Contrast enhancement of pancreatic carcinoma on dynamic CT : correlation between expression of VEGF and histopathological features

• Project/Area Number: 20591436
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Radiation science
• Research Institution: Kanazawa University
• Principal Investigator: GABATA Toshifumi Kanazawa University, 医学系, 准教授 (00169806)
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000); Fiscal Year 2010: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2009: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2008: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
• Keywords: エックス線 / CT / 膵管癌 / 膵腺管癌 / ダイナミックCT / VEGF / MVD / 膵癌腫瘍内線維化

Research Abstract

To evaluate retrospectively the correlation between enhancement patterns on dynamic computed tomography (CT) and angiogenesis and fibrosis in pancreatic adenocarcinoma. The tumors with greater MVD and higher expression of VEGF tended to show high enhancement in the arterial dominant phase. On the other hand, the tumors with a larger amount of fibrosis showed a negative correlation with the grade of enhancement during the arterial phase. In conclusion, enhancement patterns on dynamic CT correlated with angiogenesis and may be modified by the extent of fibrosis.

Research Products

• [Journal Article] Selective atrophy of the middle hepatic venous drainage area in hepatitisC-related cirrhotic liver : morphometric study by using multidetector CT. (2010)
  • Author(s): Ozaki K, Matsui O, Kobayashi S, Sanada J, Koda W, Minami T, Kawai K, Gabata T.
  • Journal Title: Radiology 257 Pages: 705-714
  • Peer Reviewed
• [Journal Article] MDCT findings of extrapancreatic nerve plexus invasion by pancreas head carcinoma : correlation with en bloc pathological specimens and diagnostic accuracy. (2010)
  • Author(s): Mochizuki L, Gabata T, Kozaka K, et al.
  • Journal Title: Eur Radiol. 20(7) Pages: 1757-1767
  • NAID: 120001940249
  • Peer Reviewed
• [Journal Article] Hepatocellular carcinoma : signal intensity at gadoxetic acid-enhanced MR Imaging-correlation with molecular transporters and histopathologic features. (2010)
  • Author(s): Kitao A, Zen Y, Matsui O, Gabata T, et al.
  • Journal Title: Radiology. 256(3) Pages: 817-826
  • Peer Reviewed
• [Journal Article] New diagnostic criteria of acute pancreatitis. (2010)
  • Author(s): Kiriyama S, Gabata T, et al.
  • Journal Title: J Hepatobiliary Pancreat Sci 17(1) Pages: 24-36
  • NAID: 10027661887
  • Peer Reviewed
• [Journal Article] MDCT findings of extrapancreatic nerve plexus invasion by pancreas head carcinoma : correlation with en bloc pathological specimens and diagnostic accuracy (2010)
  • Author(s): Mochizuki K, Gabata T, et al.
  • Journal Title: Eur Radiology Volume: 20 Pages: 1757-1767
  • NAID: 120001940249
  • Peer Reviewed
• [Journal Article] New diagnostic criteria of acute pancreatitis (2010)
  • Author(s): Kiriyama S, Gabata T, et al.
  • Journal Title: J Hepatobiliary Pancreat Sci Volume: 17 Pages: 24-36
  • NAID: 10027661887
  • Peer Reviewed
• [Journal Article] Poorly enhanced areas of pancreatic adenocarcinomas on late-phase dynamic computed tomography : comparison with pathological findings (2010)
  • Author(s): Hattori Y.Gabata T, et al.
  • Journal Title: Pancreas Volume: 39 Pages: 1263-1270
  • Peer Reviewed
• [Journal Article] Detection and characterization of focal liver lesions : a Japanese phase III, multicenter comparison between gadoxetic acid disodium-enhanced magnetic resonance imagingand contrast enhanced computed tomography predominantly in patients withhepatocellular carcinoma and chronic liver disease (2010)
  • Author(s): Ichikawa T, Saito K, Yoshioka N, Tanimoto A, Gokan T, Takehara Y, Kamura T, Gabata T, et al.
  • Journal Title: Invest Radiol Volume: 45 Pages: 133-141
  • Peer Reviewed
• [Journal Article] Selective atrophy of the middle hepatic venous drainage area in hepatitis C-related c丘rhotic liver : morphometric study by using multidetector CT (2010)
