Synthesis and Clinical Study of Diagnostic Radiopharmaceuticals labeled 18Fluorine for well differentiated carcinomas.
| Project/Area Number |
20591450
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Radiation science
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| Research Institution | Kumamoto University |
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Principal Investigator |
TOMIYOSI Katsumi Kumamoto University, 生命科学研究部, 教授 (60188802)
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| Co-Investigator(Renkei-kenkyūsha) |
ANDO Yukio 熊本大学, 生命科学研究部, 教授 (20253742)
TOMIGUCHI Seiji 熊本大学, 生命科学研究部, 教授 (20172182)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2010: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2008: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 核医学 / PET / 腫瘍検索剤 / 18F / 18Fフルオロアセテート / 高分化型腫瘍 / 11C-酢酸 / 18FDG / 18F-Acetate / 11C-Acetate / 酢酸エステル / 標識合成 / 品質検査 / 腫瘍 / 18F-酢酸 / ヨード酸エステル / 精製・分離 / 品質管理 |
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| Research Abstract |
18F-Acetate (18FAC) was synthesized with a new method. After injection of 185MBq 18FAC into Volunteers, PET and CT imaging were obtained. There is not specially trapped tissues but 18FAC was metabolized and cleared through kidney to bladder. We found also no free 18Fluorine de-ionize in vivo during the measurement. More studies need to get bio-distribution experiments for normal and tumor-mounted animals.
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Report
(4 results)
Research Products
(10 results)
