Interstitial pathological change and its imaging in myocardial ischemia and remodeling

• Project/Area Number: 20591437
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Radiation science
• Research Institution: Kanazawa University
• Principal Investigator: TAKI Junichi Kanazawa University, 附属病院, 講師 (10251927)
• Co-Investigator(Kenkyū-buntansha): SIBA Kazuhiro 金沢大学, 学際科学実験センター, 教授 (40143929) ; OGAWA Kazuma 金沢大学, 薬学系, 准教授 (30347471)
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2008: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: tenascin-C / matricellular蛋白 / リモデリング / 心筋梗塞 / 虚血 / 再還流 / Tenascin C / I-125-anti-Tenascin C antibody / matricellular protein / reperfusion / myocardial ischemia / myocardial infarction / remodeling

Research Abstract

Tenascin-C(TNC) expression was examined by autoradiography using I-125-anti-TNC-Ab (I-TNC) in a rat model of myocardial ischemia and reperfusion. I-TNC accumulation was observed in the ischemic area and its accumulation was peaked at day 3 and decreased at day 7-14 and only faint uptake was observed at day 28. Postconditioning mildly suppressed TNC expression at day 3-7 but significantly at day 14.

Research Products

• [Journal Article] Dynamic expression of tenascin-c after myocardial ischemia and reperfusion : Assessment by 125I-anti-tenascin-c antibody imaging. (2010)
  • Author(s): Taki, J., Inaki, A., Wakabayashi, H., Imanaka-Yoshida, K., Ogawa, K., Hiroe, M., Shiba, K., Yoshida, T., Kinuya, S.
  • Journal Title: J Nucl Med 51 Pages: 1116-1122
  • Peer Reviewed
• [Journal Article] Potential utility of 99mTc-annexin V imaging in ischemically damaged myocardium. (2010)
  • Author(s): Taki, J., Matsunari, I., Wakabayashi, H., Inaki, A., Kinuya, S.
  • Journal Title: Intv Cariol 2 Pages: 765-767
  • Peer Reviewed
• [Journal Article] Dynamic expression of tenascin-c after myocardial ischemia an dreperfusion : Assessment by 125i-anti-tenascin-c antibody imaging (2010)
  • Author(s): Taki J, Inaki A, Wakabayashi H, Imanaka-Yoshida K, Ogawa K, Hiroe M, Shiba K, Yoshida T, Kinuya S
  • Journal Title: J Nucl Med Volume: 51 Pages: 1116-1122
  • Peer Reviewed
• [Journal Article] Iodine-123 metaiodobenzylguanidine imaging and carbon-11 hydroxyephed rine positron emission tomography compared in patients with left ventricular dysfunction (2010)
  • Author(s): Matsunari, I., Aoki, H., Nomura, Y., Takeda, N., Chen, W.P., Taki, J, Nakajima, K, Nekolla, S.G Kinuya, S., Kajinami, K.
  • Journal Title: Circ Cardiovasc Imaging Volume: 3 Pages: 593-603
  • Peer Reviewed
• [Journal Article] ^<123>I-metaiodobenzylguanidine imaging in the era of implantable cardioverter defibrillators : Beyond ejection fraction (2010)
  • Author(s): Matsunari I, Taki J, Nakajima K, Kinuya S
  • Journal Title: J Nucl Med Volume: 51 Pages: 1171-1173
  • Peer Reviewed
• [Journal Article] Potential utility of 99mTc-annexin V imaging in ischemically damaged myocardium (2010)
  • Author(s): Taki J, Matsunari I, Wakabayashi H, Inaki A, Kinuya S
