Analysis of articular cartilage in rheumatoid arthritis by 3-Tesla MRI

• Project/Area Number: 20591448
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Radiation science
• Research Institution: Nagasaki University
• Principal Investigator: UETANI Masataka Nagasaki University, 大学院・医歯薬学総合研究科, 教授 (40176582)
• Co-Investigator(Kenkyū-buntansha): YAMAGUCHI Tetsuji 長崎大学, 病院, 助教 (30380893) ; KAWAKAMI Atsushi 長崎大学, 大学院・医歯薬学総合研究科, 教授 (90325639)
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2010: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2009: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2008: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
• Keywords: 3テスラMRI / 関節軟骨 / T2 / 関節リウマチ / 変形性関節症 / 3T MRI / T2値 / 膝関節 / 変形性関症 / 軟骨下骨 / 骨梁構造

Research Abstract

We evaluated the MR imaging technique and analyzing methods of articular cartilage of the knee. T2 values of the cartilage are different in parts of the joint without any morphological abnormalities. The cartilage damage is more frequent and T2 values are also higher in the medial compartment than other compartments of the asymptomatic knee. This variation should be considered in analyzing the cartilage damage in rheumatoid arthritis and T2 ratio is useful to analyze the cartilage in different parts of the knee.

Research Products

• [Journal Article] In vivo structural analysis of subchondral trabecular bone in osteoarthritis of the hip using multi-detector row CT. (2011)
  • Author(s): Chiba K, Ito M, Osaki M, Uetani M, Shindo H
  • Journal Title: Osteoarthritis Cartilage 19 Pages: 180-185
  • NAID: 120006984854
  • Peer Reviewed
• [Journal Article] In vivo structural analysis of subchondral trabecular bone in osteoarthritis of the hip using multidetector row CT. (2011)
  • Author(s): Chiba K, M, Ito M, Osaki M, Uetani M, Shindo H
  • Journal Title: Osteoarthritis Cartilage Volume: 19 Pages: 180-185
  • NAID: 120006984854
  • Peer Reviewed
• [Journal Article] Oseteoporotic change of subchondral trabecular bone in osteoarthritis of the knee : a 3-T MRI study (2011)
  • Author(s): Chiba K, Uetani M, Kido Y, Ito M, Okazaki N, Taguchi K, Shindo H
  • Journal Title: Osteoporosis Int Volume: (掲載確定,web閲覧可能)
  • Peer Reviewed
• [Journal Article] Age-related changes in bone density, geometry and biomechanical properties of the proximal femur : CT-based 3D hip structure analysis in normal posture nopausal women. (2011)
  • Author(s): Ito M, Nakata T, Nishida A, Uetani M
  • Journal Title: Bone Volume: (掲載確定,web閲覧可能)
  • Peer Reviewed
• [Journal Article] Comparative study of the detection of joint injury in early-stage rheumatoid arthritis by MRI of wrist and finger joints and physical examination. (2010)
  • Author(s): Tamai M, Kawakami A, Iwamoto N, Kawashiri SY, Fujikawa K, Aramaki T, Kita J, Okada A, Koga T, Arima K, Kamachi M, Yamasaki S, Nakamura H, Ida H, Origuchi T, Aoyagi K, Uetani M, Eguchi K
  • Journal Title: Arthritis Care Res 36 Pages: 1126-1129
  • Peer Reviewed
• [Journal Article] Comparative study of the detection of joint injury in early-stage rheumatoid arthritis by MRI of wrist and finger joints and physical examination. (2010)
  • Author(s): Tamai M, Kawakami A, Iwamoto N, et al.