  • Author(s): Ozaki K, Matsui O, Kobayashi S, Sanada J, Koda W, Minami T, Kawai K, Gabata T.
  • Journal Title: Radiology Volume: 257 Pages: 705-714
  • Peer Reviewed
• [Journal Article] Severe intestinal bleeding due to sinistral portal hypertension afterpylorus-preservingpancreatoduodenectomy (2010)
  • Author(s): Ozaki K, Sanada J, Gabata T, et al.
  • Journal Title: Abdom Imaging Volume: 35 Pages: 643-645
  • Peer Reviewed
• [Journal Article] Cutting-edge information for the management of acute pancreatitis (2010)
  • Author(s): Takada T, Hirata K, Mayumi T, Yoshida M, Sekimoto M, Hirota M, Kimura Y, Takeda K, Isaji S, Wada K, Amano H, Gabata T, et al.
  • Journal Title: J Hepatobiliary Pancreat Sci Volume: 17 Pages: 3-12
  • NAID: 10027661840
  • Peer Reviewed
• [Journal Article] Changes in management of acute pancreatitis before and after the publication of evidence based practice guidelines in 2003 (2010)
  • Author(s): Sekimoto M, Shikata S, Takada T, Hirata K, Yoshida M, Hirota M, Kitamura N, Shirai K, Kimura Y, Wada K, Amano H, Kiriyama S, ArataS, Gabata T, et al.
  • Journal Title: J Hepatobiliary Pancreat Sci Volume: 17 Pages: 17-23
  • NAID: 10027661868
  • Peer Reviewed
• [Journal Article] Fundamental and intensive care of acute pancreatitis (2010)
  • Author(s): Hirota M, Takada T, Kitamura N, Ito T, Hirata K, Yoshida M, Mayumi T, Kataoka K, Takeda K, Sekimoto M, Hirota M, Kimura Y, Wada K, Amano H, Gabata_T, et al.
  • Journal Title: J Hepatobiliary Pancreat Sci Volume: 17 Pages: 45-52
  • NAID: 10027662024
  • Peer Reviewed
• [Journal Article] Detection and characterization of focal liver lesions : a Japanese phase III, multicenter comparison between gadoxetic acid disodium-enhanced magnetic resonance imaging and contrast-enhanced computed tomography predominantly in patients with hepatocellular carcinoma and chronic liver disease (2010)
  • Author(s): Ichikawa T, Sauto K, Gabata T, et al.
  • Journal Title: Invest Radiol 45 Pages: 133-141
  • Peer Reviewed
• [Journal Article] Hepatocarcinogenesis : multistep changes of drainage vessels at CT during arterial portography and hepatic arteriography-radiologic-pathologic correlation. (2009)
  • Author(s): Kitao A, Zen Y, Matsui O, Gabata T, Nakamura Y.
  • Journal Title: Radiology 252 Pages: 605-614
  • Peer Reviewed
• [Journal Article] Enhancement patterns of pancreatic adenocarcinoma on conventional dynamic multi-detector row CT : correlation with angiogenesis and fibrosis. (2009)
  • Author(s): Hattori Y, Gabata T, Matsui O, et al.
  • Journal Title: World J Gastroenterol 15 Pages: 3114-3121
  • NAID: 120007139978
  • Peer Reviewed
• [Journal Article] Hepatocarcinogenesis : multistep changes of drainage vessels at CT during arterial portography and hepatic arteriography--radiologic-pathologic correlation (2009)
  • Author(s): Kitao A, Zen Y, Matsui O, Gabata T, Nakanuma Y
  • Journal Title: Radiology 252 Pages: 605-614
  • Peer Reviewed
• [Journal Article] Radiological and histopathological manifestations of hepatocellular nodular lesions concomitant with various congenital and acquired hepatic hemodynamic abnormalities (2009)
  • Author(s): Kobayashi Y, Matsui O, Gabata T, et al.
  • Journal Title: Jpn J Radiol 27 Pages: 53-68
  • NAID: 50007114076
  • Peer Reviewed
• [Journal Article] IgG4-related lung and pleural disease : a clinicopathologic study of 21 cases (2009)
  • Author(s): Zen Y, Inoue D, Gabata T, et al.
  • Journal Title: Am J Surg Pathol 33 Pages: 1886-1893
  • Peer Reviewed
• [Journal Article] Enhancement patterns of pancreatic adenocarcinoma on conventional dynamic multi-detector row CT : correlation with angiogenesis and fibrosis (2009)
  • Author(s): Hattori Y, Gabata T, Matsui O, et al.
  • Journal Title: World J Gastroenterol 15 Pages: 3114-3121
  • NAID: 120007139978
  • Peer Reviewed
