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Analyze system of multi higher brain function on impaired patients of cognitive function in diagnosis and strategy of therapy.

Research Project

Project/Area Number 20591425
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Psychiatric science
Research InstitutionKurume University

Principal Investigator

MORITA KIichiro  Kurume University, 高次脳疾患研究所, 教授 (20140642)

Co-Investigator(Kenkyū-buntansha) SHOJI Yoshihisa  久留米大学, 医学部, 講師 (50343695)
MATSUOKA Toshimasa  久留米大学, 医学部, 助教 (60441664)
MORI Keiichiro  久留米大学, 医学部, 助教 (20399182)
Project Period (FY) 2008 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2010: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2009: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2008: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Keywords認知機能 / 高次脳機能 / 事象関連電位 / 光トポグラフィ / 探索眼球運動 / 情動 / 統合失調症 / 統合失調症周辺障害 / 認知科学
Research Abstract

Changes in oxyhemoglobin (oxy-Hb) and the event-related potential during an oddball task were simultaneously measured in patients withschizophrenia and paid healthy volunteers.The changes in oxy-Hb and the P300 amplitude in the left frontal lobe of patients with schizophrenia were lower than those of healthy volunteers.The exploratory eye movements measured simultaneously with the changes in oxyhemoglobin (oxy-Hb), using an eye mark recorder, demonstrated that the total distance of eye movement in patients with schizophrenia was shorter than that in healthy volunteers Further, a significant increase in oxy-Hb was observed in the left frontal lobe of patients with schizophrenia. These results suggest that the simultaneous measurement of NIRS and cerebral waves or exploratory eye movements may be useful as a psychological and physiological indicator for the evaluation of emotional symptoms of schizophrenia and related disorders. As described below, the results of this study have been reported at meetings of domestic and international scientific societies, and the paper is currently being written. A higher brain function analysis system using 3 types of device is under development. This system should contribute to the society in order to earlier diagnosis of mental disorder as schizophrenia.

Report

(4 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (56 results)

All 2010 2009 2008 Other

All Journal Article (18 results) (of which Peer Reviewed: 10 results) Presentation (36 results) Book (1 results) Remarks (1 results)

  • [Journal Article] Effects of emotionally charged sounds in schizophrenia patients using exploratory eye movements : comparison with healthy subjects.2010

    • Author(s)
      Ishii Y, Morita K, Shouji Y, Nakashima Y, Uchimura N
    • Journal Title

      Psychiatry Clin Neurosci 64(1)

      Pages: 10-8

    • Related Report
      2010 Final Research Report
  • [Journal Article] Comparizon between a real sequential finger and imagery movements : An fMRI syudy revisited.2010

    • Author(s)
      Ueno T, Inoue M, Matsuoka T, Abe T, H, Morita K
    • Journal Title

      Brain Imaging Behav 4(1)

      Pages: 80-5

    • Related Report
      2010 Final Research Report
  • [Journal Article] Effects of emotionally charged sounds in schizophrenia patients using exploratory eye movements : comparison with healthy subjects.2010

    • Author(s)
      Ishii Y, Morita K, et al.
    • Journal Title

      Psychiatry Clin Neurosci

      Volume: 64(1) Pages: 10-18

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effects of emotionally chargeed sounds in schizophrenic patients using exproratory eye movements : Conparison with healthy subjects2010

    • Author(s)
      IshiI Y, Morita K, Shoji Y, Nakashima Y, Uchimura N
    • Journal Title

      Psychiat Clin Neurosci 64(1)

      Pages: 10-8

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Exploratory eye movement dysfunction as a discriminator for schizophrenia. -A large sample study using a newly developed digital computerized system-2009

    • Author(s)
      Suzuki M, 他, Morita K
    • Journal Title

      Eur Arch Psychiatry Clin Neurosci 259(3)

      Pages: 186-94

    • Related Report
      2010 Final Research Report
  • [Journal Article] Developmental characteristics of visual cognitive function during childhood according to Maeda exploratory eye movements.2009

    • Author(s)
      Egami C, Morita K, Ohya T, Ishii Y, Yamashita Y, Matsuishi T
    • Journal Title

      Brain Dev 31

      Pages: 750-7

    • Related Report
      2010 Final Research Report
  • [Journal Article] Exploratory eye movement dysfunction as a discriminator for schizop hrenia.-A large sample study using a newly developed digital computerized system-2009

    • Author(s)
      Suzuki M, Takahashi S, Matsushima E, Ishii Y, Morita K, Maeda H, et al.
    • Journal Title