  • Journal Title: Arthritis Care Res Volume: (掲載確定,web閲覧可能)
  • Peer Reviewed
• [Journal Article] High serum cartilage oligomeric matrix protein determines the subset of patients with early-stage rheumatoid arthritis with high serum C-reactive protein, matrix metalloproteinase-3, and MRI-proven bone erosion. (2009)
  • Author(s): Fujikawa K, Kawakami A, Tamai M, Uetani M, Takao S, Arima K, Iwamoto N, Aramaki T, Kawashiri S, Ichinose K, Kamachi M, Nakamura H, Origuchi T, Ida H, Aoyagi K, Eguchi K
  • Journal Title: J Rheumatol 36 Pages: 1126-1129
  • Peer Reviewed
• [Journal Article] A prediction rule for disease outcome in patients with undifferentiated arthritis using magnetic resonance imaging of the wrists and finger joints and serologic autoantibodies. (2009)
  • Author(s): Tamai M, Kawakami A, Uetani M, Takao S, Arima K, Iwamoto N, Fujikawa K, Aramaki T, Kawashiri SY, Ichinose K, Kamachi M, Nakamura H, Origuchi T, Ida H, Aoyagi K, Eguchi K
  • Journal Title: Arthritis Rheum 61 Pages: 772-778
  • Peer Reviewed
• [Journal Article] 目でみるシリーズMRIによる関節リウマチの評価 (2009)
  • Author(s): 上谷雅孝
  • Journal Title: Frontiers in Rheumatology & Clinical Immunology 3 Pages: 120-125
  • NAID: 40016809557
• [Journal Article] 【早期リウマチ】早期関節リウマチのMRI診断 (2009)
  • Author(s): 上谷雅孝, 川上純, 玉井慎美, 江口勝美
  • Journal Title: 整形・災害外科 52 Pages: 1169-1177
• [Journal Article] High serum cartilage oligomeric matrix protein determines the subset of patients with early-stage rheumatoid arthritis with high serum C-reactive protein, matrix metalloproteinase-3, and MRI-proven bone erosion. (2009)
  • Author(s): Fujikawa K, Kawakami A, Tamai M, et al.
  • Journal Title: J Rheumatol 36 Pages: 1126-1129
  • Peer Reviewed
• [Journal Article] A prediction rule for disease outcome in patients with undifferentiated arthritis using magnetic resonance imaging of the wrists and finger joints and serologic autoantibodies. (2009)
  • Author(s): Tamai M, Kawakami A, Uetani M, et al.
  • Journal Title: Arthritis Rheum 61 Pages: 772-778
  • Peer Reviewed
• [Journal Article] 【早期リウマチ】早期関節リウマチのMRI診断. (2009)
  • Author(s): 上谷雅孝, 他
  • Journal Title: 整形・災害外科 52 Pages: 1169-1177
• [Journal Article] 目でみるシリーズ MRIによる関節リウマチの評価 (2009)
  • Author(s): 上谷雅孝
  • Journal Title: 整形・災害外科 52 Pages: 1169-1177
  • NAID: 40016809557
• [Journal Article] 【一般医に必要なリウマチ診療の知識】関節リウマチの診療のために 画像診断 (2008)
  • Author(s): 江口勝美, 宇佐俊郎, 上谷雅孝
  • Journal Title: 綜合臨床 57 Pages: 2846-2854
• [Journal Article] 【骨関節画像診断の最前線MSKを識る】骨関節組織のMR imaging関節炎のMRI関節リウマチを中心に (2008)
  • Author(s): 上谷雅孝
  • Journal Title: 臨床画像 24 Pages: 1336-1345
• [Journal Article] 【整形外科疾患に対する最新画像診断】MRI MRIを用いた関節リウマチの早期診断予測 (2008)
  • Author(s): 江口勝美, 上谷雅孝
  • Journal Title: 関節外科 2710月増刊 Pages: 82-95
• [Journal Article] 【MRIエッセンシャル おさえておきたいポイント】スポーツ外傷と障害 (2008)
  • Author(s): 上谷雅孝
  • Journal Title: 日本医師会雑誌 137 Pages: 1003-1008
• [Journal Article] 【整形外科疾患に対する最新画像診断】MRI MRIを用いた関節リウマチの早期診断予測. (2008)
  • Author(s): 江口勝美, 上谷雅孝
  • Journal Title: 関節外科 27 Pages: 82-95
• [Journal Article] 【骨関節画像診断の最前線 MSKを識る】骨関節組織のMR imaging関節炎のMRI 関節リウマチを中心に. (2008)
  • Author(s): 上谷雅孝, 川上純, 玉井慎美, 江口勝美
  • Journal Title: 臨床画像 24 Pages: 1336-1345
• [Journal Article] 【MRIエッセンシャル おさえておきたいポイント】スポーツ外傷と障害. (2008)
  • Author(s): 上谷雅孝
  • Journal Title: 日本医師会雑誌 137 Pages: 1003-1008
• [Journal Article] 【一般医に必要なリウマチ診療の知識】関節リウマチの診療のために 画像診断 (2008)
  • Author(s): 江口勝美, 宇佐俊郎, 上谷雅孝
  • Journal Title: 綜合臨床 12 Pages: 2846-2854
• [Journal Article] Osteoporotic changes of subchondral trabecular bone in osteoarthritis of the knee : a 3-T MRI study.
