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Investigation of boundary functional modeling method which can perform accurate Monte-Carlo dosimetry in treatment planning in neutron capture therapy.

Research Project

Project/Area Number 20591487
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Radiation science
Research InstitutionJapan Atomic Energy Agency

Principal Investigator

KUMADA Hiroaki  Japan Atomic Energy Agency, 大学院・人間総合科学研究科, 准教授 (30354913)

Co-Investigator(Kenkyū-buntansha) YAMAMOTO Tetsuya  筑波大学, 大学院・人間総合科学研究科, 講師 (30375505)
Project Period (FY) 2008 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2010: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2008: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Keywords放射線医療物理学 / 中性子捕捉療法 / 治療計画 / 線量評価 / アルゴリズム / モンテカルロ / シミュレーション / BNCT / モンテカルロ輸送計算 / 粒子線治療
Research Abstract

For computational dosimetry with Monte-Carlo method which can perform accurate dose estimation in treatment planning work of radiotherapy, a new voxel modeling method ; "Multistep lattice-voxel method" was devised. Application of the method to Monte-Carlo dosimetry enables to perform high-accuracy estimation as well as fast calculation as about 2 times compared with conventional method. As a investigation result, an patent for the method was applied.

Report

(4 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (49 results)

All 2011 2010 2009 2008

All Journal Article (24 results) (of which Peer Reviewed: 18 results) Presentation (23 results) Patent(Industrial Property Rights) (2 results)

  • [Journal Article] Multistept Lattice Voxel method utilizing lattice function for Monte-Carlo treatment planning with pixel based voxel model2011

    • Author(s)
      H.Kumada, K.Saito, T.Nakamura, T.Sakae, H.Sakurai, K.Ono, A.Matsumura
    • Journal Title

      Appl. Radiat.Isot. (In-Press)

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Development of the efficient modeling method with complicated human geometry for Monte-Carlo treatment planning system2011

    • Author(s)
      H.Kumada, K.Saito, T.Sakae, A.Matsumura, T.Nakamura, K.Ono
    • Journal Title

      Progress in Nuclear Science and Technology (In-Press)

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Application of the multi-modal Monte-Carlo treatment planning system combined with PHITS to proton radiotherapy2011

    • Author(s)
      H.Kumada, T.Sakae, K.Saito, T.Isobe, T.Hashimoto, H.Sakurai
    • Journal Title

      Progress in Nuclear Science and Technology (In-Press)

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Multistep Lattice-Voxel method utilizing lattice function for Monte-Carlotreatment planning with pixel based voxel model2011

    • Author(s)
      H.Kumada, K.Saito, T.Nakamura, T.Sakae, H.Sakurai, K.Ono, A.Matsumura
    • Journal Title

      Applied Radiation and Isotopes

      Volume: In press

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Development of the Efficient Modeling Method with Complicated Human Geometry for Monte-Carlo Treatment Planning System2011

    • Author(s)
      H.Kumada, K.Saito, T.Sakae, A.Matsumura, T.Nakamura, K.Ono
    • Journal Title

      Progress in Nuclear Science and Technology

      Volume: In press

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Multistept Lattice Voxel method utilizing lattice function for Monte-Carlo treatment planning with pixel based voxel model2010

    • Author(s)
      H.Kumada, K.Saito, T.Nakamura, T.Sakae, H.Sakurai, K.Ono, A.Matsumura
    • Journal Title

      New Challenges in Neutron Capture Therapy 2010-Proceedings of ICNCT-14- 238-241

    • Related Report
      2010 Final Research Report
  • [Journal Article] Multistep Lattice-Voxel method utilizing lattice function for Monte-Carlotreatment planning with pixel based voxel model2010

    • Author(s)
      H.Kumada, K.Saito, T.Nakamura, T.Sakae, H.Sakurai, K.Ono, A.Matsumura
    • Journal Title

