| Project/Area Number |
20591471
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Radiation science
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| Research Institution | University of Tsukuba |
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Principal Investigator |
MATSUSHITA Shonosuke University of Tsukuba, 大学院・人間総合科学研究科, 講師 (70359579)
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| Co-Investigator(Kenkyū-buntansha) |
SAKAKIBARA Yuzuru 筑波大学, 大学院・人間総合科学研究科, 教授 (60192085)
HYODO Kazuyuki 高エネルギー加速器研究機構, 物質構造科学研究所, 講師 (60201729)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2008: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | HARP受像管 / ラット / 単色X線 / 希釈造影剤 / 放射光 / 血管造影 / 造影剤 / 造影剤腎症 |
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| Research Abstract |
Contrast material is essentially employed in angiography. Contrast material-induced nephropathy (CIN) is developed in dose-dependence manner. Recently, the doses of contrast material in angiography tend to increase due to frequent application of stent therapy. On the other hand, the its dose is limited for the preservation of renal function. To solve this, we thought that the combination of synchrotron radiation angiography and high sensitive HARP receiver may make it possible to reduce the dose of contrast material. In vitro examination, synchrotron radiation angiography with HARP receiver was able to identify 2% concentration of iodine contained contrast material. In vivo examination using rat angiography in lower extremity, 8% concentration of contrast material was statistically equivalent to 32% concentration of contrast material in counting the number of vascular branches. It means that a quarter of concentration in contrast material can be effectively used, if this proposed angiographic system is utilized.
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