Investigation of boundary functional modeling method which can perform accurate Monte-Carlo dosimetry in treatment planning in neutron capture therapy.

• Project/Area Number: 20591487
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Radiation science
• Research Institution: Japan Atomic Energy Agency
• Principal Investigator: KUMADA Hiroaki Japan Atomic Energy Agency, 大学院・人間総合科学研究科, 准教授 (30354913)
• Co-Investigator(Kenkyū-buntansha): YAMAMOTO Tetsuya 筑波大学, 大学院・人間総合科学研究科, 講師 (30375505)
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2010: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2008: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
• Keywords: 放射線医療物理学 / 中性子捕捉療法 / 治療計画 / 線量評価 / アルゴリズム / モンテカルロ / シミュレーション / BNCT / モンテカルロ輸送計算 / 粒子線治療

Research Abstract

For computational dosimetry with Monte-Carlo method which can perform accurate dose estimation in treatment planning work of radiotherapy, a new voxel modeling method ; "Multistep lattice-voxel method" was devised. Application of the method to Monte-Carlo dosimetry enables to perform high-accuracy estimation as well as fast calculation as about 2 times compared with conventional method. As a investigation result, an patent for the method was applied.

Research Products

• [Journal Article] Multistept Lattice Voxel method utilizing lattice function for Monte-Carlo treatment planning with pixel based voxel model (2011)
  • Author(s): H.Kumada, K.Saito, T.Nakamura, T.Sakae, H.Sakurai, K.Ono, A.Matsumura
  • Journal Title: Appl. Radiat.Isot. (In-Press)
  • Peer Reviewed
• [Journal Article] Development of the efficient modeling method with complicated human geometry for Monte-Carlo treatment planning system (2011)
  • Author(s): H.Kumada, K.Saito, T.Sakae, A.Matsumura, T.Nakamura, K.Ono
  • Journal Title: Progress in Nuclear Science and Technology (In-Press)
  • Peer Reviewed
• [Journal Article] Application of the multi-modal Monte-Carlo treatment planning system combined with PHITS to proton radiotherapy (2011)
  • Author(s): H.Kumada, T.Sakae, K.Saito, T.Isobe, T.Hashimoto, H.Sakurai
  • Journal Title: Progress in Nuclear Science and Technology (In-Press)
  • Peer Reviewed
• [Journal Article] Multistep Lattice-Voxel method utilizing lattice function for Monte-Carlotreatment planning with pixel based voxel model (2011)
  • Author(s): H.Kumada, K.Saito, T.Nakamura, T.Sakae, H.Sakurai, K.Ono, A.Matsumura
  • Journal Title: Applied Radiation and Isotopes Volume: In press
  • Peer Reviewed
• [Journal Article] Development of the Efficient Modeling Method with Complicated Human Geometry for Monte-Carlo Treatment Planning System (2011)
  • Author(s): H.Kumada, K.Saito, T.Sakae, A.Matsumura, T.Nakamura, K.Ono
  • Journal Title: Progress in Nuclear Science and Technology Volume: In press
  • Peer Reviewed
• [Journal Article] Multistept Lattice Voxel method utilizing lattice function for Monte-Carlo treatment planning with pixel based voxel model (2010)
  • Author(s): H.Kumada, K.Saito, T.Nakamura, T.Sakae, H.Sakurai, K.Ono, A.Matsumura
  • Journal Title: New Challenges in Neutron Capture Therapy 2010-Proceedings of ICNCT-14- 238-241
• [Journal Article] Multistep Lattice-Voxel method utilizing lattice function for Monte-Carlotreatment planning with pixel based voxel model (2010)
  • Author(s): H.Kumada, K.Saito, T.Nakamura, T.Sakae, H.Sakurai, K.Ono, A.Matsumura
  • Journal Title: New Challenges in Neutron Capture Therapy 2010 Pages: 238-241
• [Journal Article] Development of the Efficient Modeling Method with Complicated Human Geometry for Monte-Carlo Treatment Planning System (2010)
  • Author(s): H.Kumada, K.Saito, T.Sakae, A.Matsumura, T.Nakamura, K.Ono
  • Journal Title: Proceedings of Joint International Conference on Supercomputing in Nuclear Applications + Monte Carlozoio
• [Journal Article] Evaluation of SERA and JCDS dose Determination Methods and Comparison to Reaction Rate Measurement in Phantom (2010)
  • Author(s): H.Koivunoro, H.Kumada, T.Seppala, T.Seren, et al.
