Analyzing and exploiting the characteristics of intratumor quiescent cells in search of the potential as a cancer stem cell

• Project/Area Number: 20591493
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Radiation science
• Research Institution: Kyoto University
• Principal Investigator: MASUNAGA Shin-Ichiro Kyoto University, 原子炉実験所, 准教授 (80238914)
• Co-Investigator(Kenkyū-buntansha): KASHINO Genro 京都大学, 原子炉実験所, 助教 (00437287) ; TANO Keizo 京都大学, 原子炉実験所, 准教授 (00183468)
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2008: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
• Keywords: 休止期腫瘍細胞 / 癌幹細胞 / 低酸素腫瘍細胞 / 局所腫瘍制御 / 遠隔転移抑制 / 局所腫瘍制御効果 / 遠隔転移抑制効果 / 酸素化休止期腫瘍細胞分画 / p53 status / 硼素中性子捕捉療法(BNCT) / 血管新生阻害剤 / 急性低酸素細胞分画 / 酸素効果 / 線エネルギー付与(LET) / 急性低酸素細胞 / 慢性低酸素細胞 / 線量率効果 / 遠隔転移 / 低温度温熱処置 / ヘキサメチレンテトラミン / 低酸素細胞毒薬剤 / 腫瘍内酸素化状態 / 加速炭素線ビーム

Research Abstract

Tumor radiosensitivity can be changed through manipulating itratumor oxygenation status not only before and during irradiation but also after irradiation, and not only under high dose-rate but also under reduced dose-rate irradiation. Antiangiogenic agent, bevacizumab, led to releasing intratumor acutely hypoxic fraction, resulting in repressing distant pulmonary metastasis from local tumor. Meanwhile, the method for selectively detecting the sensitivity of oxygenated quiescent tumor cell popiulation could be established.

Research Products

• [Journal Article] Radiosensitivity and capacity to recover from radiation-induced damage in pimonidazole- unlabeled intratumor quiescent cells depend on p53 status. (2011)
  • Author(s): Masunaga S, Liu Y, Tanaka H, Sakurai Y, et al.
  • Journal Title: World Journal of Oncology 1 Pages: 1-9
  • Peer Reviewed
• [Journal Article] Synthesis and evaluation of cyclic RGD-boron cluster conjugates to develop tumor-selective boron carriers for boron neutron capture therapy. (2011)
  • Author(s): Kimura S, Masunaga S, Harada T, et al.
  • Journal Title: Bioorg & Med Chem 19 Pages: 1721-1728
  • Peer Reviewed
• [Journal Article] 中性子捕捉療法 (2011)
  • Author(s): 小野公二、鈴木実、増永慎一郎
  • Journal Title: これだけは知っておきたい!放射線療法Q&A-基本知識と最前線-(平岡真寛編集、総合医学社、がん治療レクチャー) Vol.2、No.1 Pages: 59-64
• [Journal Article] Radiosensitivity and capacity to recover from radiation-induced damage in pimonidazole-unlabeled intratumor quiescent cells depend on p53 status. (2011)
  • Author(s): Masunaga S, Liu Y, Tanaka H, Sakurai Y, et al.
  • Journal Title: World Journal of Oncology Volume: 1 Pages: 1-9
  • Peer Reviewed
• [Journal Article] Evaluation of In vivo Radiosensitizing Activity of Etanidazole as Hypoxic Radiosensitizer Using Tumor-bearing Chick Embryo. (2011)
  • Author(s): Abe C, Uto Y, Nakae T, Shinmoto Y, Sano K, Nakata H, Teraoka M, Endo Y, Maezawa H, Masunaga S, et al.
  • Journal Title: Journal of Radiation Research Volume: 52 Pages: 208-214
  • Peer Reviewed
• [Journal Article] Synthesis and evaluation of cyclic RGD-boron cluster conjugates to develop tumor-selective boron carriers for boron neutron capture therapy. (2011)
  • Author(s): Kimura S, Masunaga S, Harada T, et al.
  • Journal Title: Bioorganic & Medical Chemistry Volume: 19 Pages: 1721-1728
  • Peer Reviewed
• [Journal Article] Usefulness of combined use of hexamethylenetetramine in the treatment of solid tumors: its independency of p53 status. (2010)
  • Author(s): Masunaga S, Tano K, Nakamura J, Watanabe M, Kashino G, Takahashi A, Tanaka H, Suzuki M, Kinashi Y, Ohnishi K, Ohnishi T, Ono K.
  • Journal Title: J Radiat Res 51 Pages: 27-35
  • Peer Reviewed
• [Journal Article] Adverse effect of mild temperature hyperthermia combined with hexamethylene- tetramine in the treatment of solid tumors : compared with its effect combined with tirapazamine. (2010)
  • Author(s): Masunaga S, Tano K, Nakamura J, Watanabe M, Kashino G, Suzuki M, Kinashi Y, Ono K.
  • Journal Title: Exp Therapeut Med 1 Pages: 169-174
  • Peer Reviewed
• [Journal Article] Influence of manipulating hypoxia in solid tumors on radiation dose-rate effect in vivo, referring to that in quiescent cell population. (2010)
  • Author(s): Masunaga S, Hirayama R, Uzawa A, Kashino G, Takata T, Suzuki M, Kinashi Y, Liu Y, Koike S, Ando K, Ono K.
  • Journal Title: Jpn J Radiol 28 Pages: 132-142
  • Peer Reviewed
• [Journal Article] Evaluation of the radiosensitivity of the oxygenated tumor cell fractions in quiescent cell populations within solid tumors. (2010)
  • Author(s): Masunaga S, Nagasawa H, Liu Y, Sakurai Y, Tanaka H, Kashino G, et al.
