| Project/Area Number |
20591429
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Radiation science
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| Research Institution | Hokkaido University |
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Principal Investigator |
SHIGA Tohru Hokkaido University, 大学院・医学研究科, 講師 (80374495)
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| Co-Investigator(Kenkyū-buntansha) |
IKOMA Katsunori 北海道大学, 病院, 教授 (70202918)
TERAE Satoshi 北海道大学, 病院, 准教授 (40240634)
KATOH Chietsugu 北海道大学, 大学院・保健科学研究院, 准教授 (10292012)
KUGE Yuji 北海道大学, アイソトープ総合センター, 教授 (70321958)
伊藤 武哉 北海道大学, 病院, 医員 (80399849)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2008: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 核医学(PETを含む) / 頭部外傷 / 分子イメージング / PET / 代謝 |
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| Research Abstract |
One of the aims was to analyze the sequential and spatial change of benzodiazepine receptor density, metabolism, neuronal integrity using molecular imaging such as SPECT and PET. To clarify the sequential change, we investigate the reconstruction and analyzing method for animal C-11 flumazenil using animal PET/SPECT/CT. We developed a new method for analyzing binding potential of C-11 flumazenil using rat model. Another aim was to investigate the relationship between effect of rehabilitation and neuronal integrity in patients with brain injury. First we studied the relationship between C-11 flumazenil PET findings and I-123 Iomazenil SPECT findings. Our study indicated that although IMZ SPECT has slightly lower contrast than FMZ PET, IMZ SPECT could detect loss of neuronal integrity as almost same as FMZ PET. Second, we investigate the relationship among metabolic change, loss of neuronal integrity and effect of rehabilitation. However, we could not find the relationship among those parameters.
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