      New Challenges in Neutron Capture Therapy 2010

      Pages: 238-241

    • Related Report
      2010 Annual Research Report
  • [Journal Article] Development of the Efficient Modeling Method with Complicated Human Geometry for Monte-Carlo Treatment Planning System2010

    • Author(s)
      H.Kumada, K.Saito, T.Sakae, A.Matsumura, T.Nakamura, K.Ono
    • Journal Title

      Proceedings of Joint International Conference on Supercomputing in Nuclear Applications + Monte Carlozoio

    • Related Report
      2010 Annual Research Report
  • [Journal Article] Evaluation of SERA and JCDS dose Determination Methods and Comparison to Reaction Rate Measurement in Phantom2010

    • Author(s)
      H.Koivunoro, H.Kumada, T.Seppala, T.Seren, et al.
    • Journal Title

      New Challenges in Neutron Capture Therapy 2010

      Pages: 250-253

    • Related Report
      2010 Annual Research Report
  • [Journal Article] The status of Tsukuba BNCT trial : BPA-based boron neutron capture therapy combined with X-ray irradiation2010

    • Author(s)
      Yamamoto T, Nakai K, Nariai T, Kumada H, Matsumura A, et al.
    • Journal Title

      New Challenges in Neutron Capture Therapy 2010

      Pages: 7-8

    • Related Report
      2010 Annual Research Report
  • [Journal Article] Development of a new multi-modal Monte-Carlo radiotherapy planning system2009

    • Author(s)
      H.Kumada, T.Nakamura, M.Komeda, A.Matsumura
    • Journal Title

      Appl. Radiat. Isot. Vol.67

      Pages: 118-121

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Development of a Multi-Modal Monte-Carlo Radiation treatment planning system combined with PHITS2009

    • Author(s)
      H.Kumada, T.Nakamura, M.Komeda, A.Matsumura
    • Journal Title

      Laser-Driven Relativistic Plasmas Applied to Science, Industry and Medicine 1153

      Pages: 377-387

    • Related Report
      2010 Final Research Report 2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Boron neutron capture therapy for newly diagnosed glioblastoma2009

    • Author(s)
      T.Yamamoto, K.Nakai, T.Kageji, H.Kumada, K.Endo, M.Matsuda, et al
    • Journal Title

      Radiotherapy and Oncology Vol.91

      Pages: 80-84

    • NAID

      120007138272

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Performance measurement of the scintillator with optical fiber detector for boron neutron capture therapy2009

    • Author(s)
      M.Komeda, H.Kumada, M.Ishikawa, T.Nakamura, A.Matsumura, K.Yamamoto
    • Journal Title

      Appl. Radiat. Isot., Vol. 67

      Pages: 254-257

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Comparative study of dose calculation with SERA and JCDS treatment planning systems2009

    • Author(s)
      H.Koivunoro, H.Kumada, T.Seppala, P.Kotiluoto, I.Auterinen, L.Kankaanranta, S.Savolaine
    • Journal Title

      Appl.Radiat. Isot. Vol.67

      Pages: 126-129

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Development of a new multi-modal Monte-Carlo radiotherapy planning system2009

    • Author(s)
      H.Kumada, T.Nakamura, M.Komeda, A.Matsumura
    • Journal Title

      Applied Radiation and Isotopes 67

      Pages: 118-121

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Boron neutron capture therapy for newly diagnosed glioblastoma2009

    • Author(s)
      T.Yamamoto, K.Nakai, T.Kageji, H.Kumada, K.Endo, M.Matsuda, et al
    • Journal Title

      Radiotherapy and Oncology 91

      Pages: 80-84

    • NAID

      120007138272

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Performance measurement of the scintillator with optical fiber detector for boron neutron capture therapy2009

    • Author(s)
      M.Komeda, H.Kumada, M.Ishikawa, T.Nakamura, K.Yamamoto, A.Matsumura
    • Journal Title

      Applied Radiation and Isotopes 67

      Pages: 254-257

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Survival benefit of Boron neutron capture therapy for recurrent malignant gliomas2009

