Computer-Aided Diagnostic Tool for Identifying the Cause of Dementia

• Project/Area Number: 20591461
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Radiation science
• Research Institution: Keio University
• Principal Investigator: HASHIMOTO Jun Keio University, 医学部, 准教授 (20228414)
• Co-Investigator(Kenkyū-buntansha): SASAKI Takahiro 慶應義塾大学, 医学部, 講師 (60306694) ; IYATOMI Hitoshi 法政大学, 理工学部, 講師 (10386336)
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000); Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2009: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2008: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
• Keywords: 認知症 / 鑑別診断 / 画像診断 / MRI / 脳血流SPECT / アルツハイマー病

Research Abstract

Diagnosing the cause of dementia is often difficult even for a qualified clinical doctor. We contrived a computer-aided diagnostic system for determining the etiology of dementia. The system incorporates seven binary classifiers in which each of them judge whether the patent's manifestations are similar with a specific disease or not; these seven classifiers are for the representative seven diseases causing dementia. We would like to further investigate the system to optimize the parameters in the classifiers and to improve its diagnostic performance.

Research Products

• [Journal Article] Colour and contrast enhancement for improved skin lesion segmentation (2011)
  • Author(s): Gerald Schaefer, Maher I、Rajab M、Hitoshi Iyatomi、他
  • Journal Title: Computerized Medical Imaging and Graphics 35 Pages: 99-104
• [Journal Article] Automated color calibration method for dermoscopy images (2011)
  • Author(s): Hitoshi Iyatomi、M.Emre Celebi、Gerald Schaefer、他
  • Journal Title: Computerized Medical Imaging and Graphics 35 Pages: 89-98
• [Journal Article] Automated color calibration method for dermoscopy images. (2011)
  • Author(s): Iyatomi H, et al.
  • Journal Title: Computerized Medical Imaging and Graphics Volume: 35 Pages: 89-98
  • Peer Reviewed
• [Journal Article] Colour and contrast enhancement for improved skin lesion segmentation. (2011)
  • Author(s): Shaefer G, Iyatomi H, et al
  • Journal Title: Computerised Medical Imaging and Graphics Volume: 35 Pages: 99-104
  • Peer Reviewed
• [Journal Article] SPECTによる認知症の鑑別診断 (2010)
  • Author(s): 橋本順、佐々木貴浩
  • Journal Title: 臨床放射線 55 Pages: 1386-1407
• [Journal Article] 神経内科の病気のすべて、補助検査としての画像診断 (2010)
  • Author(s): 橋本順
  • Journal Title: (2)SPECT検査、鈴木則宏編、からだの科学 265 Pages: 26-27
• [Journal Article] 神経内科の病気のすべて、補助検査としての画像診断(2)SPECT検査 (2010)
  • Author(s): 橋本順
  • Journal Title: からだの科学 Volume: 265 Pages: 26-27
• [Journal Article] SPECTによる認知症の鑑別診断 (2010)
  • Author(s): 橋本順、佐々木貴浩
  • Journal Title: 臨床放射線 Volume: 55 Pages: 1386-1407
• [Journal Article] Lesion Border Detection in Dermoscopy Images (2009)
  • Author(s): M.Emre Celebi、Hitoshi Iyatomi、他
  • Journal Title: Computerized Medical Imaging and Graphics 33、2 Pages: 76-82
• [Journal Article] Computerized quantification of psoriasis lesions with colorcalibration : Preliminary results (2009)
  • Author(s): Iyatomi H, Oka H, Hagiwara M, et al.
  • Journal Title: Clinical and Experimental Dermatology 34 Pages: 830-833
  • Peer Reviewed
• [Journal Article] An Improved Objective Evaluation Measure for Border Detection in Dermoscopy Images (2009)
  • Author(s): Celebi ME, Schaefer G, Iyatomi H, et al
  • Journal Title: Skin Research and Technology 15 Pages: 444-450
  • Peer Reviewed
• [Journal Article] Lesion Border Detection in Dermoscopy Images (2009)
  • Author(s): Celebi ME, Iyatomi H, Schaefer G, et al.
  • Journal Title: Computerized Medical Imaging and Graphics 33 Pages: 76-82
  • Peer Reviewed
• [Journal Article] Contrast enhancement in dermoscopy images by maximizing a histogram bimodality measure (2009)
  • Author(s): Celebi ME, Iyatomi H, Schaefer G.
