The local gene transfer for prevention of thrombosis after percutaneous transluminal angioplasty.

Research Project

Project/Area Number	20591481
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Single-year Grants
Section	一般
Research Field	Radiation science
Research Institution	University of Miyazaki
Principal Investigator	TAMURA Syozo University of Miyazaki, 医学部, 教授 (60150439)
Co-Investigator(Kenkyū-buntansha)	YANO Takanori 宮崎大学, 医学部, 講師 (20315378) HATAKEYAMA Kinta 宮崎大学, 医学部, 講師 (60325735) YAMASHITA Atushi 宮崎大学, 医学部, 助教 (90372797)
Project Period (FY)	2008 – 2010
Project Status	Completed (Fiscal Year 2010)
Budget Amount *help	¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000) Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000) Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000) Fiscal Year 2008: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords	血栓 / 遺伝子 / ADAMTS13 / 静脈 / 循環器・高血圧
Research Abstract	Anticoagulation is the usual treatment for prevention of thrombosis after percutaneous transluminal angioplasty. But excessive or spontaneous bleeding may be a side effect of anticoagulation. The present study examines whether local gene transfer suppress platelet aggregation and thrombus formation after adenovirus-mediated gene transfer to injured arterial wall. Conclusion ; the local gene transfer to injured arterial wall might prevent thrombosis.

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