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Development of the integrated system for the analysis of brain function by high resolution micro-PET for small animals using high field MRI

Research Project

Project/Area Number 20591434
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Radiation science
Research InstitutionThe University of Tokyo

Principal Investigator

MOMOSE Toshimitsu  The University of Tokyo, 医学部附属病院, 准教授 (20219992)

Co-Investigator(Kenkyū-buntansha) SEKINO Masaki  東京大学, 工学系研究科, 講師 (20401036)
KOJIMA Yoshiki  国立がんセンター, がん研究所, 研究員 (20167357)
Project Period (FY) 2008 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2008: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywordsmicro-PET / high field MRI / small animal / brain imaging / molecular imaging / microPET / MRI / 小動物 / 脳解剖 / FDG / 糖代謝 / 脳機能 / fusion / 高磁場MRI / マウス / 脳解剖アトラス / 神経変性疾患 / 正常加齢
Research Abstract

The high-resolution PET for small animals is expected to be one of the important tools for the elucidation of the pathophysiology and the innovative drug development of the disease. In this study, we tried to develop the system which enables us to analyze molecular target imaging by micro-PET using high-field MRI. We attempted to design a new head fixation device for mouse which can be used commonly both for micro-PET and high-field MRI for small animals, and made a digital mouse brain atlas for anatomic delineation on micro-PET imaging and MRI utilizing an atlas of stained brain sections of mice, on which each brain domain was separated by color. We applied this technique to the analysis of FDG-PET imaging of normal and transgenic mouse. The abnormal metabolic area on the FDG-PET image of the disease model mouse (DRPLA) was successfully identified using our newly developed system.

Report

(4 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (57 results)

All 2011 2010 2009 2008 Other

All Journal Article (28 results) (of which Peer Reviewed: 27 results) Presentation (11 results) Book (17 results) Remarks (1 results)

  • [Journal Article] 認知症診療における画像診断の役割と可能性-放射線科医の立場から-認知症診療における画像診断の実際2011

    • Author(s)
      百瀬敏光
    • Journal Title

      Innervision 26(1)

      Pages: 6-9

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Impact of multiorgan fusion imaging and interactive three-dimensional visualization for intraventricular neuroendoscopic surgery.2011

    • Author(s)
      Kin T, Shin M, Oyama H, Kamada K, Kunimatsu A, Momose T, Saito N
    • Journal Title

      Neurosurgery (Epub ahead of print)

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Impact of multiorgan fusion imaging and interactive three-dimensional visualization for intraventricular neuroendoscopic surgery2011

    • Author(s)
      Kin T, Shin M, Oyama H, Kamada K, Kunimatsu A, Momose T, Saito N
    • Journal Title

      Neurosurgery (Epub ahead of print)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 認知症診療における画像診断の役割と可能性-放射線科医の立場から-認知症診療における画像診断の実際2011

    • Author(s)
      百瀬敏光
    • Journal Title

      Innervision

      Volume: 26(1) Pages: 6-9

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] SPECT-主に血流評価による早期診断と鑑別診断を中心に(心交感神経シンチグラフィーを含む)認知症診療における画像診断の実際2011

    • Author(s)
      高橋美和子、百瀬敏光
    • Journal Title

      Innervision

      Volume: 26(1) Pages: 21-24

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Relationship of detection rate of PET cancer screening examinees and risk factors : analysis of background of examinees.2010

    • Author(s)
      Shibata K, Arai M, Matsuura M, Uno K, Yoshida T, Momose T, Ohtomo K
    • Journal Title

      Ann Nucl Med (Epub ahead of print)

    • NAID

      10028999595

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] FDG-PET is effective in the detection of granulocytic sarcoma in patients with myeloid malignancy.2010

    • Author(s)
      Ueda K, Ichikawa M, Takahashi M, Momose T, Ohtomo K, Kurokawa M
    • Journal Title

      Leukemia Research 34

      Pages: 1239-1241

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Fabrication of an MRI model magnet with an off-centered distribution of homogeneous magnetic field zone2010

    • Author(s)
      M.Sekino, H.Ohsaki, H.Wada, T.Hisatsune, O.Ozaki, T.Kiyoshi
    • Journal Title

      IEEE Transactions on Applied Superconductivity vol.20

      Pages: 781-785

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] FDG-PET is effective in the detection of granulocytic sarcoma in patients with myeloid malignancy2010

    • Author(s)
      Ueda K, Ichikawa M, Takahashi M, Momose T, Ohtomo K, Kurokawa M
    • Journal Title

      Leukemia Research

      Volume: 34 Pages: 1239-1241

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Relationship of detection rate of PET cancer screening examinees and risk factors : analysis of background of examinees2010

    • Author(s)
      Shibata K, Arai M, Matsuura M, Uno K, Yoshida T, Momose T, Ohtomo K
    • Journal Title