  • Journal Title: Proc. IEEE Int Conf Imag Process ICIP 2009 Pages: 2601-2604
  • Peer Reviewed
• [Journal Article] Localization of lesions in dermoscopy images using ensembles of thresholding methods. (2009)
  • Author(s): Celebi ME, Iyatomi H, Scheafer G, Stoecker WV.
  • Journal Title: Lectures Notes in Computer Science 5414 Pages: 1094-1103
  • Peer Reviewed
• [Journal Article] Computer-based classification of dermoscopy images of melanocytic lesions on acral volar skin (2008)
  • Author(s): Hitoshi Iyatomi、Hiroshi Oka、M Emre Celebi、他
  • Journal Title: J Invest Dermatol 128 Pages: 2049-2054
• [Journal Article] An Improved Internet-based Melanoma Screening System with Dermatologist-like Tumor Area Extraction Algorithm (2008)
  • Author(s): Hitoshi Iyatomi、Hiroshi Oka、M.Emre Celebi、他
  • Journal Title: Computerized Medical Imaging and Graphics 32、7 Pages: 566-579
• [Journal Article] Preoperative risk evaluation in diabetic patients without angina (2008)
  • Author(s): Jingming Bai、Jun Hashimoto、Tadaki Nakahara、Naoto Kitamura, Takayuki Suzuki, Atsus他
  • Journal Title: Diabetes Res Clin Pract 81 Pages: 150-154
• [Journal Article] Application of support vector machine classifiers to preoperative risk stratification with myocardial perfusion scintigraphy (2008)
  • Author(s): Kasamatsu T、Jun Hashimoto、Hitoshi Iyatomi、他
  • Journal Title: Circ J 72 Pages: 1829-1835
  • NAID: 110006975576
• [Journal Article] An improved internet-based melanoma screening system with dermatologist-like tumor area extraction algorithm (2008)
  • Author(s): Iyatomi H
  • Journal Title: Computerized Medical Imaging and Graphics 32 Pages: 566-579
  • Peer Reviewed
• [Journal Article] Computer-based classification of dermoscopy images of melanocytic lesions on acral volar skin (2008)
  • Author(s): Iyatomi H
  • Journal Title: Journal of Investigative Dermatology 128 Pages: 2049-2054
  • Peer Reviewed
• [Journal Article] Application of support vector machine classifiers to preoperative risk stratification with myocardial perfusion scintigraphy (2008)
  • Author(s): Kasamatsu T
  • Journal Title: Circulation Journal 72 Pages: 1829-1835
  • Peer Reviewed
• [Presentation] 画像を知らない臨床医、臨床を知らない核医学医-脳血流SPECTの読影からみた臨床と画像の双方を理解することの難しさ- (2010)
  • Author(s): 橋本順
  • Organizer: 第334回神奈川核医学研究会
  • Place of Presentation: ブリーズベイホテル(神奈川)
  • Year and Date: 2010-12-18
• [Presentation] 画像を知らない臨床医、臨床を知らない核医学医-脳血流SPECTの読影からみた臨床と画像の双方を理解することの難しさ- (2010)
  • Author(s): 橋本順
  • Organizer: 第334回神奈川核医学研究会
  • Place of Presentation: ブリーズベイホテル(神奈川県)
  • Year and Date: 2010-12-18
• [Presentation] 認知症の鑑別診断におけるMRIと核医学検査の役割 (2010)
  • Author(s): 橋本順
  • Organizer: 平成22年度第2回神奈川県診療放射線技術講習会
  • Place of Presentation: 横浜西公会堂(神奈川)
  • Year and Date: 2010-11-28
• [Presentation] 認知症の鑑別診断におけるMR1と核医学検査の役割 (2010)
  • Author(s): 橋本順
  • Organizer: 平成22年度第2回神奈川県診療放射線技術講習会
  • Place of Presentation: 横浜西公会堂(神奈川県)
  • Year and Date: 2010-11-28
• [Presentation] hemiplegic migraineにおける脳血流の経時変化 (2010)
  • Author(s): 橋本順、柳町徳春、今井裕
  • Organizer: 第50回日本核医学会総会
  • Place of Presentation: 大宮ソニックシティ(埼玉)
  • Year and Date: 2010-11-11
• [Presentation] hemiplegic migraineにおける脳血流の経時変化 (2010)
  • Author(s): 橋本順、柳町徳春、今井裕
  • Organizer: 第50回日本核医学会総会
  • Place of Presentation: 大宮ソニックシティ(埼玉県)
  • Year and Date: 2010-11-11
• [Presentation] Robust border detection in dermosciopy images using threshold fusion (2010)
  • Author(s): M.Emre Celebi
  • Organizer: IEEE International Conference on Image Processing
  • Place of Presentation: 香港(中国)
  • Year and Date: 2010-09-28
• [Presentation] Automated color normalization for dermoscopy Images (2010)
  • Author(s): Hitoshi Iyatomi
  • Organizer: IEEE International Conference on Image Processing
  • Place of Presentation: 香港(中国)
  • Year and Date: 2010-09-28
• [Presentation] Automated color normalization for dermoscopy Images. (2010)
  • Author(s): Iyatomi H, et al.