  • Journal Title: Radiat Res 174 Pages: 459-466
  • Peer Reviewed
• [Journal Article] Significance of manipulating tumor hypoxia and radiation dose rate in terms of local tumor response and lung metastatic potential, referring to the response of quiescent cell populations. (2010)
  • Author(s): Masunaga S, Matsumoto Y, Kashino G, Hirayama R, et al.
  • Journal Title: Br J Radiol 83 Pages: 776-784
  • Peer Reviewed
• [Journal Article] Recent advances in the biology of heavy-ion cancer therapy. (2010)
  • Author(s): Hamada N, Imaoka T, Masunaga S, Ogata T, et al.
  • Journal Title: J Radiat Res 51 Pages: 365-383
  • Peer Reviewed
• [Journal Article] An alternative mechanism for radioprotection by dimethyl sulfoxide; possible facilitation of DNA double-strand break repair. (2010)
  • Author(s): Kashino G, Liu Y, Suzuki M, Masunaga S, et al.
  • Journal Title: J Radiat Res 51 Pages: 733-740
  • NAID: 10026964239
  • Peer Reviewed
• [Journal Article] Evaluation of In vivo Radiosensitizing Activity of Etanidazole as Hypoxic Radiosensitizer Using Tumor- bearing Chick Embryo. (2010)
  • Author(s): Abe C, Uto Y, Nakae T, Shinmoto Y, Sano K, Nakata H, Teraoka M, Endo Y, Maezawa H, Masunaga S, et al.
  • Journal Title: J Radiat Res 52 Pages: 208-214
  • Peer Reviewed
• [Journal Article] 加速器中性子源によるホウ素中性子捕捉療法の展望 (2010)
  • Author(s): 小野公二、鈴木実、増永慎一郎、劉勇、近藤夏子、木梨友子、菓子野元郎、櫻井良憲、田中浩基、丸橋晃
  • Journal Title: 映像情報メディカル 42(12) Pages: 1038-1041
• [Journal Article] 休止期腫瘍細胞の挙動から見た分割照射 (2010)
  • Author(s): 増永慎一郎、櫻井良憲、菓子野元郎、鈴木実、田中浩基、劉勇、近藤夏子、木梨友子、平山亮一、松本孔貴、鵜澤玲子、小池幸子、安藤興一、丸橋晃、小野公二
  • Journal Title: 癌の臨床(Jpn J Cancer Clin) 56(6) Pages: 451-456
  • Peer Reviewed
• [Journal Article] Evaluation of the radiosensitivity of the oxygenated tumor cell fractions in quiescent cell populations within solid tumors. (2010)
  • Author(s): Masunaga S, Nagasawa H, Liu Y, Sakurai Y, Tanaka H, Kashino G, et al.
  • Journal Title: Radiation Research Volume: 174 Pages: 459-466
  • Peer Reviewed
• [Journal Article] Significance of manipulating tumor hypoxia and radiation dose rate in terms of local tumor response and lung metastatic potential, referring to the response of quiescent cell populations. (2010)
  • Author(s): Masunaga S, Matsumoto Y, Kashino G, Hirayama R, et al.
  • Journal Title: British Journal of Radiology Volume: 83 Pages: 776-784
  • Peer Reviewed
• [Journal Article] Recent advances in the biology of heavy-ion cancer therapy. (2010)
  • Author(s): Hamada N, Imaoka T, Masunaga S, Ogata T, et al.
  • Journal Title: Journal of Radiation Research Volume: 51 Pages: 365-383
  • Peer Reviewed
• [Journal Article] An alternative mechanism for radioprotection by dimethyl sulfoxide ; possible facilitation of DNA double-strand break repair. (2010)
  • Author(s): Kashino G, Liu Y, Suzuki M, Masunaga S, et al.
  • Journal Title: Journal of Radiation Research Volume: 51 Pages: 733-740
  • NAID: 10026964239
  • Peer Reviewed
• [Journal Article] Influence of manipulating hypoxia in solid tumors on radiation dose-rate effect in vivo, referring to that in quiescent cell population. (2010)
  • Author(s): Masunaga S, Hirayama R, Uzawa A, Kashini G, Takata T, Suzuki M, Kinashi Y, Liu Y, Koike S, Ando K, Ono K
  • Journal Title: Jpn j Radiol 28 Pages: 132-142
  • Peer Reviewed
• [Journal Article] Usefulness of combined use of hexamethylenetetramine in the treatment of solid tumors : its independency of p53 status. (2010)
  • Author(s): Masunaga S, Tano K, Nakamura J, Watanabe M, Kashino G, Takahashi A, Tanaka H, Suzuki M, Kinashi Y, Ohnishi K, Ohnishi T, Ono K
  • Journal Title: J Radiat Res 51 Pages: 27-35
  • Peer Reviewed
• [Journal Article] Adverse effect of mild temperature hyperthermia combined with hexamethylenetetramine in the treatment of solid tumors : compared with its effect (2010)
  • Author(s): Masunaga S, Tano K, Nakamura J, Watanabe M, Kashino G, Suzuki M, Kinashi Y, Ono K
  • Journal Title: Exp Therapeut Med 1 Pages: 169-174
  • Peer Reviewed
• [Journal Article] The effect of postirradiation tumor oxygenation status on recovery from radiation-induced damage in vivo : with reference to that in quiescent cell populations. (2009)
  • Author(s): Masunaga S, Hirayama R, Uzawa A, Kashino G, Suzuki M, Kinashi Y, Liu Y, Koike S, Ando K, Ono K.