  • Author(s): Chiba K, Uetani M, Kido Y, Ito M, Okazaki N, Taguchi K, Shindo H
  • Journal Title: Osteoporos Int In press
  • Peer Reviewed
• [Journal Article] Age-related changes in bone density, geometry and biomechanical properties of the proximal femur : CT-based 3D hip structure analysis in normal postmenopausal women.
  • Author(s): Ito M, Nakata T, Nishida A, Uetani M
  • Journal Title: Bone In press
  • NAID: 120006984864
  • Peer Reviewed
• [Presentation] 超音波およびMRIの標準化・精度管理をどうするか (2010)
  • Author(s): 上谷雅孝
  • Organizer: 第5回 リウマチ画像診断研究会
  • Place of Presentation: 横浜
  • Year and Date: 2010-12-18
• [Presentation] MRI-proven bone edema of wrist and finger joints at entry is the strongest predictor toward further radiographic progression in patients with undifferentiated arthritis : results from the prospective cohort at Nagasaki University. (2010)
  • Author(s): Kita J, Kawakami A, Tamai M, Iwamoto N, Kawashiri SY, Arima K, Okada A, Koga T, Yamasaki S, Nakamura H, Origuchi T, Aoyagi K, Uetani M, Eguchi K
  • Organizer: ACR/ARHP Annual Scientific Meeting
  • Year and Date: 2010-11-07
• [Presentation] MRI-Proven Bone Edema of Wrist and Finger Joints at Entry Is the Strongest Predictor toward Further Radiografic Progression in Patients withundifferentiated Arthritis : Results from the Prospective Cohort at Nagasaki University. (2010)
  • Author(s): Kita J, Atsushi, Kawakami A, et al.
  • Organizer: ACR/ARHP Annual Scientific Meeting
  • Place of Presentation: Atlanta
  • Year and Date: 2010-11-07
• [Presentation] bone edema of wrist and finger joints at entry is the strongest predictor toward further radiographic progression in patients with undifferentiated arthritis : results from the prospective cohort at Nagasaki University. (2010)
  • Author(s): Kita J, Tamai M, Iwamoto N. Kawashiri S, Kamachi M, Arima K, Okada A, Koga T. Yamasaki S, Nakamura H, Origuchi T, Ida H, Aoyagi K, Uetani M, Eguchi K, Kawakami A
  • Organizer: EULAR 2010, Rome
  • Year and Date: 2010-06-16
• [Presentation] Evaluation of ACR/EULAR new rheumatoid arthritis criteria by nagasaki early arthritis cohort in japan : comparison with Nagasaki score for the RA development from undifferentiated arthritis. (2010)
  • Author(s): Tamai M, Kawakami A, Arima K, Iwamoto N, Kita J, Kawashiri S, Kamachi M, Okada A, Koga T, Yamasaki S, Nakamura H, Origuchi T, Ida H, Uetani M, Aoyagi K, Eguchi K
  • Organizer: EULAR 2010, Rome
  • Year and Date: 2010-06-16
• [Presentation] Bone edema of wrist and finger joints at entry is the strongest predictor toward further radiografic progression in patients with undifferentiated arthritis : results from the prospective cohort at nagasaki university (2010)
  • Author(s): Kita J, Tamai M, N.Iwamoto N, et al.
