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Establishment of a dose-conversion model for use in high-dose-per-fraction radiotherapy

Research Project

Project/Area Number 20591501
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Radiation science
Research InstitutionNagoya City University

Principal Investigator

SHIBAMOTO Yuta  Nagoya City University, 大学院・医学研究科, 教授 (20144719)

Co-Investigator(Kenkyū-buntansha) ITO Masato  名古屋市立大学, 大学院・医学研究科, 准教授 (20244569)
MURATA Rumi  名古屋市立大学, 大学院・医学研究科, 講師 (10444960)
Project Period (FY) 2008 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2008: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Keywords定位照射 / 放射線治療生物学 / LQモデル / 分割照射 / 線量換算
Research Abstract

The reliability of the linear-quadratic (LQ) formalism in assessing biological equivalence between single high and hypofractionated radiation doses were investigated using single cells, spheroids and murine tumors. Single doses of 2-26Gy and 2-5 fractions of 4-12Gy were used. The α/β ratio was obtained from the cell survival curves, and using it and the LQ formalism, equivalent single doses for the hypofractionated doses were calculated. They were then compared with actually-determined equivalent single doses for the hypofractionated doses. In all experiments, equivalent single doses for hypofractionated doses calculated from the LQ formalism were lower than the actually-measured biologically-equivalent single doses by 10-40%. Conversion of hypofractionated radiation doses to single doses using the LQ formalism underestimated the effect of hypofractionated radiation. In direct comparison of the 2- to 5-fraction schedules, respective dose-response curves almost overlapped when cell survival was plotted against actual radiation doses. However, the curves tended to shift downwards by increasing the fraction number when cell survival was plotted against biologically effective doses (BED) calculated using an α/β ratio for in vitro EMT6 cells. Thus, BED was inappropriate. Using the multi-target model, the compatibility improved at high doses, but still dose conversion was not perfect. Other biological models are now being investigated.

Report

(4 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (36 results)

All 2011 2010 2009 2008

All Journal Article (23 results) (of which Peer Reviewed: 23 results) Presentation (11 results) Book (2 results)

  • [Journal Article] Hypofractionated stereotactic body radiotherapy for primary and metastatic liver tumors using the Novalis image-guided system : Preliminary results regarding efficacy and toxicity.2010

    • Author(s)
      Iwata H, Shibamoto Y, Hashizume C, Mori Y, Kobayashi T, Hayashi N, Kosaki K, Ishikawa T, Kuzuya T, Utsunomiya S.
    • Journal Title

      Technol Cancer Res Treat 9

      Pages: 619-627

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Increases in the number of brain metastases detected at frame-fixed, thin-slice MRI for gamma knife surgery planning.2010

    • Author(s)
      Nagai A, Shibamoto Y, Mori Y, Hashizume C, Hagiwara M, Kobayashi T.
    • Journal Title

      Neuro-Oncology 12

      Pages: 1187-1192

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Clinical outcomes of stereotactic body radiotherapy for stage I non-small cell lung cancer using different doses depending on tumor size.2010

    • Author(s)
      Baba F, Shibamoto Y, Ogino H, Murata R, Sugie C, Iwata H, Otsuka S, Kosaki K, Nagai A, Murai T, Miyakawa A.
    • Journal Title

      Radiat Oncol 5

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Megavoltage photon beam attenuation by carbon fiber couch tops and its prediction using correction factors.2010

    • Author(s)
      Hayashi N, Shibamoto Y, Obata Y, Kimura T, Nakazawa H, Hagiwara M, Ikeya-Hashizume C, Mori Y, Kobayashi T.
    • Journal Title

      J Radiat Res 51

      Pages: 455-463

    • NAID

      10026564021

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Stereotactic radiotherapy using Novalis for craniopharyngioma adjacent to optic pathways.2010

    • Author(s)
      Hashizume C, Mori Y, Kobayashi T, Shibamoto Y, Nagai A, Hayashi N.
    • Journal Title

      J Neuro-Oncol 98

      Pages: 239-247

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Stereotactic radiotherapy using Novalis for skull base metastases developing with cranial nerve symptoms.2010

    • Author(s)
      Mori Y, Hashizume C, Kobayashi T, Shibamoto Y, Kosaki K, Nagai A.
    • Journal Title

      J Neuro-Oncol 98

      Pages: 213-219

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] High-dose proton therapy and carbon-ion therapy for stage I nonsmall cell lung cancer.2010

    • Author(s)
      Iwata H, Murakami M, Demizu Y, Miyawaki D, Terashima K, Niwa Y, Mima M, Akagi T, Hishikawa Y, Shibamoto Y.
    • Journal Title

      Cancer 116

      Pages: 2476-2485

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Clinical outcomes of stereotactic body radiotherapy for stage I non-small cell lung cancer using different doses depending on tumor size2010