  • Journal Title: J Cancer Res Clin Oncol 135 Pages: 1109-1116
  • NAID: 120001624124
  • Peer Reviewed
• [Journal Article] Usefulness of hexamethylenetetramine in combination with chemotherapy using free and pegylated liposomal doxorubicin in vivo, referring to the effect on quiescent cells. (2009)
  • Author(s): Masunaga S, Kono K, Nakamura J, Tano K, Yoshida H, Watanabe M, Kashino G, Suzuki M, Kinashi Y, Liu Y, Ono K.
  • Journal Title: Oncol Rep 21 Pages: 1307-1312
  • Peer Reviewed
• [Journal Article] Significance of hypoxia manipulation in solid tumors in the effect on lung metastases in radiotherapy, with reference to its effect on the sensitivity of intratumor quiescent cells. (2009)
  • Author(s): Masunaga S, Matsumoto Y, Hirayama R, Kashino G, Tanaka H, Suzuki M, Kinashi Y, Liu Y, Ando K, Ono K.
  • Journal Title: Clin Exp Metastasis 26 Pages: 693-700
  • Peer Reviewed
• [Journal Article] Evaluation of the potential of hexamethylene- tetramine in combination with γ-ray irradiation and cisplatin treatment in vivo, compared with tirapazamine. (2009)
  • Author(s): Masunaga S, Tano K, Watanabe M, Kashino G, Suzuki M, Kinashi Y, Ono K, Nakamura J.
  • Journal Title: Br J Radiol 82 Pages: 392-400
  • Peer Reviewed
• [Journal Article] Inductions of DNA double strand breaks and cellular migrations through the bystander effects in the cells irradiated with slit type microplanar beam of the SPring-8 synchrotron. (2009)
  • Author(s): Kashino G, Kondoh T, Nariyama N, Umetani K, Ohigashi T, Shinohara K, Kurihara A, Fukumoto M, Tanaka H, Maruhashi A, Suzuki M, Kinashi Y, Liu Y, Masunaga S, Watanabe M, Ono K.
  • Journal Title: Int J Radiat Oncol Biol Phys 74(1) Pages: 229-236
  • Peer Reviewed
• [Journal Article] A simple and rapid method for neasurement of 10B-para-boronophenylalanine in the blood for boron neutron capture therapy using fluorescence spectrophotometry. (2009)
  • Author(s): Kashino G, Furutani S, Suzuki M, Liu Y, Nagata K, Masunaga S, Maruhashi A, Tanaka H, Sakurai Y, Kinashi Y, Fujii N, Ono K.
  • Journal Title: J Radiat Res Vol.50, No.4 Pages: 377-382
  • Peer Reviewed
• [Journal Article] γ-Ray Irradiation Enhanced Boron-10 Compound Accumulation in Murine Tumors. (2009)
  • Author(s): Liu Y, Nagata K, Masunaga S, Suzuki M, Kashino G, Kinashi Y, Tanaka H, Sakurai Y, Maruhashi A, Ono K.
  • Journal Title: J Radiat Res 50 Pages: 553-557
  • NAID: 10025913134
  • Peer Reviewed
• [Journal Article] Impact of accelerator-based boron neutron capture therapy (AB-BNCT) on the treatment of multiple liver tumors and malignant pleural mesothelioma. (2009)
  • Author(s): Suzuki M, Tanaka H, Sakurai Y, Kashino G, Liu Y, Masunaga S, Kinashi Y, Mitsumoto T, Yajima S, Tsutsui H, Sato T, Maruhashi A, Ono K.
  • Journal Title: Radiother Oncol 92 Pages: 89-95
  • Peer Reviewed
• [Journal Article] Characteristics comparison between a cyclotron-based neutron source and KUR-HWNIF for boron neutron capture therapy. (2009)
  • Author(s): Tanaka H, Sakurai Y, Suzuki M, Masunaga S, Kinashi Y, Kashino G, Liu Y, Mitsumoto T, Yajima S, Tsutsui H, Maruhashi A, Ono K.
