Elucidation of the molecular mechanism that regulates homologous recombination and its applications to personalized radiotherapy for cancer
| Project/Area Number |
20591492
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Radiation science
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| Research Institution | The University of Tokyo |
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Principal Investigator |
HOSOYA Noriko The University of Tokyo, 大学院・医学系研究科, 助教 (00396748)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2008: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | がん / 相同組換え / 放射線治療 / 放射線 / 癌 / 薬剤反応性 / 遺伝子 |
|---|
| Research Abstract |
In order to develop an effective personalized radiotherapy for cancer according to the DNA repair status of individual patients, it is important to clarify the molecular mechanisms that regulate the DNA damage repair systems. In this study, we investigated the mitotic role of the synaptonemal complex protein SYCP3, which is not expressed in normal mitotic cells but aberrantly expressed in cancer cells. We found that SYCP3 inhibits the intrinsic homologous recombination pathway by interfering with BRCA2, leading to hypersensitivity to radiation.
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Report
(4 results)
Research Products
(54 results)
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[Journal Article] Clinical features of late cytomegalovirus infection after hematopoietic stem cell transplantation.2008
Author(s)
Asano-Mori Y, Kanda Y, Oshima K, Kako S, Shinohara A, Nakasone H, Sato H, Watanabe T, Hosoya N, Izutsu K, Asai T, Hangaishi A, Motokura T, Chiba S, Kurokawa M
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Journal Title
Int J Hematol. 87(3)
Pages: 310-318
NAID
Related Report
Peer Reviewed
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[Journal Article] Long-term ultra-low-dose acyclovir against varicella-zoster virus reactivation after allogeneic hematopoietic stem cell transplantation.2008
Author(s)
Asano-Mori Y, Kanda Y, Oshima K, Kako S, Shinohara A, Nakasone H, Sato H, Watanabe T, Hosoya N, Izutsu K, Asai T, Hangaishi A, Motokura T, Chiba S, Kurokawa M
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Journal Title
Am J Hematol. 83(6)
Pages: 472-476
Related Report
Peer Reviewed
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