    • Author(s)
      Baba F, Shibamoto Y, Ogino H, Murata R, 他
    • Journal Title

      Radiation Oncology

      Volume: 5

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Hypofractionated stereotactic body radiotherapy for primary and metastatic liver tumors using the Novalis image-guided system : Preliminary results regarding efficacy and toxicity2010

    • Author(s)
      Iwata H, Shibamoto Y, Hashizume C, 他
    • Journal Title

      Technol Cancer Res Treat

      Volume: 9 Pages: 619-627

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Megavoltage photon beam attenuation by carbon fiber couch tops and its prediction using correction factors2010

    • Author(s)
      Hayashi N, Shibamoto Y, 他
    • Journal Title

      J Radiat Res

      Volume: 51 Pages: 455-463

    • NAID

      10026564021

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Current developments in the radiotherapy approach to elderly and frail patients with glioblastoma multiforme.2009

    • Author(s)
      Roa W, Xing JZ, Small C, Kortmann R, Mirimanoff R, Okunieff P, Shibamoto Y, Jeremic B.
    • Journal Title

      Expert Rev Anticancer Ther 9

      Pages: 1643-1650

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Estimation of errors associated with use of linear-quadratic formalism for evaluation of biologic equivalence between single and hypofractionated radiation doses: an in vitro study.2009

    • Author(s)
      Iwata H, Shibamoto Y, Murata R, Tomita N, Ayakawa S, Ogino H, Ito M.
    • Journal Title

      Int J Radiat Oncol Biol Phys 75

      Pages: 482-488

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Estimation of errors associated with use of linear-quadratic formalism for evaluation of biologic equivalence between single and hypofractionated radiation doses : an in vitro study.2009

    • Author(s)
      Iwata H, Shibamoto Y, Murata R, Tomita N, Ayakawa S, Ogino H, Ito M.
    • Journal Title

      Int J Radiat Oncol Biol Phys 75

      Pages: 482-488

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Radiotherapy for metastatic brain tumors.2009

    • Author(s)
      Shibamoto Y, Sugie C, Iwata H.
    • Journal Title

      Int J Clin Oncol 14

      Pages: 281-288

    • NAID

      10025863847

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Stereotactic body radiotherapy for stage I lung cancer and small lung metastasis : Evaluation of an immobilization system for suppression of respiratory tumor movement and preliminary results.2009

    • Author(s)
      Baba F, Shibamoto Y, Tomita N, Ikeya-Hashizume C, Oda K, Ayakawa S, Ogino H, Sugie C.
    • Journal Title

      Radiat Oncol 4

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Antitumor effects of a cyclooxygenase-2 inhibitor, meloxicam, alone and in combination with radiation and/or 5-fluorouracil in cultured tumor cells.2009

    • Author(s)
      Ayakawa S, Shibamoto Y, Sugie C, Ito M, Ogino H, Tomita N, Kumagai M, Murakami H, Sawa H.
    • Journal Title

      Mol Med Rep 2

      Pages: 621-626

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Estimation of errors associated with use of linear-quadratic formalism for evaluation of biologic equivalence between single and hypofractionated radiation doses : an in vitro study2009

    • Author(s)
      Iwata H, Shibamoto Y, Murata R, Tomita N, Ayakawa S, Ogino H, Ito M
    • Journal Title

      International Journal of Radiation Oncology Biology Physics 75

      Pages: 482-488

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Antitumor effects of a cyclooxygenase-2 inhibitor, meloxicam, alone and in combination with radiation and/or 5-fluorouracil in cultured tumor cells2009

    • Author(s)
      Ayakawa S, Shibamoto Y, Sugie C, Ito M, Ogino H, Tomita N, Kumagai M, Murakami H, Sawa H.
    • Journal Title

      Molecular Medicine Reports 2

      Pages: 621-626

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Helical tomotherapy for brain metastases : dosimetric evaluation of treatment plans and early clinical results.2008

    • Author(s)
      Tomita N, Kodaira T, Tachibana H, Nakamura T, Nakahara R, Inokuchi H, Shibamoto Y.
    • Journal Title

      Technol Cancer Res Treat 7

      Pages: 417-424

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Incidence of brain atrophy and decline in mini-mental state examination score after whole-brain radiotherapy in patients with brain metastases : a prospective study.2008

    • Author(s)
      Shibamoto Y, Baba F, Oda K, Hayashi S, Kokubo M, Ishihara S, Itoh Y, Ogino H, Koizumi M.
    • Journal Title

      Int J Radiat Oncol Biol Phys 72

      Pages: 1168-1173

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Primary central nervous system lymphoma in Japan : changes in clinical features, treatment and prognosis during 1985-2004.2008

    • Author(s)
      Shibamoto Y, Ogino H, Suzuki G, Takemoto M, Araki N, Isobe K, Tsuchida T, Nakamura K, Kenjo M, Suzuki K, Hosono M, Tokumaru S, Ishihara S, Kato K, Ii N, Hayabuchi N.
    • Journal Title

      Neuro-Oncology 10

      Pages: 560-568

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Effect of low-dose total-body irradiation on transplantability of tumor cells in syngeneic mice.2008