      Ann Nucl Med (Epub ahead of print)

    • NAID

      10028999595

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 小児領域におけるPETの有用性 小児外科領域の放射線診断・治療-最近の話題2010

    • Author(s)
      高橋美和子、百瀬敏光
    • Journal Title

      小児外科

      Volume: 42 Pages: 617-621

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Brain glucose metabolism difference between bipolar and unipolar mood disorders in depressed and euthymic states.2009

    • Author(s)
      Hosokawa T, Momose T, Kasai K
    • Journal Title

      Progress in neuro-psychopharmacology & biological psychiatry 33

      Pages: 43-250

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Inflammatory Cytokines and Hypoxia Contribute to ^<18>F-FDG Uptake by Cells Involved in Pannus Formation in Rheumatoid Arthritis2009

    • Author(s)
      Matsui T, Nakata N, Nagai A, Nakatani A, Takahashi M, Momose T, Ohtomo K, Koyasu S
    • Journal Title

      J Nucl Med 50

      Pages: 920-926

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Low-frequency conductivity tensor of rat brain tissues inferred from diffusion MRI.2009

    • Author(s)
      M.Sekino, H.Ohsaki, S.Yamaguchi-Sekino, N.Iriguchi, S.Ueno
    • Journal Title

      Bioelectromagnetics vol.30

      Pages: 489-499

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Toward detection of transient changes in magnetic resonance signal intensity arising from neuronal electrical activities.2009

    • Author(s)
      M.Sekino, H.Ohsaki, S.Yamaguchi-Sekino, S.Ueno
    • Journal Title

      IEEE Transactions on Magnetics vol.45

      Pages: 4841-4844

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Inflammatory Cytokines and Hypoxia Contribute to 18F-FDG Uptake by Cells Involved in Pannus Formation in Rheumatoid Arthritis2009

    • Author(s)
      Matsui T, Nakata N, Nagai A, Nakatani A, Takahashi M, Momose T, Ohtomo K, Koyasu S
    • Journal Title

      J Nucl Med 50

      Pages: 920-926

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Brain glucose metabolism difference between bipolar and 2unipolar mood disorders in depressed and euthymic states2009

    • Author(s)
      Hosokawa T, Momose T, Kasai K
    • Journal Title

      Progress in neuro-psychopharmacology & biological psychiatry 33

      Pages: 243-250

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article]2009

    • Author(s)
      百瀬敏光
    • Journal Title

      脳卒中看護ポケットナビ(中川書店)

      Pages: 42-45

    • Related Report
      2009 Annual Research Report
  • [Journal Article] Imaging of electric permittivity and conductivity using MRI.2008

    • Author(s)
      M.Sekino, S.Tatara, H.Ohsaki
    • Journal Title

      IEEE Transactions on Magnetics vol.44

      Pages: 4460-4463

    • NAID

      110006783806

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Pure alexia for kana. Characterization of alexia with lesions of the inferior occipital cortex.2008

    • Author(s)
      Sakurai Y, Terao Y, Ichikawa Y, Ohtsu H, Momose T, Tsuji S, Mannen T
    • Journal Title

      J Neurol Sci 268

      Pages: 48-59

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Conventional allogeneic hematopoietic stem cell transplantation for lymphoma may overcome the poor prognosis associated with a positive FDG-PET scan before transplantation.2008

    • Author(s)
      Yoshimi A, Izutsu K, Takahashi M, Kako S, Oshima K, Kanda Y, Motokura T, Chiba S, Momose T, Ohtomo K, Kurokawa, M
    • Journal Title

      Am J Hematol 83

      Pages: 477-481

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Mechanisms of unilateral STN-DBS in patients with Parkinson's disease.2008

    • Author(s)
      Arai N, Yokochi F, Ohnishi T, Momose T, Okiyama R, Taniguchi M, Takahashi H, Matsuda H, Ugawa Y
    • Journal Title

      J Neurol 255

      Pages: 1236-1243

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] 特集 癌克服の総合戦略 連携科学に基づく多角的アプローチ 多様化する診断法 癌の分子イメージング2008

    • Author(s)
      百瀬敏光
    • Journal Title

      Current Therapy 26(5)

      Pages: 8-14

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Pure alexia for kana. Characterization of alexia with lesions of the inferior occipital cortex.2008

    • Author(s)
      Sakurai Y, Terao Y, Ichikawa Y, Ohtsu H, Momose T, Tsuji S, Manhen T.
    • Journal Title

      J Neurol Sci 268

      Pages: 48-59

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Conventional allogeneic hematopoietic stem cell transplan tation for lymphoma may overcome the poor ponosis associated with a positve FDG-PET scan before transplantation.2008

