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Basic studies for the development of a PET cancer imaging agent utilizing physical and biological properties of Zn-63

Research Project

Project/Area Number 20591488
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Radiation science
Research InstitutionNational Institute of Radiological Sciences

Principal Investigator

FURUKAWA Takako  National Institute of Radiological Sciences, 分子イメージング研究センター, チームリーダー (00221557)

Co-Investigator(Renkei-kenkyūsha) SAITO Yuriko  独立行政法人放射線医学総合研究所, 分子イメージング研究センター, 准技術員 (20446537)
HASEGAWA Sumitaka  独立行政法人放射線医学総合研究所, 分子イメージング研究センター, 主任研究員 (60415437)
FUKUMURA Toshimitsu  独立行政法人放射線医学総合研究所, 分子イメージング研究センター, チームリーダー (90199266)
FUJIBAYASHI Yasuhisa  独立行政法人放射線医学総合研究所, 分子イメージング研究センター, センター長 (50165411)
Project Period (FY) 2008 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2008: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords腫瘍 / PET / Zn-63 / 亜鉛 / イメージング / Zn-EDDA / 種瘍
Research Abstract

Zinc-63 is a positron emitter with 38 min half life and can be produced with a small clinical cyclotron targeting Cu-63, the most abundant Cu isotope, which makes Zn-63 attractive for clinical use. Zn is necessary for cell proliferation and supposed to be involved in cancer development. In this study, we explored the possibility to use Zn-63 for cancer imaging. We found that the uptake of Zn by cancer cells was found to be correlated with Zn content, suggesting that the uptake reflects the physiological needs of the cells, and that EDDA, a relatively weak chelator of Zn, worked favorably for caner imaging. We also found that adjusting the dose, higher accumulation of Zn into tumor mass was achievable. The small animal PET imaging of tumor in mouse model was successful with Zn-63 produced in our institute.

Report

(4 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (3 results)

All 2009 2008

All Presentation (3 results)

  • [Presentation] Basic Evaluation of Zn-EDDA for Cancer Imaging2009

    • Author(s)
      古川高子, 齋藤有里子, 長谷川純崇, 佐賀恒夫, 藤林靖久
    • Organizer
      World Molecular Imaging Congress
    • Place of Presentation
      モントリオール
    • Related Report
      2010 Final Research Report
  • [Presentation] Basic Evaluation of Zn-EDDA for Cancer Imaging2009

    • Author(s)
      Takako Furukawa, Yuriko Saito, Sumitaka Hasegawa, Tsuneo Saga, Yasuhisa Fujibayashi
    • Organizer
      World Molecular Imaging Congress
    • Place of Presentation
      Montreal, Canada
    • Related Report
      2009 Annual Research Report
  • [Presentation] Zn-EDDAのPET腫瘍診断薬としての可能性を探る2008

    • Author(s)
      古川高子、長谷川純崇、越川道子、須尭綾、齋藤有里子、曽川千鶴、佐賀恒夫、藤林靖久
    • Organizer
      第3回日本分子イメージング学会総会・学術集会
    • Place of Presentation
      さいたま市
    • Related Report
      2010 Final Research Report

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Published: 2008-04-01   Modified: 2016-04-21  

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