The local gene transfer for prevention of thrombosis after percutaneous transluminal angioplasty.
Project/Area Number |
20591481
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Radiation science
|
Research Institution | University of Miyazaki |
Principal Investigator |
TAMURA Syozo University of Miyazaki, 医学部, 教授 (60150439)
|
Co-Investigator(Kenkyū-buntansha) |
YANO Takanori 宮崎大学, 医学部, 講師 (20315378)
HATAKEYAMA Kinta 宮崎大学, 医学部, 講師 (60325735)
YAMASHITA Atushi 宮崎大学, 医学部, 助教 (90372797)
|
Project Period (FY) |
2008 – 2010
|
Project Status |
Completed (Fiscal Year 2010)
|
Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2008: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
|
Keywords | 血栓 / 遺伝子 / ADAMTS13 / 静脈 / 循環器・高血圧 |
Research Abstract |
Anticoagulation is the usual treatment for prevention of thrombosis after percutaneous transluminal angioplasty. But excessive or spontaneous bleeding may be a side effect of anticoagulation. The present study examines whether local gene transfer suppress platelet aggregation and thrombus formation after adenovirus-mediated gene transfer to injured arterial wall. Conclusion ; the local gene transfer to injured arterial wall might prevent thrombosis.
|
Report
(4 results)
Research Products
(1 results)