    • Author(s)
      S.Miyatake, S.Kawbata, K.Yokoyama, T.Kuroiwa, H.Michiue, Y.Sakura, H.Kumada, et al
    • Journal Title

      Journal of Nuero-Oncology 91

      Pages: 199-206

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Boron neutron capture therapy for newly diagnosed glioblastoma2009

    • Author(s)
      S.Kawabata, S.Miyatake, T.Kuroiwa, K.Yokoyama, A.Doi, K.Iida, S.Miyata, N.Nonoguchi, H.Kumada, et al
    • Journal Title

      Journal of Radiation Research 50

      Pages: 51-60

    • NAID

      120007138272

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Development of a new multi-modal Monte-Carlo radiotherapy planning system2009

    • Author(s)
      H. Kumada, T. Nakamura, M. Komeda, A. Matsumura
    • Journal Title

      Applied Radiation and Isotopes (印刷中)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 中性子捕捉療法の線量評価2008

    • Author(s)
      熊田博明、山本和喜、松村明、小野公二
    • Journal Title

      放射線 Vol.3, No.2

      Pages: 117-126

    • NAID

      10024750574

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] 中性子捕捉療法の線量評価2008

    • Author(s)
      熊田博明, 山本和喜, 松村明, 小野公二
    • Journal Title

      放射線(応用物理学会放射線分科会誌) Vol.34、No.2

      Pages: 117-126

    • NAID

      10024750574

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] BNCTの現状と線量評価技術の進展2008

    • Author(s)
      熊田博明
    • Journal Title

      RIST-NEWS No.46

      Pages: 20-27

    • Related Report
      2008 Annual Research Report
  • [Presentation] 粒子線治療のモンテカルロ線量評価を高速化する新しいボクセルモデリング手法2011

    • Author(s)
      熊田博明、松村明、中村剛実、小野公二、櫻井良憲
    • Organizer
      日本原子力学会2011春の年会
    • Place of Presentation
      福井
    • Year and Date
      2011-03-30
    • Related Report
      2010 Final Research Report
  • [Presentation] 粒子線治療のモンテカルロ線量評価を高速化する新しいボクセルモデリング手法2011

    • Author(s)
      熊田博明、松村明、中村剛実、小野公二、櫻井良憲
    • Organizer
      日本原子力学会2011年春の年会
    • Place of Presentation
      福井大学(福井)
    • Year and Date
      2011-03-30
    • Related Report
      2010 Annual Research Report
  • [Presentation] 先進的粒子線治療における線量評価技術2011

    • Author(s)
      熊田博明
    • Organizer
      公開シンポジウム「がん放射線治療の基礎と臨床をつなぐ」
    • Place of Presentation
      茨城大学(茨城)
    • Year and Date
      2011-02-05
    • Related Report
      2010 Annual Research Report
  • [Presentation] Multistep Lattice-Voxel method utilizing lattice function for Monte-Carlotreatment planning with pixel based voxel model2010

    • Author(s)
      H.Kumada, K.Saito, T.Nakamura, T.Sakae, H.Sakurai, K.Ono, A.Matsumura
    • Organizer
      17^<th> International Congress on Neutron Capture Therapy
    • Place of Presentation
      ブエノスアイ.レス/アルゼンチン
    • Year and Date
      2010-10-29
    • Related Report
      2010 Annual Research Report
  • [Presentation] Development of the Efficient Modeling Method with Complicated Human Geometry for Monte-Carlo Treatment Planning System2010

    • Author(s)
      H.Kumada, K.Saito, T.Sakae, A.Matsumura, T.Nakamura, K.Ono
    • Organizer
      Joint International Conference on Supercomputing in Nuclear Applications + Monte Carlo 2010
    • Place of Presentation
      一ツ橋メモリアルホール(東京)
    • Year and Date
      2010-10-19
    • Related Report
      2010 Annual Research Report
  • [Presentation] モンテカルロ線量評価の高精度化と高速化を可能にするマルチステップ・ラティス・ボクセル法2010

