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Development of radiated immunotoxin anti-cancer drug and IL13-PE38QQR positron tracer

Research Project

Project/Area Number 20591498
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Radiation science
Research InstitutionYokohama City University

Principal Investigator

CHUMPOL Theeraladanon  Yokohama City University, 医学研究科, 特任准教授 (20448682)

Co-Investigator(Kenkyū-buntansha) INOUE Tomio  横浜市立大学, 医学研究科, 教授 (80134295)
康 芸  横浜市立大学, 医学研究科, 特任准教授 (60332607)
Project Period (FY) 2008 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2008: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
KeywordsIL-13受容体 / ポジトロン製剤 / 腫瘍イメージング / ^<90>Y標識 / IL-13PE Cytotoxin / イメージング製剤 / 薬剤合成 / DOTA
Research Abstract

We performed the basic research in vitro and in vivo experiments with Y-90 labeled IL-13PE Cytotoxin after agreement of material transfer with FDA CBER, and using IL-13 PE Cytotoxin that had been offered from FDA CBER Dr. Puri. Y-90 labeled IL-13PE Cytotoxin is expected the both effect to target IL-13 receptors (IL-13R) for cancer therapy and cellular damage by β-emitter, so Y-90 labeled IL-13PE Cytotoxin is expected for the new radiation anti-cancer Imunotoxin treatment.

Report

(4 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (1 results)

All 2009

All Presentation (1 results)

  • [Presentation] Synthesis and lebeling of a novel EGFR and HER-2 tyrosine Kinase inhibitor containing 4-anilinoquinoline-3-carbonitrile nucleus.2009

    • Author(s)
      Chumpol Theeraladanon, Ukihide Tateishi, Masaaki shiina, Ryogo Minamimoto, Hisashi Endo, Takashi Oka, Nobukazu Takahashi, Tomio Inouo
    • Organizer
      Society of Nuclear Medicine Annual Meeting
    • Place of Presentation
      Toronto, Canada
    • Related Report
      2010 Final Research Report

URL: 

Published: 2008-04-01   Modified: 2016-04-21  

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