  • Organizer: EULAR 2010
  • Place of Presentation: Rome
  • Year and Date: 2010-06-16
• [Presentation] Evaluation of acr/eular new rheumatoid arthritis criteria by nagasaki early arthritis cohort in japan : comparison with nagasaki score for the ra development from undifferentiated arthritis (2010)
  • Author(s): Tamai M, Kawakami A, Arima K, et al.
  • Organizer: EULAR 2010
  • Place of Presentation: Rome
  • Year and Date: 2010-06-16
• [Presentation] 関節画像関節リウマチにおけるMRI上の骨変化の意義 (2010)
  • Author(s): 上谷雅孝, 川上純, 玉井慎美, 江口勝美
  • Organizer: 第54回日本リウマチ学会総会・学術集会
  • Place of Presentation: 横浜
  • Year and Date: 2010-04-24
• [Presentation] RAの新しい診断基準早期関節炎コホートからみたRA予備診断基準の検証 (2010)
  • Author(s): 川上純, 玉井慎美, 喜多潤子, 青柳潔, 上谷雅孝, 江口勝美
  • Organizer: 第54回日本リウマチ学会総会・学術集会
  • Place of Presentation: 横浜
  • Year and Date: 2010-04-24
• [Presentation] 関節画像 関節リウマチにおけるMRI上の骨変化の意義 (2010)
  • Author(s): 上谷雅孝, 川上純, 玉井慎美, 江口勝美
  • Organizer: 第54回 日本リウマチ学会総会・学術集会
  • Place of Presentation: 横浜
  • Year and Date: 2010-04-24
• [Presentation] RAの新しい診断基準 早期関節炎コホートからみたRA予備診断基準の検証 (2010)
  • Author(s): 川上純, 玉井慎美, 喜多潤子, 青柳潔, 上谷雅孝, 江口勝美
  • Organizer: 第54回 日本リウマチ学会総会・学術集会
  • Place of Presentation: 横浜
  • Year and Date: 2010-04-24
• [Presentation] A Prediction Rule for Disease Outcome in Patients with Undifferentiated Arthritis by MRI of the Wrists and Finger Joints and Serologic Autoantibodies : Second Report Regarding to the Utility of Plain MRI. (2009)
  • Author(s): Tamai M, Kawakami A, Uetani M, Arima S, Fujikawa K, Iwamoto T, Kawashiri S, Kita J, Koga T, Aramaki T, Kamachi M, Nakamura H, Ida H, Origuchi T, Aoyagi K, Eguchi K
  • Organizer: ACR/ARHP Annual Scientific Meeting
  • Place of Presentation: Philadelphia
  • Year and Date: 2009-10-17
• [Presentation] A Prediction Rule for Disease Outcome in Patients with Undifferentiated Arthritis by MRI of the Wrists and Finger Joints and Serologic Autoantibodies : Second Report Regarding to the Utility of Plain MRI. (2009)
  • Author(s): Tamai M, Kawakami A, Uetani M, et al
  • Organizer: ACR/ARHP Annual Scientific Meeting
  • Place of Presentation: Philadelphia, USA
  • Year and Date: 2009-10-17
• [Presentation] Early Therapeutic Intervention Toward Patients in Undifferentiated Arthritis with MEI-Proven Bone Changes and Autoantibodies by Disease Modifying Anti-Rheumatic Drugs (DMARDS) : Nagasaki Early Arthritis lntervention Trial. (2009)
  • Author(s): 玉井慎美, 川上純, 上谷雅孝, 川尻真也, 岩本直樹, 藤川敬太, 荒牧俊幸, 蒲池誠, 有馬和彦, 中村英樹, 井田弘明, 折口智樹, 青柳潔, 江口勝美
  • Organizer: EULAR2009
  • Place of Presentation: Copenhagen
  • Year and Date: 2009-06-10
• [Presentation] A Prediction Rule for Disease Outcome in Patients with Undifferentiated Arthritis Using MRI of Wrists and Finger Joints and Serologic Autoantibodies. (2009)