• [Journal Article] Ureteral cancer first recognized by mechanical ileus due to intestinal metastasis (2009)
  • Author(s): Takamatsu S, Gabata T, Kozaka K, et al.
  • Journal Title: Jpn J Radiol 27 Pages: 48-52
  • NAID: 50007134165
  • Peer Reviewed
• [Journal Article] Detection of hypervascular malignant foci in borderline lesions of hepatocellular carcinoma : comparison of dynamic multi-detector row CT, dynamic MR imaging and superparamagnetic iron oxide-enhanced MR imaging. (2008)
  • Author(s): Shinmura E, Matsui O, Kobayashi S, et al.
  • Journal Title: Eur Radiol 18 Pages: 1918-1924
  • Peer Reviewed
• [Journal Article] Optimal imagingof hepatic mass lesions. (2008)
  • Author(s): Matsui O, Gabata T, Kobayashi S.
  • Journal Title: J Gastroenterol Hepatol 23 Pages: 1466-1468
  • Peer Reviewed
• [Journal Article] Optimal imaging of hepatic mass lesions. (2008)
  • Author(s): Matsui O, Gabata T, Kobayashi S.
  • Journal Title: J Gastroenrerol Hapatol 23 Pages: 1466-1468
  • Peer Reviewed
• [Journal Article] Imaging diagnosis of hepatic metastases of pancreatic carcinoinas : significance of transient wedged-shaped contrast enhan cement mimicking arterioportal shunt. (2008)
  • Author(s): Gabata T, et al.
  • Journal Title: Abdominal Imaging 33 Pages: 437-443
  • Peer Reviewed
• [Journal Article] 画像診断の進歩 : どこまで病理診断にせまってきているか, 膵 (2008)
  • Author(s): 蒲田敏文, 他
  • Journal Title: 臨床と病理 26 Pages: 289-296
• [Journal Article] 肝内胆管癌・転移性肝腫瘍のCT診断 (2008)
  • Author(s): 蒲田敏文, 他
  • Journal Title: 消化器科 47 Pages: 181-185
• [Presentation] (2010)
  • Author(s): 蒲田敏文
  • Organizer: 第438回日本医学放射線学会関東地方会定期大会定例講座
  • Place of Presentation: 信州大学医学部附属病院(長野県)
  • Year and Date: 2010-12-11
• [Presentation] 急性膵炎のCT診断 (2010)
  • Author(s): 蒲田敏文
  • Organizer: 第438回日本医学放射線学会関東地方会定期大会定例講座
  • Place of Presentation: 信州大学医学部附属病院(松本市)(招待講演)
  • Year and Date: 2010-12-11
• [Presentation] ワークショップ2重症急性胆道炎の診断とその対策 (2010)
  • Author(s): 蒲田敏文
  • Organizer: 46回日本胆道学会学術集会
  • Place of Presentation: リーガロイヤルホテル広島(広島県)
  • Year and Date: 2010-09-24
• [Presentation] ワークショップ2重症急性胆道炎の診断とその対策 (2010)
  • Author(s): 蒲田敏文
  • Organizer: 第46回日本胆道学会学術集会
  • Place of Presentation: リーガロイヤルホテル広島(広島市)
  • Year and Date: 2010-09-24
• [Presentation] 診断に難渋したGroove膵癌の1例 (2010)
  • Author(s): 蒲田敏文
  • Organizer: 第53回日本消化器画像診断研究会
  • Place of Presentation: 門司港ホテル(福岡県)
  • Year and Date: 2010-09-03
• [Presentation] 胆膵疾患のMRI診断:MRIをやってよかった症例を中心に (2010)
  • Author(s): 蒲田敏文
  • Place of Presentation: 山形国際ホテル(山形県)
  • Year and Date: 2010-07-23
• [Presentation] 肝腫瘍のMRI診断-EOB・プリモビストを中心に- (2010)
  • Author(s): 蒲田敏文
  • Organizer: 日本消化器病学会第110回北陸支部例会,第23回教育講演会
  • Place of Presentation: 福井商工会議所(福井県)
  • Year and Date: 2010-06-06
• [Presentation] 肝腫瘍のMRI診断-EOB・プリモビストを中心に- (2010)
  • Author(s): 蒲田敏文
  • Organizer: 日本消化器病学会第110回北陸支部例会, 第23回教育講演会
  • Place of Presentation: 福井商工会議所(福井市)(招待講演)
  • Year and Date: 2010-06-06
• [Presentation] 慢性膵炎の画像診断:典型例と非典型例から学ぶ (2010)
  • Author(s): 蒲田敏文
  • Organizer: 第69回日本医学放射線学会総会
  • Place of Presentation: パシフィコ横浜(神奈川県)
  • Year and Date: 2010-04-08
• [Presentation] 早期肝細胞癌と高度異型結節との鑑別 : CTAPを推奨する立場から (2009)
  • Author(s): 蒲田敏文
  • Organizer: 第9回関西肝血流動態イメージ研究会
  • Place of Presentation: 大阪オーバルホール (大阪府)
  • Year and Date: 2009-07-11
• [Presentation] 多発AP shunt を呈した膵癌からの顕微鏡的微小肝転移の1例 (2009)
  • Author(s): 蒲田敏文
  • Organizer: 第23回腹部放射線研究会
  • Place of Presentation: 岡山コンベンションセンター (岡山県)
  • Year and Date: 2009-06-19
• [Presentation] MDCTによる膵腫瘍の診断 (2009)
  • Author(s): 蒲田敏文
  • Organizer: 超音波学会パネルディスカッション
  • Place of Presentation: 東京国際フォーラム (東京都)
  • Year and Date: 2009-05-24
• [Presentation] 胆道疾患の画像診断 (2009)
  • Author(s): 蒲田敏文
  • Organizer: 第68回日本医学放射線学会総会
  • Place of Presentation: パシフィコ横浜 (神奈川県)
  • Year and Date: 2009-04-16
• [Presentation] Imaging diagnos is of pancreatic careinoma (2008)
  • Author(s): Gabata T, et al.
  • Organizer: 12th Asian Ocean Congress of Radiology(AOCR 2008)
  • Place of Presentation: Seoul, Korea
  • Year and Date: 2008-10-27