      Eur Arch Psychiat Clin Neurosci 259(3)

      Pages: 186-94

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Developmental characteristics of visual cognitive function during child hood according to exploratory eye movements2009

    • Author(s)
      Egami C, Morita K, Ohya T, Ishii Y, Yamashita Y, Matsuishi T
    • Journal Title

      Brain Dev 31

      Pages: 750-7

    • NAID

      10026413032

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 情動関連課題遂行中の脳血流の変動-多チャンネルNIRSを用いて-2009

    • Author(s)
      山本篤、森田喜一郎、小路純央、岡本泰弘, 他3名
    • Journal Title

      久留米医学会雑誌 72(1・2)

      Pages: 69-77

    • NAID

      40016610100

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article]2009

    • Author(s)
      森田喜一郎、小路純央
    • Journal Title

      統合失調症者の精神生理学的情動の評価:多面的検討. 「精神疾患と認知機能」(精神疾患と認知機能研究会編)(新興医学出版社)

      Pages: 123-9

    • Related Report
      2009 Annual Research Report
  • [Journal Article] 統合失調症者の情動関連探索眼球運動の特性 : 視野(スクリーン)の左右差を含めて2008

    • Author(s)
      森田喜一郎, 立松康宏, 小路純央, 川辺千津子, 他2名
    • Journal Title

      臨床脳波 50(3)

      Pages: 152-158

    • Related Report
      2008 Annual Research Report
  • [Journal Article] 統合失調症の情動障害と扁桃核2008

    • Author(s)
      前田久雄, 森田喜一郎, 上野雄文
    • Journal Title

      Clinical Neuroscience 26(4)

      Pages: 447-450

    • Related Report
      2008 Annual Research Report
  • [Journal Article] 課題関連P300成分の発生源について-色彩環境の影響-2008

    • Author(s)
      兒玉隆之, 森田喜一郎, 小路純央, 土井亮, 川辺千津子
    • Journal Title

      臨床神経生理学 36(3)

      Pages: 95-101

    • NAID

      10027055412

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 近赤外線スペクトロスコピーとアイマークを用いた統合失調症者の情動関連血流変動の特性-健常者との比較検討-2008

    • Author(s)
      石井洋平, 森田喜一郎, 小路純央, 松岡稔昌, 山本篤
    • Journal Title

      日本臨床神経生理学 36(4)

      Pages: 219-225

    • NAID

      10027055819

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] ERPのMicrostate法を用いたLORETA解析.2008

    • Author(s)
      兒玉隆之, 森田喜一郎, 森圭一郎, 小路純央, 内村直尚
    • Journal Title

      臨床脳波 50(10)

      Pages: 610-614

    • Related Report
      2008 Annual Research Report
  • [Journal Article] 情動関連課題遂行中の脳血流の変動-多チャンネルNIRSを用いて-2008

    • Author(s)
      山本篤, 森田喜一郎, 小路純央, 岡本泰弘, 中島洋子, 他2名
    • Journal Title

      久留米医学会雑誌 72(1・2)

      Pages: 69-77

    • NAID

      40016610100

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Comparizon between a real sequential finger and imagery movements : An fMRI syudy revisited

    • Author(s)
      Ueno T, Inoue M, Matsuoka T, Abe T, Maeda H, Morita K
    • Journal Title

      Brain Imaging Behav (in press)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] : Developmental characteristics of visual cognitive function during childhood according to exploratory eye movements.

    • Author(s)
      Egami C, Morita K, Oya T, Ishii Y, et al.
    • Journal Title

      Brain Dev (in press)

    • NAID

      10026413032

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Presentation] Cognitive function during affective charged oddball task evaluated by LORETA analysis and NIRS in patients with schizophrenia : Comparison with healthy subjects.2010

    • Author(s)
      Morita K, Shoji Y, Yamamoto A, Kodama T, Mori K, Uchimura N
    • Organizer
      CINP (International College of Neuropsychopharmacology)
    • Place of Presentation
      Hong Kong
    • Related Report
      2010 Final Research Report
  • [Presentation] Cognitive function during affective charged oddball task evaluated by LORETA analysis and NIRS in patients with schizophrenia : Comparison with healthy subjects.2010

    • Author(s)
      Morita K, Shoji Y, et al.
    • Organizer
      International College of Neuropsychopharmacology
    • Place of Presentation
      Hgng Kong
    • Related Report
      2010 Annual Research Report
  • [Presentation] 高次脳機能障害者における情動関連探索眼球運動の特徴:健常者との比較2010