  • Journal Title: Nuclear Instruments and Methods in Physics Research B 267 Pages: 1970-1977
  • Peer Reviewed
• [Journal Article] 休止期腫瘍細胞への効果も考慮するγ線照射と比べた重イオン線照射後の感受性及び回復現象の解析 (2009)
  • Author(s): 増永慎一郎、平山亮一、鵜澤玲子、小池幸子、松本孔貴、菓子野元郎、劉勇、鈴木実、木梨友子、安藤興一、古澤佳也、小野公二
  • Journal Title: 放射線生物研究 44(2) Pages: 190-198
  • NAID: 130006999718
  • Peer Reviewed
• [Journal Article] 放射線障害からの回復と腫瘍内の低酸素状況との関連性分析に基づく放射線増感の可能性について-休止期腫瘍細胞に対する効果からの分析- (2009)
  • Author(s): 増永慎一郎、菓子野元郎、鈴木実、劉勇、木梨友子、永田憲司、小野公二
  • Journal Title: 癌の臨床 55(4) Pages: 225-229
  • Peer Reviewed
• [Journal Article] γ線照射または化学療法時に併用されるヘキサメチレンテトラミンの有用性について (2009)
  • Author(s): 増永慎一郎、田野恵三、中村純、河野健司、渡邉正巳、鈴木実、菓子野元郎、木梨友子、劉勇、小野公二
  • Journal Title: 放射線生物研究 44 Pages: 472-482
  • NAID: 40016956274
  • Peer Reviewed
• [Journal Article] The effect of postirradiation tumor oxygenation status on recovery from radiation-induced damage in vivo : with reference to that in quiescent cell populations. (2009)
  • Author(s): Masunaga S, Hirayama R, Uzawa A, Kashino G, Suzuki M, Kinashi Y, Liu Y, Koike S, Ando K, Ono K
  • Journal Title: J Cancer Res Clin Oncol 135 Pages: 1109-1116
  • NAID: 120001624124
  • Peer Reviewed
• [Journal Article] Significance of hypoxia manipulation in solid tumors in the effect on lung metastases in radiotherapy, with reference to its effect on the sensitivity of intratumor quiescent (2009)
  • Author(s): Masunaga S, Matsumoto Y, Hirayama R, Kashino G, Tanaka H, Suzuki M, Kinashi Y, Liu Y, Ando K, Ono
  • Journal Title: Clin Exp Metastasis 26 Pages: 693-700
  • Peer Reviewed
• [Journal Article] Evaluation of the potential of hexamethylenetetramine in combination with gamma-ray irradiation and cisplatin treatment in vivo, compared with tirapazamine. (2009)
  • Author(s): Masunaga S, Tano K, Watanabe M, Kashino G, Suzuki M, Kinashi Y, Ono K, Nakamura J
  • Journal Title: Br J Radiol 82 Pages: 392-400
  • Peer Reviewed
• [Journal Article] Usefulness of hexamethylenetetramine in combination with chemotherapy using free and pegylated liposomal doxorubicin in vivo, referring to the effect on quiescent cells. (2009)
  • Author(s): Masunaga S, Kono K, Nakamura J, Tano K, Yoshida H, Watanabe M, Kashino G, Suzuki M, Kinashi Y, Liu Y, Ono K
  • Journal Title: Oncol Rep 21 Pages: 1307-1312
  • Peer Reviewed
• [Journal Article] 放射線障害からの回復と腫瘍内の低酸素状況との関連性分析に基づく放射線増感の可能性について-休止期腫瘍細胞に対する効果からの (2009)
  • Author(s): 増永慎一郎、菓子野元郎、鈴木実、劉勇、木梨友子、永田憲司、小野公二
  • Journal Title: 癌の臨床(Jpn J Cancer Clin) 55 Pages: 225-229
  • Peer Reviewed
• [Journal Article] 休止期腫瘍細胞への効果も考慮するγ線照射と比べた重イオン線照射後の感受性及び回復現象の解析 (2009)
  • Author(s): 増永慎一郎、平山亮一、鵜澤玲子、小池幸子、松本孔貴、菓子野元郎、劉勇、鈴木実、木梨友子、安藤興一、古澤佳也、小野公二
  • Journal Title: 放射線生物研究(Radiation Biology Research Communications) 44 Pages: 190-198
  • NAID: 130006999718
  • Peer Reviewed
• [Journal Article] γ線照射または化学療法時に併用されるヘキサメチレンテトラミンの有用性について (2009)
  • Author(s): 増永慎一郎、田野恵三、中村純、河野健司、渡邉正巳、鈴木実、菓子野元郎、木梨友子、劉勇、小野公二
  • Journal Title: 放射線生物研究(Radiation Biology Research Communications) 44 Pages: 472-482
  • NAID: 40016956274
  • Peer Reviewed
• [Journal Article] Evalution of the potential of hexamethylenetetramine in combination with gamma-ray irradiation and cisplatin treatment in vivo, compared with tirapazamine. (2009)
  • Author(s): Masunaga S, Tano K, Watanabe M, Kashino G, Suzuki M, Kinashi Y, Ono K, Nakamura J
  • Journal Title: British Journal of Radiology 82 Pages: 392-400
  • Peer Reviewed
• [Journal Article] The effect of postirradiation tumor oxygenation status on recovery from radiation-induced damage in vivo : with reference to that in quiescent cell populations. (2009)
  • Author(s): Masunaga S, Hirayama R, Uzawa A, Kashmo G, Suzuki M, Kinashi Y, Liu Y, Koike S, Ando K, Ono K.
  • Journal Title: Journal of Cancer Research and Clinical Oncology (in press)
  • NAID: 120001624124
  • Peer Reviewed
• [Journal Article] 休止期腫瘍細胞への効果も考慮するγ線照射と比べた重イオン線照射後の感受性及び回復現象の解析 (2009)
  • Author(s): 増永慎一郎, 平山亮一, 鵜澤玲子, 小池幸子, 松本孔貴, 菓子野元郎, 劉勇, 鈴木実, 木梨友子, 安藤興一, 古澤佳也, 小野公二
  • Journal Title: 放射線生物研究(Radiation Biology Research Communications) (in press)
  • NAID: 130006999718
• [Journal Article] 放射線障害からの回復と腫瘍内の低酸素状況との関連性分析に基づく放射線増感の可能性について-休止期腫瘍細胞に対する効果からの分析- (2009)
  • Author(s): 増永慎一郎, 菓子野元郎, 鈴木実, 劉勇, 木梨友子, 永田憲司, 小野公二
  • Journal Title: 癌の臨床(Japanese Journal of Cancer Clinics) (in press) 55
• [Journal Article] Responses of total and quiescent cell populations in solid tumors to carbon ion beam irradiation (290 MeV/u) in vivo. (2008)
  • Author(s): Masunaga S, Ando K, Uzawa A, Hirayama R, Furusawa Y, Koike S, Ono K.
  • Journal Title: Radiat Med 26(5) Pages: 270-277
  • Peer Reviewed
• [Journal Article] The radiosensitivity of total and quiescent cell populations in solid tumors to 290 MeV/u carbon ion beam irradiation in vivo. (2008)
  • Author(s): Masunaga S, Ando K, Uzawa A, Hirayama R, Furusawa Y, Koike S, Ono K.
