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Correlation between neuromelanin cell density and MR signal intensity : evaluation by autoasied brains and 3 tesla MR imaging

Research Project

Project/Area Number 20591444
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Radiation science
Research InstitutionTottori University

Principal Investigator

OGAWA Toshihide  Tottori University, 医学部, 教授 (00125709)

Co-Investigator(Kenkyū-buntansha) MATSUSUE Eiji  鳥取大学, 医学部附属病院, 講師 (30325013)
FUJII Shinya  鳥取大学, 医学部附属病院, 講師 (10379638)
Project Period (FY) 2008 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2008: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords神経科学 / 脳神経疾患 / 神経メラニン / 3T MRI / パーキンソン病 / 3TMRI
Research Abstract

To clarify the histopathological background of neuromelanin imaging (NMI), we performed NMI-pathologic correlations of autopsied btrains. We also evaluated cerebral blood flow using single photon emission CT with 99mTc-ECD in patients undertaken NMI. NMI well reflected amount of neuromelanin-containing neurons of the substantia nigra of the midbrain. Patients with decreased signal intensity in NMI showed significantly lower regional cerebral blood flow in the precuneus, cuneus, and posterior part of the cingulate gyrus.

Report

(4 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (20 results)

All 2011 2010 2009 2008 Other

All Journal Article (11 results) (of which Peer Reviewed: 4 results) Presentation (8 results) Remarks (1 results)

  • [Journal Article] Demonstration of cerebral venous variations in the region of the third ventricle on phase-sensitive imaging2010

    • Author(s)
      Fujii S, Ogawa T, et al.
    • Journal Title

      AJNR Am J Neuroradiol 31

      Pages: 55-59

    • Related Report
      2010 Final Research Report
  • [Journal Article] The ability to identify the intraparotid facial nerve for locating parotid gland lesions in comparison to other indirect landmark methods : evaluation by 3.0 TMR2010

    • Author(s)
      Ishibashi M, Ogawa T, et al.
    • Journal Title

      imaging with surface coils Neuroradiology 52

      Pages: 1037-1045

    • Related Report
      2010 Final Research Report
  • [Journal Article] Demonstration of cerebral venous variations in the region of the third ventricle on phase-sensitive imaging2010

    • Author(s)
      Fujii S, Ogawa T, et al.
    • Journal Title

      AJNR Am J Neuroradiol

      Volume: 31 Pages: 55-59

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The ability to identify the intraparotid facial nerve for locating parotid gland lesions in comparison to other indirect landmark methods : evaluation by 3.0 T MR imaging with surface coils2010

    • Author(s)
      Ishibashi M, Fujii S, Ogawa T, et al.
    • Journal Title

      Neuroradiology

      Volume: 52 Pages: 1037-1045

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cerebellar lesions in multiple system atrophy : postmortem MR2009

    • Author(s)
      松末英司, 藤井進也, et al.
    • Journal Title

      image-pathologic correlations AJNR Am J Neuroradiol 30

      Pages: 1725-1730

    • Related Report
      2010 Final Research Report
  • [Journal Article] 脳変性疾患の3TMRI2009

    • Author(s)
      藤井進也、松末英司, 他
    • Journal Title

      臨放 54

      Pages: 238-245

    • Related Report
      2010 Final Research Report
  • [Journal Article] Cerebellar lesions in multiple system atrophy : postmortem MR image-pathologic correlations2009

    • Author(s)
      Matsusue E, Fujii S, et al.
    • Journal Title

      AJNR Am・J Neuroradiol 30

      Pages: 1725-1730

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 脳変性疾患の3T MRI2009

    • Author(s)
      藤井進也, 松末英司, 他
    • Journal Title

      臨床放射線 54

      Pages: 238-245

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] MRIで何がどこまでわかるか-2008年の現状-2008

    • Author(s)
      藤井進也、松末英司, 他
    • Journal Title

      臨床画像 24

      Pages: 1408-1416

    • Related Report
      2010 Final Research Report
  • [Journal Article] MRIでなにがどこまでわかるか-2008年の現状-2008

    • Author(s)
      藤井進也, 松末英司, 小川敏英, 他
    • Journal Title

      臨床画像 24

      Pages: 1408-1416

    • Related Report
      2008 Annual Research Report
  • [Journal Article] 脳変性疾患の3T MRI2008

    • Author(s)
      藤井進也, 松末英司, 小川敏英, 他
    • Journal Title

      臨床放射線 54

      Pages: 238-245

    • Related Report
      2008 Annual Research Report
  • [Presentation] 剖検脳を用いた神経メラニンイメージングの病理学的背景の検討2011

    • Author(s)
      北尾慎一郎, 小川敏英, 他
    • Organizer
      第40回日本神経放射線学会
    • Place of Presentation
      東京コンファレンスセンター・品川(東京)
    • Year and Date
      2011-02-26
    • Related Report
      2010 Annual Research Report 2010 Final Research Report
  • [Presentation] パーキンソン病における^<123>I-MIBG心筋シンチグラフィとMRIによる神経メラニンイメージングの対比検討2010

    • Author(s)
      藤井進也、小川敏英, 他
    • Organizer
      第50回日本核医学会学術総会
    • Place of Presentation
      ソニックシティ大宮(埼玉)
    • Year and Date
      2010-11-12
    • Related Report
      2010 Annual Research Report 2010 Final Research Report
  • [Presentation] 3T MRI装置を用いた脳微細構造の描出-変性疾患を中心に-2010

    • Author(s)
      松末英司
    • Organizer
      第39回日本神経放射線学会
    • Place of Presentation
      学術総合センター(東京)
    • Year and Date
      2010-02-13
    • Related Report
      2010 Final Research Report
  • [Presentation] ADC値による多系統萎縮症、進行性核上性麻痺、パーキンソン病の判別2010

    • Author(s)
      塚本和充、松末英司, 他
    • Organizer
      第39回日本神経放射線学会
    • Place of Presentation
      学術総合センター(東京)
    • Year and Date
      2010-02-13
    • Related Report
      2010 Final Research Report
  • [Presentation] 3T MRI装置を用いた脳微細構造の描出-変性疾患を中心に-2010

    • Author(s)
      松末英司
    • Organizer
      第39回日本神経放射線学会
    • Place of Presentation
      学術総合センター
    • Year and Date
      2010-02-13
    • Related Report
      2009 Annual Research Report
  • [Presentation] ADC値による多系統萎縮症、進行性核上性麻痺、パーキンソン病の判別2010

    • Author(s)
      塚本和充、松末英司, 他
    • Organizer
      第39回日本神経放射線学会
    • Place of Presentation
      学術総合センター
    • Year and Date
      2010-02-13
    • Related Report
      2009 Annual Research Report
  • [Presentation] 3T MRIの現状と展望:脳変性疾患の3T MRI2008

    • Author(s)
      藤井進也
    • Organizer
      第67回日本医学放射線学会総会
    • Place of Presentation
      パシフィコ横浜(横浜)
    • Year and Date
      2008-04-04
    • Related Report
      2010 Final Research Report
  • [Presentation] 3T MRIの現状と展望 : 脳変性疾患の3T MRI2008

    • Author(s)
      藤井進也
    • Organizer
      第67回日本医学放射線学会総会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2008-04-04
    • Related Report
      2008 Annual Research Report
  • [Remarks] ホームページ等

    • Related Report
      2010 Final Research Report

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Published: 2008-04-01   Modified: 2016-04-21  

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