECTと認知機能 (2010)
  • Author(s): 篠崎和弘
  • Organizer: 第10回精神疾患と認知機能研究会
  • Place of Presentation: 東京
  • Year and Date: 2010-11-13
• [Presentation] 精神疾患に対するrTMS治療 (2010)
  • Author(s): 鵜飼聡
  • Organizer: 第32回日本生物学的精神医学会
  • Place of Presentation: 小倉
  • Year and Date: 2010-10-23
• [Presentation] 正常脳波 (2010)
  • Author(s): 篠崎和弘
  • Organizer: 第47回日本臨床神経生理学会技術講習会
  • Place of Presentation: 神戸
  • Year and Date: 2010-10-22
• [Presentation] Relationship between the effectiveness of repetitive transcranial magnetic stimulation (rTMS) and blood flow changes in the subgenual anterior cingulate region (Cg25) in the treatment for major depression. (2010)
  • Author(s): Shun Takahashi, Satoshi Ukai, Tamikimi Tsuji, Masahiro Yamamoto, Asami Kose, Masatoshi Okumura, Masaru Shoyama, Kazuhiro Shinosaki
  • Organizer: 65th Annual Meeting of Society of Biological Psychiatry
  • Place of Presentation: New Orleans
  • Year and Date: 2010-05-27
• [Presentation] Relationship between the effectiveness of repetitive transcranial magnetic stimulation (rTMS) and blood flow changes in the subgenual anterior cingulate region (C_g25) in the treatment for major depression. (2010)
  • Author(s): Shun Takahashi, Satoshi Ukai, Tomikimi Tsuji, Masahiro Yamamoto, Asami Kose, Masatoshi Okumura, Masaru Shoyama, Kazuhiro Shinosaki
  • Organizer: 65th Annual Meeting of Society of Biological Psychiatry
  • Place of Presentation: New Orleans
  • Year and Date: 2010-05-12
• [Presentation] 精神疾患の神経回路異常 (2009)
  • Author(s): 篠崎和弘
  • Organizer: 日本臨床神経生理学会学術大会
  • Place of Presentation: 北九州 教育講演
  • Year and Date: 2009-11-18
• [Presentation] 精神疾患の神経回路異常 (2009)
  • Author(s): 篠崎和弘
  • Organizer: 日本臨床神経生理学会学術大会
  • Place of Presentation: 北九州
  • Year and Date: 2009-11-18
• [Presentation] 当科での反復経頭蓋磁気刺激の経験 (2009)
  • Author(s): 辻富基美、山本眞弘、奥村匡敏、高橋隼、正山勝、鵜飼聡、篠崎和弘
  • Organizer: 和歌山県医師会精神科部会
  • Place of Presentation: 和歌山
  • Year and Date: 2009-10-01
• [Presentation] 磁気刺激療法が奏効した難治性大うつ病患者の脳血流変化の検討 (2009)
  • Author(s): 高橋隼、辻富基美、奥村匡敏、山本眞弘、馬島將行、篠崎和弘
  • Organizer: 近畿精神神経学会
  • Place of Presentation: 大阪
  • Year and Date: 2009-07-18
• [Presentation] 磁気刺激療法が奏効した難治性 大うつ病患者の脳血流変化の検討 (2009)
  • Author(s): 高橋隼, 辻富基美, 奥村匡敏, 山本眞弘, 馬島將行, 篠崎和弘
  • Organizer: 近畿精神神経学会
  • Place of Presentation: 大阪
  • Year and Date: 2009-07-18
• [Presentation] うつ症状に対し反復経頭蓋磁気刺激を行った2症例について (2009)
  • Author(s): 辻富基美、高橋隼、山本眞弘、奥村匡敏、正山勝、小瀬朝海、鵜飼聡、篠崎和弘
  • Organizer: 和歌山医学会総会
  • Place of Presentation: 和歌山
  • Year and Date: 2009-07-05
• [Presentation] 難治うつ病での連続経頭蓋磁気刺激による効果と脳血流変化 (2009)
  • Author(s): 辻富基美、山本眞弘、奥村匡敏、高橋隼、正山勝、鵜飼聡、篠崎和弘
  • Organizer: パーキンソン病とうつ病の研究会
  • Place of Presentation: 和歌山
  • Year and Date: 2009-04-25
• [Presentation] 磁気刺激療法を施行した難治性大うつ病患者の神経生理学的評価 (2009)
  • Author(s): 高橋隼、辻富基美、小瀬朝海、奥村匡敏、正山勝、山本眞弘、鵜飼聡、篠崎和弘
  • Organizer: 第31回Fmθ研究会
  • Place of Presentation: 大阪
  • Year and Date: 2009-02-28
• [Presentation] 磁気刺激療法を施行した難治性大うつ病患者の神経生理学的評価 (2009)
  • Author(s): 高橋 隼, 辻富基美, 小瀬朝海, 奥村匡敏, 正山勝, 山本眞弘, 鵜飼聡, 篠崎和弘
  • Organizer: 第31回Fmθ研究会
  • Place of Presentation: 大阪 新梅田研修センター
  • Year and Date: 2009-02-28
• [Book] 精神科専門医のためのプラクテカル精神医学 電気けいれん療法、反復経頭蓋磁気刺激、迷走神経刺激 (2010)
  • Author(s): 鵜飼聡, 篠崎和弘
  • Publisher: 中山書店
• [Book] 電気けいれん療法、反復経頭蓋磁気刺激、迷走神経刺激.精神科専門医のためのプラクテカル精神医学 (2010)
  • Author(s): 鵜飼聡, 篠崎和弘
  • Publisher: 中山書店