  • Journal Title: Acta Oncol 19 Pages: 1-7
  • Peer Reviewed
• [Journal Article] Tissue oxygenation in a murine SCC VII tumor after X-ray irradiation as determined by EPR spectroscopy. (2008)
  • Author(s): Fujii H, Sakata K, Katsumata Y, Sato R, Kinouchi M, Someya M, Masunaga S, Hareyama M, Hirata H.
  • Journal Title: Radiother Oncol 86 Pages: 354-360
  • Peer Reviewed
• [Journal Article] A novel concept of treatment of diffuse or multiple pleural tumors by boron neutron capture therapy (BNCT). (2008)
  • Author(s): Suzuki M, Endo K, Satoh H, Sakurai Y, Kumada H, Kimura H, Masunaga S, Kinashi Y, Nagata K, Maruhashi A, Ono K.
  • Journal Title: Radiother Oncol 88 Pages: 192-195
  • Peer Reviewed
• [Journal Article] Treatment results of boron neutron capture therapy using intra-arterial administration of boron compounds for recurrent head and neck cancer. (2008)
  • Author(s): Fuwa N, Suzuki M, Sakurai Y, Nagata K, Kinashi Y, Masunaga S, Maruhashi A, Imahori Y, Kodaira T, Tachibana H, Nakamura T, Ono K
  • Journal Title: Br J Radiol 81 Pages: 749-752
  • Peer Reviewed
• [Journal Article] Responses of total and quiescent cell populations in solid tumors to carbon ion beam irradiation(290MeV/u)in vivo. (2008)
  • Author(s): Masunaga S, Ando K, Uzawa A, Hirayama R, Furusawa Y, Koike S, Ono K.
  • Journal Title: Radiation Medicine 26(5) Pages: 270-277
  • Peer Reviewed
• [Journal Article] The radiosensitivity of total and quiescent cell populations in solid tumors to 290 MeV/u carbon ion beam irradiation in vivo. (2008)
  • Author(s): Masunaga S, Ando K, Uzawa A, Hirayama R, Furusawa Y, Koike S, Ono K.
  • Journal Title: Acta Oncologica 19 Pages: 1-7
  • Peer Reviewed
• [Journal Article] Reducing intratumor acute hypoxia through bevacizumab treatment, referring to the response of quiescent tumor cells and metastatic potential.
  • Author(s): Masunaga S, Liu Y, Tanaka H, Sakurai Y, Kashino G, et al.
  • Journal Title: British Journal of Radiology Volume: (in press)
  • Peer Reviewed
• [Journal Article] Usefulness of hexamethylenetetramine in combination with chemotherapy using free and pegylated liposomal doxorubicin in vivo, referring to the effect on quiescent cells.
  • Author(s): Masunaga S, Kono K, Nakamura J, Tano K, Yoshida H, Watanabe M, Kashino G, Suzuki M, Kinashi Y, Liu Y, Ono K.
  • Journal Title: Oncology Reports (in press)
  • Peer Reviewed
• [Presentation] アバスチン処理による固形腫瘍内急性低酸素細胞分画の低下と肺転移抑制効果について (2011)
  • Author(s): 増永慎一郎、劉勇、田中浩基, 他
  • Organizer: 第13回癌治療増感研究シンポジウム
  • Place of Presentation: 猿沢荘,奈良
• [Presentation] アバスチン処理による固形腫瘍内急性低酸素細胞分画の低下と肺転移抑制効果について (2011)
  • Author(s): 増永慎一郎、劉勇、田中浩基, 他
  • Organizer: 第13回治療増感研究シンポジウム
  • Place of Presentation: 奈良、猿沢荘(招待講演)
• [Presentation] 休止期腫瘍細胞の挙動から見た分割照射 (2010)
  • Author(s): 増永慎一郎、鈴木実、菓子野元郎、木梨友子、安藤興一、小野公二
  • Organizer: 第40回放射線による制癌シンポジウム
  • Place of Presentation: 札幌
  • Year and Date: 2010-07-10
• [Presentation] 休止期腫瘍細胞の挙動から見た分割照射 (2010)
  • Author(s): 増永慎一郎、鈴木実、菓子野元郎、木梨友子、安藤興一、小野公二
  • Organizer: 第40回放射線による制癌シンポジウム
  • Place of Presentation: 札幌(招待講演)
  • Year and Date: 2010-07-10
• [Presentation] 静止期腫瘍細胞の反応も加味した、腫瘍内酸素化状況の操作と照射線量率が放射線治療後の局所腫瘍制御と肺転移に及ぼす影響 (2010)
  • Author(s): 増永慎一郎、松本孔貴、菓子野元郎, 他
  • Organizer: 第16回国際癌治療増感研究会
  • Place of Presentation: 岐阜
  • Year and Date: 2010-06-19
• [Presentation] 休止期腫瘍細胞の挙動をも加味した腫瘍内酸素化状態の操作が及ぼす放射線照射後の肺転移への影響 (2010)
  • Author(s): 増永慎一郎、松本孔貴、平山亮一、菓子野元郎, 他
  • Organizer: 日本医学放射線学会第69回総会
  • Place of Presentation: パシフィコ横浜,横浜
  • Year and Date: 2010-04-11
• [Presentation] 休止期腫瘍細胞の挙動をも加味した腫瘍内酸素化状態の換作が及ぼす放躯線照射後の肺転移への影響 (2010)
  • Author(s): 増永慎一郎、松本孔貴、平山亮一、菓子野元郎, 他
  • Organizer: 日本医学放射線学会第69回総会
  • Place of Presentation: 横浜(パシフィコ横浜)
  • Year and Date: 2010-04-11
• [Presentation] Reoxygenation現象の解析と低酸素細胞分画に関するin vivo治療生物的考察 (2010)
  • Author(s): 増永慎一郎
  • Organizer: 第12回癌治療増感研究シンポジウム
  • Place of Presentation: 奈良
  • Year and Date: 2010-02-14
• [Presentation] Influence of manipulating intratumor oxygenation status on radiation dose-rate effect in vivo, referring to that in quiescent tumor cell population. (2010)
  • Author(s): 増永慎一郎, 平山亮一, 鵜澤玲子, et al.