  • Organizer: IEEF, Internafional Conference an Iwage Processing (ICIP 2010)
  • Place of Presentation: 香港
  • Year and Date: 2010-09-28
• [Presentation] Robust border detection in dermoscopy images using threshold fusion. (2010)
  • Author(s): Celebi ME, Iyatomi H., et al.
  • Organizer: IEEE International Conference on Image Processing (ICIP 2010)
  • Place of Presentation: 香港
  • Year and Date: 2010-09-28
• [Presentation] Quantitative and objective area extraction of tinea unguium (2010)
  • Author(s): Yasuki Hata
  • Organizer: The 40th European Society of Dermatological Research (ESDR) Meeting
  • Place of Presentation: ヘルシンキ(フィンランド)
  • Year and Date: 2010-09-09
• [Presentation] Quantitativo and objective area extraction of tinea unguium. (2010)
  • Author(s): Hata Y, Iyatomi H, et al
  • Organizer: The 40th European Society of Dermatlogical Research (ESDR) Meeting
  • Place of Presentation: ヘルシンキ
  • Year and Date: 2010-09-09
• [Presentation] 脳機能イメージング 機能診断としての核医学検査:MRIとの関係を中心に (2010)
  • Author(s): 橋本順
  • Organizer: 第29回日本医用画像工学会
  • Place of Presentation: 東海大学医学部(神奈川)
  • Year and Date: 2010-07-30
• [Presentation] 脳機能イメージング機能診断としての核医学検査:MRIとの関係を中心に (2010)
  • Author(s): 橋本順
  • Organizer: 第29回日本医用画像工学会
  • Place of Presentation: 東海大学医学部(神奈川県)
  • Year and Date: 2010-07-30
• [Presentation] Automated melanoma diagnosis (2009)
  • Author(s): Hitoshi Iyatomi
  • Organizer: The International Workshop on Medical Imaging and Visualization
  • Place of Presentation: カイロ(エジプト)
  • Year and Date: 2009-11-12
• [Presentation] Automated melanoma diagnosis (2009)
  • Author(s): Iyatomi H
  • Organizer: The International Workshop on Medical Imaging and Visualization
  • Place of Presentation: カイロ大学(エジプト)
  • Year and Date: 2009-11-12
• [Presentation] MIBGシンチを用いたパーキンソン病と多系統委縮の鑑別診断における散乱線補正の効果 (2009)
  • Author(s): 橋本順
  • Organizer: 第49回日本核医学会総会
  • Place of Presentation: 旭川市文化会館(北海道)
  • Year and Date: 2009-10-02
• [Presentation] MIBGシンチを用いたパーキンソン病と多系統委縮の鑑別診断における散乱線補正の効果 (2009)
  • Author(s): 橋本順、大平雅之、尾川浩一, 他
  • Organizer: 第49回日本核医学会総会
  • Place of Presentation: 旭川文化云館(北海道)
  • Year and Date: 2009-10-02
• [Presentation] Supervised Learning Methodologyの核医学検査への応用 (2009)
  • Author(s): 橋本順
  • Organizer: 第313回神奈川核医学研究会
  • Place of Presentation: 神奈川労働プラザ(神奈川)
  • Year and Date: 2009-07-17
• [Presentation] Efficacy of Scatter Correction in I-123 MIBG Scintigraphy for Patients with Parkinsonism (2009)
  • Author(s): Ohira M
  • Organizer: 第13回International Congress of Parkinson's Disease and Movement Disorders
  • Place of Presentation: パリ(フランス)
  • Year and Date: 2009-06-10
• [Presentation] Efficacy of Scatter Correction in I-123 MIBG Scintigraphy for Patients with Parkinsonism (2009)
  • Author(s): Ohira M, Takahashi K, Hashimoto J, et al.