    • Author(s)
      井上雅之、森田喜一郎, 他2名
    • Organizer
      第106回日本精神神経学会学術総会
    • Place of Presentation
      広島
    • Related Report
      2010 Annual Research Report
  • [Presentation] 情動関連探索眼球運動課題時の脳血流変動および眼球運動の同時測定2010

    • Author(s)
      石井洋平、森田喜一郎, 他3名
    • Organizer
      第34回日本神経生理学会総会
    • Place of Presentation
      京都
    • Related Report
      2010 Annual Research Report
  • [Presentation] 統合失調症患者におげる情動関連探索課題時の脳血流変動および眼球運動:健常者との比較検討2010

    • Author(s)
      石井洋平、森田喜一郎, 他3名
    • Organizer
      第32回日本生物学的精神医学会
    • Place of Presentation
      北九州
    • Related Report
      2010 Annual Research Report
  • [Presentation] 統失調症と健常者のしりとり課題中の酸化ヘモグロビンの変動:表情認知・情動の影響2010

    • Author(s)
      小路純央、森田喜一郎
    • Organizer
      第5回日本統合失調症学会
    • Place of Presentation
      福岡
    • Related Report
      2009 Annual Research Report
  • [Presentation] 情動関連確認課題時の脳血流変動および眼球運動~健常者と統合失調症者の比較検討~2010

    • Author(s)
      石井洋平、森田喜一郎、小路純央、松岡稔昌, 他2名
    • Organizer
      第5回日本統合失調症学会
    • Place of Presentation
      福岡
    • Related Report
      2009 Annual Research Report
  • [Presentation] 統合失調症における視覚オドボール課題遂行中の情動関連酸化ヘモグロビンとP300成分の検討:健常者との比較検討2010

    • Author(s)
      森圭一郎、森田喜一郎、山本篤、藤木僚, 他3名
    • Organizer
      第5回日本統合失調症学会
    • Place of Presentation
      福岡
    • Related Report
      2009 Annual Research Report
  • [Presentation] 統合失調症者の樹木画(バウム)テスト施行中の酸化ヘモグロビンの変動:健常者との比較検討2010

    • Author(s)
      五十君啓泰、森田喜一郎、山本篤、小路純央、堀川週一
    • Organizer
      第5回日本統合失調症学会
    • Place of Presentation
      福岡
    • Related Report
      2009 Annual Research Report
  • [Presentation] Characteristics of emotional charged P300 component in patients with schizophrenia : comparison with healthy controls.2009

    • Author(s)
      Mori K, Morita K, Shoji Y, Matsuoka T, Uchimura N
    • Organizer
      9th World Congress of Biological Psychiatry
    • Place of Presentation
      Pari
    • Related Report
      2010 Final Research Report
  • [Presentation] Changes in Oxy-hemoglobin during emotionally loaded Shiritori task in Schizophrenic patients evaluation by NIRS.2009

    • Author(s)
      Morita K, Shoji Y, Yamamoto H, Uchimura N
    • Organizer
      9^<th> World Congress of Biological Psychiatry
    • Place of Presentation
      Pari
    • Related Report
      2010 Final Research Report
  • [Presentation] Cognitive function during affective charged oddball task evaluated by LORETA analysis and NIRS.2009

    • Author(s)
      Kodama T, Shoji Y, Morita K, Yamamoto H, Yamamoto A
    • Organizer
      Neuroscience2009
    • Place of Presentation
      Chicago, USA
    • Related Report
      2010 Final Research Report
  • [Presentation] Changes in Oxy-hemoglobin during emotionally loaded Shiritori task in Schizophrenic patients evaluation by NIRS2009

    • Author(s)
      Morita K, Shoji Y, Yamamoto H, Uchimura N
    • Organizer
      9^<th> World Congress of Biological Psychiatry
    • Place of Presentation
      Pari
    • Related Report
      2009 Annual Research Report
  • [Presentation] Characteristics of emotional charged P300 component in patients with schizophrenia : comparison with healthy controls2009

    • Author(s)
      Mori K, Morita K, Shoji Y, Matsuoka T, Uchimura N
    • Organizer
      9^<th> World Congress of Biological Psychiatry
    • Place of Presentation
      Pari
    • Related Report
      2009 Annual Research Report
  • [Presentation] 多チャンネルNIRSを用いてしりとり課題中の脳血流の変動:健常群と統合失調症群の比較検討2009