  • Organizer: The 49th Annual Meeting of the Particle Therapy Co-Operative Group.
  • Place of Presentation: Maebashi, Gunma, Japan.
• [Presentation] The effects of heavy-ion and photon beams to mouse malignant melanoma cell line having highly metastatic potential. (2010)
  • Author(s): Matsumoto Y, Koike S, Uzawa A, Hirayama R, Okayasu R, Ando K, Masunaga S, Furusawa Y
  • Organizer: The 49th Annual Meeting of the Particle Therapy Co-Operative Group.
  • Place of Presentation: Maebashi, Gunma, Japan.
• [Presentation] Influence of manipulating tumor hypoxia including mild hyperthermia and radiation dose rate on local control and lung metastasis in radiotherapy. (2010)
  • Author(s): Masunaga S, Matsumoto Y, Kashino G, et al.
  • Organizer: The 5th Asian Congress of Hyperthermic Oncology/The 27th Japanese Congress of Thermal Medicine
  • Place of Presentation: Hakata, Fukuoka, Japan.
• [Presentation] Detection of the radio-sensitivity of oxygenated cell fractions in quiescent cell populations within solid tumors. (2010)
  • Author(s): Masunaga S, Nagasawa H, Liu Y, et al.
  • Organizer: The 56th Annual Meeting of Radiation Research Society
  • Place of Presentation: Maui, Hawaii, USA.
• [Presentation] The usefulness of mild temperature hyperthermia combined with a new hypoxia-oriented 10B compund, TX-2100 for BNCT. (2010)
  • Author(s): Masunaga S, Nagasawa H, Sakurai Y, et al.
  • Organizer: The 14th International Congress on Neutron Capture Therapy
  • Place of Presentation: Buenos Aires, Argentina
• [Presentation] 固形腫瘍内の酸素化休止期腫瘍細胞分画の放射線感受性及び回復能検出の試み (2010)
  • Author(s): 増永慎一郎、永澤秀子、劉勇, 他
  • Organizer: 日本放射線影響学会第53回大会
  • Place of Presentation: 京都テルサ,京都
• [Presentation] アバスチン処理後の血管正常化腫瘍における急性低酸素細胞分画の解除と肺転移抑制効果 (2010)
  • Author(s): 増永慎一郎、劉勇、櫻井良憲, 他
  • Organizer: 日本放射線腫瘍学会第23回学術大会
  • Place of Presentation: 舞浜、千葉
• [Presentation] 固形腫瘍内の酸素化休止期腫瘍細胞の放射線感受性検出の試み (2010)
  • Author(s): 増永慎一郎、永澤秀子、菓子野元郎、鈴木実、小野公二
  • Organizer: 第69回日本癌学会学術総会
  • Place of Presentation: 大阪国際会議場,大阪
• [Presentation] Detection of the radio-sensitivity of oxygenated cell factions in quiescent cell populations within solid tumors. (2010)
  • Author(s): Masunaga S, Nagasawa H, Liu Y, et al.
  • Organizer: The 56th Annual Meeting of Radiation Research Society
  • Place of Presentation: Maui, Hawaii, USA.
• [Presentation] The usefulness of mild temperature hyperthermia combined with a new hypoxia-oriented ^<10>B compound, TX-2100 for BNCT. (2010)
  • Author(s): Masunaga S, Nagasawa H, Sakurai Y, et al.