    • Author(s)
      Yoshimi A, Izutsu K, Takahashi M, Kako S, Oshima K, Kanda Y, Motokura T, Chiba S, Momose T, Ohtomo K, Kurokawa, M.
    • Journal Title

      Am J Hematol 83

      Pages: 477-481

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Mechanisums of unilateral STN-DBS in patients with Parkinson's disease.2008

    • Author(s)
      Arai N, Yokochi F, Ohnishi T, Momose T, Okiyama R, Taniguchi M, Takahashi H, Matsuda H, Ugawa.
    • Journal Title

      J Neruol 255

      Pages: 1236-43

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Brain glucose metabolism difference between bipolar and unip olar mood disordes in depressed and euthymic states.2008

    • Author(s)
      Hosokawa T, Momose T, Kasai K
    • Journal Title

      Brog Neuropsychopharmcol Biol Psychiatry (In press)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 特集癌克服の総合戦略連携科学に基づく多角的アプローチ多様化する診断法癌の分子イメージング2008

    • Author(s)
      百瀬敏光
    • Journal Title

      Current Therapy 26(5)

      Pages: 8-14

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Presentation] PETによる脳内アミロイド蓄積の画像化と定量化-早期加算画像をROI設定基準とする手法の検討-2010

    • Author(s)
      百瀬敏光,高橋美和子,小島良紀,古山桂太郎,藤原健太郎,北田孝幸,大友邦
    • Organizer
      第50回日本核医学会学術総会
    • Place of Presentation
      大宮
    • Year and Date
      2010-11-12
    • Related Report
      2010 Annual Research Report 2010 Final Research Report
  • [Presentation] Y-90標識抗ROBO1抗体を用いた肝腫瘍モデルマウスに対する放射免疫療法2010

    • Author(s)
      藤原健太郎,古山桂太郎,熊倉嘉貴,高橋美和子,百瀬敏光
    • Organizer
      第50回日本核医学会学術総会
    • Place of Presentation
      埼玉
    • Year and Date
      2010-11-11
    • Related Report
      2010 Annual Research Report 2010 Final Research Report
  • [Presentation] ヒトにおける咀嚼時の脳内ドーパミン放出の測定2010

    • Author(s)
      百瀬敏光
    • Organizer
      日本咀嚼学会第21回総会・学術大会シンポジウム咀嚼のここちよさをもたらすもの
    • Place of Presentation
      東京
    • Year and Date
      2010-10-02
    • Related Report
      2010 Annual Research Report 2010 Final Research Report
  • [Presentation] 難治性てんかんに対する外科的治療における核医学検査の有効性の検討2009

    • Author(s)
      高橋美和子,百瀬敏光,古山桂太郎,大友邦
    • Organizer
      第49回日本核医学会学術総会
    • Place of Presentation
      旭川
    • Year and Date
      2009-10-02
    • Related Report
      2010 Final Research Report 2009 Annual Research Report
  • [Presentation] 長期経過観察されたMCIにおける初回時脳血流SPECTおよび経済時変化に関する検討2009

    • Author(s)
      古山桂太郎,百瀬敏光,高橋美和子,大友邦
    • Organizer
      第49回日本核医学会学術総会
    • Place of Presentation
      旭川
    • Year and Date
      2009-10-01
    • Related Report
      2010 Final Research Report 2009 Annual Research Report
  • [Presentation] Differential Diagnosis of Parkinsonian Patients by I-123 MIBG Scintigraphy2009

    • Author(s)
      百瀬敏光
    • Organizer
      2009 SNM Annual Meeting
    • Place of Presentation
      カナダ(トロント)
    • Year and Date
      2009-06-16
    • Related Report
      2009 Annual Research Report
  • [Presentation] 18F-FDG MicroPETを用いたDRPLAトランスジェニックマウスの脳局所糖代謝の検討2009

    • Author(s)
      鈴木一詩、百瀬敏光
    • Organizer
      第50回日本神経学会
    • Place of Presentation
      仙台
    • Year and Date
      2009-05-22
    • Related Report
      2010 Final Research Report 2009 Annual Research Report
  • [Presentation] Differential Diagnosis of Parkinsonian Patients by I-123 MIBG Scintigraphy.2009

    • Author(s)
      百瀬敏光
    • Organizer
      2009 SNM Annual Meeting
    • Place of Presentation
      Tronto, Canada
    • Related Report
      2010 Final Research Report
  • [Presentation] FDG-PET画像の視覚的評価によるうつ病と健常者の鑑別に関する検討2008

    • Author(s)
      百瀬敏光
    • Organizer
      第48回日本核医学会学術総会
    • Place of Presentation
      千葉
    • Year and Date
      2008-10-26
    • Related Report
      2010 Final Research Report 2008 Annual Research Report
  • [Presentation] C-11 racloprideとPETを用いた咀嚼運動時脳内ドーパミン放出に関する検討2008