  • Journal Title: New Challenges in Neutron Capture Therapy 2010 Pages: 250-253
• [Journal Article] The status of Tsukuba BNCT trial : BPA-based boron neutron capture therapy combined with X-ray irradiation (2010)
  • Author(s): Yamamoto T, Nakai K, Nariai T, Kumada H, Matsumura A, et al.
  • Journal Title: New Challenges in Neutron Capture Therapy 2010 Pages: 7-8
• [Journal Article] Development of a new multi-modal Monte-Carlo radiotherapy planning system (2009)
  • Author(s): H.Kumada, T.Nakamura, M.Komeda, A.Matsumura
  • Journal Title: Appl. Radiat. Isot. Vol.67 Pages: 118-121
  • Peer Reviewed
• [Journal Article] Development of a Multi-Modal Monte-Carlo Radiation treatment planning system combined with PHITS (2009)
  • Author(s): H.Kumada, T.Nakamura, M.Komeda, A.Matsumura
  • Journal Title: Laser-Driven Relativistic Plasmas Applied to Science, Industry and Medicine 1153 Pages: 377-387
  • Peer Reviewed
• [Journal Article] Boron neutron capture therapy for newly diagnosed glioblastoma (2009)
  • Author(s): T.Yamamoto, K.Nakai, T.Kageji, H.Kumada, K.Endo, M.Matsuda, et al
  • Journal Title: Radiotherapy and Oncology Vol.91 Pages: 80-84
  • NAID: 120007138272
  • Peer Reviewed
• [Journal Article] Performance measurement of the scintillator with optical fiber detector for boron neutron capture therapy (2009)
  • Author(s): M.Komeda, H.Kumada, M.Ishikawa, T.Nakamura, A.Matsumura, K.Yamamoto
  • Journal Title: Appl. Radiat. Isot., Vol. 67 Pages: 254-257
  • Peer Reviewed
• [Journal Article] Comparative study of dose calculation with SERA and JCDS treatment planning systems (2009)
  • Author(s): H.Koivunoro, H.Kumada, T.Seppala, P.Kotiluoto, I.Auterinen, L.Kankaanranta, S.Savolaine
  • Journal Title: Appl.Radiat. Isot. Vol.67 Pages: 126-129
  • Peer Reviewed
• [Journal Article] Development of a new multi-modal Monte-Carlo radiotherapy planning system (2009)
  • Author(s): H.Kumada, T.Nakamura, M.Komeda, A.Matsumura
  • Journal Title: Applied Radiation and Isotopes 67 Pages: 118-121
  • Peer Reviewed
• [Journal Article] Boron neutron capture therapy for newly diagnosed glioblastoma (2009)
  • Author(s): T.Yamamoto, K.Nakai, T.Kageji, H.Kumada, K.Endo, M.Matsuda, et al
  • Journal Title: Radiotherapy and Oncology 91 Pages: 80-84
  • NAID: 120007138272
  • Peer Reviewed
• [Journal Article] Performance measurement of the scintillator with optical fiber detector for boron neutron capture therapy (2009)
  • Author(s): M.Komeda, H.Kumada, M.Ishikawa, T.Nakamura, K.Yamamoto, A.Matsumura
  • Journal Title: Applied Radiation and Isotopes 67 Pages: 254-257
  • Peer Reviewed
• [Journal Article] Survival benefit of Boron neutron capture therapy for recurrent malignant gliomas (2009)
  • Author(s): S.Miyatake, S.Kawbata, K.Yokoyama, T.Kuroiwa, H.Michiue, Y.Sakura, H.Kumada, et al
  • Journal Title: Journal of Nuero-Oncology 91 Pages: 199-206
  • Peer Reviewed
• [Journal Article] Boron neutron capture therapy for newly diagnosed glioblastoma (2009)
  • Author(s): S.Kawabata, S.Miyatake, T.Kuroiwa, K.Yokoyama, A.Doi, K.Iida, S.Miyata, N.Nonoguchi, H.Kumada, et al
  • Journal Title: Journal of Radiation Research 50 Pages: 51-60
  • NAID: 120007138272
  • Peer Reviewed
• [Journal Article] Development of a new multi-modal Monte-Carlo radiotherapy planning system (2009)
  • Author(s): H. Kumada, T. Nakamura, M. Komeda, A. Matsumura
