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Brain structural change in child and adolescent depression

Research Project

Project/Area Number 20591423
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Psychiatric science
Research InstitutionNippon Medical School

Principal Investigator

SAITO Takuya  日本医科大学, 医学部, 准教授 (20246961)

Co-Investigator(Kenkyū-buntansha) OKUBO Yoshiro  日本医科大学, 大学院・医学研究科, 教授 (20213663)
TATENO Amane  日本医科大学, 医学部, 講師 (50297917)
Project Period (FY) 2008 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2009: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2008: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords児童精神医学 / 児童思春期精神医学 / 児童・思春期精神医学
Research Abstract

Depression is a major mental health problem in child and adolescent and the prevalence is estimated approximately 5-8% and is gradually increased. However, there is no biological maker for child and adolescent for diagnosis and treatment. To find association between biomarkers and symptoms for child depression is important. 8 major depressive disorder child and age matched non-depressive 7clinical samples are participated in an MRI experiment. Whole-brain analyses were conducted and the results of these analyses were examined for potential relationships with depression severity, Quality of life and General psychopathology.

Report

(4 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (23 results)

All 2011 2010 2009 2008 Other

All Journal Article (12 results) (of which Peer Reviewed: 3 results) Presentation (9 results) Book (2 results)

  • [Journal Article] Functional magnetic resonance imaging study on the effects of acute single administration of paroxetine on motivation-related brain activity2011

    • Author(s)
      Marutani T, Yahata N, Ikeda Y, Ito T, Yamamoto M, Matsuura M, Matsushima E, Okubo Y, Suzuki H, Matsuda T
    • Journal Title

      Psychiatry Clin Neurosci

      Volume: 65(2) Pages: 191-8

    • Related Report
      2010 Final Research Report
  • [Journal Article] Contribution of dopamine D1 and D2 receptors to amygdala activity in human2010

    • Author(s)
      Takahashi H, Takano H, Kodaka F, Arakawa R, Yamada M, Otsuka T, Hirano Y, Kikyo H, Okubo Y, Kato M, Obata T, Ito H, Suhara T
    • Journal Title

      J Neurosci

      Volume: 30(8) Pages: 3043-7

    • Related Report
      2010 Final Research Report
  • [Journal Article] 児童青年期双極性障害に対する抗うつ薬の使用とその影響2010

    • Author(s)
      齊藤卓弥
    • Journal Title

      臨床精神薬理

      Volume: 13巻5号 Pages: 907-912

    • Related Report
      2010 Annual Research Report 2010 Final Research Report
  • [Journal Article] 思春期の自殺 救命救急センターでの取り組み2010

    • Author(s)
      川島義高, 伊藤敬雄, 成重竜一郎, 大高靖史, 齊藤卓弥, 大久保善朗
    • Journal Title

      臨床精神医学

      Volume: 39 Pages: 1397-1404

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 成人期の発達障害と心身医療気分障害と発達障害、および米国における成人発達障害の取り組み2010

    • Author(s)
      齊藤卓弥
    • Journal Title

      心身医学

      Volume: 50 Pages: 303-311

    • Related Report
      2010 Annual Research Report
  • [Journal Article] When your gain is my pain and your pain is my gain : neural correlates of envy and schadenfreude2009

    • Author(s)
      Takahashi H, Kato M, Matsuura M, Mobbs D, Suhara T, Okubo Y
    • Journal Title

      Science

      Volume: 323(5916) Pages: 937-9

    • Related Report
      2010 Final Research Report
  • [Journal Article] アメリカにおける精神科と他の職種との連携 -不登校へのチーム・アプローチの紹介-2009

    • Author(s)
      齊藤卓弥
    • Journal Title

      臨床精神医学 38

      Pages: 1286-1296

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 児童精神科領域における薬物療法2009

    • Author(s)
      齊藤卓弥
    • Journal Title

      児童青年精神医学とその近接領域 50

      Pages: 292-297

    • NAID

      10025341746

    • Related Report
      2009 Annual Research Report
  • [Journal Article] 小児・思春期のうつ病に対する薬物療法の実際2009