    • Author(s)
      百瀬敏光
    • Organizer
      第48回日本核医学会学術総会
    • Place of Presentation
      千葉
    • Year and Date
      2008-10-26
    • Related Report
      2010 Final Research Report
  • [Presentation] C-llracloprideとPETを用いた咀嚼運動時脳内ドーパミン放出に関する検討2008

    • Author(s)
      百瀬敏光,高橋美和子,小島良紀
    • Organizer
      第48回日本核医学会学術総会
    • Place of Presentation
      千葉
    • Year and Date
      2008-10-26
    • Related Report
      2008 Annual Research Report
  • [Book] 日本臨牀68(IV.脳腫瘍の診断 脳腫瘍の画像診断PET-FDGとメチオニンの臨床応用-新時代の脳腫瘍学-診断・治療の最前線-)2010

    • Author(s)
      百瀬敏光,高橋美和子
    • Related Report
      2010 Final Research Report
  • [Book] 精神科臨床評価検査法マニュアル(改訂版)臨床精神医学(臨床精神医学編集委員会(編))(第39巻増刊号 画像検査 PET)2010

    • Author(s)
      百瀬敏光
    • Related Report
      2010 Final Research Report
  • [Book] Isotope News(書評 医療用PET薬剤講座 10)2010

    • Author(s)
      小島良紀
    • Total Pages
      27
    • Related Report
      2010 Final Research Report
  • [Book] 臨床精神医学(精神科臨床評価検査法マニュアル(改訂版) 第39巻 増刊号)2010

    • Author(s)
      百瀬敏光
    • Publisher
      臨床精神医学編集委員会 アークメデイア社
    • Related Report
      2010 Annual Research Report
  • [Book] 日本臨牀68 新時代の脳腫瘍学-診断・治療の最前線-2010

    • Author(s)
      百瀬敏光、高橋美和子
    • Publisher
      日本臨牀社
    • Related Report
      2010 Annual Research Report
  • [Book] 看護大事典第2版2010

    • Author(s)
      百瀬敏光
    • Publisher
      医学書院
    • Related Report
      2009 Annual Research Report
  • [Book] 看護大事典第2版2010

    • Author(s)
      高橋美和子, 百瀬敏光
    • Publisher
      医学書院
    • Related Report
      2009 Annual Research Report
  • [Book] 病態の理解と診断・治療の進歩(大内尉義 編)(Alzeimer病の早期画像診断-発症前診断を目指して-老化と疾患-)2008

    • Author(s)
      百瀬敏光
    • Publisher
      医歯薬出版株式会社
    • Related Report
      2010 Final Research Report
  • [Book] 頭部 腫瘍 FDGを中心とした臨床応PET-CT画像診断マニュアル2008

    • Author(s)
      百瀬敏光、村上康二(編著)
    • Publisher
      中外医学社
    • Related Report
      2010 Final Research Report
  • [Book] 病態の理解と診断・治療の進歩(Alzeimer病の早期画像診断-発症前診断を目指して-老化と疾患-)2008

    • Author(s)
      百瀬敏光、大内尉義 編
    • Publisher
      医歯薬出版株式会社
    • Related Report
      2010 Final Research Report
  • [Book] 月刊薬事(特集 院内で目にする医療機器の基礎知識診断用医療機器 画像診断関連機器-X線CT、MRIなど 50)2008

    • Author(s)
      小島良紀
    • Publisher
      じほう
    • Related Report
      2010 Final Research Report
  • [Book] 頭部腫瘍FDGを中心としたPET-CT画像診断マニュアル2008

    • Author(s)
      百瀬敏光
    • Publisher
      中外医学社
    • Related Report
      2008 Annual Research Report
  • [Book] 頭部てんかん病巣診断PET-CT画像診断マニュアル2008

    • Author(s)
      高橋美和子、百瀬敏光
    • Publisher
      中外医学社
    • Related Report
      2008 Annual Research Report
  • [Book] Alzheimer病の早期画像診断一発症前診断を目指して2008

    • Author(s)
      百瀬敏光
    • Publisher
      医歯薬出版株式会社
    • Related Report
      2008 Annual Research Report
  • [Book] アルツハイマー型認知症精神疾患の脳画像解析・診断学2008

    • Author(s)
      細川大雅、百瀬敏光
    • Publisher
      南山堂
    • Related Report
      2008 Annual Research Report
  • [Book] PETで何を見るのか2008

    • Author(s)
      百瀬敏光
    • Publisher
      中山書店
    • Related Report
      2008 Annual Research Report
  • [Book] SPECTで何を見るのか2008

    • Author(s)
      百瀬敏光
    • Publisher
      中山書店
    • Related Report
      2008 Annual Research Report
  • [Remarks] ホームページ等

    • Related Report
      2010 Final Research Report

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Published: 2008-04-01   Modified: 2016-04-21  

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