  • Journal Title: Applied Radiation and Isotopes (印刷中)
  • Peer Reviewed
• [Journal Article] 中性子捕捉療法の線量評価 (2008)
  • Author(s): 熊田博明、山本和喜、松村明、小野公二
  • Journal Title: 放射線 Vol.3, No.2 Pages: 117-126
  • NAID: 10024750574
  • Peer Reviewed
• [Journal Article] 中性子捕捉療法の線量評価 (2008)
  • Author(s): 熊田博明, 山本和喜, 松村明, 小野公二
  • Journal Title: 放射線(応用物理学会放射線分科会誌) Vol.34、No.2 Pages: 117-126
  • NAID: 10024750574
  • Peer Reviewed
• [Journal Article] BNCTの現状と線量評価技術の進展 (2008)
  • Author(s): 熊田博明
  • Journal Title: RIST-NEWS No.46 Pages: 20-27
• [Presentation] 粒子線治療のモンテカルロ線量評価を高速化する新しいボクセルモデリング手法 (2011)
  • Author(s): 熊田博明、松村明、中村剛実、小野公二、櫻井良憲
  • Organizer: 日本原子力学会2011春の年会
  • Place of Presentation: 福井
  • Year and Date: 2011-03-30
• [Presentation] 粒子線治療のモンテカルロ線量評価を高速化する新しいボクセルモデリング手法 (2011)
  • Author(s): 熊田博明、松村明、中村剛実、小野公二、櫻井良憲
  • Organizer: 日本原子力学会2011年春の年会
  • Place of Presentation: 福井大学(福井)
  • Year and Date: 2011-03-30
• [Presentation] 先進的粒子線治療における線量評価技術 (2011)
  • Author(s): 熊田博明
  • Organizer: 公開シンポジウム「がん放射線治療の基礎と臨床をつなぐ」
  • Place of Presentation: 茨城大学(茨城)
  • Year and Date: 2011-02-05
• [Presentation] Multistep Lattice-Voxel method utilizing lattice function for Monte-Carlotreatment planning with pixel based voxel model (2010)
  • Author(s): H.Kumada, K.Saito, T.Nakamura, T.Sakae, H.Sakurai, K.Ono, A.Matsumura
  • Organizer: 17^<th> International Congress on Neutron Capture Therapy
  • Place of Presentation: ブエノスアイ.レス/アルゼンチン
  • Year and Date: 2010-10-29
• [Presentation] Development of the Efficient Modeling Method with Complicated Human Geometry for Monte-Carlo Treatment Planning System (2010)
  • Author(s): H.Kumada, K.Saito, T.Sakae, A.Matsumura, T.Nakamura, K.Ono
  • Organizer: Joint International Conference on Supercomputing in Nuclear Applications + Monte Carlo 2010
  • Place of Presentation: 一ツ橋メモリアルホール(東京)
  • Year and Date: 2010-10-19
• [Presentation] モンテカルロ線量評価の高精度化と高速化を可能にするマルチステップ・ラティス・ボクセル法 (2010)
  • Author(s): 熊田博明
  • Organizer: 第7回日本中性子捕捉療法学会学術大会
  • Place of Presentation: 東京
  • Year and Date: 2010-08-05
• [Presentation] モンテカルロ線量評価の高精度化と高速化を可能にするマルチステップ・ラティス・ボクセル法 (2010)
  • Author(s): 熊田博明
  • Organizer: 第7回日本中性子捕捉療法学会学術大会
  • Place of Presentation: 学習院大学(東京)
  • Year and Date: 2010-08-05
• [Presentation] Multistept Lattice Voxel method utilizing lattice function for Monte-Carlo treatment planning with pixel based voxel model (2009)
  • Author(s): H.Kumada, K.Saito, T.Nakamura, T.Sakae, H.Sakurai, K.Ono, A.Matsumura
  • Organizer: 14th International Congress on Neutron Capture Therapy
  • Place of Presentation: ブエノスアイレス
  • Year and Date: 2009-10-29
• [Presentation] Development of the efficient modeling method with complicated human geometry for Monte-Carlo treatment planning system (2009)
  • Author(s): H.Kumada, K.Saito, T.Sakae, A.Matsumura, T.Nakamura, K.Ono
  • Organizer: Joint International Conference on Supercomputing in Nuclear Applications + Monte Carlo 2010
  • Place of Presentation: 東京
  • Year and Date: 2009-10-19
• [Presentation] BNCTの中性子照射技術、治療計画技術 (2009)
  • Author(s): 熊田博明、松村明、中村剛実、小野公二、櫻井良憲
  • Organizer: 日本放射線腫瘍学会第22回学術大会
  • Place of Presentation: 京都
  • Year and Date: 2009-09-18
• [Presentation] BNCTの中性子照射技術、治療計画技術 (2009)
  • Author(s): 熊田博明、松村明、中村剛実、小野公二、櫻井良憲
  • Organizer: 日本放射線腫瘍学会第22回学術大会
  • Place of Presentation: 国立京都国際会館(京都)
  • Year and Date: 2009-09-18