    • Author(s)
      熊田博明
    • Organizer
      第7回日本中性子捕捉療法学会学術大会
    • Place of Presentation
      東京
    • Year and Date
      2010-08-05
    • Related Report
      2010 Final Research Report
  • [Presentation] モンテカルロ線量評価の高精度化と高速化を可能にするマルチステップ・ラティス・ボクセル法2010

    • Author(s)
      熊田博明
    • Organizer
      第7回日本中性子捕捉療法学会学術大会
    • Place of Presentation
      学習院大学(東京)
    • Year and Date
      2010-08-05
    • Related Report
      2010 Annual Research Report
  • [Presentation] Multistept Lattice Voxel method utilizing lattice function for Monte-Carlo treatment planning with pixel based voxel model2009

    • Author(s)
      H.Kumada, K.Saito, T.Nakamura, T.Sakae, H.Sakurai, K.Ono, A.Matsumura
    • Organizer
      14th International Congress on Neutron Capture Therapy
    • Place of Presentation
      ブエノスアイレス
    • Year and Date
      2009-10-29
    • Related Report
      2010 Final Research Report
  • [Presentation] Development of the efficient modeling method with complicated human geometry for Monte-Carlo treatment planning system2009

    • Author(s)
      H.Kumada, K.Saito, T.Sakae, A.Matsumura, T.Nakamura, K.Ono
    • Organizer
      Joint International Conference on Supercomputing in Nuclear Applications + Monte Carlo 2010
    • Place of Presentation
      東京
    • Year and Date
      2009-10-19
    • Related Report
      2010 Final Research Report
  • [Presentation] BNCTの中性子照射技術、治療計画技術2009

    • Author(s)
      熊田博明、松村明、中村剛実、小野公二、櫻井良憲
    • Organizer
      日本放射線腫瘍学会第22回学術大会
    • Place of Presentation
      京都
    • Year and Date
      2009-09-18
    • Related Report
      2010 Final Research Report
  • [Presentation] BNCTの中性子照射技術、治療計画技術2009

    • Author(s)
      熊田博明、松村明、中村剛実、小野公二、櫻井良憲
    • Organizer
      日本放射線腫瘍学会第22回学術大会
    • Place of Presentation
      国立京都国際会館(京都)
    • Year and Date
      2009-09-18
    • Related Report
      2009 Annual Research Report
  • [Presentation] Development of a new Monte-Carlo radiation treatment planning system for boron neutr on capture therapy2009

    • Author(s)
      H.Kumada, T.Nakamura, A.Matsumura, K.Ono
    • Organizer
      17th International Conference on Nuclear and Engineering
    • Place of Presentation
      ブリュッセル
    • Year and Date
      2009-07-14
    • Related Report
      2010 Final Research Report
  • [Presentation] Development of a new Monte-Carlo radiation treatment planning system for boron neutron capture therapy2009

    • Author(s)
      熊田博明, 中村剛実, 松村明, 小野公二
    • Organizer
      17^<th> International Conference on Nuclear Engineering
    • Place of Presentation
      ブリュッセル/ベルギー
    • Year and Date
      2009-07-14
    • Related Report
      2009 Annual Research Report
  • [Presentation] 新しい汎用放射線治療用モンテカルロ治療計画システムの線量評価性能の検証2009

    • Author(s)
      熊田博明、中村剛実、松村明
    • Organizer
      第97回日本医学物理学会学術大会
    • Place of Presentation
      横浜
    • Year and Date
      2009-04-17
    • Related Report
      2010 Final Research Report
  • [Presentation] 新しい汎用放射線治療用モンテカルロ治療計画システムの線量評価性能の検証2009

    • Author(s)
      熊田博明、中村剛実、松村明
    • Organizer
      第97回日本医学物理学会学術大会
    • Place of Presentation
      パシフィコ横浜(横浜)
    • Year and Date
      2009-04-17
    • Related Report
      2009 Annual Research Report
  • [Presentation] 線量計算にPHITS を適用した汎用モンテカルロ粒子線治療計画システムの開発2009

