Clinical characteristics and quality of life among CNS hypersomnias (narcolepsy related disorders)

• Project/Area Number: 20591428
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Psychiatric science
• Research Institution: Neuropsychiatric Research Institute
• Principal Investigator: HAYASHIDA Kenichi (2010) Neuropsychiatric Research Institute, 研究部, 研究員 (30338933); 杉浦 建生 (2008-2009) Neuropsychiatric Research Institute, 研究部, 研究員 (30378202)
• Co-Investigator(Kenkyū-buntansha): SUGIURA Tatsuki 財団法人神経研究所, 研究部, 研究員 (30378202) ; 林田 健一 財団法人神経研究所, 研究部, 研究員 (30338933)
• Co-Investigator(Renkei-kenkyūsha): INOUE Yuichi 財団法人神経研究所, 研究部, センター長 (50213179) ; YASUNORI Oka 財団法人神経研究所, 研究部, 研究員 (60419025) ; KOMADA Yoko 財団法人神経研究所, 研究部, 研究員 (40451380) ; KANBAYASHI Takashi 秋田大学, 医学部, 准教授 (50323150)
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2010: ¥260,000 (Direct Cost: ¥200,000、Indirect Cost: ¥60,000); Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2008: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
• Keywords: ナルコレプシー / 情動脱力発作 / 特発性過眠症 / 事故 / 反復睡眠潜時検査 / 夜間睡眠 / SF36 / 睡眠構造 / 日内変動 / QOL / Epworth sleepiness scale / 覚醒維持薬 / 経頭蓋磁気刺激 / ヒト白血球抗原 / 交通事故 / 治療反応

Research Abstract

This series of studies have been made to investigate the differences and similarities of clinical characteristics and quality of life among CNS hypersomnias (narcolepsy related disorders). As a result, it was shown that nocturnal sleep disruption is the specific symptom of narcolepsy with cataplexy among the CNS hypersomnias. The decrease in CSF orexin secretion was significantly associated with the increased propensity of sleep induction and appearance of stage REM, both of which are the cardinal feature of narcolepsy. Based on this, CNS hypersomnias showed difference in both the severity of hypersomnia and the treatment response. However, of note, quality of life the patients manifested on the score of SF36 seemed to be deteriorated depending not on the subjective severity of hypersomnia but on the degree of the lack of familial and social support.

Research Products

• [Journal Article] Relationship between clinical characteristics of narcolepsy and CSF orexin-A levels. (2011)
  • Author(s): Nakamura M, Kanbayashi T, Sugiura T, Inoue Y.
  • Journal Title: J Sleep Res. 20(1 Pt 1) Pages: 45-49
  • Peer Reviewed
• [Journal Article] Relationship between clinical characteristics of narcolepsy and CSForexin-A levels. (2011)
  • Author(s): Nakamura M, Kanbayashi T, Sugiura T, Inoue Y.
  • Journal Title: J Sleep Res Volume: 20 Pages: 45-49
  • Peer Reviewed
• [Journal Article] Clinical characteristics in two subgroups of obstructive sleep apnea syndrome in the elderly : comparison between cases with elderly and middle-age onset (2010)
  • Author(s): Kobayashi M, Namba K, Tsuiki S, Matsuo A, Sugiura T, Inoue Y.
  • Journal Title: Chest. 137(6) Pages: 1310-1315
  • Peer Reviewed
• [Journal Article] Exploring the daily activities associated with delayed bedtime of Japanese university students (2010)
  • Author(s): Asaoka S, Komada Y, Fukuda K, Sugiura T, Inoue Y, Yamazaki K.
  • Journal Title: Tohoku J Exp Med. 221(3) Pages: 245-249
  • NAID: 10027085202
  • Peer Reviewed
• [Journal Article] Short sleep duration and long spells of driving are associated with the occurrence of Japanese drivers' rear-end collisions and single-car accidents. (2010)
  • Author(s): Abe T, Komada Y, Nishida Y, Hayashida K, Inoue Y.
  • Journal Title: J Sleep Res. 19(2) Pages: 310-316
  • Peer Reviewed
• [Journal Article] Exploring the daily activities associated with delayed bedtime of Japanese university students. (2010)
  • Author(s): Asaoka S, Komada Y, Fukuda K, Sugiura T, Inoue Y, Yamazaki K.
  • Journal Title: Tohoku J Exp Med Volume: 221 Pages: 245-249
  • NAID: 10027085202
  • Peer Reviewed
• [Journal Article] Comparison of clinical characteristics among narcolepsy with and without cataplexy and idiopathic hypersomnia without long sleep time, focusing on HLA-DRB1( *)1501/DQB1( *)0602 finding. (2009)
  • Author(s): Sasai T, Inoue Y, Komada Y, Sugiura T, Matsushima E.
  • Journal Title: Sleep Med. 10(9) Pages: 961-966
  • Peer Reviewed
• [Journal Article] Comparison of clinical characteristics among narcolepsy with and without cataplexy and idiopathic hypersomnia without long sleep time, focusing on HLA-DRB1(*)1501/DQB1(*)0602 finding (2009)
  • Author(s): Sasai T, et al
  • Journal Title: Sleep Med. 10(9) Pages: 961-966
  • Peer Reviewed
• [Journal Article] Comparison of clinical characteristics among narcolepsy with and without cataplexy and idiopathic hypersomnia without long sleep time, focusing on HLA-DRB1 (*) 1501/DQB1 (*) 0602 finding (2009)
  • Author(s): Sasai T, et al
  • Journal Title: Sleep Med. (In press)
  • Peer Reviewed
• [Journal Article] Health-related quality of life among drug-naive patients with narcolepsy with cataplexy, narcolepsy without cataplexy, and idiopathic hypersomnia without long sleep time. (2008)
  • Author(s): Ozaki A, Inoue Y, Nakajima T, Hayashida K, Honda M, Komada Y, Takahashi K.
  • Journal Title: J Clin Sleep Med. 4(6) Pages: 572-578
  • Peer Reviewed
• [Journal Article] Health-related quality of life among drug-naive patients with narcolepsy with cataplexy, narcolepsy without cataplexy, and idiopathic hypersomnia without long sleep time (2008)
  • Author(s): Ozaki A, et al
  • Journal Title: J Clin Sleep Med. 4(6) Pages: 572-578
  • Peer Reviewed
• [Presentation] パーキンソン病と進行性核上麻痺において過眠症状へのオレキシン神経系の関与 (2010)
  • Author(s): 伊東若子, 若井正一, 杉浦建生, 前田哲也, 服部優子, 安部俊一郎, 高野大樹, 近藤英明, 井上雄一, 神林崇, 清水徹男
  • Organizer: 日本睡眠学会第35回定期学術集会
  • Place of Presentation: 名古屋
  • Year and Date: 2010-07-01
• [Book] 睡眠教室 (2011)
  • Author(s): 杉浦建生, 他
  • Total Pages: 178
  • Publisher: 株式会社新興医学出版社
• [Book] 睡眠呼吸障害Update2011 (2011)
  • Author(s): 林田健一, 他
  • Total Pages: 223
  • Publisher: ライフ・サイエンス
• [Remarks] ホームページ等