    • Author(s)
      小路純央、森田喜一郎、森圭一郎、松岡稔昌, 他2名
    • Organizer
      第31回日本生物学的精神医学会
    • Place of Presentation
      京都
    • Related Report
      2009 Annual Research Report
  • [Presentation] 統合失調症群のLORETA解析による情動関連 P300成分の特徴:健常群と比較検討2009

    • Author(s)
      森圭一郎、森田喜一郎、小路純央、松岡稔昌, 他2名
    • Organizer
      第31回日本生物学的精神医学会
    • Place of Presentation
      京都
    • Related Report
      2009 Annual Research Report
  • [Presentation] 多チャンネル近赤外線スペクトロピーと事象関連電位計測システムを用いた統合失調症者の情動関連機能の特性 健常者との比較検討2009

    • Author(s)
      森圭一郎、森田喜一郎、小路純央、松岡稔昌, 他3名
    • Organizer
      第105回日本精神神経学会総会
    • Place of Presentation
      神戸
    • Related Report
      2009 Annual Research Report
  • [Presentation] 多チャンネルNIRSを用いた統合失調症患者におげる情動喚起時「しりとり課題」中の脳血流変化について:健常者と統合失調亜型での比較検討2009

    • Author(s)
      小路純央、森田喜一郎、松岡稔昌、山本寛子、森圭一郎、内村直尚
    • Organizer
      第105回日本精神神経学会総会
    • Place of Presentation
      神戸
    • Related Report
      2009 Annual Research Report
  • [Presentation] 多チャンネルNIRSを用いた統合失調症者におけるしりとり課題中の酸化ヘモグロビンの変動について:健常者との比較検討2009

    • Author(s)
      森田喜一郎、小路純央、松岡稔昌、石井洋平, 他2名
    • Organizer
      第29回日本精神科診断学会
    • Place of Presentation
      東京
    • Related Report
      2009 Annual Research Report
  • [Presentation] Cognitive function during affective charged oddball task evaluated by LORETA analysis and NIRS2009

    • Author(s)
      Kodama T, Shoji Y, Morita K, Yamamoto H, Yamamoto A
    • Organizer
      Neuroscience2009
    • Place of Presentation
      Chicago, USA
    • Related Report
      2009 Annual Research Report
  • [Presentation] fMRIを用いた神経衰弱(カードゲーム)課題における認知機能の特徴2009

    • Author(s)
      松岡稔昌、井上雅之、森田喜一郎、安陪等思, 他2名
    • Organizer
      第32回日本神経科学大会/Neuroscience2009
    • Place of Presentation
      名古屋
    • Related Report
      2009 Annual Research Report
  • [Presentation] 成人健常者における情動オドボール課題遂行中の脳血流の変動2009

    • Author(s)
      山本篤、森田喜一郎、小路純央、兒玉隆之
    • Organizer
      第32回日本神経科学大会/Neuroscience2009
    • Place of Presentation
      名古屋
    • Related Report
      2009 Annual Research Report
  • [Presentation] 統合失調症者の多チャンネルNIRSを用いた情動関連しりとり課題遂行中の脳血流流動の特徴:健常者との比較検討2009

    • Author(s)
      堀田雄介、森田喜一郎、山本篤、山本寛子、松岡稔昌, 他2名
    • Organizer
      第62回九州精神神経学会
    • Place of Presentation
      熊本
    • Related Report
      2009 Annual Research Report
  • [Presentation] 多面的評価を用いて急性期からの回復過程を検討した統合失調症の一例2009

    • Author(s)
      鎌田裕之、山本寛子、大島勇人、森田喜一郎, 他4名
    • Organizer
      第62回九州精神神経学会
    • Place of Presentation
      熊本
    • Related Report
      2009 Annual Research Report
  • [Presentation] 近赤外線スペクトロスコピーを用いたトランプ実施時の脳血流について一健常者と高次脳機能障害者との比較2009

    • Author(s)
      近藤くにこ、川辺千津子、山本篤、森田喜一郎, 他2名
    • Organizer
      第55回九州精神保健学会
    • Place of Presentation
      熊本
    • Related Report
      2009 Annual Research Report
  • [Presentation] 近赤外線スペクトロスコピーを用いた統合失調症患者のイメージ課題中の脳血流変動~健常者との比較検討~2009

    • Author(s)
      浦田千穂子、森田喜一郎、石井洋平、小路純央
    • Organizer
      第55回九州精神保健学会
    • Place of Presentation
      熊本
    • Related Report
      2009 Annual Research Report
  • [Presentation] 健常者における母子表情写真提示時の特徴:近赤外線スペクトロスコピーと探索眼球運動の同時測定からの検討2009