    • Author(s)
      Ito M, Shibamoto Y, Ayakawa S, Tomita N, Sugie C, Ogino H.
    • Journal Title

      J Radiat Res 49

      Pages: 197-201

    • NAID

      110006633662

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Biological effect of intermittent radiation exposure in vivo : recovery from sublethal damage versus reoxygenation.2008

    • Author(s)
      Tomita N, Shibamoto Y, Ito M, Ogino H, Sugie C, Ayakawa S, Iwata H.
    • Journal Title

      Radiother Oncol 86

      Pages: 369-374

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Presentation] 寡分割定位照射の線量換算にBED(LQモデル)を使用してはならない2011

    • Author(s)
      芝本雄太、大塚信哉、宮川聡史、岩田宏満
    • Organizer
      第23回日本高精度放射線外部照射研究会
    • Place of Presentation
      東京(秋葉原コンベンションホール)
    • Year and Date
      2011-02-11
    • Related Report
      2010 Annual Research Report
  • [Presentation] LQモデル線量換算式は何fractionから適用できるか?(第1報)2010

    • Author(s)
      芝本雄太、宮川聡史、大塚信哉、岩田宏満、竹本真也
    • Organizer
      第19回日本定位放射線治療学会シンポジウム
    • Place of Presentation
      大津
    • Year and Date
      2010-07-30
    • Related Report
      2010 Final Research Report
  • [Presentation] LQモデル線量換算式は何fractionから適用できるか?(第1報)2010

    • Author(s)
      芝本雄太、宮川聡史、大塚信哉、岩田宏満、竹本真也
    • Organizer
      第19回日本定位放射線治療学会
    • Place of Presentation
      大津(ピアザ淡海)
    • Year and Date
      2010-07-30
    • Related Report
      2010 Annual Research Report
  • [Presentation] 寡分割定位照射の基礎と臨床2010

    • Author(s)
      芝本雄太、荻野浩幸、綾川志保、宮川聡史、岩田宏満、大塚信哉
    • Organizer
      第40回放射線による制癌シンポジウム
    • Place of Presentation
      札幌
    • Year and Date
      2010-07-10
    • Related Report
      2010 Final Research Report
  • [Presentation] 寡分割定位照射の基礎と臨床2010

    • Author(s)
      芝本雄太
    • Organizer
      第40回放射線による制癌シンポジウム
    • Place of Presentation
      札幌(ホテルさっぽろ芸文館)
    • Year and Date
      2010-07-10
    • Related Report
      2010 Annual Research Report
  • [Presentation] 放射線生物学 臨床の立場から2010

    • Author(s)
      芝本雄太
    • Organizer
      第69回日本医学放射線学会総会教育講演
    • Place of Presentation
      横浜
    • Related Report
      2010 Final Research Report
  • [Presentation] 高精度放射線治療によるSLD修復と再酸素化2010

    • Author(s)
      芝本雄太
    • Organizer
      第12回癌治療増感研究シンポジウム
    • Place of Presentation
      奈良
    • Related Report
      2010 Final Research Report
  • [Presentation] 1回ないし少数回分割照射における線量の評価2009

    • Author(s)
      芝本雄太、森美雅
    • Organizer
      第18回日本定位放射線治療学会教育講演
    • Place of Presentation
      仙台
    • Year and Date
      2009-07-17
    • Related Report
      2010 Final Research Report
  • [Presentation] 1回ないし少数回分割照射における線量の評価2009

    • Author(s)
      芝本雄太, 森美雅
    • Organizer
      第18回日本定位放射線治療学会
    • Place of Presentation
      仙台
    • Year and Date
      2009-07-17
    • Related Report
      2009 Annual Research Report
  • [Presentation] 高精度放射線治療のための放射線生物学2009

    • Author(s)
      芝本雄太、岩田宏満、大塚信哉
    • Organizer
      平成21年度京都大学原子炉実験所専門研究会招待講演
    • Place of Presentation
      熊取
    • Related Report
      2010 Final Research Report
  • [Presentation] マウス腫瘍における1回大線量照射と少数回分割照射の生物学的等効果線量の検討2008

    • Author(s)
      大塚信哉, 芝本雄太, 他
    • Organizer
      日本放射線腫瘍学会第21回学術大会
    • Place of Presentation
      札幌パークホテル
    • Year and Date
      2008-10-16
    • Related Report
      2008 Annual Research Report
  • [Book] 三つの力で腫瘍だけをたたく「アイマックスがん治療」東京2009

    • Author(s)
      高橋豊、芝本雄太、岡本正人著
    • Publisher
      講談社
    • Related Report
      2010 Final Research Report
  • [Book] NPO法人ミーネット編:切らないがん治療~東海最先端ガイド~ 名古屋2008

    • Author(s)
      芝本雄太監修
    • Publisher
      中日新聞社
    • Related Report
      2010 Final Research Report

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Published: 2008-04-01   Modified: 2016-04-21  

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