  • Organizer: The 14th International Congress on Neutron Capture Therapy
  • Place of Presentation: Buenos Aires, Argentina
• [Presentation] 固形腫瘍内の酸素化休止期腫瘍細胞分画の放射線感受性及び回復能検出の試み (2010)
  • Author(s): 増永慎一郎、永澤秀子、劉勇, 他
  • Organizer: 日本放射線影響学会第53回大会
  • Place of Presentation: 京都
• [Presentation] アバスチン処理後の血管正常化腫瘍における急性低酸素細胞分画の解除と肺転移抑制効果 (2010)
  • Author(s): 増永慎一郎、劉勇、櫻井良憲, 他
  • Organizer: 日本放射線腫瘍学会第23回学術大会
  • Place of Presentation: 千葉、舞浜
• [Presentation] 固形腫瘍内の酸素化休止期腫瘍細胞の放射線感受性検出の試み (2010)
  • Author(s): 増永慎一郎、永澤秀子、菓子野元郎、鈴木実、小野公二
  • Organizer: 第69回日本癌学会学術総会
  • Place of Presentation: 大阪国際会議場
• [Presentation] 休止期腫瘍細胞の反応をも加味した腫瘍内酸素化状態の操作処置が及ぼす放射線照射後の肺転移への影響 (2009)
  • Author(s): 増永慎一郎、松本良貴、平山亮一、菓子野元郎、鈴木実、木梨友子、劉勇、小野公二
  • Organizer: 第7回がんとハイポキシア研究会
  • Place of Presentation: 京都
  • Year and Date: 2009-12-05
• [Presentation] 休止期腫瘍細胞の感受性をも加味した腫瘍内酸素化状態の操作処置が及ぼす放射線照射後の肺転移への影響の解析 (2009)
  • Author(s): 増永慎一郎、松本良貴、平山亮一、菓子野元郎、田中浩基、鈴木実、木梨友子、劉勇、安藤興一、小野公二
  • Organizer: 日本放射線影響学会第52回大会
  • Place of Presentation: 広島
  • Year and Date: 2009-11-11
• [Presentation] 遠隔制御も加味した局所腫瘍制御のための中性子捕捉療法の可能性について (2009)
  • Author(s): 増永慎一郎、櫻井良憲、鈴木実、菓子野元郎、田中浩基、木梨友子、劉勇、丸橋晃、小野公二
  • Organizer: 第6回日本中性子捕捉療法学会学術大会
  • Place of Presentation: 京都
  • Year and Date: 2009-09-20
• [Presentation] がんの治療生物学から見た中性子捕捉療法の特徴 (2009)
  • Author(s): 増永慎一郎、櫻井良憲、菓子野元郎、鈴木実、永田憲司、木梨友子、劉勇、田中浩基、丸橋晃、小野公二
  • Organizer: 日本放射線腫瘍学会第22回学術大会
  • Place of Presentation: 京都国際会議場、京都
  • Year and Date: 2009-09-18
• [Presentation] がんの治療生物学から見た中性子捕捉療法の特徴 (2009)
  • Author(s): 増永慎一郎、櫻井良憲、菓子野元郎、鈴木実、永田憲司、木梨友子、劉勇、田中浩基、丸橋晃、小野公二
  • Organizer: 日本放射線腫瘍学会第22回学術大会
  • Place of Presentation: 京都
  • Year and Date: 2009-09-18
• [Presentation] γ線又は加速重イオン線照射後の腫瘍の酸素化状態が及ぼす放射線損傷からの回復現象への影響 (2009)
  • Author(s): 増永慎一郎、平山亮一、鵜澤玲子、安藤興一、小池幸子、菓子野元郎、鈴木実、木梨友子、劉勇、小野公二
  • Organizer: 日本医学放射線学会第68回学術発表会
  • Place of Presentation: パシフィコ横浜、横浜
  • Year and Date: 2009-04-19
• [Presentation] γ線又は加速重イオン線照射後の腫瘍の酸素化状態が及ぼす放射線損傷からの回復現象への影響 (2009)
  • Author(s): 増永慎一郎、平山亮一、鵜澤玲子、安藤興一、小池幸子、菓子野元郎、鈴木実、木梨友子、劉勇、小野公二
  • Organizer: 日本医学放射線学会第68回学術発表会
  • Place of Presentation: 横浜
  • Year and Date: 2009-04-19
• [Presentation] Oxygenation status in irradiated tumors can produce an effect on recovery from radiation-induced damage in vivo. (2009)
  • Author(s): Masunaga S, Hirayama R, Ando K, Uzawa A, Koike S, Kashino G, Suzuki M, Kinashi Y, Liu Y, Ono K
  • Organizer: Fourth International Conference on Translational Research and Pre-Clinical Strategies in Radio-Oncology.
  • Place of Presentation: Centre International de Conferences Geneva
  • Year and Date: 2009-03-12
• [Presentation] Development of new tumor targeting <10>^B-carrier : Boron cluster-cyclic RGD conjugates for boron neutron capture therapy. (2009)
  • Author(s): Kimura S, Inaba Y, Kawamura Y, Ueda S, Okuda K, Masunaga S, Nagasawa H
  • Organizer: Presented at the 100th Annual Meeting of AACR
  • Place of Presentation: Denver, Colorado, USA.
• [Presentation] Hypoxia Manipulation in Solid Tumors Has the Potential to Influence Lung Metastases in Vivo. (2009)
  • Author(s): Masunaga S, Matsumoto Y, Hirayama R, Kashino G, Suzuki M, Kinashi Y, Liu Y, Ando K, Ono K
  • Organizer: Presented at the 51st Annual Meeting of the American Society for Therapeutic Radiology and Oncology.
  • Place of Presentation: Chicago, IL, USA.
