| Project/Area Number |
20591428
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Psychiatric science
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| Research Institution | Neuropsychiatric Research Institute |
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Principal Investigator |
HAYASHIDA Kenichi (2010) Neuropsychiatric Research Institute, 研究部, 研究員 (30338933)
杉浦 建生 (2008-2009) Neuropsychiatric Research Institute, 研究部, 研究員 (30378202)
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| Co-Investigator(Kenkyū-buntansha) |
SUGIURA Tatsuki 財団法人神経研究所, 研究部, 研究員 (30378202)
林田 健一 財団法人神経研究所, 研究部, 研究員 (30338933)
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| Co-Investigator(Renkei-kenkyūsha) |
INOUE Yuichi 財団法人神経研究所, 研究部, センター長 (50213179)
YASUNORI Oka 財団法人神経研究所, 研究部, 研究員 (60419025)
KOMADA Yoko 財団法人神経研究所, 研究部, 研究員 (40451380)
KANBAYASHI Takashi 秋田大学, 医学部, 准教授 (50323150)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2010: ¥260,000 (Direct Cost: ¥200,000、Indirect Cost: ¥60,000)
Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2008: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | ナルコレプシー / 情動脱力発作 / 特発性過眠症 / 事故 / 反復睡眠潜時検査 / 夜間睡眠 / SF36 / 睡眠構造 / 日内変動 / QOL / Epworth sleepiness scale / 覚醒維持薬 / 経頭蓋磁気刺激 / ヒト白血球抗原 / 交通事故 / 治療反応 |
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| Research Abstract |
This series of studies have been made to investigate the differences and similarities of clinical characteristics and quality of life among CNS hypersomnias (narcolepsy related disorders). As a result, it was shown that nocturnal sleep disruption is the specific symptom of narcolepsy with cataplexy among the CNS hypersomnias. The decrease in CSF orexin secretion was significantly associated with the increased propensity of sleep induction and appearance of stage REM, both of which are the cardinal feature of narcolepsy. Based on this, CNS hypersomnias showed difference in both the severity of hypersomnia and the treatment response. However, of note, quality of life the patients manifested on the score of SF36 seemed to be deteriorated depending not on the subjective severity of hypersomnia but on the degree of the lack of familial and social support.
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