| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2008: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
|
|---|
| Research Abstract |
In order to develop an effective personalized radiotherapy for cancer according to the DNA repair status of individual patients, it is important to clarify the molecular mechanisms that regulate the DNA damage repair systems. In this study, we investigated the mitotic role of the synaptonemal complex protein SYCP3, which is not expressed in normal mitotic cells but aberrantly expressed in cancer cells. We found that SYCP3 inhibits the intrinsic homologous recombination pathway by interfering with BRCA2, leading to hypersensitivity to radiation.
|