  • Journal Title: Intv Cardiol Volume: 2 Pages: 765-767
  • Peer Reviewed
• [Journal Article] 心臓核医学の基礎と臨床 基礎編 (2010)
  • Author(s): 滝淳一
  • Journal Title: 臨床放射線 45 Pages: 53-65
• [Journal Article] 心臓の画像診断10年の軌跡 核医学 (SPECT) のアプローチ (2009)
  • Author(s): 滝淳一
  • Journal Title: Digital Medicine No42 Pages: 30-32
• [Presentation] ラット心筋虚血再還流モデルにおけるTenascin-Cイメージング:I-125一抗Tenascin C抗体の体内分布の検討 (2010)
  • Author(s): 滝淳一、若林大志、稲木杏吏、小川数馬、柴和弘、今中恭子、廣江道昭、松成一朗、中嶋憲一、松尾信郎、絹谷清剛
  • Organizer: 第50回日本核医学会総会
  • Place of Presentation: 大宮ソニックシティ(大宮)
  • Year and Date: 2010-11-12
• [Presentation] 悪性骨軟部腫瘍患者における99mTc-MIBI心筋SPECTを用いたドキソルビシン心毒性の評価 (2010)
  • Author(s): 若林大志、滝淳一、稲木杏吏、隅屋寿、土屋弘行、絹谷清剛
  • Organizer: 第50回日本核医学会総会
  • Place of Presentation: 大宮ソニックシティ(大宮)
  • Year and Date: 2010-11-12
• [Presentation] ラット心筋虚血再還流モデルにおけるTenascin-Cイメージング:1-125一抗Tenascin C抗体の体内分布の検討 (2010)
  • Author(s): 滝淳一、若林大志、稲木杏吏、小川数馬、柴和弘、今中恭子、廣江道昭、松成一朗、中嶋憲一、松尾信郎、絹谷清剛
  • Organizer: 第50回日本核医学会総会
  • Place of Presentation: 大宮ソニックシティ(大宮)
  • Year and Date: 2010-11-12
• [Presentation] Detection of ischemia and apoptosis in the diseased myocardium. (2010)
  • Author(s): Taki, J.
  • Organizer: World Molecular Imaging Congress 2010.
  • Place of Presentation: Kyoto International Conference Center (Kyoto)
  • Year and Date: 2010-09-08
• [Presentation] Detection of ischemia and apoptosis in the diseased myocardium (2010)
  • Author(s): Junichi Taki
  • Organizer: World Molecular lmaging Congess 2010
  • Place of Presentation: Kyoto International ConferenceCenter(Kyoto)(招待講演)
  • Year and Date: 2010-09-08
• [Presentation] Temporal change of Tnascin-C expression in a rat model of moderate and severe ischemia : Assessment by I-125-anti tenascin-C antibody imaging. (2010)
  • Author(s): Taki, J., Wakabayashi, H., Inaki, A., Imanaka-Yoshida, K., Ogawa, K., Shiba, K., Hiroe, M., Nakajima, K., Matsuo, S., Kinuya, S.
  • Organizer: 57th Annual Meeting of the Society of Nuclear Medicine.
  • Place of Presentation: Salt Place Convention Center (USA)
  • Year and Date: 2010-06-08
• [Presentation] Assessment of doxorubicin cardiac toxicity using 99mTc-MIBI myoacardial gated SPECT in patients with malignant bone and soft tissue sarcoma (2010)
  • Author(s): Wakabayashi H, Taki J, Inaki A, Sumiya H, Tsuchiya H, Kinuya S
  • Organizer: 57th Annual Meeting of the Society of Nuclear Medicine
  • Place of Presentation: Salt Place ConventionCenter(Salt Lake City)
  • Year and Date: 2010-06-08
• [Presentation] Temporal change of Tnascin-C expression in a rat model of moderate andsevere ischemia : Assessment by I-125-anti tenascin-C antibody imaging (2010)
  • Author(s): Taki J, Wakabayashi H, Inaki A, Imanaka-Yoshida K, Ogawa K, Shiba K, Hiroe M, Nakajima K, Matsuo S, Kinuya S
  • Organizer: 57th Annual Meeting of the Society of Nuclear Medicine
  • Place of Presentation: Salt Place ConventionCenter(Salt Lake City)
  • Year and Date: 2010-06-07