  • Author(s): Tamai M, Kawakami A, Uetani M, Arima S, Fujikawa K, Iwamoto T, Kawashiri S, Kita J, Koga T, Aramaki T, Kamachi M, Nakamura H, Ida H, Origuchi T, Aoyagi K, Eguchi K
  • Organizer: EULAR 2009
  • Place of Presentation: Copenhagen
  • Year and Date: 2009-06-10
• [Presentation] Early Therapeutic Intervention Toward Patients in Undifferentiated Arthritis with MEI-Proven Bone Changes and Autoantibodies by Disease Modifying Anti-Rheumatic Drugs(DMARDS) : Nagasaki Early Arthritis Intervention Trial (2009)
  • Author(s): Tamai M, Kawakami A, Uetani M, et al
  • Organizer: EULAR 2009
  • Place of Presentation: Copenhagen, Denmark
  • Year and Date: 2009-06-10
• [Presentation] A Prediction Rule for Disease Outcome in Patients with Undifferentiated Arthritis Using MRI of Wrists and Finger Joints and Serologic Autoantibodies (2009)
  • Author(s): Tamai M, Kawakami A, Uetani M, et al
  • Organizer: EULAR 2009
  • Place of Presentation: Copenhagen, Denmark
  • Year and Date: 2009-06-10
• [Presentation] シンポジウム 画像診断2 早期関節リウマチにおける非造影手関節MRIの有用性の検討. (2009)
  • Author(s): 玉井慎美, 川上純, 上谷雅孝, 他
  • Organizer: 第53回 日本リウマチ学会総会・学術集会
  • Place of Presentation: 東京
  • Year and Date: 2009-04-24
• [Presentation] 診断未確定関節炎の評価. (2009)
  • Author(s): 玉井慎美, 川上純, 上谷雅孝, 他
  • Organizer: 第53回 日本リウマチ学会総会・学術集会
  • Place of Presentation: 東京
  • Year and Date: 2009-04-24
• [Presentation] シンポジウム 画像診断2 早期関節リウマチにおける非造影手関節MRIの有用性の検討 (2009)
  • Author(s): 玉井慎美, 川上純, 上谷雅孝, 有馬和彦, 岩本直樹, 藤川敬太, 山崎聡士, 川尻真也, 荒牧俊幸, 一瀬邦弘, 蒲池誠, 中村英樹, 井田弘明, 折口智樹, 青柳潔, 江口勝美
  • Organizer: 第53回日本リウマチ学会総会・学術集会
  • Place of Presentation: 東京
  • Year and Date: 2009-04-23
• [Presentation] リウマチ診断学の進歩関節リウマチを早期に予測するには? (2009)
  • Author(s): 川上純, 玉井慎美, 岩本直樹, 川尻真也, 藤川敬太, 荒牧俊幸, 一瀬邦広, 有馬和彦, 蒲池誠, 中村英樹, 井田弘明, 折口智樹, 上谷雅孝, 青柳潔, 江口勝美
  • Organizer: 第53回日本リウマチ学会総会・学術集会
  • Place of Presentation: 東京
  • Year and Date: 2009-04-23
• [Presentation] 診断未確定関節炎の評価 (2009)
  • Author(s): 玉井慎美, 川上純, 上谷雅孝, 有馬和彦, 岩本直樹, 藤川敬太, 川尻真也, 荒牧俊幸, 一瀬邦弘, 蒲池誠, 山崎聡士, 中村英樹, 井田弘明, 折口智樹, 青柳潔, 江口勝美
  • Organizer: 第53回日本リウマチ学会総会・学術集会
  • Place of Presentation: 東京
  • Year and Date: 2009-04-23
• [Presentation] 関節リウマチのMRI診断 (2009)
  • Author(s): 上谷雅孝
  • Organizer: 第68回日本放射線学会総会 教育講演
  • Place of Presentation: 横浜
  • Year and Date: 2009-04-19
• [Presentation] 教育講演 関節リウマチのMRI. (2009)
  • Author(s): 上谷雅孝
  • Organizer: 第68回 日本医学放射線学会学術集会
  • Place of Presentation: 横浜
  • Year and Date: 2009-04-19
• [Presentation] シンポジウム 早期リウマチ早期RAのMRI診断 (2008)
  • Author(s): 上谷雅孝
  • Organizer: 第36回日本関節病学会
  • Place of Presentation: 神戸
  • Year and Date: 2008-11-07
• [Presentation] 早期リウマチ 早期RAのMRI診断 (2008)
  • Author(s): 上谷雅孝
  • Organizer: 日本関節病学会
  • Place of Presentation: 神戸
  • Year and Date: 2008-11-07
• [Presentation] Symposium : Assessment of prognosis using MR Imaging. (2008)
  • Author(s): 上谷雅孝
  • Organizer: Congress of Asian Oceanian League of Associations for Rheumatology.
