| Project/Area Number |
20591458
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Radiation science
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| Research Institution | Iwate Medical University |
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Principal Investigator |
SASAKI Makoto Iwate Medical University, 医学部, 教授 (80205864)
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| Co-Investigator(Kenkyū-buntansha) |
TOHYAMA Koujiro 岩手医科大学, 医学部, 教授 (10129033)
OTSUKA Kotaro 岩手医科大学, 医学部, 講師 (00337156)
SAKAI Akio 岩手医科大学, 医学部, 教授 (30146063)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2009: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2008: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
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| Keywords | MRI / 神経メラニン / うつ病 / 統合失調症 / カテコラミン / 黒質 / 青斑核 / 磁気共鳴画像 / 神経伝達物質 / ノルアドレナリン / ドパミン |
|---|
| Research Abstract |
We investigated signal changes in catecholamine nuclei of the brain stem by using neuromelanin- sensitive magnetic resonance imaging (MRI). In the depressive patients, signal intensity of the locus ceruleus was attenuated as compared with schizophrenic patients and healthy controls with high sensitivity and specificity, suggesting hypofunction of the noradrenergic system. In schizophrenia, signals from the substantia nigra pars compacta tended to be augmented and those from the ventral tegmental area tended to be reduced, suggesting dysfunction of the dopaminergic system. Neuromelanin MRI is a promising technique to elucidate functional changes in the catecholamine neurons of the brain stem that occur in psychiatric diseases.
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