    • Author(s)
      川辺千津子、森田喜一郎、石井洋平、山本篤, 他2名
    • Organizer
      第39回日本臨床神経生理学会学術大会
    • Place of Presentation
      北九州
    • Related Report
      2009 Annual Research Report
  • [Presentation] 統合失調症者及び統合失調症圏障害者の情動関連脳血流変動と眼球運動~健常者との比較検討~2009

    • Author(s)
      石井洋平、森田喜一郎、小路純央、松岡稔昌, 他2名
    • Organizer
      第39回日本臨床神経生理学会学術大会
    • Place of Presentation
      北九州
    • Related Report
      2009 Annual Research Report
  • [Presentation] 健常者における迷路課題遂行中の眼球運動及び多チャンネルNIRSを用いた脳活動についての検討2009

    • Author(s)
      井上雅之、森田喜一郎、小路純央、石井洋平, 他2名
    • Organizer
      第39回日本臨床神経生理学会学術大会
    • Place of Presentation
      北九州
    • Related Report
      2009 Annual Research Report
  • [Presentation] 表情のもつ情動的作用が認知機能へ及ぼす影響-LORETA解析とNIRSの同時測定-2009

    • Author(s)
      兒玉隆之、森田喜一郎、山本篤
    • Organizer
      第39回日本臨床神経生理学会学術大会
    • Place of Presentation
      北九州
    • Related Report
      2009 Annual Research Report
  • [Presentation] Effects of atypical antipsychotic drugs of the emotionally charged exploratory eye movements in schizophrenia : comparison with healthy subjects2008

    • Author(s)
      Shoji Y, Morita K, Matsuoka T, Yamamoto H, Mori K, Uchimura N
    • Organizer
      XXVI CINP Cogress 2008
    • Place of Presentation
      Munich, Germany
    • Related Report
      2008 Annual Research Report
  • [Presentation] Improvement of emotionally charged P300 component after treatment with atypical antipsychotics in patients with schizophrenia : comparison with healthy subjects.2008

    • Author(s)
      Mori K, Morita K, Shoji Y, Yamamoto H, Uchimura N
    • Organizer
      XXVI CINP Cogress 2008
    • Place of Presentation
      Munich, Germany
    • Related Report
      2008 Annual Research Report
  • [Presentation] Effects of the color environments on the human cognitive function.2008

    • Author(s)
      Kodama T, Morita K
    • Organizer
      XXIX International Congress of Psychology
    • Place of Presentation
      Berlin, Germany
    • Related Report
      2008 Annual Research Report
  • [Presentation] Effects of affective stimuli for the concentration of Oxy-Hb and eye movements in schizophrenia.2008

    • Author(s)
      Ishii Y, Morita K, Shoji Y, Matsuoka T, Mori K
    • Organizer
      2^<nd> Asia-Pacific Congress and 30^<th> Annual WFSBP Meeting of JSBP
    • Place of Presentation
      Toyama, Japan
    • Related Report
      2008 Annual Research Report
  • [Presentation] Effects of affective stimuli in patients with schizophrenia during shiritori task measured by NIRS.2008

    • Author(s)
      Shoji Y, Morita K, Yamamoto A, Matsuoka T, Mori K, et al
    • Organizer
      2^<nd> Asia-Pacific Congress and 30^<th> Annual WFSBP Meeting of JSBP
    • Place of Presentation
      Toyama, Japan
    • Related Report
      2008 Annual Research Report
  • [Presentation] Improvement of emotionally charged P300 component after treatment in schizophrenia patients.2008

    • Author(s)
      Mori K, Morita K, Shoji Y, Matsuoka T, Uchimura N
    • Organizer
      2^<nd> Asia-Pacific Congress and 30^<th> Annual WFSBP Meeting of JSBP
    • Place of Presentation
      Toyama, Japan
    • Related Report
      2008 Annual Research Report
  • [Book] 精神 疾患と認知機能(精神疾患と認知機能研究会編)(統合失調症者の精神生理学的情動の評価:多面的検討)2009

    • Author(s)
      森田喜一郎、小路純央
    • Publisher
      東京,新興医学出版社
    • Related Report
      2010 Final Research Report
  • [Remarks] ホームページ等

    • Related Report
      2010 Final Research Report

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Published: 2008-04-01   Modified: 2016-04-21  

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