• [Presentation] 休止期腫瘍細胞への効果も考慮するγ線照射と比べた重イオン線照射後の感受性及び回復現象の解析 (2008)
  • Author(s): 増永慎一郎、平山亮一、安藤興一、鵜澤玲子、古澤佳也、小池幸子、菓子野元郎、鈴木実、木梨友子、劉勇、小野公二
  • Organizer: 日本放射線影響学会第51回大会
  • Place of Presentation: 北九州国際会議場
  • Year and Date: 2008-11-16
• [Presentation] The potential of transferrin-polyethyleneglycol liposomes encapsulating GB-10 as 10B-Carriers for boron neutron capture therapy. (2008)
  • Author(s): Masunaga S, Kasaoka S, Maruyama K, Nigg D, Sakurai Y, Nagata K, Suzuki M, Kashino G, Kinashi Y, Tanaka H, Maruhashi A, Ono K
  • Organizer: the 13th International Congress on Neutron Capture Therapy
  • Place of Presentation: Palazzo dei Congressi-Villa Vittoria
  • Year and Date: 2008-11-05
• [Presentation] ガンマ線照射またはシスプラチン治療におけるヘキサメチレンテトラミン併用投与の有効性について-低酸素細胞毒併用時との比較- (2008)
  • Author(s): 増永慎一郎、渡邉正巳、菓子野元郎、鈴木実、小野公二
  • Organizer: 第67回日本癌学会学術総会
  • Place of Presentation: 名古屋国際会議場
  • Year and Date: 2008-10-28
• [Presentation] 放射線照射やシスプラチン投与時の併用薬剤としてのヘキサメチレンテトラミンの有用性 (2008)
  • Author(s): 増永慎一郎、田野恵三、渡邉正巳、菓子野元郎、鈴木実、小野公二、木梨友子、中村純
  • Organizer: 日本放射線腫瘍学会第21回学術大会
  • Place of Presentation: 札幌パークホテル
  • Year and Date: 2008-10-17
• [Presentation] 治療抵抗性休止期腫瘍細胞への効果解析を加味した治療完遂性の高い低温度温熱治療の癌治療併用処置としての有用性の考察 (2008)
  • Author(s): 増永慎一郎
  • Organizer: 日本放射線腫瘍学会第21回学術大会
  • Place of Presentation: 札幌パークホテル
  • Year and Date: 2008-10-16
• [Presentation] 低温度温熱処置による固形腫瘍特に休止期腫瘍細胞における放射線損傷からの回復の効率的抑制効果について (2008)
  • Author(s): 増永慎一郎、永田憲司、鈴木実、菓子野元郎、木梨友子、小野公二
  • Organizer: 日本ハイパーサーミア学会第25回大会
  • Place of Presentation: 中部大学,名古屋
  • Year and Date: 2008-09-13
• [Presentation] 低温度温熱処置による固形腫瘍特に休止期腫瘍細胞における放射線損傷からの回復の効率的抑制効果について (2008)
  • Author(s): 増永慎一郎, 永田憲司, 鈴木実, 菓子野元郎, 本梨友子, 小野公二
  • Organizer: 日本ハイパーサーミア学会第25回大会
  • Place of Presentation: 中部大学名古屋キャンパス
  • Year and Date: 2008-09-13
• [Presentation] (2008)
  • Author(s): 増永慎一郎、田野恵三、中村純、渡邉正巳、菓子野元郎、鈴木実、劉勇、木梨友子、小野公二
  • Organizer: 第10回関西ハイパーサーミア研究会、第19回高温度療法臨床研究会 合同研究会
  • Place of Presentation: 大阪国際交流センター
  • Year and Date: 2008-07-26
• [Presentation] 放射線照射、シスプラチン投与時の併用薬剤としてのヘキサメチレンテトラミン(HMTA)の有用性と低温度温熱処置(MTH)併用の意義について (2008)
  • Author(s): 増永慎一郎, 田野恵三, 中村純, 渡邉正巳, 菓子野元郎, 鈴木実, 劉勇, 木梨友子, 小野公二
  • Organizer: 第10回関西ハイパーサーミア研究会、第19回高温度療法臨床研究会 合同研究会
  • Place of Presentation: 大阪国際交流センター2階第C, D会議室
  • Year and Date: 2008-07-26
• [Presentation] 放射線障害からの回復と腫瘍内の低酸素状況との関連性分析に基づく放射線増感の可能性について-休止期腫瘍細胞に対する効果からの分析- (2008)
  • Author(s): 増永慎一郎、菓子野元郎、鈴木実、永田憲司、木梨友子、小野公二
  • Organizer: 第38回放射線による制癌シンポジウム
  • Place of Presentation: ホテル日航高知旭ロイヤル
  • Year and Date: 2008-06-20
• [Presentation] 休止期腫瘍細胞反応を加味したγ線及び加速炭素イオン線と比べた原子炉中性子線照射の抗腫瘍効果 (2008)
  • Author(s): 増永慎一郎、安藤興一、鵜澤玲子、平山亮一、櫻井良憲、丸橋晃、鈴木実、菓子野元郎、木梨友子、小野公二
  • Organizer: 日本医学放射線学会第67回総会
  • Place of Presentation: パシフィコ横浜、横浜
  • Year and Date: 2008-04-06
• [Presentation] The potential of transferrin- polyethylene- glycol liposomes encapsulating GB-10 as <10>^B-carriers for boron neutron capture therapy. (2008)
  • Author(s): Masunaga S, Kasaoka S, Maruyama K, Nigg D, Sakurai Y, Nagata K, Suzuki M, Kashino G, Kinashi Y, Tanaka H, Maruhashi A, Ono K
  • Organizer: the 13th International Congress on Neutron Capture Therapy
  • Place of Presentation: Firenze, Italy.
• [Book] 分割照射の基礎(がん・放射線療法2010)(大西洋、唐澤克之、唐澤久美子監修) (2010)
  • Author(s): 増永慎一郎
  • Publisher: (株)篠原出版新社
• [Book] がん・放財線療法2010(大西洋、唐澤克之、唐澤久美子 監修) (2010)
  • Author(s): 増永慎一郎:分割照射の基礎
  • Total Pages: 1320
  • Publisher: (株)篠原出版新社
• [Book] 乳腺腫瘍inハイパーサーミア がん温熱療法ガイドブック(pp. 92-95) (2008)
  • Author(s): 増永慎一郎, 光森通英, 西村恭昌, 平岡真寛
  • Total Pages: 200
  • Publisher: 日本ハイパーサーミア学会編、毎日健康サロン発行(2008年5月20日第1刷発行)
• [Book] 温熱感受性の修飾一腫瘍の温熱感受性を高める方法-in ハイパーサーミア がん温熱療法ガイドブック(pp. 146-147) (2008)
  • Author(s): 増永慎一郎, 小野公二
  • Total Pages: 200
  • Publisher: 日本ハイパーサーミア学会編、毎日健康サロン発行(2008年5月20日第1刷発行)