  • Organizer: 第13回International Congress of Parkinson's Disease and Movement Disorders
  • Place of Presentation: Le Palais des Congresde Paris(フランス)
  • Year and Date: 2009-06-10
• [Presentation] Efficacy of Scatter Correction in I-123 MIBG Scintigraphy for Patients with Parkinsonism (2009)
  • Author(s): Masahiro Ohira
  • Organizer: The 13^<th> International Congress of Parkinson's Disease and Movement Disorders
  • Place of Presentation: バンクーバー(カナダ)
  • Year and Date: 2009-06-08
• [Presentation] 人工ニューラルネットワークを用いた散乱線補正法によるTc-99m/I-123の2核種同時心筋SPECT (2009)
  • Author(s): 橋本順
  • Organizer: 第843回放射線診療研究会
  • Place of Presentation: 新宿住友ビル(東京)
  • Year and Date: 2009-01-18
• [Presentation] 臨床情報と核医学検査データから心事故を予測するための識別器の作成 (2008)
  • Author(s): 神應 百重
  • Organizer: 第48回日本核医学会総会
  • Place of Presentation: 千葉
  • Year and Date: 2008-10-26
• [Presentation] 人工ニューラルネットワークを用いた散乱線補正法による安静/ダイアモックス負荷2核種同時脳血流SPECT (2008)
  • Author(s): 橋本 順
  • Organizer: 第48回日本核医学会総会
  • Place of Presentation: 千葉
  • Year and Date: 2008-10-25
• [Presentation] 臨床情報と核医学検査データから心事故を予測するための識別器の作成 (2008)
  • Author(s): 神應百重
  • Organizer: 第48回日本核医学会総会
  • Place of Presentation: 幕張メッセ(千葉)
  • Year and Date: 2008-10-24
• [Presentation] 人工ニューラルネットワークを用いた散乱線補正法による安静/ダイアモックス負荷2核種同時脳血流SPECT (2008)
  • Author(s): 橋本順
  • Organizer: 第48回日本核医学会総会
  • Place of Presentation: 幕張メッセ(千葉)
  • Year and Date: 2008-10-24
• [Presentation] I-123-MIBG心筋シンチグラフィの散乱線補正法の効果-パーキンソン病関連疾患における検討 (2008)
  • Author(s): 大平雅之
  • Organizer: 第2回MDSJ学術集会
  • Place of Presentation: 東京国際フォーラム(東京)
  • Year and Date: 2008-10-08
• [Presentation] 人工ニューラルネットワークを用いた散乱線補正法による安静Tc-99m-ECD/ダイアモックス負荷I-123-IMPの2核種同時脳血流SPECT (2008)
  • Author(s): 橋本順
  • Organizer: 第6回脳核医学画像処理研究会
  • Place of Presentation: 東京ステーションコンファレンス(東京)
  • Year and Date: 2008-09-15
• [Presentation] An internet-based melanoma screening system-supported acralvolar lesions (2008)
  • Author(s): Iyatomi H
  • Organizer: Proceedings of IEEE EMBC 2008
  • Place of Presentation: バンクーバー
  • Year and Date: 2008-08-22
• [Book] In-tech (2010)
  • Author(s): Iyatomi H
  • Total Pages: 351
  • Publisher: New Developments in Biomedical Engineering
• [Book] 金原出版 (2010)
  • Author(s): 橋本順編集
  • Total Pages: 274
  • Publisher: 知っておきたい認知症の臨床と画像
• [Book] 知っておきたい認知症の臨床と画像 (2010)
  • Author(s): 橋本順編集
  • Total Pages: 274
  • Publisher: 金原出版
• [Book] New Developments in Biomedical Engineering (2010)
  • Author(s): Iyatomi H
  • Total Pages: 351
  • Publisher: In-tech