Correlation between neuromelanin cell density and MR signal intensity : evaluation by autoasied brains and 3 tesla MR imaging

• Project/Area Number: 20591444
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Radiation science
• Research Institution: Tottori University
• Principal Investigator: OGAWA Toshihide Tottori University, 医学部, 教授 (00125709)
• Co-Investigator(Kenkyū-buntansha): MATSUSUE Eiji 鳥取大学, 医学部附属病院, 講師 (30325013) ; FUJII Shinya 鳥取大学, 医学部附属病院, 講師 (10379638)
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2008: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
• Keywords: 神経科学 / 脳神経疾患 / 神経メラニン / 3T MRI / パーキンソン病 / 3TMRI

Research Abstract

To clarify the histopathological background of neuromelanin imaging (NMI), we performed NMI-pathologic correlations of autopsied btrains. We also evaluated cerebral blood flow using single photon emission CT with 99mTc-ECD in patients undertaken NMI. NMI well reflected amount of neuromelanin-containing neurons of the substantia nigra of the midbrain. Patients with decreased signal intensity in NMI showed significantly lower regional cerebral blood flow in the precuneus, cuneus, and posterior part of the cingulate gyrus.

Research Products

• [Journal Article] Demonstration of cerebral venous variations in the region of the third ventricle on phase-sensitive imaging (2010)
  • Author(s): Fujii S, Ogawa T, et al.
  • Journal Title: AJNR Am J Neuroradiol 31 Pages: 55-59
• [Journal Article] The ability to identify the intraparotid facial nerve for locating parotid gland lesions in comparison to other indirect landmark methods : evaluation by 3.0 TMR (2010)
  • Author(s): Ishibashi M, Ogawa T, et al.
  • Journal Title: imaging with surface coils Neuroradiology 52 Pages: 1037-1045
• [Journal Article] Demonstration of cerebral venous variations in the region of the third ventricle on phase-sensitive imaging (2010)
  • Author(s): Fujii S, Ogawa T, et al.
  • Journal Title: AJNR Am J Neuroradiol Volume: 31 Pages: 55-59
  • Peer Reviewed
• [Journal Article] The ability to identify the intraparotid facial nerve for locating parotid gland lesions in comparison to other indirect landmark methods : evaluation by 3.0 T MR imaging with surface coils (2010)
  • Author(s): Ishibashi M, Fujii S, Ogawa T, et al.
  • Journal Title: Neuroradiology Volume: 52 Pages: 1037-1045
  • Peer Reviewed
• [Journal Article] Cerebellar lesions in multiple system atrophy : postmortem MR (2009)
  • Author(s): 松末英司, 藤井進也, et al.
  • Journal Title: image-pathologic correlations AJNR Am J Neuroradiol 30 Pages: 1725-1730
• [Journal Article] 脳変性疾患の3TMRI (2009)
  • Author(s): 藤井進也、松末英司, 他
  • Journal Title: 臨放 54 Pages: 238-245
• [Journal Article] Cerebellar lesions in multiple system atrophy : postmortem MR image-pathologic correlations (2009)
  • Author(s): Matsusue E, Fujii S, et al.
  • Journal Title: AJNR Am・J Neuroradiol 30 Pages: 1725-1730
  • Peer Reviewed
• [Journal Article] 脳変性疾患の3T MRI (2009)
  • Author(s): 藤井進也, 松末英司, 他
  • Journal Title: 臨床放射線 54 Pages: 238-245
  • Peer Reviewed
• [Journal Article] MRIで何がどこまでわかるか-2008年の現状- (2008)
  • Author(s): 藤井進也、松末英司, 他
  • Journal Title: 臨床画像 24 Pages: 1408-1416
• [Journal Article] MRIでなにがどこまでわかるか-2008年の現状- (2008)
  • Author(s): 藤井進也, 松末英司, 小川敏英, 他
  • Journal Title: 臨床画像 24 Pages: 1408-1416
• [Journal Article] 脳変性疾患の3T MRI (2008)
  • Author(s): 藤井進也, 松末英司, 小川敏英, 他
  • Journal Title: 臨床放射線 54 Pages: 238-245
• [Presentation] 剖検脳を用いた神経メラニンイメージングの病理学的背景の検討 (2011)
  • Author(s): 北尾慎一郎, 小川敏英, 他
  • Organizer: 第40回日本神経放射線学会
  • Place of Presentation: 東京コンファレンスセンター・品川(東京)
  • Year and Date: 2011-02-26
• [Presentation] パーキンソン病における^<123>I-MIBG心筋シンチグラフィとMRIによる神経メラニンイメージングの対比検討 (2010)
  • Author(s): 藤井進也、小川敏英, 他
  • Organizer: 第50回日本核医学会学術総会
  • Place of Presentation: ソニックシティ大宮(埼玉)
  • Year and Date: 2010-11-12
• [Presentation] 3T MRI装置を用いた脳微細構造の描出-変性疾患を中心に- (2010)
  • Author(s): 松末英司
  • Organizer: 第39回日本神経放射線学会
  • Place of Presentation: 学術総合センター(東京)
  • Year and Date: 2010-02-13
• [Presentation] ADC値による多系統萎縮症、進行性核上性麻痺、パーキンソン病の判別 (2010)
  • Author(s): 塚本和充、松末英司, 他
  • Organizer: 第39回日本神経放射線学会
  • Place of Presentation: 学術総合センター(東京)
  • Year and Date: 2010-02-13
• [Presentation] 3T MRI装置を用いた脳微細構造の描出-変性疾患を中心に- (2010)
  • Author(s): 松末英司
  • Organizer: 第39回日本神経放射線学会
  • Place of Presentation: 学術総合センター
  • Year and Date: 2010-02-13
• [Presentation] ADC値による多系統萎縮症、進行性核上性麻痺、パーキンソン病の判別 (2010)
  • Author(s): 塚本和充、松末英司, 他
  • Organizer: 第39回日本神経放射線学会
  • Place of Presentation: 学術総合センター
  • Year and Date: 2010-02-13
• [Presentation] 3T MRIの現状と展望:脳変性疾患の3T MRI (2008)
  • Author(s): 藤井進也
  • Organizer: 第67回日本医学放射線学会総会
  • Place of Presentation: パシフィコ横浜(横浜)
  • Year and Date: 2008-04-04
• [Presentation] 3T MRIの現状と展望 : 脳変性疾患の3T MRI (2008)
  • Author(s): 藤井進也
  • Organizer: 第67回日本医学放射線学会総会
  • Place of Presentation: パシフィコ横浜
  • Year and Date: 2008-04-04
• [Remarks] ホームページ等