| Project/Area Number |
20591457
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Radiation science
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| Research Institution | Health Sciences University of Hokkaido |
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Principal Investigator |
OHKURA Kazue Health Sciences University of Hokkaido, 薬学部, 教授 (60094827)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
KUGE Yuji 北海道大学, アイソトープ総合センター, 教授 (70321958)
AKIZAWA Hiromichi 北海道医療大学, 薬学部, 准教授 (90311795)
関 興一 北海道大学, 学内共同利用施設, 教授 (60094835)
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| Project Period (FY) |
2008 – 2010
|
| Project Status |
Completed (Fiscal Year 2010)
|
| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2009: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2008: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
|
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| Keywords | 放射線 / 核医学診断 / ポジトロンCT / 腫瘍 / 血管新生 |
|---|
| Research Abstract |
The expression of thymidine phosphorylase (TP) is closely associated with angiogenesis and invasiveness of tumors. We evaluated ^<11>C labeled 5-bromo-6-oxoimidazolidinylmethyluracil having TP-inhibitory potency, as a new radiotracer for PET targeting TP expression in tumors. In vivo distribution of the radiotracer in A431 tumor bearing mice revealed tumor/blood and tumor/muscle activity uptake ratios of 5 and 12, respectively, at 1 h post-injection. To develop novel potential PET tracers having longer half-life, the synthesis of the precursor of ^<18>F-labeled uracil derivative was performed.
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