Synthesis and Clinical Study of Diagnostic Radiopharmaceuticals labeled 18Fluorine for well differentiated carcinomas.

• Project/Area Number: 20591450
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Radiation science
• Research Institution: Kumamoto University
• Principal Investigator: TOMIYOSI Katsumi Kumamoto University, 生命科学研究部, 教授 (60188802)
• Co-Investigator(Renkei-kenkyūsha): ANDO Yukio 熊本大学, 生命科学研究部, 教授 (20253742) ; TOMIGUCHI Seiji 熊本大学, 生命科学研究部, 教授 (20172182)
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2010: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2008: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: 核医学 / PET / 腫瘍検索剤 / 18F / 18Fフルオロアセテート / 高分化型腫瘍 / 11C-酢酸 / 18FDG / 18F-Acetate / 11C-Acetate / 酢酸エステル / 標識合成 / 品質検査 / 腫瘍 / 18F-酢酸 / ヨード酸エステル / 精製・分離 / 品質管理

Research Abstract

18F-Acetate (18FAC) was synthesized with a new method. After injection of 185MBq 18FAC into Volunteers, PET and CT imaging were obtained. There is not specially trapped tissues but 18FAC was metabolized and cleared through kidney to bladder. We found also no free 18Fluorine de-ionize in vivo during the measurement. More studies need to get bio-distribution experiments for normal and tumor-mounted animals.

Research Products

• [Journal Article] 全身性アミロイドーシス試薬(FESB)の開発 (2010)
  • Author(s): 竹松泰宏、冨吉勝美
  • Journal Title: 熊本大学医学部保健学科、論文集 3巻 Pages: 130-137
• [Journal Article] 11C-acetate for positron emission tomography imaging of clinical stage IA lung adenocarcinoma (2009)
  • Author(s): H.Shibata, H.Nomori, K.Tomiyosi, et.al.
  • Journal Title: Ann.Nucl.Med. 23 Pages: 609-616
  • Peer Reviewed
• [Journal Article] ^<18>F-Fluorodeoxyglucose and ^<11>C-Acetate Positron Emission Tomography are Useful Modalities for Diagnosing the Histological Type of Thymoma
  • Author(s): Hidekatsu Shibata
  • Journal Title: Cancer in press
• [Presentation] L-Methyl-DOPAの125Iによる標識と分取・精製 (2010)
  • Author(s): 大塚俊亮、冨吉勝美
  • Organizer: 第5回九州放射線医療技術学会
  • Place of Presentation: 崇城大学市民ホール
  • Year and Date: 2010-11-20
• [Presentation] 18F-酢酸エステルの標識合成と分取精製 (2010)
  • Author(s): 浜崎彩子、冨吉勝美
  • Organizer: 第47回放射線影響懇話会
  • Place of Presentation: 九州大学
  • Year and Date: 2010-07-17
• [Presentation] 18F酢酸エステルの標識合成と分取精製 (2010)
  • Author(s): 浜崎彩子、冨吉勝美
  • Organizer: 放射線影響懇話会
  • Place of Presentation: 九州大学コラボステーション
  • Year and Date: 2010-07-17
• [Presentation] ^<18>Fl酢酸エステルの標識合成と分取精製 (2009)
  • Author(s): 山野正起
  • Organizer: 第4回九州放射線医療技術大会
  • Place of Presentation: 沖縄県宜野湾市 沖縄コンベンションセンター
  • Year and Date: 2009-11-21
• [Presentation] 18F酢酸の標識合成と分離 18F-Acetate Syntheiss and Purification for Clinical Purposes. (2008)
  • Author(s): 竹永枝里子
  • Organizer: 九州放射線医療技術学術大会
  • Place of Presentation: 宮崎市民ブラザ
  • Year and Date: 2008-11-01
• [Book] 平成22年度 卒業論文・報告書集 (2011)
  • Author(s): 浜崎彩子、竹松泰宏、冨吉勝美
  • Total Pages: 8
  • Publisher: 18F酢酸エステルの標識合成と分取精製
• [Remarks] ホームページ等