Contrast enhancement of pancreatic carcinoma on dynamic CT : correlation between expression of VEGF and histopathological features
| Project/Area Number |
20591436
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Radiation science
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| Research Institution | Kanazawa University |
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Principal Investigator |
GABATA Toshifumi Kanazawa University, 医学系, 准教授 (00169806)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2010: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2009: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2008: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | エックス線 / CT / 膵管癌 / 膵腺管癌 / ダイナミックCT / VEGF / MVD / 膵癌腫瘍内線維化 |
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| Research Abstract |
To evaluate retrospectively the correlation between enhancement patterns on dynamic computed tomography (CT) and angiogenesis and fibrosis in pancreatic adenocarcinoma. The tumors with greater MVD and higher expression of VEGF tended to show high enhancement in the arterial dominant phase. On the other hand, the tumors with a larger amount of fibrosis showed a negative correlation with the grade of enhancement during the arterial phase. In conclusion, enhancement patterns on dynamic CT correlated with angiogenesis and may be modified by the extent of fibrosis.
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Report
(4 results)
Research Products
(41 results)
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[Journal Article] Cutting-edge information for the management of acute pancreatitis2010
Author(s)
Takada T, Hirata K, Mayumi T, Yoshida M, Sekimoto M, Hirota M, Kimura Y, Takeda K, Isaji S, Wada K, Amano H, Gabata T, et al.
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Journal Title
J Hepatobiliary Pancreat Sci
Volume: 17
Pages: 3-12
NAID
Related Report
Peer Reviewed
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[Journal Article] Changes in management of acute pancreatitis before and after the publication of evidence based practice guidelines in 20032010
Author(s)
Sekimoto M, Shikata S, Takada T, Hirata K, Yoshida M, Hirota M, Kitamura N, Shirai K, Kimura Y, Wada K, Amano H, Kiriyama S, ArataS, Gabata T, et al.
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Journal Title
J Hepatobiliary Pancreat Sci
Volume: 17
Pages: 17-23
NAID
Related Report
Peer Reviewed
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[Journal Article] Fundamental and intensive care of acute pancreatitis2010
Author(s)
Hirota M, Takada T, Kitamura N, Ito T, Hirata K, Yoshida M, Mayumi T, Kataoka K, Takeda K, Sekimoto M, Hirota M, Kimura Y, Wada K, Amano H, Gabata_T, et al.
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Journal Title
J Hepatobiliary Pancreat Sci
Volume: 17
Pages: 45-52
NAID
Related Report
Peer Reviewed
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[Presentation] 胆道疾患の画像診断2009
Author(s)
蒲田敏文
Organizer
第68回日本医学放射線学会総会
Place of Presentation
パシフィコ横浜 (神奈川県)
Year and Date
2009-04-16
Related Report
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