  • Place of Presentation: Yokohama
  • Year and Date: 2008-09-24
• [Presentation] Bone changes detected by plain MRI of both wrists and finger joints in early-stage rheumatoid arthritis accurately reflect the bone changes in Gd-enhanced MRI. (2008)
  • Author(s): 玉井慎美, 上谷雅孝, 川上純, et al
  • Organizer: EULAR2008
  • Place of Presentation: Paris
  • Year and Date: 2008-06-13
• [Presentation] Bone changes detected by plain MRI of both wrists and finger joints in early-stage rheumatoid arthritis accurately reflect the bone changes in Gd-enhanced MRI (2008)
  • Author(s): Mami Tamai, Masataka Uetani, et al
  • Organizer: EULAR 2008-Annual European Congress of Rheumatology
  • Place of Presentation: Paris, France
  • Year and Date: 2008-06-13
• [Presentation] 関節リウマチの予後改善のために 抗CCP抗体と関節リウマチの診断・病態 (2008)
  • Author(s): 川上純, 玉井慎美, 上谷雅孝, 他
  • Organizer: 日本リウマチ学会総会・学術集会
  • Place of Presentation: 札幌
  • Year and Date: 2008-04-23
• [Presentation] リウマチ診療における画像診断学MRI画像による関節リウマチの早期診断予測と関節破壊進行予測 (2008)
  • Author(s): 江口勝美, 上谷雅孝, 川上純, 玉井慎美
  • Organizer: 日本リウマチ学会総会・学術集会
  • Place of Presentation: 札幌
  • Year and Date: 2008-04-22
• [Presentation] リウマチ診療における画像診断学MRI画像による関節リウマチの早期診断予測と関節破壊進行予測 (2008)
  • Author(s): 江口勝美, 上谷雅孝, 川上純, 玉井慎美
  • Organizer: 第52回日本リウマチ学会学術集会
  • Place of Presentation: 札幌
  • Year and Date: 2008-04-21
• [Presentation] 関節リウマチの予後改善のために抗CCP抗体と関節リウマチの診断・病態 (2008)
  • Author(s): 川上純, 玉井慎美, 岩本直樹, 川尻真也, 藤川敬太, 荒牧俊幸, 一瀬邦広, 蒲池誠, 中村英樹, 井田弘明, 折口智樹, 上谷雅孝, 青柳潔, 江口勝美
  • Organizer: 第52回日本リウマチ学会学術集会
  • Place of Presentation: 札幌
  • Year and Date: 2008-04-21
• [Presentation] 早期関節リウマチでの両手撮像MRI. (2008)
  • Author(s): 玉井慎美, 上谷雅孝, 川上純, 川尻真也, 岩本直樹, 藤川敬太, 荒牧俊幸, 一瀬邦弘, 蒲池誠, 有馬和彦, 中村英樹, 井田弘明, 折口智樹, 青柳潔, 江口勝美
  • Organizer: 第52回日本リウマチ学会学術集会
  • Place of Presentation: 札幌
  • Year and Date: 2008-04-21
• [Presentation] 早期関節リウマチでの両手撮像MRI (2008)
  • Author(s): 玉井慎美, 上谷雅孝, 川上純, 他
  • Organizer: 日本リウマチ学会総会・学術集会
  • Place of Presentation: 札幌
  • Year and Date: 2008-04-21
• [Book] 骨軟部疾患の画像診断 第2版 (2010)
  • Author(s): 上谷雅孝 編著
  • Total Pages: 421
  • Publisher: 秀潤社