    • Author(s)
      齊藤卓弥
    • Journal Title

      Progress in Medicine 7

      Pages: 82-88

    • Related Report
      2009 Annual Research Report
  • [Journal Article]2009

    • Author(s)
      齊藤卓弥
    • Journal Title

      児童青年精神医学セミナー(金剛出版)

      Pages: 173-198

    • Related Report
      2009 Annual Research Report
  • [Journal Article] 重度の制止に対し ECT のみで効果がみられずベンゾジアゼピン併用後に劇的に改善したうつ病の一例2008

    • Author(s)
      上田 諭, 河嶌 譲, 齊藤卓弥, 他
    • Journal Title

      精神科治療学 23

      Pages: 885-890

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 児童期の大うつ病性障害の非定型性

    • Author(s)
      齊藤卓弥
    • Journal Title

      精神医学

      Volume: 52巻5号 Pages: 433-438

    • Related Report
      2010 Annual Research Report 2010 Final Research Report
  • [Presentation] 子どものうつ病とその背景2011

    • Author(s)
      齊藤卓弥
    • Organizer
      第8回関東子ども精神保健学会
    • Place of Presentation
      東京
    • Related Report
      2010 Annual Research Report
  • [Presentation] 小児のせん妄の診断と診断アルゴリズム2010

    • Author(s)
      齊藤卓弥
    • Organizer
      第23回日本総合病院精神医学会
    • Place of Presentation
      東京
    • Year and Date
      2010-11-26
    • Related Report
      2010 Annual Research Report
  • [Presentation] 精神科外来での発達障害併存症例へのアプローチ精神科外来における発達障害併存例への治療的なかかわり2010

    • Author(s)
      齊藤卓弥
    • Organizer
      第10回日本外来精神医療学会総会
    • Place of Presentation
      東京
    • Year and Date
      2010-07-24
    • Related Report
      2010 Annual Research Report
  • [Presentation] 児童青年精神科と精神科の接点:さまざまな疾患を中心に 気分障害について2010

    • Author(s)
      齊藤卓弥
    • Organizer
      第106回日本精神神経学会
    • Place of Presentation
      広島
    • Year and Date
      2010-05-21
    • Related Report
      2010 Annual Research Report
  • [Presentation] 子どもの精神疾患の薬物療法の将来2010

    • Author(s)
      齊藤卓弥
    • Organizer
      第51回日本児童青年精神医学会総会
    • Place of Presentation
      群馬
    • Related Report
      2010 Annual Research Report 2010 Final Research Report
  • [Presentation] Models of training in child and adolescent psychiatry in Japan2010

    • Author(s)
      Takuya Saito
    • Organizer
      The 19th World Congress of IACAPAP
    • Place of Presentation
      北京
    • Related Report
      2010 Annual Research Report
  • [Presentation] 成人期の発達障害と心身医療 気分障害と発達障害、および、米国における成人期発達障害の取り組み2009

    • Author(s)
      齊藤卓弥
    • Organizer
      心身医学会総会
    • Place of Presentation
      東京
    • Year and Date
      2009-06-07
    • Related Report
      2009 Annual Research Report
  • [Presentation] 児童精神科領域における薬物療法2008

    • Author(s)
      齊藤卓弥
    • Organizer
      日本児童青年精神医学会総会
    • Place of Presentation
      広島
    • Related Report
      2008 Annual Research Report
  • [Presentation] 児童思春期症例に対するsertraline投与による有害事象の出現について2008

    • Author(s)
      齊藤卓弥
    • Organizer
      日本児童青年精神医学会総会
    • Place of Presentation
      広島
    • Related Report
      2008 Annual Research Report
  • [Book] 子どもの不安障害と抑うつ総編集,子どもの抑うつとその周辺2010

    • Author(s)
      齊藤万比古, 齊藤卓弥
    • Publisher
      中山書店
    • Related Report
      2010 Final Research Report
  • [Book] 子どもの精神病性障害2009

    • Author(s)
      齊藤卓弥
    • Publisher
      中山書店
    • Related Report
      2008 Annual Research Report

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Published: 2008-04-01   Modified: 2016-04-21  

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