Correlation between neuromelanin cell density and MR signal intensity : evaluation by autoasied brains and 3 tesla MR imaging
| Project/Area Number |
20591444
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Radiation science
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| Research Institution | Tottori University |
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Principal Investigator |
OGAWA Toshihide Tottori University, 医学部, 教授 (00125709)
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| Co-Investigator(Kenkyū-buntansha) |
MATSUSUE Eiji 鳥取大学, 医学部附属病院, 講師 (30325013)
FUJII Shinya 鳥取大学, 医学部附属病院, 講師 (10379638)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2008: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 神経科学 / 脳神経疾患 / 神経メラニン / 3T MRI / パーキンソン病 / 3TMRI |
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| Research Abstract |
To clarify the histopathological background of neuromelanin imaging (NMI), we performed NMI-pathologic correlations of autopsied btrains. We also evaluated cerebral blood flow using single photon emission CT with 99mTc-ECD in patients undertaken NMI. NMI well reflected amount of neuromelanin-containing neurons of the substantia nigra of the midbrain. Patients with decreased signal intensity in NMI showed significantly lower regional cerebral blood flow in the precuneus, cuneus, and posterior part of the cingulate gyrus.
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Report
(4 results)
Research Products
(20 results)