• [Presentation] Dynamic change of Tc-99m Annexin V uptake after myocardial ischemia and reperfusion, and its relation to inflammatory cell infiltration (2010)
  • Author(s): Junichi Taki, Takahiro Higuchi, Atsuhiro Kawashima, Hiroshi Wakabayashi, Anri Inaki, Ichiro Matsunari, Seigo Kinuya
  • Organizer: 20th International Society for Heart Research
  • Place of Presentation: Kyoto International ConferenceCenter(Kyoto)
  • Year and Date: 2010-05-16
• [Presentation] Tenascin-C expression in a rat model of variable ischemic severity and reperfusion time : Assessment by I-125-anti tenascin-C antibody imaging (2010)
  • Author(s): Junichi Taki, Kyoko Imanaka-Yoshida, Michiaki Hiroe, Masaya Kawano, Shinro Matsuo, Kenichi Nakajima, Ichiro Matsunari
  • Organizer: The 74th Annual Scientific Meeting of the Japanese Circulation Society
  • Place of Presentation: 京都国際会館 (Kyoto)
  • Year and Date: 2010-03-07
• [Presentation] I-125-抗 Tenascin C抗体イメージングによるラット心筋虚血再還流モデルにおける Tenascin C発現の検討 (2009)
  • Author(s): 滝淳一, 稲木杏吏, 若林大志, 小川数馬, 柴和弘, 今中恭子, 廣江道昭, 松成一朗, 中嶋憲一, 松尾信郎, 絹谷清剛
  • Organizer: 第49回日本核医学学術総会
  • Place of Presentation: 旭川市文化会館・旭川グランドホテル (旭川)
  • Year and Date: 2009-10-02
• [Presentation] Temporal assessment of Tnascin-C expression in a rat model of myocardial ischemia and reperfusion. (2009)
  • Author(s): Taki, J., Inaki, A., Wakabayashi, H., Ogawa, K., Shiba, K., Hiroe, M., Imanaka-Yoshida, K., Kayano, D., Nakajima, K., Kinuya, S.
  • Organizer: 56th Annual Meeting of the Society of Nuclear Medicine.
  • Place of Presentation: Toronto Convention Center (Canada)
  • Year and Date: 2009-06-15
• [Presentation] Temporal assessment of Tnascin-C expression in a rat model of myocardial ischemia and reperfusion (2009)
  • Author(s): Taki J, Inaki A, Wakabayashi H, Ogawa K, Shiba K, Hiroe M, Imanaka-Yoshida K, Kayano D, Nakajima K, Kinuya S.
  • Organizer: 56th Annual Meeting of the Society of Nuclear Medicine
  • Place of Presentation: Toronto Convention Center (Toronto)
  • Year and Date: 2009-06-15
• [Presentation] 心臓核医学の基礎と臨床 : 基礎編 (2009)
  • Author(s): 滝淳一
  • Organizer: 第68回日本医学放射線学会総会
  • Place of Presentation: パシフィコ横浜 (横浜)
  • Year and Date: 2009-04-17
• [Presentation] Temporal assessment of Tenascin-C expression after myocardial ischemia and reperfusion using I-125-anti Tenascin-C antibody (2009)
  • Author(s): Taki J, Wakabayashi H, Imanaka-Yoshida K, Jiroe M, Kawano M, Higuchi T, Matsuo S, Nakajima K, Matsunari I
  • Organizer: The 73rd annual scientific meeting of the Japanese Circulation Society
  • Place of Presentation: Osaka
  • Year and Date: 2009-03-20
• [Presentation] ラット心筋虚血再還流モデルにおけるTenascin C発現の鶏時的変化 : I-125-抗Tenascin C抗体による検討 (2008)
  • Author(s): 滝淳一, 稲木杏吏, 若林大志, 福岡誠, 萱野大樹, 小川数馬, 柴和弘, 廣江道昭, 今中恭子, 中嶋憲一, 絹谷清剛
  • Organizer: 第48回日本核医学学術総会
  • Place of Presentation: 千葉市、幕張メッセ
  • Year and Date: 2008-10-25
• [Book] 臨床医とコメディカルのための最新クリニカルPET (2010)
  • Author(s): 滝淳一
  • Publisher: 先端医療技術研究所
• [Book] 臨床医とコメディカルのための最新クリニカルPET (2010)
  • Author(s): 滝淳一(分担執筆)
  • Total Pages: 427
  • Publisher: 先端医療技術研究所