• [Presentation] Development of a new Monte-Carlo radiation treatment planning system for boron neutr on capture therapy (2009)
  • Author(s): H.Kumada, T.Nakamura, A.Matsumura, K.Ono
  • Organizer: 17th International Conference on Nuclear and Engineering
  • Place of Presentation: ブリュッセル
  • Year and Date: 2009-07-14
• [Presentation] Development of a new Monte-Carlo radiation treatment planning system for boron neutron capture therapy (2009)
  • Author(s): 熊田博明, 中村剛実, 松村明, 小野公二
  • Organizer: 17^<th> International Conference on Nuclear Engineering
  • Place of Presentation: ブリュッセル/ベルギー
  • Year and Date: 2009-07-14
• [Presentation] 新しい汎用放射線治療用モンテカルロ治療計画システムの線量評価性能の検証 (2009)
  • Author(s): 熊田博明、中村剛実、松村明
  • Organizer: 第97回日本医学物理学会学術大会
  • Place of Presentation: 横浜
  • Year and Date: 2009-04-17
• [Presentation] 新しい汎用放射線治療用モンテカルロ治療計画システムの線量評価性能の検証 (2009)
  • Author(s): 熊田博明、中村剛実、松村明
  • Organizer: 第97回日本医学物理学会学術大会
  • Place of Presentation: パシフィコ横浜(横浜)
  • Year and Date: 2009-04-17
• [Presentation] 線量計算にPHITS を適用した汎用モンテカルロ粒子線治療計画システムの開発 (2009)
  • Author(s): 熊田博明、中村剛実、松村明、小野公二
  • Organizer: 春季第56回応用物理学会関係連合講演会
  • Place of Presentation: つくば
  • Year and Date: 2009-03-30
• [Presentation] 線量計算にPHITSを適用した汎用モンテカルロ粒子線治療計画システムの開発 (2009)
  • Author(s): 熊田博明, 中村剛実, 松村明, 小野公二
  • Organizer: 春季第56回応用物理学会関係連合講演会
  • Place of Presentation: つくば市(筑波大学)
  • Year and Date: 2009-03-30
• [Presentation] Development of a Multi-Modal Monte-Carlo Radiation treatment planning system combined with PHITS (2009)
  • Author(s): H.Kumada, T.Nakamura, M.Komeda, A.Matsumura
  • Organizer: 2nd International Symposium on Laser- Driven Relativistic Plasmas Applied to Science, Industry and Medicine
  • Place of Presentation: 京都
  • Year and Date: 2009-01-19
• [Presentation] Development of a multi-modal Monte-Carlo radiation treatment planning system combined with PHITS (2009)
  • Author(s): H. Kumada, T. Nakamura, M. Komeda, A. Matsumura
  • Organizer: 2nd International Symposium on Laser-Driven Relativistic Plasmas Applied to Science, Industry and Medicine
  • Place of Presentation: 木津市(原子力機構関西研究所)
  • Year and Date: 2009-01-19
• [Presentation] Development of a new multi-modal Monte-Carlo radiotherapy, planning system (2008)
  • Author(s): H.Kumada, T.Nakamura, M.Komeda, A.Matsumura
  • Organizer: 13th International Congress on Neutron Capture Therapy
  • Place of Presentation: フィレンツェ(イタリア)
  • Year and Date: 2008-11-06
• [Presentation] Development of a new multi-modal Monte-Carlo radiotherapy planning system (2008)
  • Author(s): H. Kumada, T. Nakamura, M. Komeda, A. Matsumura
  • Organizer: 13^<th> International Congress on Neutron Capture Therapy
  • Place of Presentation: フィレンツェ/イタリア
  • Year and Date: 2008-11-06
• [Presentation] 中性子捕捉療法の治療計画 (2008)
  • Author(s): 熊田博明
  • Organizer: 第5回日本中性子捕捉療法学会学術大会
  • Place of Presentation: 岡山
  • Year and Date: 2008-07-26
• [Presentation] 中性子捕捉療法の治療計画 (2008)
  • Author(s): 熊田博明
  • Organizer: 第5回 日本中性子捕捉療法学会学術大会
  • Place of Presentation: 倉敷市
  • Year and Date: 2008-07-26
• [Patent(Industrial Property Rights)] マルチステップ・ラティス・ボクセル法 (2011)
  • Inventor(s): 熊田博明
  • Industrial Property Rights Holder: 筑波大学
  • Industrial Property Number: 2010-232524
  • Filing Date: 2011-10-15
• [Patent(Industrial Property Rights)] マルチステップ・ラティス・ボクセル法 (2010)
  • Inventor(s): 熊田博明
  • Industrial Property Rights Holder: 筑波大学
  • Industrial Property Number: 2010-232524
  • Filing Date: 2010-10-15