    • Author(s)
      熊田博明、中村剛実、松村明、小野公二
    • Organizer
      春季第56回応用物理学会関係連合講演会
    • Place of Presentation
      つくば
    • Year and Date
      2009-03-30
    • Related Report
      2010 Final Research Report
  • [Presentation] 線量計算にPHITSを適用した汎用モンテカルロ粒子線治療計画システムの開発2009

    • Author(s)
      熊田博明, 中村剛実, 松村明, 小野公二
    • Organizer
      春季第56回応用物理学会関係連合講演会
    • Place of Presentation
      つくば市(筑波大学)
    • Year and Date
      2009-03-30
    • Related Report
      2008 Annual Research Report
  • [Presentation] Development of a Multi-Modal Monte-Carlo Radiation treatment planning system combined with PHITS2009

    • Author(s)
      H.Kumada, T.Nakamura, M.Komeda, A.Matsumura
    • Organizer
      2nd International Symposium on Laser- Driven Relativistic Plasmas Applied to Science, Industry and Medicine
    • Place of Presentation
      京都
    • Year and Date
      2009-01-19
    • Related Report
      2010 Final Research Report
  • [Presentation] Development of a multi-modal Monte-Carlo radiation treatment planning system combined with PHITS2009

    • Author(s)
      H. Kumada, T. Nakamura, M. Komeda, A. Matsumura
    • Organizer
      2nd International Symposium on Laser-Driven Relativistic Plasmas Applied to Science, Industry and Medicine
    • Place of Presentation
      木津市(原子力機構関西研究所)
    • Year and Date
      2009-01-19
    • Related Report
      2008 Annual Research Report
  • [Presentation] Development of a new multi-modal Monte-Carlo radiotherapy, planning system2008

    • Author(s)
      H.Kumada, T.Nakamura, M.Komeda, A.Matsumura
    • Organizer
      13th International Congress on Neutron Capture Therapy
    • Place of Presentation
      フィレンツェ(イタリア)
    • Year and Date
      2008-11-06
    • Related Report
      2010 Final Research Report
  • [Presentation] Development of a new multi-modal Monte-Carlo radiotherapy planning system2008

    • Author(s)
      H. Kumada, T. Nakamura, M. Komeda, A. Matsumura
    • Organizer
      13^<th> International Congress on Neutron Capture Therapy
    • Place of Presentation
      フィレンツェ/イタリア
    • Year and Date
      2008-11-06
    • Related Report
      2008 Annual Research Report
  • [Presentation] 中性子捕捉療法の治療計画2008

    • Author(s)
      熊田博明
    • Organizer
      第5回日本中性子捕捉療法学会学術大会
    • Place of Presentation
      岡山
    • Year and Date
      2008-07-26
    • Related Report
      2010 Final Research Report
  • [Presentation] 中性子捕捉療法の治療計画2008

    • Author(s)
      熊田博明
    • Organizer
      第5回 日本中性子捕捉療法学会学術大会
    • Place of Presentation
      倉敷市
    • Year and Date
      2008-07-26
    • Related Report
      2008 Annual Research Report
  • [Patent(Industrial Property Rights)] マルチステップ・ラティス・ボクセル法2011

    • Inventor(s)
      熊田博明
    • Industrial Property Rights Holder
      筑波大学
    • Industrial Property Number
      2010-232524
    • Filing Date
      2011-10-15
    • Related Report
      2010 Final Research Report
  • [Patent(Industrial Property Rights)] マルチステップ・ラティス・ボクセル法2010

    • Inventor(s)
      熊田博明
    • Industrial Property Rights Holder
      筑波大学
    • Industrial Property Number
      2010-232524
    • Filing Date
      2010-10-15
    • Related Report
      2010 Annual Research Report

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Published: 2008-04-01   Modified: 2016-04-21  

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