Study on diagnosis of early Alzheimer's disease by β-amyloid imaging(BF227).
| Project/Area Number |
20591470
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Radiation science
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| Research Institution | Aichi Shukutoku University (2009-2011)
National Institute for Longevity Sciences,NCGG (2008) |
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Principal Investigator |
MAENO Nobuhisa 愛知淑徳大学, 健康医療科学部, 准教授 (90463207)
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| Co-Investigator(Kenkyū-buntansha) |
KATO Takashi 国立長寿医療研究センター, 脳機能画像診断開発部・分子画像開発室, 室長 (60242864)
ITO Kengo 国立長寿医療研究センター, 脳機能画像診断開発部, 部長 (70184653)
HATANO Kentaro 国立長寿医療研究センター, 脳機能画像診断開発部・分子探索開発室, 部長 (50228475)
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| Project Period (FY) |
2008 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2009: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2008: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
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| Keywords | 核医学(PETを含む) / アルツハイマー病 / アミロイドイメージング / アミロイド・イメージング |
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| Research Abstract |
The subjects were 15 cognitively normal subjects(NL), 20 patients with mild cognitive impairment(MCI) and 21 patients with Alzheimer disease(AD) recruited in Tohoku University. They underwent BF227-PET, 3D-MRI, and neuropsychological examination. The gray matter volume on VBM-MRI was lowest in the AD, followed by MCI, and NL. It has been suggested that this results correspond in each stage in the development of AD. In contrast, as for Aβ deposition on BF227-PET, AD and MCI showed significantly higher accumulation than NL. No significant differences were observed between AD and MCI in the Aβ deposition. The fact suggests that the Aβ deposition already reached a plateau in a stage of MCI. Moreover, in the relation with neuropsychological examination, gray matter loss may influence the cognitive function, however, the Aβ deposition may not influence the cognitive function at least in AD onset.
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Report
(6 results)
Research Products
(83 results)
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[Presentation] もの忘れ外来グループ。[C-11] BF-227集積と脳糖代謝変動の関係:認知機能正常から健忘型MCIまで2011
Author(s)
加藤隆司, 伊藤健吾, 籏野健太郎, 藤原謙, 中村昭範, 三浦久幸, 服部英幸, 新畑豊, 鷲見幸彦, 岡村信行, 谷内一彦
Organizer
第30回認知症学会学術集会
Place of Presentation
タワーホール船堀東京
Year and Date
2011-11-11
Related Report
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[Presentation] Relationship between cerebral glucose metabolism and [C-11] BF-227 accumulation in the stages from cognitively normal to amnestic MCI2011
Author(s)
Kato T, Ito K, Hatano K, Fujiwara K, Nakamura A, Washimi Y, Arahata Y, Hattori H, Miura H, Okamura N, Yanai K
Organizer
Alzheimer's Association International Conference 2011, Paris Porte de Versailles Convention and Exhibition Center
Place of Presentation
Paris, Republic of France
Year and Date
2011-07-20
Related Report
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[Presentation] Relationship between cerebral glucose metabolism and [C-11]BF-227 accumulation in the stages from cognitively normal to amnestic MCI2011
Author(s)
Kato T, Ito K, Hatano K, Fujiwara K, Nakamura A, Washimi Y, Arahata Y, Hattori H, Miura H, Okamura N, Yanai K
Organizer
Alzheimer's Association International Conference 2011
Place of Presentation
Paris Porte de Versailles Convention and Exhibition Center, Paris, Republic of France
Related Report
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[Presentation] [C-11]BF-227集積と脳糖代謝変動の関係:認知機能正常から健忘型MCIまで2011
Author(s)
加藤隆司, 伊藤健吾, 籏野健太郎, 藤原謙, 中村昭範, 三浦久幸, 服部英幸, 新畑豊, 鷲見幸彦, 岡村信行, 谷内一彦, もの忘れ外来グループ
Organizer
第30回認知症学会学術集会
Place of Presentation
タワーホール船堀東京
Related Report
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[Presentation] 認知症脳をみる2010
Author(s)
伊藤健吾
Organizer
平成22年度日本基礎老化学会秋期シンポジウム
Place of Presentation
長崎県長崎市長崎市歴史文化博物館(招待講演)
Year and Date
2010-11-21
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[Presentation] PET UPDATES2009
Author(s)
伊藤健吾
Organizer
World-wide ADNIの展望
Place of Presentation
宮城県仙台市東北大学百周年記念会館
Year and Date
2009-11-20
Related Report
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